International journal of statistics in medical research最新文献_第9页

Determinants of Intraocular Pressure of Glaucoma Patients: A Case Study at Menelik II Referral Hospital, Addis Ababa, Ethiopia 青光眼患者眼压的决定因素:埃塞俄比亚亚的斯亚贝巴Menelik II转诊医院的案例研究

International journal of statistics in medical research Pub Date : 2021-02-26 DOI: 10.6000/1929-6029.2021.10.04

Molalign Emirie, M. Sharma

{"title":"Determinants of Intraocular Pressure of Glaucoma Patients: A Case Study at Menelik II Referral Hospital, Addis Ababa, Ethiopia","authors":"Molalign Emirie, M. Sharma","doi":"10.6000/1929-6029.2021.10.04","DOIUrl":"https://doi.org/10.6000/1929-6029.2021.10.04","url":null,"abstract":"The main theme of the paper is the well-known problem of glaucoma which is the main cause of blindness worldwide and is also considered a major public health issue. It is usually associated with intraocular pressure above the normal range. The normal range is considered to be 10-21mmHg. Elevated intraocular pressure is a major risk factor for the development and/or progression of glaucoma, and intraocular pressure reduction is a well-known treatment strategy for slowing the progression of the disease. The objective of this article is to identify factors/covariates which affect intraocular pressure on glaucoma patients taking into consideration various demographic, socio-economic, and clinical factors. A retrospective longitudinal cohort study was conducted; the study was based on data from all glaucoma patients who visit at least 3 times repeatedly six waves from January 2016 to December 2018 at Menelik II Referral Hospital Eye Clinic. Profile plots, univariate and multivariate linear mixed effect models were used to explore the major risk factors for the progression of intraocular pressure of a patient. The predictor variables gender (p-value=0.0218), occupation (p-value=0.0025), blood pressure (p-value, 0.0263), diabetes (p-value=0.0139), ocular problem (p-value=0.0290) and type of treatment (p-value=0.0176) found statistically significant effects on intraocular pressure of glaucoma patient. The interaction effects, i.e. time with age (p-value<.0001), time with ocular problem (p-value=0.0002), time with cataract surgery (p-value=0.0002), time with duration of treatment (p-value=0.0014) and time with type of treatment (p-value=0.0262) were found statistically significant on intraocular pressure of glaucoma patient.","PeriodicalId":73480,"journal":{"name":"International journal of statistics in medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46731467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Generalized Log-Weibull Distribution with Bio-Medical Applications 一种具有生物医学应用的广义对数-威布尔分布

International journal of statistics in medical research Pub Date : 2021-02-26 DOI: 10.6000/1929-6029.2021.10.02

C. Kumar, Subha R. Nair

引用次数: 4

Estimation of Parent-Sib Correlations for Quantitative Traits Using the Linear Mixed Regression Model: Applications to Arterial Blood Pressures Data Collected From Nuclear Families 使用线性混合回归模型估计数量性状的父母-兄弟相关：应用于从核心家族收集的动脉血压数据

International journal of statistics in medical research Pub Date : 2020-11-13 DOI: 10.6000/1929-6029.2020.09.07

Maha Al-Eid, Sarah Al-Gahtani, M. Shoukri

{"title":"Estimation of Parent-Sib Correlations for Quantitative Traits Using the Linear Mixed Regression Model: Applications to Arterial Blood Pressures Data Collected From Nuclear Families","authors":"Maha Al-Eid, Sarah Al-Gahtani, M. Shoukri","doi":"10.6000/1929-6029.2020.09.07","DOIUrl":"https://doi.org/10.6000/1929-6029.2020.09.07","url":null,"abstract":": A fundamental question in quantitative genetics is whether observed variation in the phenotypic values of a particular trait is due to environmental or to biological factors. Proportion of variations attributed to genetic factors is known as heritability of the trait. Heritability is a concept that summarizes how much of the variation in a trait is due to variation in genetic factors. Often, this term is used in reference to the resemblance between parents and their offspring. In this context, high heritability implies a strong resemblance between parents and offspring with regard to a specific trait, while low heritability implies a low level of resemblance. While many applications measure the offspring resemblance to their parents using the mid-parental value of a quantitative trait of interest as an input parameter, others focus on estimating maternal and paternal heritability. In this paper we address the problem of estimating parental heritability using the nuclear family as a unit of analysis. We derive moment and maximum likelihood estimators of parental heritability, and test their equality using the likelihood ratio test, the delta method. We also use Fieller’s interval on the ratio of parental heritability to address the question of bioequivalence. The methods are illustrated on published arterial blood pressures data collected from nuclear families.","PeriodicalId":73480,"journal":{"name":"International journal of statistics in medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44556720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of the Health Personnel Exposed to the Attack of Patients and Relatives on the Perception of Aggression 遭受病人及亲属攻击的医护人员对攻击知觉的影响

International journal of statistics in medical research Pub Date : 2020-11-01 DOI: 10.6000/1929-6029.2020.09.06

M. Kılıç

引用次数: 0

Inference Procedures on the Ratio of Modified Generalized Poisson Distribution Means: Applications to RNA_SEQ Data 修正广义泊松分布均值比值的推理方法:在RNA_SEQ数据中的应用

International journal of statistics in medical research Pub Date : 2020-06-02 DOI: 10.6000/1929-6029.2020.09.05

M. Shoukri, Maha Al-Eid

{"title":"Inference Procedures on the Ratio of Modified Generalized Poisson Distribution Means: Applications to RNA_SEQ Data","authors":"M. Shoukri, Maha Al-Eid","doi":"10.6000/1929-6029.2020.09.05","DOIUrl":"https://doi.org/10.6000/1929-6029.2020.09.05","url":null,"abstract":": The Poisson and the Negative Binomial distributions are commonly used as analytic tools to model count data. The Poisson is characterized by the equality of mean and variance whereas the Negative Binomial has a variance larger than the mean and therefore is appropriate to model over-dispersed count data. The Generalized Poisson Distribution is becoming a popular alternative to the Negative Binomial. We have considered inference procedures on a modified form of this distribution when two samples are available from two independent populations and the target effect size of interest is the ratio of the two population means. The statistical objective is to construct confidence limits on the ratio. We first test the presence of over dispersion and derive several estimators in the single sample situation. When two samples are available, our interest is focused on the estimation of an effect size measured by the ratio of the respective population means. We have compared two methods; namely the Fieller’s and the delta methods in terms of coverage probabilities. We have illustrated the methodologies on published genomic datasets.","PeriodicalId":73480,"journal":{"name":"International journal of statistics in medical research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46952275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Heterogeneity of Viral Suppression and Viral Rebound Patterns among ART Patients in Zimbabwe from 2004 to 2017: A Bayesian Mixed Effects Multistate Model 2004年至2017年津巴布韦ART患者病毒抑制和病毒反弹模式的空间异质性：贝叶斯混合效应多状态模型

International journal of statistics in medical research Pub Date : 2020-05-25 DOI: 10.6000/1929-6029.2019.08.13

Zvifadzo Matsena Zingoni, T. Chirwa, J. Todd, E. Musenge

引用次数: 3

Adverse Event Risk Assessment on Patients Receiving Combination Antiretroviral Therapy in South Africa 南非接受联合抗逆转录病毒治疗患者的不良事件风险评估

International journal of statistics in medical research Pub Date : 2020-03-02 DOI: 10.6000/1929-6029.2020.09.02

B. Omolo, P. Njuho

引用次数: 0

Maximum Likelihood and Bayesian Estimation of Repeatability Index: Application of Estimating Ratio of Variance Components 重复性指标的最大似然与贝叶斯估计:方差成分比估计的应用

International journal of statistics in medical research Pub Date : 2020-02-04 DOI: 10.6000/1929-6029.2020.09.01

Maha Al-Eid, M. Shoukri, London Ontario Canada Dentistry

{"title":"Maximum Likelihood and Bayesian Estimation of Repeatability Index: Application of Estimating Ratio of Variance Components","authors":"Maha Al-Eid, M. Shoukri, London Ontario Canada Dentistry","doi":"10.6000/1929-6029.2020.09.01","DOIUrl":"https://doi.org/10.6000/1929-6029.2020.09.01","url":null,"abstract":": An index of repeatability is constructed to evaluate the relative magnitude of measurement error. This index is constructed as a ratio of two variance components. Estimation of the index is derived under the one-way random effects model. We compare the well-known maximum likelihood estimator to the Bayesian estimation procedure using non-informative prior. Large sample variance of the of the maximum likelihood estimator are obtained using the inverse of Fisher’s information matrix and the delta method. Inference procedure using the. We also construct a test statistic on the equality of two repeatability indices using the Monte Carlo integration and sampling Importance re-sampling method. We illustrate the methodologies on the estimation of the index of repeatability of Gamma-glutamyl-transferase, an enzyme found in many organs all over the human body, with the highest concentrations found in the liver. This enzyme’s level is raised in the blood in most diseases that cause damage to the liver or bile ducts and is considered an essential serum marker for alcohol-related liver disease.","PeriodicalId":73480,"journal":{"name":"International journal of statistics in medical research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43308799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Property of Melatonin of Acting as an Antihypertensive Agent to Antagonize Nocturnal High Blood Pressure: A Meta-Analysis 褪黑素作为抗高血压药物对抗夜间高血压的特性:一项荟萃分析

International journal of statistics in medical research Pub Date : 2019-10-18 DOI: 10.6000/1929-6029.2019.08.09

R. Vecchis, A. Paccone, M. Maio

引用次数: 2

Meta-Analysis of Incidence Rate Data in the Presence of Zero-Event and Single-Arm Studies 零事件和单组研究中发病率数据的荟萃分析

International journal of statistics in medical research Pub Date : 2019-10-10 DOI: 10.6000/1929-6029.2019.08.08

Romain Piaget-Rossel, P. Taffé

引用次数: 2