Itch (Philadelphia, Pa.)最新文献_第2页

Pruritic eruptions in older adults: characterization of a patch test negative cohort 老年人瘙痒性皮疹:斑贴试验阴性队列的特征

Itch (Philadelphia, Pa.) Pub Date : 2023-01-01 DOI: 10.1097/itx.0000000000000067

S. Sreekantaswamy, Jane Tully, N. Botto, Carina M. Woodruff, D. Butler

引用次数: 0

Role of antioxidants in itch treatment: lessons learned from pain management 抗氧化剂在瘙痒治疗中的作用:从疼痛管理中获得的经验教训

Itch (Philadelphia, Pa.) Pub Date : 2023-01-01 DOI: 10.1097/itx.0000000000000068

Georgia Biazus Soares, O. Mahmoud, G. Yosipovitch

引用次数: 1

Severity stages of chronic nodular prurigo: analysis of associated itch intensity and quality of life impairment 慢性结节性瘙痒症的严重程度分期：相关瘙痒强度和生活质量损害的分析

Itch (Philadelphia, Pa.) Pub Date : 2022-10-01 DOI: 10.1097/itx.0000000000000061

C. Zeidler, M. Pereira, M. Storck, Aysenur Suer, S. Ständer

{"title":"Severity stages of chronic nodular prurigo: analysis of associated itch intensity and quality of life impairment","authors":"C. Zeidler, M. Pereira, M. Storck, Aysenur Suer, S. Ständer","doi":"10.1097/itx.0000000000000061","DOIUrl":"https://doi.org/10.1097/itx.0000000000000061","url":null,"abstract":"Introduction: Chronic nodular prurigo (CNPG) is a pruritic neuroinflammatory skin disease characterized by the presence of multiple pruriginous nodules. Previous psychometric analyzes showed the presence of moderate to severe pruritus and a considerable impairment of quality of life. A detailed study of these parameters in relation to the severity of the disease defined by the number of lesions is lacking. Methods: A total of 131 adult patients with CNPG were included. The number of pruriginous lesions and disease stage was determined by using the Prurigo Activity and Severity (PAS) scale and the prurigo-specific Investigator’s Global Assessment (IGA) scale. Patient-reported outcomes comprised pruritus intensity (worst itch intensity of the previous 24 h using the numerical rating scale; WI-NRS/24 h) and the impairment of quality of life (ItchyQol, Dermatology Life Quality Index; DLQI). Results: The counted and estimated number of pruriginous nodules correlated strongly with each other (r=0.82; P<0.001), moderately with the WI-NRS/24 h (counted number: r=0.44, P<0.001; estimated number: r=0.45, P<0.001) and with the DLQI score (counted number: r=0.40, P<0.001; estimated number: r=0.38, P<0.001). The severity groups of the CNPG, as defined by the IGA scale, correlated strongly with the WINRS/24 h and DLQI scores. With increasing severity of CNPG, increasing pruritus intensity and DLQI/ItchyQoL scores were recorded. Conclusion: The correlation between objective (disease stage) and subjective (itch intensity, quality of life) CNPG disease parameters argues for a representative disease severity characterization via physician assessments using either PAS or IGA.","PeriodicalId":73523,"journal":{"name":"Itch (Philadelphia, Pa.)","volume":"7 1","pages":"e61 - e61"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47657189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global epidemiology of itch from 1990 to 2017: gender, age, sanitation, and air pollution as risk factors 1990年至2017年全球瘙痒流行病学:性别、年龄、卫生条件和空气污染为危险因素

Itch (Philadelphia, Pa.) Pub Date : 2022-04-01 DOI: 10.1097/itx.0000000000000060

Vishnutheertha Kulkarni, David Liu, P. Aggarwal, V. Gamsarian, A. Fleischer

{"title":"Global epidemiology of itch from 1990 to 2017: gender, age, sanitation, and air pollution as risk factors","authors":"Vishnutheertha Kulkarni, David Liu, P. Aggarwal, V. Gamsarian, A. Fleischer","doi":"10.1097/itx.0000000000000060","DOIUrl":"https://doi.org/10.1097/itx.0000000000000060","url":null,"abstract":"Background: Itch is a symptom with significant physical, psychological, and financial burden worldwide. Symptom-specific and demographic risk factors have been published although community-level risk factors have not been thoroughly studied. Objectives: To describe the epidemiological risk factors of itch and to present a hypothesis that can account for these trends. Materials and methods: Itch incidence, prevalence, and years lost to disability (YLD) by age, sex, world region, socio-demographic index, percent of population using basic sanitation services, mortality due to air pollution, and gross domestic product (GDP) per capita were obtained from the University of Washington Institute for Health Metrics and Evaluation Global Burden of Disease (GBD), World Health Organization Global Health Observatory (WHO GHO), and Worldometer databases. Linear regression models were utilized to analyze the relationship of sanitation, air pollution, and GDP with itch incidence, prevalence and YLD. Results: Female sex and age were positively associated with higher incidence of itch. The percent of population using basic sanitation services was also positively correlated with itch incidence, prevalence, and YLD (P<0.001). Mortality rate due to air pollution was negatively associated with itch incidence, prevalence, and YLD (P<0.001). However, GDP per capita was not associated with the incidence (P=0.5), prevalence (P=0.8), and YLD (P=0.7) of itch. Conclusions: The “hygiene hypothesis” might explain global trends of itch as more industrialized countries have higher itch incidence rates. Thus, approaches which target molecular pathways involved in the “hygiene hypothesis” may lead to a decreased global itch burden.","PeriodicalId":73523,"journal":{"name":"Itch (Philadelphia, Pa.)","volume":"7 1","pages":"e60 - e60"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46578706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Tacrolimus suppresses itch-related response in diet-induced atopic dermatitis model mice by reducing chloroquine-sensitive sensory neurons 他克莫司通过减少氯喹敏感感觉神经元抑制饮食诱导的特应性皮炎模型小鼠的瘙痒相关反应

Itch (Philadelphia, Pa.) Pub Date : 2022-04-01 DOI: 10.1097/itx.0000000000000062

M. Fujii, Shota Imahori, Misao Nakayama, T. Nabe, S. Ohya

{"title":"Tacrolimus suppresses itch-related response in diet-induced atopic dermatitis model mice by reducing chloroquine-sensitive sensory neurons","authors":"M. Fujii, Shota Imahori, Misao Nakayama, T. Nabe, S. Ohya","doi":"10.1097/itx.0000000000000062","DOIUrl":"https://doi.org/10.1097/itx.0000000000000062","url":null,"abstract":"Introduction: Itch (or pruritus) is a common symptom of atopic dermatitis (AD), which significantly decreases the patient’s quality of life. Tacrolimus ointment reduces pruritus in AD; however, the underlying mechanism is not fully understood. Methods: In the present study, we used a diet-induced AD mouse model to examine the antipruritic mechanism of tacrolimus. After induction of AD symptoms, the tacrolimus-containing ointment was applied once daily for 7 days. Responsiveness of isolated dorsal root ganglion (DRG) cells to various stimuli was examined by monitoring intracellular Ca2+ levels. Results: Repeated application of tacrolimus ointment attenuated spontaneous itch-related responses, even when skin barrier dysfunction, skin inflammation, and epidermal nerve sprouting were not ameliorated. Tacrolimus-treated mice also exhibited reduced scratching behavior induced by several pruritogens, such as histamine, SLIGRL-NH2, and chloroquine (CQ), although capsaicin-induced pain behavior was not affected. DRG cells from tacrolimus-treated mice showed significantly lower Ca2+ responses to CQ. Furthermore, a reduction in CQ-sensitive DRG neurons was observed after in vitro treatment with either tacrolimus or rapamycin. Discussion: CQ-sensitive (MrgprA3-expressing) DRG neurons are implicated as itch-specific sensory neurons. Therefore, topically applied tacrolimus may act directly on itch-signaling neurons, consequently suppressing various itch responses in AD mice.","PeriodicalId":73523,"journal":{"name":"Itch (Philadelphia, Pa.)","volume":"7 1","pages":"e62 - e62"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44980893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Attentional interference, but no attentional bias, by tonic itch and pain stimulation 注意干扰，但没有注意偏误，通过滋补痒和疼痛刺激

Itch (Philadelphia, Pa.) Pub Date : 2022-04-01 DOI: 10.1097/itx.0000000000000063

Jennifer M Becker, Sarah R. Vreijling, S. Van Damme, Elisa A. Kovacs, D. Veldhuijzen, A. Lavrijsen, D. V. Van Ryckeghem, G. Crombez, A. Evers, A. V. Van Laarhoven

{"title":"Attentional interference, but no attentional bias, by tonic itch and pain stimulation","authors":"Jennifer M Becker, Sarah R. Vreijling, S. Van Damme, Elisa A. Kovacs, D. Veldhuijzen, A. Lavrijsen, D. V. Van Ryckeghem, G. Crombez, A. Evers, A. V. Van Laarhoven","doi":"10.1097/itx.0000000000000063","DOIUrl":"https://doi.org/10.1097/itx.0000000000000063","url":null,"abstract":"Introduction: Attentional processes are involved in the experience of itch and pain. They interrupt task performance (ie, attentional interference) or bias allocation of attention toward the somatosensory stimulation, that is, attentional bias (AB). Research on AB toward pain is mostly focused on stimuli with short durations; hampering generalization to tonic pain sensations. Evidence for AB toward itch is lacking so far. This study investigated attentional interference by—and AB toward—experimentally induced tonic itch and pain. Methods: Fifty healthy volunteers performed a somatosensory attention task (SAT), that measured attentional interference and AB during tonic (35 s duration) pain, itch and vibrotactile stimuli. In addition, a dot-probe task measured AB toward visual representations of itch and pain, a Flanker task was used to assess attentional inhibition, and self-reported characteristics were measured. Results: Attentional interference during itch and pain stimuli compared with vibrotactile stimuli was found during the SAT. Exploration of shorter time segments within one tonic stimulus showed slowed responses for all three stimulus types during the first 5 seconds of stimulation. However, no prolonged interference in the following time segments was found. There was no AB toward somatosensory and visual stimuli. Furthermore, there was no association between any of the attentional measures and self-reported characteristics. Discussion: These findings suggest that the beginning of any somatosensory stimulus is interfering with cognitive performance, but the results for prolonged interference by itch and pain are equivocal. There was no indication for biased attention allocation. Whether this pattern is different in patients remains to be investigated in the future.","PeriodicalId":73523,"journal":{"name":"Itch (Philadelphia, Pa.)","volume":"7 1","pages":"e63 - e63"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43650701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Dorsal root ganglion neurostimulation: a target for treatment for intractable neuropathic itch? 背根神经节神经刺激:治疗顽固性神经性瘙痒的靶点?

Itch (Philadelphia, Pa.) Pub Date : 2021-10-01 DOI: 10.1097/itx.0000000000000059

A. Hawash, L. Kapural, G. Yosipovitch

引用次数: 0

Prurigo pigmentosa: a case with rapid response to doxycycline and the likely pathogenetic role of neutrophils 一例对多西环素有快速反应的色素变性患者及中性粒细胞可能的致病作用

Itch (Philadelphia, Pa.) Pub Date : 2021-10-01 DOI: 10.1097/itx.0000000000000051

Laura Hui, J. Lee, H. Tey

引用次数: 0

Alan Cowan, an itch pioneer (1942–2020) 艾伦·考恩，瘙痒先驱(1942-2020)

Itch (Philadelphia, Pa.) Pub Date : 2021-07-01 DOI: 10.1097/itx.0000000000000056

G. Yosipovitch

引用次数: 0

Malcolm Greaves (1933–2021) the itch master 马尔科姆·格里夫斯（1933–2021）瘙痒大师

Itch (Philadelphia, Pa.) Pub Date : 2021-07-01 DOI: 10.1097/itx.0000000000000057

G. Yosipovitch

引用次数: 0