Hypoxia (Auckland, N.Z.)最新文献

Abstract PO-035: Understanding the role of hypoxia and PTEN loss in driving prostate cancer progression 摘要PO-035：了解缺氧和PTEN缺失在推动前列腺癌症进展中的作用

Hypoxia (Auckland, N.Z.) Pub Date : 2021-04-15 DOI: 10.1158/1557-3265.RADSCI21-PO-035

Alexandru Suvac, R. Rebello, S. Lyons, R. Bristow

引用次数: 0

Abstract PO-033: Papaverine derivative smv-32 alleviates tumor hypoxia and radiosensitizes tumors by inhibiting mitochondrial metabolism PO-033:罂粟碱衍生物smv-32通过抑制线粒体代谢减轻肿瘤缺氧和放射致敏

Hypoxia (Auckland, N.Z.) Pub Date : 2021-04-15 DOI: 10.1158/1557-3265.RADSCI21-PO-033

M. Benej, Jinghai Wu, McKenzie Kreamer, Sandip Vibhute, I. Papandreou, N. Denko

引用次数: 0

Abstract PO-032: Mechanistic studies of hypoxia as a driver of genomic instability in prostate cancer 摘要PO-032：低氧作为前列腺癌症基因组不稳定性驱动因素的机制研究

Hypoxia (Auckland, N.Z.) Pub Date : 2021-04-15 DOI: 10.1158/1557-3265.RADSCI21-PO-032

J. Ashton, R. Rebello, S. Lyons, R. Bristow

引用次数: 0

Abstract IA-017: Chromatin and gene transcription in hypoxia 摘要IA-017：染色质与缺氧条件下的基因转录

Hypoxia (Auckland, N.Z.) Pub Date : 2021-04-15 DOI: 10.1158/1557-3265.RADSCI21-IA-017

M. Batie, Julianty Frost, S. Rocha

引用次数: 0

Abstract IA-015: Hypoxia-induced SETX links replication stress with the unfolded protein response IA-015:缺氧诱导的SETX将复制应激与未折叠蛋白应答联系起来

Hypoxia (Auckland, N.Z.) Pub Date : 2021-04-15 DOI: 10.1158/1557-3265.RADSCI21-IA-015

E. Hammond

引用次数: 0

Abstract PO-034: Changes in cancer associated fibroblast subsets following angiotensin II type I receptor blocker (ARB) treatment reduces transient hypoxia and radiation resistance PO-034:血管紧张素II I型受体阻滞剂(ARB)治疗后癌症相关成纤维细胞亚群的变化可减少短暂缺氧和放射抵抗

Hypoxia (Auckland, N.Z.) Pub Date : 2021-04-15 DOI: 10.1158/1557-3265.RADSCI21-PO-034

Che-Min Lee, Brennan J. Wadsworth, K. Bennewith

引用次数: 0

Abstract IA-016: Metabolic deregulation drives a redox vulnerability in pancreatic cancer 摘要IA-016：代谢失调驱动癌症胰腺氧化还原脆弱性

Hypoxia (Auckland, N.Z.) Pub Date : 2021-04-15 DOI: 10.1158/1557-3265.RADSCI21-IA-016

M. Koritzinsky, P. Jain, A. Dvorkin-Gheva, Lucie Malbeteau, Piriththiv Dhavarasa, K. Brown, G. Jang, P. Vora, F. Notta, J. Moffat, P. Boutros

引用次数: 0

Markers of Hypoxia Correlate with Histologic and Endoscopic Severity of Colitis in Inflammatory Bowel Disease. 缺氧标记物与炎症性肠病结肠炎的组织学和内窥镜严重程度相关。

Hypoxia (Auckland, N.Z.) Pub Date : 2020-02-10 eCollection Date: 2020-01-01 DOI: 10.2147/HP.S219049

Edwin F deZoeten, Kayla D Battista, Steven B Colson, Mark A Lovell, Brittelle E Kessler, Robert W Isfort, Blair P Fennimore, Joseph C Onyiah, Daniel J Kao, Alyson Yeckes, Simon Keely, Monica Murray, Edward J Hoffenberg, Sean P Colgan, Mark E Gerich

{"title":"Markers of Hypoxia Correlate with Histologic and Endoscopic Severity of Colitis in Inflammatory Bowel Disease.","authors":"Edwin F deZoeten, Kayla D Battista, Steven B Colson, Mark A Lovell, Brittelle E Kessler, Robert W Isfort, Blair P Fennimore, Joseph C Onyiah, Daniel J Kao, Alyson Yeckes, Simon Keely, Monica Murray, Edward J Hoffenberg, Sean P Colgan, Mark E Gerich","doi":"10.2147/HP.S219049","DOIUrl":"10.2147/HP.S219049","url":null,"abstract":"Background: Inflammation results in significant shifts in tissue metabolism. Recent studies indicate that inflammation and hypoxia occur concomitantly. We examined whether circulating and tissue markers of hypoxia could serve as surrogate indicators of disease severity in adult and pediatric patients with inflammatory bowel disease (IBD).Methods: Serum and colonic biopsies were obtained from pediatric subjects with active IBD colitis and adult subjects with active and inactive ulcerative colitis, along with healthy non-colitis controls of all ages. Disease activity was evaluated by endoscopy and histopathology. Levels of serum hypoxia markers (macrophage inflammatory protein-3α [MIP-3α], vascular endothelial growth factor [VEGF], and erythropoietin [EPO]) were measured.Results: Children with active IBD colitis had higher levels of serum MIP-3α and VEGF compared to non-colitis controls (p<0.01 and p<0.05, respectively). In adult subjects with endoscopically active ulcerative colitis, serum MIP-3α and EPO were significantly elevated compared to non-colitis controls (both p<0.01). In parallel, analysis of colon tissue MIP-3α mRNA and protein in pediatric subjects revealed increased expression in those with IBD colitis compared to controls (p<0.05 and p<0.01 for mRNA and protein, respectively). Serum MIP-3α and VEGF significantly increased with histology grade.Conclusion: Peripheral blood hypoxia markers may be useful indicators of disease activity for pediatric and adult IBD patients.","PeriodicalId":73270,"journal":{"name":"Hypoxia (Auckland, N.Z.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5d/24/hp-8-1.PMC7026141.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37683409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoxia Induces Pro-Fibrotic and Fibrosis Marker Genes in Hepatocellular Carcinoma Cells Independently of Inflammatory Stimulation and the NF-κΒ Pathway. 缺氧诱导肝癌细胞中不依赖炎症刺激和NF-κΒ通路的促纤维化和纤维化标记基因。

Hypoxia (Auckland, N.Z.) Pub Date : 2019-12-24 eCollection Date: 2019-01-01 DOI: 10.2147/HP.S235967

Eleni-Anastasia Triantafyllou, Ilias Mylonis, George Simos, Efrosyni Paraskeva

{"title":"Hypoxia Induces Pro-Fibrotic and Fibrosis Marker Genes in Hepatocellular Carcinoma Cells Independently of Inflammatory Stimulation and the NF-κΒ Pathway.","authors":"Eleni-Anastasia Triantafyllou, Ilias Mylonis, George Simos, Efrosyni Paraskeva","doi":"10.2147/HP.S235967","DOIUrl":"https://doi.org/10.2147/HP.S235967","url":null,"abstract":"Hypoxia and its key mediators hypoxia inducible Factors (HIFs) are implicated in the development of liver diseases of diverse etiologies, often in interplay with inflammatory mediators. We investigated the interplay between hypoxia and proinflammatory mediators in the development of liver fibrosis, using human hepatocellular carcinoma Huh7 cells as a model. Treatment of Huh7 with DMOG or under hypoxia, induced HIF-1α protein levels and the expression of genes for pro-fibrotic (TGF-β1, PDGFC, PAI-1) and fibrosis (LOX, P4HA1, P4HB) markers. Knockdown of HIF-1α decreased the induction of PDGFC, LOX and P4HA1, showing the involvement of HIF-1 in their regulation. Interestingly, incubation of Huh7 cells under hypoxia did not cause activation of the NF-κΒ pathway. In contrast, inflammatory mediators such as tumor necrosis factor α (TNFα) and lipopolysaccharides (LPS) activated the NF-κΒ pathway, but failed to increase HIF-1α protein levels. Moreover, TNFα had a weaker effect than hypoxia on the induction or did not induce pro-fibrotic and fibrosis markers, respectively, while LPS enhanced only the hypoxic induction of P4HB. In conclusion, the above findings suggest that hypoxia and HIF-1 play an important role in the development of fibrosis in hepatocellular carcinoma, which appears to be independent of the activation of the NF-κΒ pathway.","PeriodicalId":73270,"journal":{"name":"Hypoxia (Auckland, N.Z.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/HP.S235967","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37529724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

An Erythrocytosis-Associated Mutation in the Zinc Finger of PHD2 Provides Insights into Its Binding of p23. PHD2锌指中与红细胞增多症相关的突变提供了其与p23结合的见解。

Hypoxia (Auckland, N.Z.) Pub Date : 2019-12-13 eCollection Date: 2019-01-01 DOI: 10.2147/HP.S230502

Daisheng Song, Wei Guan, Lea M Coon, Aref Al-Kali, Jennifer L Oliveira, Frank S Lee

{"title":"An Erythrocytosis-Associated Mutation in the Zinc Finger of PHD2 Provides Insights into Its Binding of p23.","authors":"Daisheng Song, Wei Guan, Lea M Coon, Aref Al-Kali, Jennifer L Oliveira, Frank S Lee","doi":"10.2147/HP.S230502","DOIUrl":"https://doi.org/10.2147/HP.S230502","url":null,"abstract":"Background: Loss of function mutations in the EGLN1 gene are a cause of erythrocytosis. EGLN1 encodes for prolyl hydroxylase domain protein 2 (PHD2). PHD2 hydroxylates and downregulates hypoxia-inducible factor-2α (HIF-2α), a transcription factor that regulates erythropoiesis. While the large majority of erythrocytosis-associated EGLN1 mutations occur within its catalytic domain, rare mutations reside in its zinc finger. This zinc finger binds a Pro-Xaa-Leu-Glu motif in p23, an HSP90 cochaperone that facilitates hydroxylation of HIF-α, an HSP90 client. Essentially nothing is known about the specific interactions between the PHD2 zinc finger and p23.Results: Here, we characterize an erythrocytosis-associated mutation in the zinc finger, K55N, that abolishes interaction with p23. We provide evidence that the affected residue, Lys-55, interacts with Asp-152 of p23. We also present results that indicate that PHD2 Arg-32 interacts with p23 Glu-160.Conclusion: These studies not only reinforce the importance of the PHD2 zinc finger in the control of erythropoiesis, but also lead to a model in which a peptide motif in p23 binds in a specific orientation to a predicted groove in the zinc finger of PHD2.","PeriodicalId":73270,"journal":{"name":"Hypoxia (Auckland, N.Z.)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2147/HP.S230502","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37471385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1