JMA journal最新文献_第3页

Development of Adult Renal Tubular Organoids from Different Human Individuals in a Single Medium. 不同人成人肾小管类器官在单一培养基中的发育。

IF 1.5

JMA journal Pub Date : 2025-01-15 Epub Date: 2024-12-20 DOI: 10.31662/jmaj.2024-0244

Makiko Mori, Yutaro Mori, Yuki Nakao, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida

{"title":"Development of Adult Renal Tubular Organoids from Different Human Individuals in a Single Medium.","authors":"Makiko Mori, Yutaro Mori, Yuki Nakao, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida","doi":"10.31662/jmaj.2024-0244","DOIUrl":"10.31662/jmaj.2024-0244","url":null,"abstract":"Introduction: Organoids are miniature organs developed through technology. Kidney organoids that originate from human inducible pluripotent stem cells (iPSCs) were developed to recreate renal diseases. However, it is impossible to simultaneously produce kidney organoids from iPSCs of multiple individuals and in a single medium. We herein report the development of adult renal tubular organoids, namely, \"tubuloids,\" from primary renal epithelial cells from multiple human individuals in a single medium.Methods: Kidneys from eight patients who underwent nephrectomy due to malignancy were sectioned, and primary renal epithelial tubule cells were cultured; four had normal kidney function, and four had mild chronic kidney disease (CKD). Growth factors and Matrigel were added to the primary culture.Results: Primary cultured renal epithelial cells from normal kidneys exhibited a fine and swollen epithelial appearance, whereas those from kidneys with mild CKD were smaller and slightly elongated. Growth was faster in normal kidney cells than in mild CKD cells. At the beginning of the three-dimensionalization (day 0), normal renal tubuloids grew faster than mild CKD tubuloids. The difference in size between normal and mild CKD tubuloids was not obvious by day 5. Both tubuloid types had comparable sizes by day 21.Conclusions: Renal tubular organoids can be developed simultaneously and in a single medium. Our method is expected to be used as a human pathological model.","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 1","pages":"191-197"},"PeriodicalIF":1.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical AI and AI for Medical Sciences. 医学人工智能和医学科学人工智能。

IF 1.5

JMA journal Pub Date : 2025-01-15 Epub Date: 2024-11-25 DOI: 10.31662/jmaj.2024-0185

Kazuhiro Sakurada, Tetsuo Ishikawa, Junna Oba, Masahiro Kuno, Yuji Okano, Tomomi Sakamaki, Tomohiro Tamura

{"title":"Medical AI and AI for Medical Sciences.","authors":"Kazuhiro Sakurada, Tetsuo Ishikawa, Junna Oba, Masahiro Kuno, Yuji Okano, Tomomi Sakamaki, Tomohiro Tamura","doi":"10.31662/jmaj.2024-0185","DOIUrl":"10.31662/jmaj.2024-0185","url":null,"abstract":"Digital transformation of healthcare is rapidly progressing. Digital transformation improves the quality of services and access to health information for users, reduces the workload and associated costs for healthcare providers, and supports clinical decision-making. Data and artificial intelligence (AI) play a key role in this process. The AI used for this purpose is called medical AI. Medical AI is currently undergoing a shift from task-specific to general-purpose models. Large language models have the potential to systematize existing medical knowledge in a standardized way. The usage of AI in medicine is not limited to digital transformation; it plays a pivotal role in fundamentally changing the state of medical science. This approach, known as \"AI for Medical Science,\" focuses on pioneering a form of medical science that predicts the onset and progression of disease based on the underlying causes of disease. The key to such predictive medicine is the concept of \"states,\" which can be sought through machine learning. Using states instead of symptoms not only dramatically improves the accuracy of identification (diagnosis) and prediction (prognosis) but also potentially pioneers P4 medicine by integrating it with empirical knowledge and theories based on natural principles.","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 1","pages":"26-37"},"PeriodicalIF":1.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Undernutrition at Admission and Improvement in Balance Function Post-stroke. 入院时营养不良与中风后平衡功能改善之间的关系。

IF 1.5

JMA journal Pub Date : 2025-01-15 Epub Date: 2024-11-01 DOI: 10.31662/jmaj.2024-0228

Keisuke Sato, Seiji Tanaka, Masaki Koike, Takahiro Ogawa

{"title":"Association between Undernutrition at Admission and Improvement in Balance Function Post-stroke.","authors":"Keisuke Sato, Seiji Tanaka, Masaki Koike, Takahiro Ogawa","doi":"10.31662/jmaj.2024-0228","DOIUrl":"10.31662/jmaj.2024-0228","url":null,"abstract":"Introduction: The prognosis for activities of daily living (ADL) ability after stroke is negatively influenced by undernutrition and impaired balance. However, the association between undernutrition and balance improvement has not yet been elucidated. This study aimed to investigate the influence of undernutrition on balance function improvement in patients with stroke.Methods: This retrospective observational study included patients with cerebral infarction aged ≥65 years. The study period was from May 2018 to May 2022. The patients were divided into undernutrition and intact nutrition groups according to the Global Leadership Initiative on Malnutrition criteria. The primary outcome was the change in the Berg Balance Scale (BBS) score (BBS score at discharge - BBS score at admission).Results: This study included 304 patients (mean age, 79.2 ± 8.1 years; 173 men and 131 women). These patients were divided into the undernutrition (N = 114) and intact nutrition (N = 190) groups. The undernutrition group demonstrated lower BBS scores at admission (16.0 ± 17.1 vs. 28.3 ± 18.4, p < 0.001) and at discharge (24.2 ± 19.6 vs. 40.0 ± 16.9, p < 0.001) than the intact nutrition group. After adjusting for confounding factors, undernutrition was associated with a smaller change in the BBS score (coefficient = -2.988, 95% confidence interval = -5.481 to -0.495, p = 0.019).Conclusions: Undernutrition negatively influences balance function recovery in post-stroke patients. A strategy aimed at improving nutritional status could have beneficial effects on patients' balance function.","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 1","pages":"218-225"},"PeriodicalIF":1.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relation of Social Participation Restrictions with Worsening Quality of Life in Japanese Patients with Behçet's Disease: The 36-item Short Form Survey. 日本behaperet病患者社会参与限制与生活质量恶化的关系：36项简短调查

IF 1.5

JMA journal Pub Date : 2025-01-15 Epub Date: 2024-11-18 DOI: 10.31662/jmaj.2024-0054

Hideyo Tsutsui, Hiroaki Hoshino, Keiji Shiba, Taketoshi Fukasawa, Hirotoshi Kikuchi, Hiroko Oguchi, Takayoshi Ohkubo, Hajime Kono

{"title":"Relation of Social Participation Restrictions with Worsening Quality of Life in Japanese Patients with Behçet's Disease: The 36-item Short Form Survey.","authors":"Hideyo Tsutsui, Hiroaki Hoshino, Keiji Shiba, Taketoshi Fukasawa, Hirotoshi Kikuchi, Hiroko Oguchi, Takayoshi Ohkubo, Hajime Kono","doi":"10.31662/jmaj.2024-0054","DOIUrl":"10.31662/jmaj.2024-0054","url":null,"abstract":"Introduction: Patients with Behçet's disease (BD) have a variety of symptoms, and the exacerbation of these symptoms affects their daily life and social participation and reduces their quality of life (QOL). This study aimed to clarify the relationship between social participation and QOL in BD patients.Methods: The BD-checklist 92 and 36-item Short Form Survey (SF-36) questionnaires were mailed to 10 affiliates. A total of 174 patients with BD completed the questionnaire. The patients were divided into two groups according to the presence or absence of problems in each \"participation\" category of the BD-checklist 92, and the SF-36 scores were compared. Subsequently, a correlational analysis was used to examine the relationship between the number of problem categories extracted from \"participation\" and scores on the eight subscales of the SF-36. Multiple regression analyses were performed to identify factors associated with SF-36 scores.Results: The SF-36 subscale scores were significantly lower in patients with problems in the participation category, particularly in those with difficulties in shopping, housework, relationships with friends and family, and community activities. A multiple regression analysis revealed that \"basic interpersonal relationships\" and \"community life\" were associated with the SF-36 subscales \"role physical\", \"social functioning\", \"role emotional\", and \"mental health\".Conclusions: This study showed that despite excluding the effects of BD-specific primary and secondary symptoms, problems with basic interpersonal relationships, such as those with friends and family, and restricted community activities were associated with reduced QOL.","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 1","pages":"151-164"},"PeriodicalIF":1.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence in Minimally Invasive Surgery: Current State and Future Challenges. 微创手术中的人工智能：现状与未来挑战。

IF 1.5

JMA journal Pub Date : 2025-01-15 Epub Date: 2024-11-18 DOI: 10.31662/jmaj.2024-0175

Shintaro Arakaki, Shin Takenaka, Kimimasa Sasaki, Daichi Kitaguchi, Hiro Hasegawa, Nobuyoshi Takeshita, Mitsuhisa Takatsuki, Masaaki Ito

引用次数: 0

Functional Assessment for Control of the Trunk Predicts Independent Walking in Patients with Stroke. 躯干控制功能评估预测脑卒中患者独立行走。

IF 1.5

JMA journal Pub Date : 2025-01-15 Epub Date: 2024-11-01 DOI: 10.31662/jmaj.2024-0212

Keisuke Sato, Takahiro Ogawa

{"title":"Functional Assessment for Control of the Trunk Predicts Independent Walking in Patients with Stroke.","authors":"Keisuke Sato, Takahiro Ogawa","doi":"10.31662/jmaj.2024-0212","DOIUrl":"10.31662/jmaj.2024-0212","url":null,"abstract":"Introduction: This study examined the association of trunk function evaluated using Functional Assessment for Control of Trunk (FACT) with independent walking. It aimed to determine the effectiveness of the FACT cutoff score in predicting independent walking at hospital discharge.Methods: This retrospective observational study included patients with cerebral infarction. The patients were categorized into the independent (Functional Independence Measure [FIM] locomotion walking score of the patient was ≥6; n = 102) and dependent (≤5; n = 111) groups based on the FIM locomotion scale at discharge. Multivariate logistic regression analysis was employed to determine the significant independent variables on admission for predicting independent walking at discharge. Furthermore, the receiver operating characteristic was used to calculate the cutoff value for admission status.Results: A total of 213 patients (122 men and 91 women) were included in this study. The independent group had higher scores in FACT (15.0 [12.0-20.0] vs. 6.0 [2.0-12.0], P < 0.001) on admission than the dependent group. The results of the multivariate logistic regression analysis indicated that the factors associated with independent walking were the FACT and Mini-Mental State Examination-Japanese (MMSE-J) on admission. The optimal cutoff score for the FACT on admission was 8, and the area under the curve for the FACT scores on admission when discriminating between independent walking at discharge was 0.82.Conclusions: The results of this study can facilitate the optimization of patient rehabilitation as early as possible. The effects of improved trunk function require further validation through prospective observational studies.","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 1","pages":"226-233"},"PeriodicalIF":1.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hospital-based Introduction of Untested High-risk Foods for Down Syndrome Infant with Severe Food Protein-induced Enterocolitis Syndrome: A Case Report. 医院为唐氏综合症婴儿引入未经检测的高风险食物并伴有严重食物蛋白诱导的小肠结肠炎综合征：一例报告

IF 1.5

JMA journal Pub Date : 2025-01-15 Epub Date: 2024-12-06 DOI: 10.31662/jmaj.2024-0188

Chisato Jimbo, Kouhei Hagino, Daichi Suzuki, Tomoki Yaguchi, Marei Omori, Daisuke Harama, Kotaro Umezawa, Sayaka Hamaguchi, Fumi Ishikawa, Seiko Hirai, Kenji Toyokuni, Tatsuki Fukuie, Yukihiro Ohya, Kiwako Yamamoto-Hanada

{"title":"Hospital-based Introduction of Untested High-risk Foods for Down Syndrome Infant with Severe Food Protein-induced Enterocolitis Syndrome: A Case Report.","authors":"Chisato Jimbo, Kouhei Hagino, Daichi Suzuki, Tomoki Yaguchi, Marei Omori, Daisuke Harama, Kotaro Umezawa, Sayaka Hamaguchi, Fumi Ishikawa, Seiko Hirai, Kenji Toyokuni, Tatsuki Fukuie, Yukihiro Ohya, Kiwako Yamamoto-Hanada","doi":"10.31662/jmaj.2024-0188","DOIUrl":"10.31662/jmaj.2024-0188","url":null,"abstract":"Down syndrome (DS) is a risk factor for severe food protein-induced enterocolitis syndrome (FPIES), with DS patients tending to have multiple-food FPIES. This is the first case where a DS infant with a history of severe chronic FPIES to milk and soy could effectively be introduced with some untested high-risk foods through hospital-based oral food challenges (OFCs). The infant is a 20-month-old girl with DS, who was diagnosed with milk- and soy-induced FPIES. Considering her history of intensive care unit care for severe FPIES reactions, we considered that introducing other high-risk foods, such as wheat and hen's egg (white and yolk), at home was not appropriate for her. We offered hospital-based OFCs effectively and safely by introducing wheat and hen's egg as high-risk foods against FPIES to the 20-month-old infant. As a result, she tolerated soy-based seasoning, wheat, and egg whites without any symptoms, but she developed frequent vomiting after ingesting egg yolk. We did a prompt intervention with intravenous fluid replacement to prevent severe adverse conditions. After discharge, she exhibited an FPIES symptom as a consequence of ingesting green peas and miso; hence, we recommended the elimination of peas, in addition to soy, milk, and egg yolk, from her diet. She remained symptom-free since adhering to this dietary regimen. In severe FPIES children, it is encouraged to introduce unconsumed high-risk foods in the hospital safely to avoid severe reactions at home and prevent unnecessary food eliminations.","PeriodicalId":73550,"journal":{"name":"JMA journal","volume":"8 1","pages":"306-309"},"PeriodicalIF":1.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

How Will Work Hour Restrictions Transform the Working Conditions of Resident Physicians? 工作时间限制将如何改变住院医师的工作条件？

IF 1.5

JMA journal Pub Date : 2025-01-15 Epub Date: 2024-11-25 DOI: 10.31662/jmaj.2024-0297

Kazuya Nagasaki

引用次数: 0

Hypotensive Dumping Syndrome in Hypertrophic Obstructive Cardiomyopathy. 肥厚性梗阻性心肌病的低血压倾倒综合征。

IF 1.5

JMA journal Pub Date : 2025-01-15 Epub Date: 2024-11-01 DOI: 10.31662/jmaj.2024-0194

Takahiko Kinjo, Shogo Hamaura, Hirofumi Tomita

引用次数: 0

Temporal Changes in HbA1c Levels after Sacubitril/Valsartan Initiation in a Real-world Japanese Cohort: REVIEW-HF Registry. 在真实世界的日本队列中，沙比坦/缬沙坦起始后HbA1c水平的时间变化：REVIEW-HF Registry。

IF 1.5

JMA journal Pub Date : 2025-01-15 Epub Date: 2024-11-11 DOI: 10.31662/jmaj.2024-0242

Yukihiro Watanabe, Yoshiaki Kubota, Takuya Nishino, Takahito Nasu, Shunsuke Ishii, Nobuyuki Kagiyama, Keisuke Kida, Wataru Fujimoto, Koshiro Kanaoka, Shingo Matsumoto

引用次数: 0