Frontiers in urology最新文献

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Hysterectomy and the risk of urinary incontinence: a systematic review and meta-analysis. 子宫切除术和尿失禁的风险:一项系统回顾和荟萃分析。
IF 1.7
Frontiers in urology Pub Date : 2026-06-04 eCollection Date: 2026-01-01 DOI: 10.3389/fruro.2026.1816956
Liping Wang, Leilei Gao, Xuechai Bai, Juan Gu
{"title":"Hysterectomy and the risk of urinary incontinence: a systematic review and meta-analysis.","authors":"Liping Wang, Leilei Gao, Xuechai Bai, Juan Gu","doi":"10.3389/fruro.2026.1816956","DOIUrl":"10.3389/fruro.2026.1816956","url":null,"abstract":"<p><strong>Object: </strong>To evaluate the association between hysterectomy and the risk of developing urinary incontinence (UI) based on observational studies.</p><p><strong>Methods: </strong>We conducted a systematic search of PubMed, Embase, and Cochrane Library for observational studies from inception to December 14, 2025, using medical subject headings (MeSH) and keywords. The risk of bias and the quality of evidence were assessed using the Newcastle-Ottawa Scale (NOS), the Agency for Healthcare Research and Quality (AHRQ) criteria, and the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system, respectively. To derive overall summary estimates of odds ratios (OR), a random-effects meta-analysis was performed, complemented by subgroup analyses to explore potential effect modifiers. And the presence of publication bias was evaluated through funnel plots and Egger's regression test.</p><p><strong>Results: </strong>This meta-analysis is registered with PROSPERO (CRD42024587774) and follows PRISMA guidelines, including 12 studies with a cumulative total of 146,759 individuals who underwent hysterectomy. The pooled analysis revealed a significant association between hysterectomy and an increased risk of UI, yielding an OR of 1.31, (95% CI: 1.03-1.66, I<sup>2</sup> = 88.5%, <i>P</i> = 0.029). Subgroup analyses showed that the risk of UI was notably higher among patients who underwent abdominal hysterectomy (OR = 1.21, 95% CI: 1.10-1.34, I<sup>2</sup> = 0.0%, <i>P</i> = 0.000). Furthermore, it was observed that the incidence of UI was particularly elevated in studies conducted in Asia, while no significant association was reported for regions such as Europe and North America.</p><p><strong>Conclusion: </strong>Hysterectomy is associated with an increased risk of urinary incontinence, based on synthesized evidence from observational studies.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/, identifier CRD42024587774.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1816956"},"PeriodicalIF":1.7,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13275263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148297408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative outcomes of focal HIFU versus active surveillance in low- and intermediate-risk localized prostate cancer: a 75-month retrospective cohort study. 局灶HIFU与主动监测治疗低、中危局限性前列腺癌的比较结果:一项为期75个月的回顾性队列研究
IF 1.7
Frontiers in urology Pub Date : 2026-06-02 eCollection Date: 2026-01-01 DOI: 10.3389/fruro.2026.1801127
Mohammad Jaabou, Maurizio Buscarini, Osama Zaytoun, Zachary Dovey, Brooke Hildebrand, Modassar Awan, Maida Bada, Mohammad Al Ogaili, Ahmad Rabie
{"title":"Comparative outcomes of focal HIFU versus active surveillance in low- and intermediate-risk localized prostate cancer: a 75-month retrospective cohort study.","authors":"Mohammad Jaabou, Maurizio Buscarini, Osama Zaytoun, Zachary Dovey, Brooke Hildebrand, Modassar Awan, Maida Bada, Mohammad Al Ogaili, Ahmad Rabie","doi":"10.3389/fruro.2026.1801127","DOIUrl":"10.3389/fruro.2026.1801127","url":null,"abstract":"<p><strong>Objective: </strong>Focal high-intensity focused ultrasound (HIFU) is a minimally invasive treatment for localized prostate cancer. Its comparative effectiveness against active surveillance (AS) remains underexplored in patients eligible for either strategy.</p><p><strong>Methods: </strong>This retrospective cohort study analyzed 635 men with localized prostate cancer treated between 2018 and 2023: 303 received focal HIFU and 332 underwent AS. Only low-risk and favorable intermediate-risk patients per NCCN guidelines were included (PSA <20 ng/mL, stage ≤T2b, ISUP ≤2, <50% positive cores). Multiparametric MRI and targeted biopsies confirmed eligibility. Outcomes included progression to clinically significant prostate cancer (csPC: ISUP ≥3 or ISUP 2 with PIRADS ≥4), radical treatment-free survival, PSA kinetics, and functional outcomes (IPSS, IIEF-5, continence).</p><p><strong>Results: </strong>Baseline characteristics were comparable. At 12 months, csPC-free survival was higher with HIFU in intermediate-risk patients (95.8% vs. 84.0%, p=0.0018) and low-risk patients (97.6% vs. 88.3%, p=0.0035). At a median follow-up of 75 months, HIFU maintained superior csPC-free rates in both risk groups. Radical treatment-free survival was similar in both low and intermediate risk group 76% vs 77.1% and 83.2% vs 80.3% respectively, time to radical treatment was significantly longer in the HIFU group. PSA reductions at 3 and 6 months were greater with HIFU. Functional outcomes, including erectile function, continence, and urinary symptoms, were comparable between groups.</p><p><strong>Conclusions: </strong>Focal HIFU offers better short-term oncological control and delays the need for radical treatment compared to AS, with similar preservation of urinary and sexual function. These results support its use in selected patients seeking a balance between cancer control and quality of life.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1801127"},"PeriodicalIF":1.7,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13231475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current views on sustainability in urology: findings from the North Central Section of American Urological Association membership survey. 关于泌尿科可持续性的当前观点:来自美国泌尿科协会会员调查的中北部部分的发现。
IF 1.7
Frontiers in urology Pub Date : 2026-06-01 eCollection Date: 2026-01-01 DOI: 10.3389/fruro.2026.1818561
Chloe Shi, Susanna Wang, Ryan Steinberg, John O DeLancy, Keow Goh, Sarah Adelstein, Pankaj Dangle, Frank C Lin, Adam Miller, Matthew Gettman
{"title":"Current views on sustainability in urology: findings from the North Central Section of American Urological Association membership survey.","authors":"Chloe Shi, Susanna Wang, Ryan Steinberg, John O DeLancy, Keow Goh, Sarah Adelstein, Pankaj Dangle, Frank C Lin, Adam Miller, Matthew Gettman","doi":"10.3389/fruro.2026.1818561","DOIUrl":"10.3389/fruro.2026.1818561","url":null,"abstract":"<p><strong>Objective: </strong>The United Nations defines sustainability as meeting needs of the present without compromising future generations. While often equated to \"saving the planet\", sustainability is a diverse topic. Healthcare generates >5% of CO<sub>2</sub> emissions worldwide, yet sustainability efforts in urology are limited. The North Central Section of the American Urological Association (NCSAUA) recently convened a Sustainability Task Force to address this topic. This study queried members on sustainability in urologic practice.</p><p><strong>Methods: </strong>Following literature review on sustainability in surgery/urology, a 19-item anonymous REDCap survey was developed and distributed via email to NCSAUA members (N = 1607). The survey assessed current best practice, institutional/personal sustainability, and demographics. Responses were compiled and summarized using descriptive statistics.</p><p><strong>Results: </strong>Survey response rate was 4.9% (79/1607). Respondents were most commonly from metropolitan areas (82%), male (71%), and in practice for 5-14 years (29%). Sustainability topics were prioritized as: (1) financial, (2) future workforce, (3) environmental. Over half (56%) reported no institutional sustainability programs or were unaware of them. Instrument (67%), computer (68%), and paper (65%) recycling were supported by a majority of respondents. However, only 28% and 29% of respondents reported current institutional use of instrument and computer recycling, respectively. Telemedicine was infrequent, with most urologists (58%) conducting 0-5% of visits virtually.</p><p><strong>Conclusions: </strong>Current institutional and urologic practice emphasis on sustainability is low. Respondents ranked highest sustainability priorities as financial and future workforce. Efforts to address environmental sustainability were also supported, namely reduction of disposables and waste. The findings support the development of targeted programs to advance sustainability priorities widely.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1818561"},"PeriodicalIF":1.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13265346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148267115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next-generation imaging in prostate cancer. 新一代前列腺癌影像学研究。
IF 1.7
Frontiers in urology Pub Date : 2026-05-29 eCollection Date: 2026-01-01 DOI: 10.3389/fruro.2026.1829407
Ahmed Rabie, Maurizio Buscarini, Osama Zaytoun
{"title":"Next-generation imaging in prostate cancer.","authors":"Ahmed Rabie, Maurizio Buscarini, Osama Zaytoun","doi":"10.3389/fruro.2026.1829407","DOIUrl":"10.3389/fruro.2026.1829407","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Early detection of clinically significant prostate cancer (csPCa) remains a major challenge in urologic oncology. Although prostate-specific antigen (PSA) screening and systematic transrectal ultrasound- guided biopsy has historically been the main diagnostic approaches, these strategies are associated with both overdiagnosis of indolent disease and underdetection of clinically significant tumors. Recent advances in imaging technologies-including multiparametric magnetic resonance imaging (mpMRI), high-resolution micro-ultrasound (MUS), and prostate-specific membrane antigen positron emission tomography (PSMA PET)-have significantly improved the diagnostic pathway for prostate cancer. In parallel, artificial intelligence (AI)-based algorithms have emerged as promising tools for enhancing image interpretation and reducing diagnostic variability.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This review aims to summarize current evidence regarding the diagnostic performance of micro- ultrasound, mpMRI, and PSMA PET in prostate cancer detection and to explore the potential role of artificial intelligence in integrating these imaging modalities to improve diagnostic accuracy.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A systematic literature search was performed using PubMed and MEDLINE databases for articles published between January 2013 and December 2024. The following search strategy was employed using combinations of MeSH terms and keywords: ('prostate cancer' OR 'prostate neoplasm' OR 'prostatic carcinoma') AND ('micro-ultrasound' OR 'high-resolution micro-ultrasound' OR 'micro-US' OR 'PRI-MUS' OR 'ExactVu') OR ('multiparametric MRI' OR 'mpMRI' OR 'multi-parametric magnetic resonance imaging' OR 'PI-RADS') OR ('PSMA PET' OR 'prostate-specific membrane antigen' OR '68Ga-PSMA' OR '18F-DCFPyL' OR 'PSMA-11') OR ('artificial intelligence' OR 'machine learning' OR 'deep learning' OR 'radiomics' OR 'neural network'). Only English-language, peer-reviewed original research articles, systematic reviews, meta-analyses, and major consensus guidelines were included. Case reports, editorials, conference abstracts, and non-peer-reviewed publications were excluded. Two authors (A.R. and O.Z.) independently screened titles and abstracts for relevance. Full texts of potentially eligible articles were retrieved and assessed against predefined inclusion criteria: (1) evaluation of mpMRI, micro-ultrasound, or PSMA PET for prostate cancer detection, localization, or staging; (2) reported diagnostic accuracy metrics (sensitivity, specificity, AUC) or biopsy outcomes; (3) sample size ≥20 patients for original studies. Disagreements were resolved by consensus with a third author (M.B.). Reference lists of included articles were hand-searched for additional relevant studies. A narrative synthesis was conducted due to heterogeneity in study designs, populations, and outcome measures.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Multiparametric MRI has become a cornerstone in","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1829407"},"PeriodicalIF":1.7,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13259704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urodynamic characteristics of different types of detrusor overactivity in patients with benign prostatic obstruction. 良性前列腺梗阻患者不同类型逼尿肌过度活动的尿动力学特征。
IF 1.7
Frontiers in urology Pub Date : 2026-05-22 eCollection Date: 2026-01-01 DOI: 10.3389/fruro.2026.1845544
Xiao Zeng, Bo Huang, Hong Shen, De-Yi Luo, Tao Jin
{"title":"Urodynamic characteristics of different types of detrusor overactivity in patients with benign prostatic obstruction.","authors":"Xiao Zeng, Bo Huang, Hong Shen, De-Yi Luo, Tao Jin","doi":"10.3389/fruro.2026.1845544","DOIUrl":"10.3389/fruro.2026.1845544","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;This study aimed to investigate whether the presence or the absence of detrusor overactivity (DO) in patients with urodynamic-confirmed benign prostatic obstruction (BPO) leads to alterations in urodynamic parameters.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This study is a retrospective analysis of patients with urodynamic-confirmed BPO [Bladder Outlet Obstruction Index (BOOI) &gt;40]. Patients with a clinical diagnosis of benign prostatic hyperplasia (BPH) or benign prostatic enlargement (BPE) were initially screened, but only those with BOOI &gt; 40 were included. Based on the presence or absence of DO during urodynamics, patients were categorized into two groups: BPO with DO and BPO without DO. Subsequently, the BPO with DO group was further stratified according to DO subtype into BPO with terminal DO (TDO) and BPO with phasic DO (PDO). Differences in the urodynamic parameters and the DO-related indices among these groups were then evaluated. In addition, correlations between the DO-related indicators and the urodynamic parameters within each DO subtype were further examined.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There were 75 patients assigned to the BPO with DO group and 71 to the BPO without DO group. There was a statistically significant difference in the maximum cystometric capacity (MCC) and bladder compliance (BC) between the BPO with DO group and the BPO without DO group: 259.05 ± 44.54 &lt;i&gt;vs.&lt;/i&gt; 273.13 ± 36.69 (&lt;i&gt;p&lt;/i&gt; = 0.04) and 158.71 ± 83.86 &lt;i&gt;vs&lt;/i&gt;. 210.95 ± 82.58 (&lt;i&gt;p&lt;/i&gt; &lt; 0.001), respectively. The BPO with PDO group comprised 38 patients, while the BPO with TDO cohort included 37 patients. There exists a statistically significant difference between MCC and BC: 291.50 (248.75-301.75) &lt;i&gt;vs&lt;/i&gt;. 250.00 (210.00-296.00) (&lt;i&gt;p&lt;/i&gt; = 0.02) and 184.00 (150.50-286.75) &lt;i&gt;vs&lt;/i&gt;. 103.00 (85.00-141.50) (&lt;i&gt;p&lt;/i&gt; &lt; 0.001), respectively. Univariate regression analysis revealed a statistically significant negative correlation between the maximum contraction amplitude of DO and BC exclusively within the BPO with TDO cohort (&lt;i&gt;r&lt;/i&gt; &lt;sub&gt;s&lt;/sub&gt; = -0.34, &lt;i&gt;p&lt;/i&gt; = 0.03). Multivariable analysis confirmed this independent correlation (&lt;i&gt;β&lt;/i&gt; = -0.33, 95%CI = -0.59 to -0.07, &lt;i&gt;p&lt;/i&gt; &lt; 0.05). Age was identified as an independent risk factor for DO (OR = 1.19, &lt;i&gt;p&lt;/i&gt; &lt; 0.001) and first desire to void (FD) as an independent protective factor (OR = 0.98, &lt;i&gt;p&lt;/i&gt; &lt; 0.001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This preliminary study indicates that DO is associated with storage-phase urodynamic alterations in BPO patients, with no notable association with the voiding phase parameters. Multivariable analysis identified age as an independent risk factor for DO and FD as an independent protective factor. TDO is associated with more pronounced storage-phase changes than PDO. In the TDO subgroup, the correlation between BC and DO contraction amplitude was independent of age. However, several other comparisons remain unadjusted; there","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1845544"},"PeriodicalIF":1.7,"publicationDate":"2026-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13236510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148201274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report: Low-frequency tibial nerve stimulation: demonstrating a novel therapeutic option for Fowler's syndrome through a pilot case series. 病例报告:低频胫骨神经刺激:通过试点病例系列展示福勒综合征的一种新的治疗选择。
IF 1.7
Frontiers in urology Pub Date : 2026-05-20 eCollection Date: 2026-01-01 DOI: 10.3389/fruro.2026.1854503
Aidan McConnell-Trevillion, Ingrid Hoeritzauer, Helen Simpson, Jalesh N Panicker, Jon Stone, Dani Coombe, Kianoush Nazarpour
{"title":"Case Report: Low-frequency tibial nerve stimulation: demonstrating a novel therapeutic option for Fowler's syndrome through a pilot case series.","authors":"Aidan McConnell-Trevillion, Ingrid Hoeritzauer, Helen Simpson, Jalesh N Panicker, Jon Stone, Dani Coombe, Kianoush Nazarpour","doi":"10.3389/fruro.2026.1854503","DOIUrl":"10.3389/fruro.2026.1854503","url":null,"abstract":"<p><p>Fowler's Syndrome is a critically under-researched area of Women's Urological health. The condition, which causes severe urinary retention in the absence of any obvious obstructive pathology, lacks any non-invasive options for treatment. Transcutaneous Tibial Nerve Stimulation (TTNS) is an established treatment strategy for disorders of incontinence that is non-invasive, safe, and efficacious. Computer based modelling and preliminary animal experimentation indicates that ultra-low frequency TTNS (1-2 Hz) may induce an excitatory effect on bladder function that is of particular therapeutic relevance to Fowler's Syndrome. Therefore, the present case series describes a three-armed randomised-control (crossover) pilot study conducted from a biomechanical perspective in a population suffering from Fowler's Syndrome. The study aimed to address the question of if the novel application of low-frequency TTNS could ameliorate the symptoms of Fowler's Syndrome. Patients (<i>N</i> = 6) were administered either ultra-low frequency TTNS (1 Hz) or placebo. The objective outcome measure of the study was the change in voiding efficiency in response to intervention. 50% (<i>N</i> = 3) participants displayed a positive response to treatment, with a median increase in Voiding Efficiency of 6.3 to 12.6% across test conditions. Two participants displayed a negative response to the intervention, (median -3.6 to -20.9%) which may have been due to placebo effects but should be considered in future. The study indicated that TTNS may be capable of ameliorating the symptoms of Fowler's Syndrome, to a significant degree in one case. The work provides a foundation for future clinical research. The authors hope that should the results be confirmed by further clinical study they will have considerable impact on patient care.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1854503"},"PeriodicalIF":1.7,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13229719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148165938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimal artificial urine formulations for in vitro urolithiasis models. 体外尿石症模型的最佳人工尿液配方。
IF 1.7
Frontiers in urology Pub Date : 2026-05-14 eCollection Date: 2026-01-01 DOI: 10.3389/fruro.2026.1806726
Deok Hyun Han, Jae Hoon Chung
{"title":"Optimal artificial urine formulations for <i>in vitro</i> urolithiasis models.","authors":"Deok Hyun Han, Jae Hoon Chung","doi":"10.3389/fruro.2026.1806726","DOIUrl":"10.3389/fruro.2026.1806726","url":null,"abstract":"<p><strong>Purpose: </strong>To develop and characterize standardized <i>in vitro</i> artificial urine (AU) models for three major stone-forming environments-calcium oxalate (CaOx), uric acid (UA), and infection-related struvite-and to identify assay operating conditions that maximize stent-associated surface deposition while limiting excessive bulk precipitation.</p><p><strong>Materials and methods: </strong>Homemade AU models were formulated from a physiologic base composition and modified to create disease-specific lithogenic conditions. The CaOx model used sodium oxalate fixed at 80 mg/L with stepwise calcium chloride escalation to 600%. The UA model was tested at uric acid concentrations of 500-1000 mg/L under acidic pH. The bacterial infection model was tested as two independent live-bacterial arms preset at bulk pH 6.5 or 9.0 before immersion to capture urease-driven alkalinization and surface colonization, and a non-bacterial ammonia-alkalinized control was also evaluated. Stents of three commercial types were immersed for 48 h under CDC biofilm-reactor conditions, and surface deposition was quantified as weight change per unit length (mg/mm).</p><p><strong>Results: </strong>In the CaOx model, surface-associated weight gain increased with calcium concentration up to 200% (0.98 g/L) but declined at higher levels owing to competing bulk precipitation. The UA model produced minimal deposition, with maximal weight gain at 600 mg/L. In the bacterial infection assay, weight gain was numerically highest in the arm preset at bulk pH 6.5 before immersion and remained substantial in the arm preset at pH 9.0, whereas the non-bacterial alkalinization model resulted in negligible deposits.</p><p><strong>Conclusions: </strong>These stone type-specific AU models provide defined, lab-preparable lithogenic screening conditions. Within this 48-h reactor assay, CaCl<sub>2</sub> 200% + oxalate 80 mg/L, uric acid 600 mg/L, and the bacterial infection model initiated at preset bulk pH 6.5 yielded the highest observed stent-associated deposition. The platform may serve as an accelerated screening tool for evaluating stent materials, coatings, and anti-encrustation strategies.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1806726"},"PeriodicalIF":1.7,"publicationDate":"2026-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13215919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148140080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determinants of pediatric urolithiasis hospitalizations in endemic and non-endemic regions of Mexico. 墨西哥流行和非流行地区小儿尿石症住院的决定因素
IF 1.7
Frontiers in urology Pub Date : 2026-05-05 eCollection Date: 2026-01-01 DOI: 10.3389/fruro.2026.1704853
Xally Camila Cahuantzi-Flores, Daniel Flores-Ocotzi, Juan Pablo Flores-Tapia, Rosa Esther Moo-Puc, Edgar Villarreal-Jimenez, Antonio Esqueda-Mendoza, Salvador Gomez-Carro, Nina Mendez-Dominguez
{"title":"Determinants of pediatric urolithiasis hospitalizations in endemic and non-endemic regions of Mexico.","authors":"Xally Camila Cahuantzi-Flores, Daniel Flores-Ocotzi, Juan Pablo Flores-Tapia, Rosa Esther Moo-Puc, Edgar Villarreal-Jimenez, Antonio Esqueda-Mendoza, Salvador Gomez-Carro, Nina Mendez-Dominguez","doi":"10.3389/fruro.2026.1704853","DOIUrl":"10.3389/fruro.2026.1704853","url":null,"abstract":"<p><strong>Background: </strong>Urolithiasis in pediatric populations is increasing worldwide, with environmental and social determinants playing key roles. In Mexico, Yucatan is an endemic area for urolithiasis in adults. However, pediatric data are scarce.</p><p><strong>Objective: </strong>This study aimed to describe the clinical and ecological characteristics of pediatric urolithiasis hospitalizations in endemic (Yucatan) and non-endemic areas of Mexico.</p><p><strong>Methods: </strong>We conducted a retrospective, cross-sectional analysis of national hospital discharge records (2018-2024) for patients <18 years with ICD-10 codes N20.0, N20.1, N20.9, N21.0, and N21.1. The sociodemographic and clinical variables were compared between Yucatan and other states. Non-parametric regression models were used to examine the associations between ecological indicators and hospitalization rates.</p><p><strong>Results: </strong>A total of 2,238 hospitalizations were identified, with a national rate of 3.28 per 10,000 <i>versus</i> 28.03 in Yucatan. Patients in Yucatan were younger (mean = 111 <i>vs</i>. 128 months, <i>p</i> < 0.001) and more likely to self-report as indigenous (4.9% <i>vs</i>. 2.3%, <i>p</i> = 0.01). The majority of admissions originated from the emergency department (76% <i>vs</i>. 64%, <i>p</i> < 0.001). In the adjusted models, poverty was positively associated with hospitalization rates (<i>β</i> = 0.06, <i>p</i> = 0.032), while water hardness and marginalization lost significance.</p><p><strong>Conclusion: </strong>Pediatric urolithiasis in Yucatan is associated with younger age, indigenous status, and higher hospitalization rates, highlighting the combined role of environmental and socioeconomic factors. Poverty emerged as a key determinant, underscoring the need for targeted preventive strategies, improved access to safe hydration, and culturally sensitive interventions in vulnerable populations.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1704853"},"PeriodicalIF":1.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13183545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147984720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case Report: Till death - or the urologist - do us part: management of penile wedding-ring incarceration. 病例报告:直到死亡——或泌尿科医生——将我们分开:阴茎婚戒监禁的管理。
IF 1.7
Frontiers in urology Pub Date : 2026-04-29 eCollection Date: 2026-01-01 DOI: 10.3389/fruro.2026.1767585
Jaisukh Kalathia, Bharti Talreja, Kaushal Patel, Arvind Valiya, Giriraj Vala, Ayush Khetarpal
{"title":"Case Report: Till death - or the urologist - do us part: management of penile wedding-ring incarceration.","authors":"Jaisukh Kalathia, Bharti Talreja, Kaushal Patel, Arvind Valiya, Giriraj Vala, Ayush Khetarpal","doi":"10.3389/fruro.2026.1767585","DOIUrl":"10.3389/fruro.2026.1767585","url":null,"abstract":"<p><p>Penile strangulation is a rare urological emergency that can rapidly progress to vascular compromise and irreversible tissue damage. Metallic constricting devices pose the greatest challenge due to their rigidity and resistance to conventional removal techniques. We report the case of an adult male who developed progressive penile swelling and pain after self-application of a metallic wedding ring during an episode of emotional distress, necessitating mechanical sectioning with a tungsten-carbide orthopaedic cutter under continuous protective shielding for safe removal.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1767585"},"PeriodicalIF":1.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13167412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report: Pleasure gone wrong": a case of endoscopic removal of an extra-long urethral electric cable self-inserted for sexual gratification. 病例报告:“快感出错”:一例内窥镜切除为获得性满足而自行插入的超长尿道电缆。
IF 1.7
Frontiers in urology Pub Date : 2026-04-23 eCollection Date: 2026-01-01 DOI: 10.3389/fruro.2026.1768406
Jaisukh Kalathia, Bharti Talreja
{"title":"Case report: Pleasure gone wrong\": a case of endoscopic removal of an extra-long urethral electric cable self-inserted for sexual gratification.","authors":"Jaisukh Kalathia, Bharti Talreja","doi":"10.3389/fruro.2026.1768406","DOIUrl":"10.3389/fruro.2026.1768406","url":null,"abstract":"<p><p>Foreign bodies in lower urinary tract, once regarded as rare, are now increasingly recognized and demand urgent urological intervention. Spectrum of self-inserted urethral objects is remarkably wide, ranging from household items to sharp instruments and cables, with motivations spanning sexual-gratification, autoerotic experimentation and psychiatric illnesses. Clinical presentation varies from acute pain, retention, or haematuria to chronic recurrent infections and unexplained voiding symptoms. We present a case of a 49-year-old male who self-inserted an electric cable, which was successfully retrieved intact through endoscopic intervention within six hours of insertion. This case highlights early recognition, minimally invasive retrieval, and attention to underlying behavioural and psychological risk factors to prevent recurrence.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1768406"},"PeriodicalIF":1.7,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13149054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147870781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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