Global journal of epidemiology and infectious disease最新文献_第2页

Role of Ivermectin in Management of COVID-19 伊维菌素在新冠肺炎管理中的作用

Global journal of epidemiology and infectious disease Pub Date : 2022-03-27 DOI: 10.31586/gjeid.2022.238

Areej Mohamed Abdelhady Ahmed Helaly, G. Amin, S. A. Rahman, M. Allam

引用次数: 0

Prevalence and Determinants of Acute Respiratory Infections among Children under Five Years in Rural Settings of The Gambia: Evidence from a National Survey 冈比亚农村地区5岁以下儿童急性呼吸道感染的患病率和决定因素:来自全国调查的证据

Global journal of epidemiology and infectious disease Pub Date : 2022-02-25 DOI: 10.31586/gjeid.2022.247

A. Barrow, Afape Ayobami, Precious Chidozie Azubuike, D. Cham

引用次数: 3

Melatonin could be used for Treatment of COVID-19? 褪黑素可用于治疗COVID-19?

Global journal of epidemiology and infectious disease Pub Date : 2022-02-22 DOI: 10.31586/gjeid.2022.188

Rehab Mohamed Ali Mohamed, Ghada Essam El-Din Amin, Salwa Mostafa Mohammad Abdel Rahman, Mohamed Farouk Allam

引用次数: 0

A Retrospective, Cross-sectional Hospital-based Study to Determine the Epidemiological, Clinical and Comorbidity Characteristics in Older Adults with Psoriasis 一项以医院为基础的回顾性横断面研究，以确定老年银屑病的流行病学、临床和合并症特征

Global journal of epidemiology and infectious disease Pub Date : 2022-02-10 DOI: 10.31586/gjeid.2022.182

K. Minni, M. Rajagopalan

引用次数: 0

Role of Colchicine in Management of COVID-19? 秋水仙碱在新冠肺炎治疗中的作用？

Global journal of epidemiology and infectious disease Pub Date : 2021-12-16 DOI: 10.31586/gjeid.2022.177

Kholoud Mohamed Elawady Elhefnawy Elshiwy, Ghada Essam El-Din Amin, M. Nazmy, R. Samir, Mohamed Farouk Allam

{"title":"Role of Colchicine in Management of COVID-19?","authors":"Kholoud Mohamed Elawady Elhefnawy Elshiwy, Ghada Essam El-Din Amin, M. Nazmy, R. Samir, Mohamed Farouk Allam","doi":"10.31586/gjeid.2022.177","DOIUrl":"https://doi.org/10.31586/gjeid.2022.177","url":null,"abstract":": CoV-2 disease 2019 (COVID-19) pandemic has exerted a great burden on the health and economic systems worldwide. One of the most important factors that affect the severity and prognosis of COVID-19 is the occurrence of hyperstimulation of the immune system resulting in “cytokine storm”. Similar to SARS -CoV, an intracellular complex called nod like receptor family pyrin domain containing 3 (NLRP3) inflammasome was found to be activated by SARS-CoV-2, then in turn stimulates several interleukins and initiates the inflammatory cascade. In addition, other inflammatory mediators such as interferons e.g., IFN- α, and IFN - γ, interleukins e.g., IL - 1β, IL-12, IL-18, tumor necrosis factor- α (TNF - α), and chemokines e.g., CCL2, CXCL10 have been reported in severely ill patients. These mediators represent the corner stone in developing cytokine storm that results in uncontrolled systemic inflammatory reaction with subsequent acute respiratory distress syndrome (ARDS), multiple organ failure and eventually death. Based on its an-ti-inflammatory effects, colchicine has also gained attention to be utilized in the management of COVID-19 patient. Colchicine exerts its anti-inflammatory effect through inhibition of formation of microtubules which is considered an essential step in several cellular processes such as division, signalling, and migration. Also, colchicine affects the cytokine cascade by inhibiting IL- 1β leading to reduction in neutrophils recruitment, free radicles production and inflammasome stimulation. This raises the concerns about the effectiveness of colchicine in COVID-19 treatment and the possibility of providing an improvement of the clinical course of the disease.","PeriodicalId":73167,"journal":{"name":"Global journal of epidemiology and infectious disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48437871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Note on Excess Mortality Attributable to COVID-19 in the United States. 关于美国 COVID-19 引起的超额死亡率的说明。

Global journal of epidemiology and infectious disease Pub Date : 2021-01-01 Epub Date: 2021-11-10 DOI: 10.31586/gjeid.2021.164

James A Koziol, Jan E Schnitzer

{"title":"A Note on Excess Mortality Attributable to COVID-19 in the United States.","authors":"James A Koziol, Jan E Schnitzer","doi":"10.31586/gjeid.2021.164","DOIUrl":"10.31586/gjeid.2021.164","url":null,"abstract":"Background: Annual influenza outbreaks constitute a major public health concern in the United States. But this health burden appears dwarfed by the impact of COVID-19. Our aim is to quantify the excess mortality attributable to COVID-19, compared to previous influenza seasons.Methods: We retrospectively compare weekly mortality figures attributable to influenza and pneumonia in the United States from 2013 to 2019 with corresponding figures attributable to influenza, pneumonia, and COVID-19 from 2019 to 2021. We utilize a difference in differences regression methodology to estimate excess mortality observed in 2019-21 compared to 2013-2019.Results: Mortality patterns attributable to influenza, pneumonia, and COVID-19 differ significantly from the 2013-19 experience. Notably, distinct, aperiodic mortality waves occur in the 2019-2021 window, and mortality is well in excess of what is observed in typical influenza seasons.Conclusions: The COVID-19 pandemic has led to considerable excess mortality in the United States, and has strained public health resources. One might expect that the mortality waves observed during the pandemic will be damped by increasing levels of vaccination, and prior infections.","PeriodicalId":73167,"journal":{"name":"Global journal of epidemiology and infectious disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10002049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0