International journal of pancreatology : official journal of the International Association of Pancreatology最新文献_第7页

Preventing effect of anti-ICAM-1 and anti-LFA-1 monoclonal antibodies on murine islet allograft rejection. 抗icam -1和抗lfa -1单克隆抗体对小鼠胰岛移植排斥反应的预防作用。

International journal of pancreatology : official journal of the International Association of Pancreatology Pub Date : 1999-08-01 DOI: 10.1385/IJGC:26:1:23

K Arai, M Sunamura, Y Wada, M Takahashi, M Kobari, K Kato, H Yagita, K Okumura, S Matsuno

{"title":"Preventing effect of anti-ICAM-1 and anti-LFA-1 monoclonal antibodies on murine islet allograft rejection.","authors":"K Arai, M Sunamura, Y Wada, M Takahashi, M Kobari, K Kato, H Yagita, K Okumura, S Matsuno","doi":"10.1385/IJGC:26:1:23","DOIUrl":"https://doi.org/10.1385/IJGC:26:1:23","url":null,"abstract":"Immunosuppressive potentials of the blockade of intercellular adhesion molecule-1 (ICAM)-1/leukocyte function-associated antigen 1 (LFA-1) were examined in a murine islet allotransplantation model by using blocking monoclonal antibodies (MAbs) against these molecules. Isolated islets from ICR mice were transplanted into the renal subcapsular space of streptozotocin-induced diabetic C57BL/6 mice. Antibodies were administered immediately after transplantation at a dose of 100 micrograms/mouse/d for 3 or 7 d. In non-treated mice, islet grafts were rejected within 16 d, but the treatment with an anti-ICAM-1 MAb (KAT-1) alone, with anti-LFA-1 MAb (KBA) alone, or with both MAbs significantly prolonged the graft survival. In particular, the combination of KAT-1 and KBA in a 7-d course produced a marked prolongation and induced indefinite graft survivals over 100 d in 88% of recipients. Expression of cytokine transcripts within the islet allografts was analyzed by reverse transcriptase polymerase chain reaction (RT-PCR). In the mice treated with KAT-1 and KBA, the transcripts for Th1 cytokines (interleukin 2 [IL-2] and interferon gamma [IFN-gamma]) were not detected, but the expression of Th2 cytokines (IL-4 and IL-10) was enhanced and persisted over 140 d. In contrast, Th1 cytokines were dominantly expressed in the grafts from untreated mice. These results indicate that administration of anti-ICAM-1 and/or anti-LFA-1 MAbs prolongs murine islet allograft survival potentially by indicating a Th2 deviation.","PeriodicalId":73464,"journal":{"name":"International journal of pancreatology : official journal of the International Association of Pancreatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/IJGC:26:1:23","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21424400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 33

alpha-Fetoprotein-producing adenocarcinoma of the pancreas presenting focal hepatoid differentiation. 胰腺产生甲胎蛋白的腺癌，呈局灶性肝样分化。

International journal of pancreatology : official journal of the International Association of Pancreatology Pub Date : 1999-08-01 DOI: 10.1385/IJGC:26:1:43

S Tanno, T Obara, T Fujii, T Izawa, Y Mizukami, Y Saitoh, H Ura, Y Kohgo

引用次数: 28

Human pancreatic leiomyosarcoma (PZX-7) growing as a serially transplantable xenograft in immunosuppressed mice. 人类胰腺平滑肌肉瘤(PZX-7)在免疫抑制小鼠体内作为连续移植的异种移植物生长。

International journal of pancreatology : official journal of the International Association of Pancreatology Pub Date : 1999-08-01 DOI: 10.1385/IJGC:26:1:33

A Zalatnai, J Bocsi, T Csákány, T Fekete, J Lásztity

{"title":"Human pancreatic leiomyosarcoma (PZX-7) growing as a serially transplantable xenograft in immunosuppressed mice.","authors":"A Zalatnai, J Bocsi, T Csákány, T Fekete, J Lásztity","doi":"10.1385/IJGC:26:1:33","DOIUrl":"https://doi.org/10.1385/IJGC:26:1:33","url":null,"abstract":"Background: Several human leiomyosarcoma xenografts have been established, but pancreatic smooth muscle sarcomas have never been serially transplanted and investigated.Method: Immunosuppression of CBA/CA mice was achieved by thymectomy, whole-body irradiation, and bone marrow reconstruction. Tumor fragments were subcutaneously implanted from a Grade III pancreatic leiomyosarcoma and serially passaged for more than 24 mo. The xenografted tumors were characterized by morphological, morphometrical, biochemical, and flow cytometric methods.Results: The tumor has retained its characteristic morphology and no further differentiation occurred. The mitotic counts and the amount of the connective tissue all remained constant. The calculated volume doubling time was 11.3 d. Immunohistochemically, the tumor proved to be p53-negative, but the strong expression of the bcl-2 remained as a constant feature throughout successive transplantations. The DNA index and the proliferation indices did not change significantly with the time (mean DI: 1.65, range: 1.561-1.70; mean PI: 17.9%, range: 15.3-20.7%). Lactose dehydrogenase (LDH) isoenzyme electrophoresis evidenced a retained human pattern of the tumor even after 32 mo of transplantations.Conclusion: The first human pancreatic leiomyosarcoma xenograft (PZX-7) growing in immuno-suppressed mice is described and characterized.","PeriodicalId":73464,"journal":{"name":"International journal of pancreatology : official journal of the International Association of Pancreatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1385/IJGC:26:1:33","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21424402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Massive intraperitoneal bleeding from tryptic erosions of the splenic vein. Another cause of sudden deterioration during recovery from acute pancreatitis. 脾静脉胰蛋白酶侵蚀导致大量腹腔内出血。急性胰腺炎恢复期突然恶化的另一个原因。

International journal of pancreatology : official journal of the International Association of Pancreatology Pub Date : 1999-08-01 DOI: 10.1385/IJGC:26:1:49

C H Müller, U Lahnert, A Schafmayer, P G Lankisch

引用次数: 15

Diagnosis, objective assessment of severity, and management of acute pancreatitis. Santorini Consensus Conference. 诊断，客观评估严重程度，和管理急性胰腺炎。圣托里尼共识会议。

International journal of pancreatology : official journal of the International Association of Pancreatology Pub Date : 1999-08-01 DOI: 10.1385/ijgc:26:1:1

H G Beger, R Isenmann

引用次数: 214

The potential for gene therapy in pancreatic cancer. 胰腺癌基因治疗的潜力。

International journal of pancreatology : official journal of the International Association of Pancreatology Pub Date : 1999-08-01 DOI: 10.1385/IJGC:26:1:5

M J Humphreys, W Greenhalf, J P Neoptolemos, P Ghaneh

引用次数: 22

Proximal migration of transanastomotic pancreatic stent following pancreaticoduodenectomy and pancreaticojejunostomy. 经吻合口胰腺支架在胰十二指肠切除术和胰空肠吻合术后的近端移位。

International journal of pancreatology : official journal of the International Association of Pancreatology Pub Date : 1999-06-01 DOI: 10.1007/BF02925969

B J Ammori, C M White

{"title":"Proximal migration of transanastomotic pancreatic stent following pancreaticoduodenectomy and pancreaticojejunostomy.","authors":"B J Ammori, C M White","doi":"10.1007/BF02925969","DOIUrl":"https://doi.org/10.1007/BF02925969","url":null,"abstract":"Background: The use of catheters to stent the pancreaticojejunal anastomosis following pancreaticoduodenectomy is practiced by some surgeons. Their long-term effects in this setting, however, remain unknown.Methods: A 60-yr-old woman underwent a potentially curative pylorus preserving pancreaticoduodenectomy for Stage I ampullary carcinoma. Roux-en-Y pancreaticojejunostomy was constructed over a short stent. She presented 4 yr later with abdominal pain, steatorrhea, and weight loss. Computed tomography revealed a stent within the proximal pancreatic duct, with gross upstream ductal dilatation and parenchymal features of chronic pancreatitis.Results: Laparotomy revealed no disease recurrence. The stent, removed through a jejunotomy, was occluded. On-table pancreatogram demonstrated a 3-cm proximal duct stricture. Drainage was achieved with a lateral pancreaticojejunostomy (modified Puestow procedure). Recovery was uneventful, with clinical recovery of pancreatic exocrine function at 6 mo follow-up.Conclusion: Proximal migration of transanastomotic pancreatic stent with subsequent development of chronic pancreatitis is a potential complication following pancreaticoduodenectomy. It can be managed effectively with stent removal and a lateral pancreaticojejunostomy.","PeriodicalId":73464,"journal":{"name":"International journal of pancreatology : official journal of the International Association of Pancreatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02925969","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21317630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Acute pancreatitis secondary to 5-aminosalicylic acid therapy in a patient with ulcerative colitis. 溃疡性结肠炎患者5-氨基水杨酸治疗继发急性胰腺炎1例。

International journal of pancreatology : official journal of the International Association of Pancreatology Pub Date : 1999-06-01 DOI: 10.1007/BF02925970

E Adachi, K Okazaki, Y Matsushima, H Seno, K Uchida, H Nakase, C Kawanami, T Nakamura, T Chiba

引用次数: 23

The "two-hit" pathogenetic concept of chronic pancreatitis. 慢性胰腺炎的“双重打击”发病概念。

International journal of pancreatology : official journal of the International Association of Pancreatology Pub Date : 1999-06-01

R W Ammann, P U Heitz, G Klöppel

引用次数: 0

Different patterns in immunoreactive anionic and cationic trypsinogen in urine and serum in human acute pancreatitis. 急性胰腺炎患者尿和血清中免疫反应性阴离子和阳离子胰蛋白酶原的不同模式。

International journal of pancreatology : official journal of the International Association of Pancreatology Pub Date : 1999-06-01 DOI: 10.1007/BF02925965

U Petersson, S Appelros, A Borgström

{"title":"Different patterns in immunoreactive anionic and cationic trypsinogen in urine and serum in human acute pancreatitis.","authors":"U Petersson, S Appelros, A Borgström","doi":"10.1007/BF02925965","DOIUrl":"https://doi.org/10.1007/BF02925965","url":null,"abstract":"Background: Acute pancreatitis (AP) results in elevated concentrations of trypsinogen (T) isoenzymes in serum. Immunoreactive anionic trypsinogen in urin (irAT/u) is elevated in AP, and has recently been proposed as a rapid diagnostic instrument and severity predictor. These results have not been confirmed by other groups, and irAT/u has not been further characterized. The concentration of immunoreactive cationic trypsinogen in urine (irCT/u) and the serum irAT/irCT ratio in AP have not been extensively examined.Methods: Levels of irAT and irCT were studied in urine and serum from 50 AP patients and in urine from 41 non-AP patients. Severity was assessed according to the Atlanta classification. irAT/u was characterized by gel filtration.Results: Gel filtration revealed only AT in the urine. Highly significant differences in irAT/u were seen between AP/non-AP (p < 0.0001) and mild/severe disease (p = 0.0012). The irAT/irCT ratio in serum changed from normal 0.8 to 1.3 in AP.Conclusions: IrAT and only traces of irCT were found in the urine in AP. IrAT/u was higher in AP than in other acute abdominal disorders (non-AP) and also higher in severe than in mild AP. IrAT in serum (irAT/s) increased proportionally more than irCT/s in AP, but did not discriminate mild from severe forms. High levels of irAT/u in some non-AP cases and a wide range in AP cases make the clinical value of the test questionable.","PeriodicalId":73464,"journal":{"name":"International journal of pancreatology : official journal of the International Association of Pancreatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1999-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/BF02925965","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21317627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27