Joint diseases and related surgery最新文献

{"title":"Predisposing factors for contralateral hip fractures in elderly patients over 80 years old.","authors":"Li-Ping Ma, Bei-Chen Cui, Jin-Qi Li, Zhao-Xing Tian","doi":"10.52312/jdrs.2026.2290","DOIUrl":"10.52312/jdrs.2026.2290","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to identify risk factors associated with contralateral hip fractures in elderly patients over 80 years old following an initial hip fracture.</p><p><strong>Patients and methods: </strong>Between May 2015 and April 2018, a total of 1,138 elderly patients (303 males, 805 females; median age: 85 years; interquartile range [IQR], 82 to 88 years) who were hospitalized for hip fractures were retrospectively analyzed. Data on demographics, comorbidities, and biochemical markers were collected during the initial hospitalization. Patients were followed for up to two years to identify cases of contralateral hip fractures. Risk factors were analyzed using univariate analyses and a Cox proportional hazards model using odds ratios (ORs) and confidence intervals (CIs).</p><p><strong>Results: </strong>Of the patients, 98 (8.61%) experienced a contralateral hip fracture within two years. The incidence rates at 12 months and 24 months were 4.3% and 8.61%, respectively. Multivariable analysis identified chronic obstructive pulmonary disease (OR = 0.393, 95% CI 0.183-0.841), increasing Charlson Comorbidity Index (OR = 1.308, 95% CI 1.029-1.662), lower extremity deep vein thrombosis (OR = 0.168, 95% CI 0.079-0.354), pneumonia (OR = 0.133, 95% CI 0.075-0.236), and urinary tract infection (OR = 0.113, 95% CI 0.058-0.220) as significant risk factors for contralateral hip fractures.</p><p><strong>Conclusion: </strong>Several key risk factors were found to be associated with contralateral hip fractures in elderly patients over 80 years old. Specifically, chronic obstructive pulmonary disease, increased Charlson Comorbidity Index, lower extremity deep vein thrombosis, pneumonia, and urinary tract infections significantly increased the risk of contralateral hip fractures. These findings highlight the importance of comprehensive assessment and targeted interventions in high-risk patients to mitigate the risk of subsequent fractures. Our results underscore the need for early identification of at-risk individuals and the implementation of preventive strategies to improve patient outcomes.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"37 2","pages":"314-324"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13374168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of WALANT on outcomes of flexor tenolysis.","authors":"Özgün Barış Güntürk, Deniz Dikmen Meral, Can Yener, Kubilay Erol, Anıl Koca","doi":"10.52312/jdrs.2026.2600","DOIUrl":"10.52312/jdrs.2026.2600","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the outcomes of the flexor tenolysis cases with wide-awake local anesthesia no tourniquet (WALANT) and to compare them with cases with other anesthesia types.</p><p><strong>Patients and methods: </strong>Between March 2004 and March 2024, a total of 104 patients with 150 fingers with flexor tenolysis (71 males, 33 females; mean age: 32.67 ± 11.64 years; range, 16 to 62 years) were included in the study. The WALANT group consisted of 41 patients with 53 fingers, while the conventional anesthesia group consisted of 63 patients with 97 fingers. Pre- and postoperative total active motion (TAM) gains were compared between the two groups and relevant factors were investigated.</p><p><strong>Results: </strong>Overall TAM gain was 47% in our study cohort. The TAM gain was 55% and 43% in the WALANT group and in the conventional anesthesia group, indicating a statistically significant difference (p = 0.005). The best TAM gains were observed in the clean-cut injury type. The TAM gains were better in the cases without fractures. Age was a significant factor in the tenolysis outcomes, and younger patients had improved outcomes.</p><p><strong>Conclusion: </strong>Our study results indicate a significant difference in the TAM gain between the WALANT and conventional methods. Taken together, we believe that the application of WALANT in tenolysis of flexor tendon adhesions represents a significant advancement in hand surgery. The ability to perform the procedure under local anesthesia while allowing for immediate assessment of tendon function enhances the surgical precision and results.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"37 2","pages":"510-518"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13386354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volumetric relationships of foot bones and the role of the talus in hallux valgus.","authors":"Yakup Ekinci, Ahmet Payas, Ahmet Yesevi Sarıaslan, Zeliha Kaya Erten, Feridun Arat, Sabri Batın","doi":"10.52312/jdrs.2026.2537","DOIUrl":"10.52312/jdrs.2026.2537","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the foot as a whole, to compare the foot bones in terms of volume, and investigate the role of the foot bones in the formation of hallux valgus (HV).</p><p><strong>Patients and methods: </strong>Between February 2024 and September 2024, a total of 21 patients (6 males, 15 females; mean age: 29.04 ± 5.21 years; range, 19 to 38 years) with an HVA of ≥ 30° and intermetatarsal angle (IMA) of ≥ 13° were included in this prospective study. The control group consisted of 18 patients (5 males, 13 females; mean age: 28.94 ± 5.56 years; range, 20 to 39 years) with an HVA of < 15°. Computed tomography (CT) images were uploaded to the 3D Slicer program, and the volumes of the foot bones were measured and calculated as percentages.</p><p><strong>Results: </strong>In terms of volume percentage, the mean talus (22.68 ± 1.62 vs. 21.37 ± 1.81; d = 0.78; 95% CI 0.10-1.44) and the fifth metatarsal (4.63 ± 0.85 vs. 4.15 ± 0.52; d = 0.65; 95% CI -0.01-1.29) were higher, while the mean cuboid volume (5.31 ± 0.71 vs. 5.89 ± 0.55; d = 0.90; 95% CI 0.23-1.57) was lower in the HV group, indicating a statistically significant difference (p<0.05). No significant difference was observed in the volume ratios between the bones of the medial and lateral rays (p ≥ 0.05). When medial ray bones were combined, the ratios of talus/medial cuneiform (d = 0.92) and (talus + 1^st metatarsal)/medial cuneiform (d = 0.82; 95% CI 0.20-1.52) were found to be significantly higher in the HV group (p < 0.05).</p><p><strong>Conclusion: </strong>Although genetic factors are widely considered to play a key role in HV development, we propose that the process originates more proximally, most likely at the level of the talus. Based on our study results, we conclude that an increase in talar volume may lead to a compensatory reduction in the volumes of the cuboid and medial cuneiform bones, initiating a sequence in which soft-tissue forces contribute to progressive pronation of the first metatarsal, ultimately resulting in HV.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"37 2","pages":"461-469"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13374309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond numbers: Clinical significance in orthopedic treatment outcomes.","authors":"Ethem Burak Oklaz, Erdem Aras Sezgin, O Şahap Atik","doi":"10.52312/jdrs.2026.57932","DOIUrl":"10.52312/jdrs.2026.57932","url":null,"abstract":"","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"37 2","pages":"289-290"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13374111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total knee arthroplasty with \"Collar Tightening Technique\" for advanced knee osteoarthritis with concurrent chronic posterolateral knee dislocation and lateral patellar dislocation: A case report.","authors":"Wen-Shuo Chang, Chi-Sheng Chien, Tsung-Mu Wu, Kin-Weng Wong","doi":"10.52312/jdrs.2026.2569","DOIUrl":"10.52312/jdrs.2026.2569","url":null,"abstract":"<p><p>Chronic posterolateral knee dislocation with concurrent lateral patellar dislocation is a rare and challenging pathology. Without appropriate treatment, it invariably leads to advanced osteoarthritis, frequently necessitating total knee arthroplasty. However, achieving optimal patellofemoral tracking remains a primary challenge, and no consensus on a definitive surgical technique exists. In this article, we introduce a novel \"Collar Tightening Technique\" to address this complex clinical scenario. A 66-year-old male with a complex medical history, including prior right knee medial collateral ligament/posterior cruciate ligament reconstruction, presented with chronic right knee pain with difficulty in ambulation. Imaging revealed advanced osteoarthritis, posterolateral knee dislocation, and lateral patellar dislocation with a fixed 20-degree tibial external rotation deformity. The patient underwent total knee arthroplasty, during which the collar tightening technique was employed to restore patellofemoral stability. This technique consisted of three key components: (1) an extensive lateral release, (2) distal and lateral advancement of the quadriceps tendon, and (3) medialization of the patellar component. A hinged prosthesis was utilized to address the underlying global instability. Postoperatively, the patient could walk smoothly with single cane assistance. In conclusion, restoring stable patellofemoral tracking is of paramount importance in complex total knee arthroplasty. The collar tightening technique provides an effective solution by combining dynamic stabilization from muscle advancement with static stabilization from component positioning. This comprehensive approach warrants consideration when a simple lateral retinacular release is insufficient to achieve proper patellofemoral alignment.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"37 2","pages":"565-571"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13374055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction of volar tilt using the lift technique with fixed-angle volar locking plate in distal radius fractures.","authors":"Ahmet Alperen Öztürk","doi":"10.52312/jdrs.2026.2644","DOIUrl":"10.52312/jdrs.2026.2644","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study is to evaluate the radiological effectiveness of restoring volar tilt in dorsally displaced distal radius fractures using the lift technique performed with a fixedangle volar locking plate.</p><p><strong>Patients and methods: </strong>Between January 2023 and February 2025, a total of 14 patients (5 males, 9 females; median age: 46.9 years; range, 32 to 72 years) with dorsally displaced intraarticular or extra-articular distal radius fractures who underwent fixation with a fixed-angle volar plate using the visually estimated lift technique were retrospectively analyzed. Fractures were classified according to the AO classification. Pre-lift and post-lift volar tilt angles as well as plate-shaft angles were measured from fluoroscopy images, and control volar tilt angles were measured from radiographs. Actual angular correction was defined as the difference between pre-lift and post-lift volar tilt angles.</p><p><strong>Results: </strong>Fracture types were AO Type A in nine patients, AO Type C in four patients, and AO Type B in one patient. The median volar tilt angle at the time of fracture was -24.9° (range, -4° to -56°). Following traction and reduction maneuvers, the median pre-lift volar tilt was -4.9° (range, -20° to 4°), the median post-lift volar tilt was 9.5° (range, 0° to 15°), and the median volar tilt at follow-up was 9.4° (range, 1° to 16°). Plate-shaft angles ranged from 6° to 25° (median: 14.2°). Actual angular correction ranged from 5° to 25°. In 11 cases (78.5%), intraoperative correction achieved the target range of 5° to 15°. In three cases (15.4%), volar tilt correction was insufficient, with final values of 0°, 3°, and 4°. The ratio (R) of actual angular correction to theoretical angular correction was approximately 0.67.</p><p><strong>Conclusion: </strong>The lift technique using a fixed-angle volar plate is a reliable and effective method for intraoperative correction of volar tilt in dorsally displaced distal radius fractures. The technique provides a valuable alternative, particularly in cases where manual reduction fails to achieve sufficient volar tilt restoration.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"37 2","pages":"454-460"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13386356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating deepresearch and deepthink in total knee arthroplasty patient education: ChatGPT-4o excels in comprehensiveness, Deepseek R1 leads in clarity and readability of orthopedic information.","authors":"Onur Gultekin, Michael T Hirschmann, Halil İbrahim Arıkan, Bekir Eray Kilinc, Baris Yilmaz, Süleyman Abul, Jumpei Inoue, Mahmut Enes Kayaalp","doi":"10.52312/jdrs.2026.2645","DOIUrl":"10.52312/jdrs.2026.2645","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to directly compare ChatGPT and DeepSeek, both equipped with DeepResearch/DeepThink capabilities, based on their responses to frequently asked questions (FAQs) on total knee arthroplasty (TKA).</p><p><strong>Materials and methods: </strong>Thirty frequently asked questions related to TKA were compiled from validated patient education sources, including American Academy of Orthopaedic Surgeons (AAOS) OrthoInfo, National Institute for Health and Care Excellence (NICE) guidelines, and popular patient discussion forums, and verified for clinical relevance by two independent arthroplasty surgeons. Two orthopedic surgeons, blinded to model identity, evaluated each response using a five-point Likert scale across five domains: accuracy, comprehensiveness, readability, relevance, and ethical and safety considerations. The maximum total score per response was 25. Readability was also assessed using the Flesch-Kincaid Grade Level (FKGL) and Flesch Reading Ease Score (FRES). Inter-rater and intra-rater reliability were calculated using intraclass correlation coefficients (ICCs).</p><p><strong>Results: </strong>The ChatGPT-4o scored significantly higher in comprehensiveness and clinical detail, whereas DeepSeek R1 produced responses with superior readability, indicated by a lower FKGL (7.5 vs. 10.2) and higher FRES (62.3 vs. 45.6) (p < 0.05). Both models demonstrated high accuracy and safety, with no factual errors identified. Intra-rater reliability was excellent (ICC > 0.81), and inter-rater agreement ranged from fair to substantial (ICC 0.31 to 0.63).</p><p><strong>Conclusion: </strong>Both ChatGPT-4o and DeepSeek R1 are capable of generating accurate, ethically sound, and clinically relevant educational content for patients undergoing TKA. While ChatGPT-4o offers more comprehensive information, DeepSeek R1 provides content that is more accessible to patients with lower health literacy. Model selection should be tailored to the target population to optimize educational effectiveness in clinical practice. The ability of real-time data retrieval to incorporate the most current clinical evidence and guideline updates may further enhance the educational quality, reliability, and clinical relevance of AI-generated patient information.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"37 2","pages":"470-476"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13374050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A meta-analysis of Allgöwer-Donati versus interrupted vertical mattress suturing in preventing postoperative incisional complications of calcaneal fracture surgery: A systematic review and meta-analysis.","authors":"Hua-Xin Lai, Li-Ping Peng, Lian-Hua Wu, Wei Ye","doi":"10.52312/jdrs.2026.2500","DOIUrl":"10.52312/jdrs.2026.2500","url":null,"abstract":"<p><strong>Objectives: </strong>In this meta-analysis, we systematically compared the efficacy of the Allgöwer-Donati suture technique versus the interrupted vertical mattress suture technique in preventing postoperative incision complications following calcaneal fracture surgery.</p><p><strong>Materials and methods: </strong>A systematic search of PubMed, Embase, the Cochrane Library, and Web of Science was conducted from their inceptions up to May 2025. This study included randomized-controlled trials (RCTs) involving adults (18-80 years) with closed calcaneal fractures who underwent open reduction and internal fixation (ORIF) via a lateral incision. The primary outcomes were surgical suture time, wound suture time, drainage tube removal time, and the incidence of postoperative complications. Standardized mean differences (SMDs) and odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using fixed-effect or random-effects models based on heterogeneity (I² statistic).</p><p><strong>Results: </strong>Eight RCTs comprising 640 patients were included. The Allgöwer-Donati technique significantly reduced surgical suture time (SMD = 0.81, 95% CI 0.22 to 1.39, p = 0.007; I² = 47%), drainage tube removal time (SMD = 4.94, 95% CI 4.42-5.47, p < 0.00001; I² = 65%), and wound suture time (SMD = -3.36, 95% CI -3.90 to -2.81, p < 0.00001; I² = 34%) compared to the interrupted vertical mattress technique. However, there was no significant difference in the overall rate of postoperative complications between the two techniques (OR = 1.32, 95% CI 0.95-1.82, p = 0.10; I² = 0%).</p><p><strong>Conclusion: </strong>The Allgöwer-Donati suture technique offers significant advantages in operative efficiency by reducing suture times and drainage duration without increasing the risk of postoperative complications compared to the interrupted vertical mattress technique. It represents a promising suturing option for calcaneal fracture surgery, particularly in settings valuing procedural efficiency.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"37 2","pages":"390-401"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13402922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of soluble guanylate cyclase activator vericiguat on fracture healing in rats.","authors":"Azat Dzhumukov, Bilal Karabak, Aziz Demirci, Ferhat Yıldırım Hoyur, Muhammed Çağatay Engin","doi":"10.52312/jdrs.2026.2655","DOIUrl":"10.52312/jdrs.2026.2655","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to assess the healing effects of vericiguat at various concentrations on rat femur fractures through clinical and radiological and biomechanical and histopathological assessments.</p><p><strong>Materials and methods: </strong>In this study, a total of 60 female Wistar-Albino rats were used. The study comprised of six rat groups with 10 rats in each group: Group 1 (normal controls), Group 2 (positive controls - only fracture), Group 3 (low-dose vericiguat - 3 mg/kg), Group 4 (high-dose vericiguat - 6 mg/kg), Group 5 (fracture + low-dose vericiguat), Group 6 (fracture + high-dose vericiguat). Under general anesthesia, standard closed fractures were created in the right femurs of rats in the fracture groups. Radiological examinations were performed on Days 7, 14, and 28. The Lane-Sandhu scoring system was used for radiological assessment. At the end of Day 28, the rats were sacrificed, and the fracture healing tissues were examined biomechanically and histologically using the Huo scale.</p><p><strong>Results: </strong>The 28^th day biomechanical assessment showed significant differences in maximum load values between the fractured groups (Group 2: 88.75 ± 23.25 N, Group 5: 83.54 ± 23.15 N, Group 6: 39.07 ± 10.38 N; p = 0.003). The stiffness values showed similar patterns (Group 2: 64.71 ± 45.52 N/mm, Group 5: 99.20 ± 43.82 N/mm, Group 6: 40.47 ± 19.27 N/mm; p = 0.088). In the histological evaluation according to the Huo scale, Group 5 showed the highest quality of healing (8.6 ± 1.14) and a significant difference was found between Group 2 and Group 5 (p = 0.009). Group 6 demonstrated necrosis in four out of 10 animals and severe inflammation in eight out of 10 animals. In the radiological evaluation on Days 7, 14, and 28, no statistically significant differences were observed between the groups according to the Lane-Sandhu scoring system (p = 0.811 on Day 14; p = 0.299 on Day 28).</p><p><strong>Conclusion: </strong>Our study results suggest that soluble guanylate cyclase (sGC) activators show promise for fracture healing treatment when used at specific concentrations, but their therapeutic range remains limited and their toxic effects at high doses need careful consideration.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"37 2","pages":"519-530"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13386387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of recombinant human bone morphogenetic protein-2 biomaterials in promoting bone regeneration: A systematic review and meta-analysis.","authors":"Yue Li, Jun Zhao, Chunxia Chen","doi":"10.52312/jdrs.2026.2523","DOIUrl":"10.52312/jdrs.2026.2523","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to systematically evaluate the efficacy and safety of recombinant human bone morphogenetic protein-2 (rhBMP-2) in promoting bone regeneration.</p><p><strong>Materials and methods: </strong>A comprehensive search of PubMed, Embase, Web of Science, and Scopus was conducted from inception to May 2024. Fifteen randomized-controlled trials involving 2,137 cases were included. Traditional and network meta-analyses were performed, machine learning techniques were applied to explore heterogeneity, and subgroup analyses were carried out to assess efficacy across anatomical sites including alveolar sockets, palatal clefts, and spinal fusion.</p><p><strong>Results: </strong>No significant difference was found in the overall bone healing rate between the rhBMP-2 and control groups (relative risk [RR] = 1.02, 95% confidence interval [CI] 0.87-1.20). However, rhBMP-2 demonstrated a significant advantage in spinal fusion (RR = 1.09, 95% CI 1.01-1.17) and a positive, although not statistically significant, trend in small oral and jaw bone defects. The incidence of serious adverse events was comparable (RR = 0.97, 95% CI 0.66-1.42). Network meta-analysis indicated that the overall success rate of bone regeneration with rhBMP-2 (odds ratio [OR] = 1.53, 95% CI 0.54-4.33) and other bone substitutes (OR = 1.42, 95% CI 0.39-5.21) did not significantly exceed autograft treatment, although both showed a trend toward superiority. Direct pairwise comparison revealed that rhBMP-2 was significantly more effective than autograft (OR = 1.54, 95% CI 1.02-2.33, p < 0.05), with low heterogeneity (I² = 0%).</p><p><strong>Conclusion: </strong>While the overall healing rate was comparable to controls, rhBMP-2 showed significant efficacy in spinal fusion and a favorable safety profile. Its effectiveness was context-specific, influenced by anatomical site and patient factors. These findings support the selective use of rhBMP-2 in specific clinical contexts such as spinal surgery, while further research is needed to optimize its application in other indications.</p>","PeriodicalId":73560,"journal":{"name":"Joint diseases and related surgery","volume":"37 2","pages":"325-343"},"PeriodicalIF":2.5,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13428272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}