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Future drug discovery最新文献

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CXCR4 as a novel target in immunology: moving away from typical antagonists. 作为免疫学新靶点的 CXCR4：摆脱典型拮抗剂的束缚。
Future drug discovery Pub Date : 2022-06-01 Epub Date: 2022-07-19 DOI: 10.4155/fdd-2022-0007
Birgit Caspar, Pietro Cocchiara, Armelle Melet, Kristof Van Emelen, Annegret Van der Aa, Graeme Milligan, Jean-Philippe Herbeuval
{"title":"CXCR4 as a novel target in immunology: moving away from typical antagonists.","authors":"Birgit Caspar, Pietro Cocchiara, Armelle Melet, Kristof Van Emelen, Annegret Van der Aa, Graeme Milligan, Jean-Philippe Herbeuval","doi":"10.4155/fdd-2022-0007","DOIUrl":"10.4155/fdd-2022-0007","url":null,"abstract":"<p><p>CXCR4 has been a target of interest in drug discovery for numerous years. However, so far, most if not all studies focused on finding antagonists of CXCR4 function. Recent studies demonstrate that targeting a minor allosteric pocket of CXCR4 induces an immunomodulating effect in immune cells expressing CXCR4, connected to the TLR pathway. Compounds binding in this minor pocket seem to be functionally selective with inverse agonistic properties in selected GPCR signaling pathways (G<sub>i</sub> activation), but additional signaling pathways are likely to be involved in the immunomodulating effects. In depth research into these CXCR4-targeted immunomodulators could lead to novel treatment options for (auto)-immune diseases.</p>","PeriodicalId":73122,"journal":{"name":"Future drug discovery","volume":"4 2","pages":"FDD77"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/b8/fdd-04-77.PMC9298491.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40645838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The possible drug for cancer and metastasis prevention 预防癌症和转移的可能药物
Future drug discovery Pub Date : 2022-05-18 DOI: 10.4155/fdd-2022-0008
V. Pak
{"title":"The possible drug for cancer and metastasis prevention","authors":"V. Pak","doi":"10.4155/fdd-2022-0008","DOIUrl":"https://doi.org/10.4155/fdd-2022-0008","url":null,"abstract":"","PeriodicalId":73122,"journal":{"name":"Future drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42431723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Multitargeted anti-infective drugs: resilience to resistance in the antimicrobial resistance era 多靶点抗感染药物:耐药时代的耐药韧性
Future drug discovery Pub Date : 2022-04-01 DOI: 10.4155/fdd-2022-0001
C. Suckling, I. Hunter, Fraser J. Scott
{"title":"Multitargeted anti-infective drugs: resilience to resistance in the antimicrobial resistance era","authors":"C. Suckling, I. Hunter, Fraser J. Scott","doi":"10.4155/fdd-2022-0001","DOIUrl":"https://doi.org/10.4155/fdd-2022-0001","url":null,"abstract":"The standard drug discovery paradigm of single molecule – single biological target – single biological effect is perhaps particularly unsuitable for anti-infective drug discovery. This is due to the rapid evolution of resistance likely to be observed with single target drugs. Multitargeted anti-infective drugs are likely to be superior due to their lower susceptibility to target-related resistance mechanisms. Strathclyde minor groove binders are a class of compounds which have been developed by adopting the multitargeted anti-infective drugs paradigm, and their effectiveness against a wide range of pathogenic organisms is discussed. The renaming of this class to Strathclyde nucleic acid binders is also presented due to their likely targets including both DNA and RNA.","PeriodicalId":73122,"journal":{"name":"Future drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42437797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Welcome to Volume 4 of Future Drug Discovery 欢迎收看《未来药物发现》第4卷
Future drug discovery Pub Date : 2022-03-01 DOI: 10.4155/fdd-2022-0006
H. Wall
{"title":"Welcome to Volume 4 of Future Drug Discovery","authors":"H. Wall","doi":"10.4155/fdd-2022-0006","DOIUrl":"https://doi.org/10.4155/fdd-2022-0006","url":null,"abstract":"","PeriodicalId":73122,"journal":{"name":"Future drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47682253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The promise of psychedelic research 迷幻药研究的前景
Future drug discovery Pub Date : 2022-02-18 DOI: 10.4155/fdd-2021-0012
Carina S Peritore
{"title":"The promise of psychedelic research","authors":"Carina S Peritore","doi":"10.4155/fdd-2021-0012","DOIUrl":"https://doi.org/10.4155/fdd-2021-0012","url":null,"abstract":"The use of psychedelics as medicines and for overall better brain health is potentially one of the most transformative developments given their immediate and long-lasting therapeutic effects across a plethora of neuropsychiatric disorders and, more recently, some neurodegenerative diseases. The US psychedelic drugs market is forecasted to grow by 16.3% by 2027 due to the increasing prevalence of treatment-resistant depression and mental health disorders. Decades-long restrictions, which date back to when psychedelics were declared controlled substances in 1970, have been lifted to allow researchers to publish on the therapeutic benefits of psychedelics. This review will feature the incredible depth of research underway revealing how psychedelics impact brain structure and function to treat mental health and other neurological disorders.","PeriodicalId":73122,"journal":{"name":"Future drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45818816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Interview with Hunterian CEO Dr Vinod Jaskula-Ranga Hunterian首席执行官Vinod Jaskula Ranga博士访谈
Future drug discovery Pub Date : 2022-01-17 DOI: 10.4155/fdd-2021-0011
Vinod Jaskula-Ranga
{"title":"Interview with Hunterian CEO Dr Vinod Jaskula-Ranga","authors":"Vinod Jaskula-Ranga","doi":"10.4155/fdd-2021-0011","DOIUrl":"https://doi.org/10.4155/fdd-2021-0011","url":null,"abstract":"","PeriodicalId":73122,"journal":{"name":"Future drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48740374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The case for cancer-associated fibroblasts: essential elements in cancer drug discovery? 癌症相关成纤维细胞的案例:癌症药物发现的基本要素?
Future drug discovery Pub Date : 2022-01-01 DOI: 10.4155/fdd-2021-0004
Gabrielle Brewer, Anne-Marie Fortier, Morag Park, Christopher Moraes
{"title":"The case for cancer-associated fibroblasts: essential elements in cancer drug discovery?","authors":"Gabrielle Brewer,&nbsp;Anne-Marie Fortier,&nbsp;Morag Park,&nbsp;Christopher Moraes","doi":"10.4155/fdd-2021-0004","DOIUrl":"https://doi.org/10.4155/fdd-2021-0004","url":null,"abstract":"<p><p>Although cancer-associated fibroblasts (CAFs) have gained increased attention for supporting cancer progression, current CAF-targeted therapeutic options are limited and failing in clinical trials. As the largest component of the tumor microenvironment (TME), CAFs alter the biochemical and physical structure of the TME, modulating cancer progression. Here, we review the role of CAFs in altering drug response, modifying the TME mechanics and the current models for studying CAFs. To provide new perspectives, we highlight key considerations of CAF activity and discuss emerging technologies that can better address CAFs; and therefore, increase the likelihood of therapeutic efficacy. We argue that CAFs are crucial components of the cancer drug discovery pipeline and incorporating these cells will improve drug discovery success rates.</p>","PeriodicalId":73122,"journal":{"name":"Future drug discovery","volume":"4 1","pages":"FDD71"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/c6/fdd-04-71.PMC9112234.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10249947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Breakthrough medicines during the COVID-19 pandemic era. COVID-19大流行时期的突破性药物。
Future drug discovery Pub Date : 2022-01-01 DOI: 10.4155/fdd-2022-0002
Eswara Naga Hanuma Kumar Ghali, Vijian Dhevan, Shravan K Narmala, Meena Jaggi, Subhash C Chauhan, Murali M Yallapu
{"title":"Breakthrough medicines during the COVID-19 pandemic era.","authors":"Eswara Naga Hanuma Kumar Ghali,&nbsp;Vijian Dhevan,&nbsp;Shravan K Narmala,&nbsp;Meena Jaggi,&nbsp;Subhash C Chauhan,&nbsp;Murali M Yallapu","doi":"10.4155/fdd-2022-0002","DOIUrl":"https://doi.org/10.4155/fdd-2022-0002","url":null,"abstract":"Eswara Naga Hanuma Kumar Ghali1,2, Vijian Dhevan3, Shravan K Narmala4, Meena Jaggi1,2, Subhash C Chauhan1,2 & Murali M Yallapu*,1,2 1Department of Immunology & Microbiology, School of Medicine, The University of Texas Rio Grande Valley, McAllen, TX 78504, USA 2South Texas Center of Excellence in Cancer Research, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA 3Department of Surgery, University of Texas Rio Grande Valley, Harlingen, TX 78550, USA 4DHR Health Hematology Oncology Institute, DHR Health, Edinburg, TX 78539, USA *Author for correspondence: Tel.: +956 296 1734; murali.yallapu@utrgv.edu","PeriodicalId":73122,"journal":{"name":"Future drug discovery","volume":"4 1","pages":"FDD69"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a2/4b/fdd-04-69.PMC8842712.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9730310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinetic intracellular assay measures compound binding kinetics at intracellular targets within living cells 细胞内动力学测定测量活细胞内细胞内靶标处的化合物结合动力学
Future drug discovery Pub Date : 2021-12-01 DOI: 10.4155/fdd-2021-0010
Charles S Lay, Daniel A. Thomas, P. Craggs
{"title":"Kinetic intracellular assay measures compound binding kinetics at intracellular targets within living cells","authors":"Charles S Lay, Daniel A. Thomas, P. Craggs","doi":"10.4155/fdd-2021-0010","DOIUrl":"https://doi.org/10.4155/fdd-2021-0010","url":null,"abstract":"","PeriodicalId":73122,"journal":{"name":"Future drug discovery","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43935920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quo vadis artificial intelligence and personalized medicine? Quovadis人工智能和个性化医疗？
Future drug discovery Pub Date : 2021-11-12 DOI: 10.4155/fdd-2021-0009
A. Banegas-Luna, Miguel Carmena-Bargueño, H. Pérez‐Sánchez
{"title":"Quo vadis artificial intelligence and personalized medicine?","authors":"A. Banegas-Luna, Miguel Carmena-Bargueño, H. Pérez‐Sánchez","doi":"10.4155/fdd-2021-0009","DOIUrl":"https://doi.org/10.4155/fdd-2021-0009","url":null,"abstract":"","PeriodicalId":73122,"journal":{"name":"Future drug discovery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44664356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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