ISRN obstetrics and gynecology最新文献_第2页

Molecular patterns of neurodevelopmental preconditioning: a study of the effects of antenatal steroid therapy in a protein-restriction mouse model. 神经发育预适应的分子模式:产前类固醇治疗对蛋白质限制小鼠模型的影响研究。

ISRN obstetrics and gynecology Pub Date : 2014-03-13 eCollection Date: 2014-01-01 DOI: 10.1155/2014/193816

Clarissa Velayo, Takuya Ito, Yupeng Dong, Miyuki Endo, Rika Sugibayashi, Kiyoe Funamoto, Keita Iida, Nobuo Yaegashi, Yoshitaka Kimura

{"title":"Molecular patterns of neurodevelopmental preconditioning: a study of the effects of antenatal steroid therapy in a protein-restriction mouse model.","authors":"Clarissa Velayo, Takuya Ito, Yupeng Dong, Miyuki Endo, Rika Sugibayashi, Kiyoe Funamoto, Keita Iida, Nobuo Yaegashi, Yoshitaka Kimura","doi":"10.1155/2014/193816","DOIUrl":"https://doi.org/10.1155/2014/193816","url":null,"abstract":"Introduction. Prenatal programming secondary to maternal protein restriction renders an inherent susceptibility to neural compromise in neonates and any addition of glucocorticosteroids results in further damage. This is an investigation of consequent global gene activity due to effects of antenatal steroid therapy on a protein restriction mouse model. Methods. C57BL/6N pregnant mice were administered control or protein restricted diets and subjected to either 100 μ g/Kg of dexamethasone sodium phosphate with normosaline or normosaline alone during late gestation (E10-E17). Nontreatment groups were also included. Brain samples were collected on embryonic day 17 and analyzed by mRNA microarray analysis. Results. Microarray analyses presented 332 significantly regulated genes. Overall, neurodevelopmental genes were overrepresented and a subset of 8 genes allowed treatment segregation through the hierarchical clustering method. The addition of stress or steroids greatly affected gene regulation through glucocorticoid receptor and stress signaling pathways. Furthermore, differences between dexamethasone-administered treatments implied a harmful effect during conditions of high stress. Microarray analysis was validated using qPCR. Conclusion. The effects of antenatal steroid therapy vary in fetuses according to maternal-fetal factors and environmental stimuli. Defining the key regulatory networks that signal either beneficial or damaging corticosteroid action would result in valuable adjustments to current treatment protocols. ","PeriodicalId":73520,"journal":{"name":"ISRN obstetrics and gynecology","volume":"2014 ","pages":"193816"},"PeriodicalIF":0.0,"publicationDate":"2014-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/193816","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32491737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Environmental Tobacco Smoke Exposure during Intrauterine Period, Promotes Caspase Dependent and Independent DNA Fragmentation in Sertoli-Germ Cells. 环境烟草烟雾暴露在宫内期间，促进半胱天冬酶依赖和独立DNA片段在支持生殖细胞。

ISRN obstetrics and gynecology Pub Date : 2014-03-12 eCollection Date: 2014-01-01 DOI: 10.1155/2014/170124

Beril Yüksel, Sevtap Kilic, Nese Lortlar, Nicel Tasdemir, Semra Sertyel, Yesim Bardakci, Tarik Aksu, Sertaç Batioglu

{"title":"Environmental Tobacco Smoke Exposure during Intrauterine Period, Promotes Caspase Dependent and Independent DNA Fragmentation in Sertoli-Germ Cells.","authors":"Beril Yüksel, Sevtap Kilic, Nese Lortlar, Nicel Tasdemir, Semra Sertyel, Yesim Bardakci, Tarik Aksu, Sertaç Batioglu","doi":"10.1155/2014/170124","DOIUrl":"https://doi.org/10.1155/2014/170124","url":null,"abstract":"Objectives. To investigate the effect of cigarette smoke exposure during intrauterine period on neonatal rat testis. Methods. Twenty-five rats were randomized to be exposed to cigarette smoke with the Walton Smoking Machine or to room air during their pregnancies. The newborn male rats (n = 21) were grouped as group 1 (n = 15) which were exposed to cigarette smoke during intrauterine life and group 2 (n = 6) which were exposed to room air during intrauterine life. The orchiectomy materials were analyzed with TUNEL immunofluorescent staining for detection of DNA damage. To detect apoptosis, immunohistochemical analyses with caspase-3 were performed. Primary outcomes were apoptotic index and immunohistochemical scores (HSCORES); secondary outcomes were Sertoli-cell count and birth-weight of rats. Results. Sertoli cell apoptosis was increased in group 1 (HSCORE = 210.6 ± 41.9) when compared to group 2 (HSCORE = 100.0 ± 17.8) (P = 0.001). Sertoli cell count was decreased in group 1 (P = 0.043). The HSCORE for the germ cells was calculated as 214.0 ± 46.2 in group 1 and 93.3 ± 10.3 in group 2 (P = 0.001) referring to an increased germ cell apoptosis in group 1. The apoptotic indexes for group 1 were 49.6 ± 9.57 and 29.98 ± 2.34 for group 2 (P = 0.001). The immunofluorescent technique demonstrated increased DNA damage in seminiferous epithelium in group 1. Conclusions. Intrauterine exposure to cigarette smoke adversely affects neonatal testicular structuring and diminishes testicular reserve. ","PeriodicalId":73520,"journal":{"name":"ISRN obstetrics and gynecology","volume":"2014 ","pages":"170124"},"PeriodicalIF":0.0,"publicationDate":"2014-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/170124","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32521253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

HPV Vaccination in India: Critical Appraisal. 印度HPV疫苗接种:关键评价。

ISRN obstetrics and gynecology Pub Date : 2014-03-11 eCollection Date: 2014-01-01 DOI: 10.1155/2014/394595

Aruna Nigam, Pikee Saxena, Anita S Acharya, Archana Mishra, Swaraj Batra

引用次数: 28

Genital infection with herpes simplex virus types 1 and 2 in women from natal, Brazil. 巴西纳塔尔妇女生殖器感染 1 型和 2 型单纯疱疹病毒的情况。

ISRN obstetrics and gynecology Pub Date : 2014-03-11 eCollection Date: 2014-01-01 DOI: 10.1155/2014/323657

Cleine Aglacy Nunes Miranda, Erika Galvão Lima, Diego Breno Soares de Lima, Ricardo Ney Oliveira Cobucci, Maria da Conceição de Mesquita Cornetta, Thales Allyrio Araújo de Medeiros Fernandes, Paulo Roberto Medeiros de Azevedo, Jenner Chrystian Veríssimo de Azevedo, Josélio Maria Galvão de Araújo, José Veríssimo Fernandes

{"title":"Genital infection with herpes simplex virus types 1 and 2 in women from natal, Brazil.","authors":"Cleine Aglacy Nunes Miranda, Erika Galvão Lima, Diego Breno Soares de Lima, Ricardo Ney Oliveira Cobucci, Maria da Conceição de Mesquita Cornetta, Thales Allyrio Araújo de Medeiros Fernandes, Paulo Roberto Medeiros de Azevedo, Jenner Chrystian Veríssimo de Azevedo, Josélio Maria Galvão de Araújo, José Veríssimo Fernandes","doi":"10.1155/2014/323657","DOIUrl":"10.1155/2014/323657","url":null,"abstract":"Objective. To evaluate the prevalence of HSV-1 and HSV-2 in pregnant and nonpregnant women, testing the correlation between DNA of the viruses with colposcopic and/or cytological changes, and evaluate association with sociodemographic characteristics and sexual activity. Methods. Included in this study were 106 pregnant and 130 nonpregnant women treated at primary health care units of Natal, Brazil, in the period 2010-2011. The patients were examined by colposcopy, and two cervical specimens were collected: one for cytology examination and another for analysis by PCR for detection of HSV-1 and HSV-2. Results. HSV-1 alone was detected in 16.0% of pregnant and 30.0% of nonpregnant women. For HSV-2, these rates were 12.3% and 15.5%, respectively. HSV-2 had a higher correlation with cytology and/or colposcopy changes than HSV-1 did. Genital HSV-1 infection was not associated with any of the variables tested, whereas HSV-2 infection was associated with ethnicity, marital status, and number of sexual partners. Conclusions. The prevalence of HSV-1 was higher than that observed for HSV-2 in both pregnant and nonpregnant women. The genital infection by HSV-2 was higher in women with changed colposcopy and/or cytology, and it was associated with ethnicity, marital status, and number of sexual partners. ","PeriodicalId":73520,"journal":{"name":"ISRN obstetrics and gynecology","volume":"2014 ","pages":"323657"},"PeriodicalIF":0.0,"publicationDate":"2014-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32491740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postnatal systemic blood flow in neonates with abnormal fetal umbilical artery Doppler. 胎儿脐动脉多普勒异常新生儿的产后全身血流。

ISRN obstetrics and gynecology Pub Date : 2014-03-05 eCollection Date: 2014-01-01 DOI: 10.1155/2014/957180

Richelle N Olsen, Jennifer Shepherd, Anup Katheria

{"title":"Postnatal systemic blood flow in neonates with abnormal fetal umbilical artery Doppler.","authors":"Richelle N Olsen, Jennifer Shepherd, Anup Katheria","doi":"10.1155/2014/957180","DOIUrl":"https://doi.org/10.1155/2014/957180","url":null,"abstract":"Objective. Abnormal umbilical artery Doppler (UAD) studies are associated with poor neonatal outcomes. We sought to determine if postnatal measures of systemic blood flow (SBF), as measured by functional echocardiography (fECHO), could identify which fetuses with abnormal UAD were at the highest risk of adverse outcomes. Study Design. This is a retrospective review of fetuses with abnormal UAD who received fECHO in the first 72 hours of life. Measures of SBF (right ventricular output (RVO) and superior vena cava (SVC) flow) were performed and compared with prenatal variables and postnatal outcomes. Result. 63 subjects had abnormal UAD, 20 of which also had fECHO. Six subjects had abnormal flow. Gestational age at delivery was similar between the two groups. Those with abnormal SBF had fewer days of abnormal UAD prior to delivery and developed RDS (P < 0.001). Conclusion. Postnatal measures of SBF were associated with poor postnatal outcomes in fetuses with abnormal UAD. Future studies incorporating antenatal measures of SBF may help obstetricians determine which pregnancies complicated by UAD are likely to have postnatal morbidity. ","PeriodicalId":73520,"journal":{"name":"ISRN obstetrics and gynecology","volume":"2014 ","pages":"957180"},"PeriodicalIF":0.0,"publicationDate":"2014-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/957180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32261097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Evaluation of the Oncogenic Human Papillomavirus DNA Test with Liquid-Based Cytology in Primary Cervical Cancer Screening and the Importance of the ASC/SIL Ratio: A Belgian Study. 致瘤性人乳头瘤病毒DNA检测液基细胞学在原发性宫颈癌筛查中的评价及ASC/SIL比值的重要性:一项比利时研究

ISRN obstetrics and gynecology Pub Date : 2014-02-18 eCollection Date: 2014-01-01 DOI: 10.1155/2014/536495

Xavier Catteau, Philippe Simon, Jean-Christophe Noël

{"title":"Evaluation of the Oncogenic Human Papillomavirus DNA Test with Liquid-Based Cytology in Primary Cervical Cancer Screening and the Importance of the ASC/SIL Ratio: A Belgian Study.","authors":"Xavier Catteau, Philippe Simon, Jean-Christophe Noël","doi":"10.1155/2014/536495","DOIUrl":"https://doi.org/10.1155/2014/536495","url":null,"abstract":"Objectives. In Belgium, very few studies have focused on cervical high-risk human papillomaviruses (hrHPV) prevalence and the relationship between HPV and cervical cytological abnormalities. The aim of this study was to investigate hrHPV prevalence and its relationship with cytological screening and histological results in the French-speaking community in Belgium (Brussels and Wallonia). Methods. A total of 58,265 liquid-based cytology tests were performed during this period. All cases of ASC-US, ASC-H, LSIL, and HSIL were tested by Hybrid Capture 2 for hrHPV screening. Results. The prevalence of cytological abnormalities was 3.1% for ASC-US, 0.3% for ASC-H, 1.5% for LSIL, and 0.3% for HSIL. The frequency of hrHPV infection was 47% in ASC-US, 90% in ASC-H, 86% in LSIL, and 98.4% in HSIL. CIN 2+ lesions were found in 12.2% of smears with an ASC-US result, in 54% of smears with an ASC-H result, in 12.5% of smears with a LSIL result, and in 89.3% of smears with a HSIL result. The ASC/SIL ratio was 1.9%. Conclusions. This study provides a good representation of cytological abnormalities and HPV status in patients living in Belgium's French-speaking community. The prevalence in our study was similar to that derived from meta-analyses of European studies. Our ASC/SIL ratio was 1.9%, being within the lower and upper limits proposed in the literature, which tends to prove the good quality diagnosis of cervical smears in our laboratory. ","PeriodicalId":73520,"journal":{"name":"ISRN obstetrics and gynecology","volume":"2014 ","pages":"536495"},"PeriodicalIF":0.0,"publicationDate":"2014-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/536495","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32229875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Review of Management and Outcomes in Women with Thrombophilia Risk during Pregnancy at a Single Institution. 单一机构妊娠期有血栓形成风险的妇女的管理和结局回顾。

ISRN obstetrics and gynecology Pub Date : 2014-02-17 eCollection Date: 2014-01-01 DOI: 10.1155/2014/381826

Alhossain A Khalafallah, Abdul-Rauf O Ibraheem, Qiong Yue Teo, Abdul-Majeed Albarzan, Ramanathan Parameswaran, Emily Hooper, Toly Pavlov, Amanda E Dennis, Terry Hannan

{"title":"Review of Management and Outcomes in Women with Thrombophilia Risk during Pregnancy at a Single Institution.","authors":"Alhossain A Khalafallah, Abdul-Rauf O Ibraheem, Qiong Yue Teo, Abdul-Majeed Albarzan, Ramanathan Parameswaran, Emily Hooper, Toly Pavlov, Amanda E Dennis, Terry Hannan","doi":"10.1155/2014/381826","DOIUrl":"https://doi.org/10.1155/2014/381826","url":null,"abstract":"Pregnancy is a hypercoagulable state associated with an increased risk of venous thromboembolic disease (VTE). We retrospectively studied 38 Caucasian pregnant women with thrombophilia risk and compared their obstetric outcomes with a matched cohort without known thrombophilia risk during the period between January 2007 and December 2010. There were (2) cases with factor V Leiden, (6) prothrombin gene mutation, (1) antithrombin III deficiency, (2) protein C deficiency, (3) protein S deficiency, (10) MTHFR mutation, (7) anti-cardiolipin antibodies, and (1) lupus anticoagulant. Patients without thrombophilia who presented with recurrent unprovoked VTE were considered as high risk (6 cases). Most patients received anticoagulation (34/38) with aspirin only (6), enoxaparin (27), and warfarin (1). Twenty-six out of thirty-eight pregnant women (68.4%) with an increased risk of thrombophilia experienced one or more obstetric complications defined as hypertension, preeclampsia, placenta abruptio, VTE, and oligohydramnios, compared with 15 out of 40 (37.5%) pregnant women in the control group (OR 3.6; 95% CI 1.42, 9.21, P < 0.001). The incidence of obstetric complications was significantly higher in the thrombophilia group compared to the controls. However, these complications were the lowest among patients who received full-dose anticoagulation. Our study suggests that strict application of anticoagulation therapy for thrombophilia of pregnancy is associated with an improved pregnancy outcome. The study was registered in the Australian and New Zealand Clinical Trials Registry under ACTRN12612001094864. ","PeriodicalId":73520,"journal":{"name":"ISRN obstetrics and gynecology","volume":"2014 ","pages":"381826"},"PeriodicalIF":0.0,"publicationDate":"2014-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/381826","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32229874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Occurrence of pre- and postoperative stress urinary incontinence in 105 patients who underwent tension-free vaginal mesh surgery for pelvic organ prolapse: a retrospective study. 105例盆腔器官脱垂患者行无张力阴道补片手术前后应激性尿失禁的回顾性研究

ISRN obstetrics and gynecology Pub Date : 2014-02-06 eCollection Date: 2014-01-01 DOI: 10.1155/2014/643495

Haruhiko Kanasaki, Aki Oride, Tomomi Mitsuo, Kohji Miyazaki

{"title":"Occurrence of pre- and postoperative stress urinary incontinence in 105 patients who underwent tension-free vaginal mesh surgery for pelvic organ prolapse: a retrospective study.","authors":"Haruhiko Kanasaki, Aki Oride, Tomomi Mitsuo, Kohji Miyazaki","doi":"10.1155/2014/643495","DOIUrl":"https://doi.org/10.1155/2014/643495","url":null,"abstract":"Objective. To examine retrospectively the occurrence of stress urinary incontinence (SUI) in patients who underwent transvaginal mesh repair (TVM) for pelvic organ prolapse (POP). Methods. The presence of preoperative SUI and postoperative changes in SUI was retrospectively analyzed for 105 patients who underwent TVM for POP between September 2009 and September 2012. Results. Preoperative SUI was observed in almost half of the patients (n = 50) who underwent TVM surgery. No significant differences were seen in patient age, pelvic organ prolapse quantification (POP-Q) stage, or primary POP complaint between those with and without preoperative SUI. Of the 50 patients with preoperative SUI, SUI was resolved in 14 (28%) following TVM surgery. Of the 55 patients without preoperative SUI, de novo postoperative SUI appeared in 26 (47.3%), of whom approximately half experienced resolution or improvement of SUI within 6 months postoperatively. There was no relationship between preoperative residual urine volume and occurrence of postoperative SUI. Conclusion. TVM surgery is a useful surgical method that can replace traditional methods for treating POP, but sufficient informed consent with regards to the onset of postoperative SUI is required. ","PeriodicalId":73520,"journal":{"name":"ISRN obstetrics and gynecology","volume":"2014 ","pages":"643495"},"PeriodicalIF":0.0,"publicationDate":"2014-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/643495","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32197029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Fenestration labioreduction of the labium minus: a new surgical intervention concept. 开窗阴唇减缩术:一种新的手术干预概念。

ISRN obstetrics and gynecology Pub Date : 2014-02-04 eCollection Date: 2014-01-01 DOI: 10.1155/2014/671068

Adam Ostrzenski

{"title":"Fenestration labioreduction of the labium minus: a new surgical intervention concept.","authors":"Adam Ostrzenski","doi":"10.1155/2014/671068","DOIUrl":"https://doi.org/10.1155/2014/671068","url":null,"abstract":"Objectives. To test applicability of the new surgical concept for labioreduction of the labia minora. Study Design. The observational, prospective, case series study was designed. Subjects. Three consecutive subjects were included. Methods. The application of new surgical intervention was tested. Main Outcome Measures. A primary outcome measured applicability of the fenestration labioplasty and secondary measures was used to evaluate surgical resolution of medical, emotional, and social symptoms; aesthetic outcomes; and potential complications. Results. Symptomatic, asymmetrical, and enlarged labia minora were associated with aesthetic dissatisfaction from deformations of the labia minora. The new operation was applied easily and without complications. The procedure reduced height and length, accomplished symmetries, preserved natural color and contour, and accomplished the labium minus expected appearance. Postoperatively, physical, emotional, social symptoms and signs resolved, pleasing surgical outcomes exceeded subjects' aesthetic expectations. Meaningfully, self-image and self-confidence improved in all subjects. No feelings of regrets were reported. Emotional tensions were reduced, social openness improved, intimate interaction increased, and their body image perception improved following the operation. Conclusion. In this study group, fenestration labioreduction with inferior flap transposition was easy to execute without complications and the method was reproducible; the new operation achieves pleasing aesthetic results and the procedure improves physical, emotional, and social wellbeing. ","PeriodicalId":73520,"journal":{"name":"ISRN obstetrics and gynecology","volume":"2014 ","pages":"671068"},"PeriodicalIF":0.0,"publicationDate":"2014-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/671068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32229876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Posterior Deep Infiltrating Endometriotic Nodules: Operative Considerations according to Lesion Size, Location, and Geometry, during One's Learning Curve. 后深浸润性子宫内膜异位结节:在学习曲线期间，根据病变大小、位置和几何形状考虑手术。

ISRN obstetrics and gynecology Pub Date : 2014-01-20 eCollection Date: 2014-01-01 DOI: 10.1155/2014/853902

Athanasios Protopapas, Georgios Giannoulis, Ioannis Chatzipapas, Stavros Athanasiou, Themistoklis Grigoriadis, Dimitrios Haidopoulos, Dimitrios Loutradis, Aris Antsaklis

{"title":"Posterior Deep Infiltrating Endometriotic Nodules: Operative Considerations according to Lesion Size, Location, and Geometry, during One's Learning Curve.","authors":"Athanasios Protopapas, Georgios Giannoulis, Ioannis Chatzipapas, Stavros Athanasiou, Themistoklis Grigoriadis, Dimitrios Haidopoulos, Dimitrios Loutradis, Aris Antsaklis","doi":"10.1155/2014/853902","DOIUrl":"https://doi.org/10.1155/2014/853902","url":null,"abstract":"We conducted this prospective cohort study to standardize our laparoscopic technique of excision of posterior deep infiltrating endometriosis (DIE) nodules, according to their size, location, and geometry, including 36 patients who were grouped, according to principal pelvic expansion of the nodule, into groups with central (group 1) and lateral (group 2) lesions, and according to nodule size, into ≤2 cm (group A) and >2 cm (group B) lesions, respectively. In cases of group 1 the following operative steps were more frequently performed compared to those of group 2: suspension of the rectosigmoid, colpectomy, and placement of bowel wall reinforcement sutures. The opposite was true regarding suspension of the adnexa, systematic ureteric dissection, and removal of the diseased pelvic peritoneum. When grouping patients according to nodule size, almost all of the examined parameters were more frequently applied to patients of group B: adnexal suspension, suspension of the rectosigmoid, systematic ureteric dissection, division of uterine vein, colpectomy, and placement of bowel wall reinforcement sutures. Nodule size was the single most important determinant of duration of surgery. In conclusion, during the building-up of one's learning curve of laparoscopic excision of posterior DIE nodules, technique standardization is very important to avoid complications. ","PeriodicalId":73520,"journal":{"name":"ISRN obstetrics and gynecology","volume":"2014 ","pages":"853902"},"PeriodicalIF":0.0,"publicationDate":"2014-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/853902","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32163137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9