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Immuno-oncology therapies: a looming mid-life crisis? 免疫肿瘤疗法:迫在眉睫的中年危机?
Immuno-oncology insights Pub Date : 2022-03-21 DOI: 10.18609/ioi.2022.010
Hansoo Kim, D. Liew, Stephen Goodall
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引用次数: 0
Raiders of the lost art: finding immuno-oncology treasure 失传艺术的掠夺者:寻找免疫肿瘤学的宝藏
Immuno-oncology insights Pub Date : 2022-03-21 DOI: 10.18609/ioi.2022.015
Kishore K Gangangari, A. Murphy, Reni Benjamin
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引用次数: 0
Early-stage investment in immuno oncology: riding the waves of hope & hype 免疫肿瘤学的早期投资:乘着希望和炒作的浪潮
Immuno-oncology insights Pub Date : 2022-03-21 DOI: 10.18609/ioi.2022.009
W. Lesterhuis, H. Mikkelsen, Jonathan Tobin, Michael Bettess
{"title":"Early-stage investment in immuno oncology: riding the waves of hope & hype","authors":"W. Lesterhuis, H. Mikkelsen, Jonathan Tobin, Michael Bettess","doi":"10.18609/ioi.2022.009","DOIUrl":"https://doi.org/10.18609/ioi.2022.009","url":null,"abstract":"","PeriodicalId":73351,"journal":{"name":"Immuno-oncology insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49178942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BCMA targeting CAR T cells using a novel D-domain binder for multiple myeloma: clinical development update 使用新型d结构域结合剂靶向CAR - T细胞治疗多发性骨髓瘤的BCMA:临床进展更新
Immuno-oncology insights Pub Date : 2022-01-26 DOI: 10.18609/ioi.2022.003
Anand Rotte, C. Heery, B. Gliner, D. Tice, D. Hilbert
{"title":"BCMA targeting CAR T cells using a novel D-domain binder for multiple myeloma: clinical development update","authors":"Anand Rotte, C. Heery, B. Gliner, D. Tice, D. Hilbert","doi":"10.18609/ioi.2022.003","DOIUrl":"https://doi.org/10.18609/ioi.2022.003","url":null,"abstract":"","PeriodicalId":73351,"journal":{"name":"Immuno-oncology insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43662382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A need to update paradigms for myeloid cells within the tumor microenvironment to advance immunotherapy 需要更新骨髓细胞在肿瘤微环境中的范式以推进免疫治疗
Immuno-oncology insights Pub Date : 2022-01-26 DOI: 10.18609/ioi.2022.004
M. Kinder
{"title":"A need to update paradigms for myeloid cells within the tumor microenvironment to advance immunotherapy","authors":"M. Kinder","doi":"10.18609/ioi.2022.004","DOIUrl":"https://doi.org/10.18609/ioi.2022.004","url":null,"abstract":"","PeriodicalId":73351,"journal":{"name":"Immuno-oncology insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42072323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing engineered cell & gene therapy with precision gene editing 利用精确的基因编辑技术推进工程细胞和基因治疗
Immuno-oncology insights Pub Date : 2022-01-26 DOI: 10.18609/ioi.2022.005
J. Lambourne
{"title":"Advancing engineered cell & gene therapy with precision gene editing","authors":"J. Lambourne","doi":"10.18609/ioi.2022.005","DOIUrl":"https://doi.org/10.18609/ioi.2022.005","url":null,"abstract":"","PeriodicalId":73351,"journal":{"name":"Immuno-oncology insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42986280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Realizing the potential of NK cell therapy 认识到NK细胞治疗的潜力
Immuno-oncology insights Pub Date : 2022-01-26 DOI: 10.18609/ioi.2022.001
Alvin M Shih
{"title":"Realizing the potential of NK cell therapy","authors":"Alvin M Shih","doi":"10.18609/ioi.2022.001","DOIUrl":"https://doi.org/10.18609/ioi.2022.001","url":null,"abstract":"","PeriodicalId":73351,"journal":{"name":"Immuno-oncology insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48834756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging LAG-3 for improved patient outcomes 利用LAG-3改善患者预后
Immuno-oncology insights Pub Date : 2022-01-26 DOI: 10.18609/ioi.2022.002
P. Basciano
{"title":"Leveraging LAG-3 for improved patient outcomes","authors":"P. Basciano","doi":"10.18609/ioi.2022.002","DOIUrl":"https://doi.org/10.18609/ioi.2022.002","url":null,"abstract":"","PeriodicalId":73351,"journal":{"name":"Immuno-oncology insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45130096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Prognostic Value of Classical Immunoparesis in Multiple Myeloma 典型免疫轻瘫在多发性骨髓瘤中的预后价值
Immuno-oncology insights Pub Date : 2022-01-01 DOI: 10.55085/oi.2022.602
{"title":"The Prognostic Value of Classical Immunoparesis in Multiple Myeloma","authors":"","doi":"10.55085/oi.2022.602","DOIUrl":"https://doi.org/10.55085/oi.2022.602","url":null,"abstract":"","PeriodicalId":73351,"journal":{"name":"Immuno-oncology insights","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77569356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preclinical models for development of immune-oncology therapies. 开发免疫肿瘤疗法的临床前模型。
Immuno-oncology insights Pub Date : 2022-01-01 Epub Date: 2022-09-26 DOI: 10.18609/ioi.2022.41
Yufei Wang, Sarah E Shelton, Gabriella Kastrunes, David A Barbie, Gordon J Freeman, Wayne A Marasco
{"title":"Preclinical models for development of immune-oncology therapies.","authors":"Yufei Wang, Sarah E Shelton, Gabriella Kastrunes, David A Barbie, Gordon J Freeman, Wayne A Marasco","doi":"10.18609/ioi.2022.41","DOIUrl":"10.18609/ioi.2022.41","url":null,"abstract":"<p><p>Immunotherapy has demonstrated great success in clinical treatment, especially for cancer care. Here we review preclinical models, including cell lines, three dimensional (3D) cultures, and mouse models to support the need for tools enabling the development of novel immune-oncology (I-O) therapies. While <i>in vitro</i> studies have the advantage of being relatively simpler, faster, and higher throughput than <i>in vivo</i> models, they must be designed carefully to recapitulate the biological conditions that influence drug efficacy. The growing prevalence of 3D <i>in vitro</i> and <i>ex vivo</i> models has enabled screening and mechanistic studies in more complex, tissue-like environments containing multiple interacting cell types. On the other hand, syngeneic mouse models have been instrumental in the historical development of immunotherapies and remain an important tool in drug development, despite lacking fidelity to certain aspects of human physiology and pathology. Xenograft and humanized mouse models address some of these challenges, yet present limitations of their own. Successful development and translation of new I-O therapies will likely require thoughtful combination of several of these preclinical models, and we aim to help research and development scientists utilize the appropriate tools and technologies to facilitate rapid transition from preclinical evaluation to clinical trials.</p>","PeriodicalId":73351,"journal":{"name":"Immuno-oncology insights","volume":"3 8","pages":"379-398"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150782/pdf/nihms-1894239.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9415792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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