Frontiers in urology最新文献

{"title":"Bridging to systemic therapy: PSMA-PET-based early and repetitive stereotactic body radiotherapy for nodal and bone oligo-recurrent prostate cancer.","authors":"Arne Grün, Alexandra Partyka, Markus Galler, Torsten Schlomm, Dirk Böhmer, Kurt Miller, Daniel Zips, Goda Kalinauskaite","doi":"10.3389/fruro.2026.1738508","DOIUrl":"10.3389/fruro.2026.1738508","url":null,"abstract":"<p><strong>Introduction: </strong>To provide a detailed analysis regarding survival, local control and toxicity of nodal/bone oligo-recurrent prostate cancer identified and treated with PSMA-PET/CT and robotic SBRT using a uniform dose/fractionation scheme. The use of ADT was excluded.</p><p><strong>Methods: </strong>Retrospective analysis of patients with initial high-risk factors presenting with nodal/bone oligo-recurrent PCA in Ga68- or F18-PSMA-PET/CT treated with 1-3 fraction robotic SBRT.</p><p><strong>Results: </strong>60 patients/172 metastases were treated in 95 treatment series with 43 patients receiving >1 SBRT course. Median FU was 22 months. bPFS/SBRT-FS/ADT-FS was 6/23/32 months at 89.7% local control and 6.5/1.1% acute/late grade 1 AE. High PSA-nadir, initial pN1-status and longer time to PSA-nadir were predictive for worse bPFS/SBRT-FS.</p><p><strong>Discussion: </strong>Metastasis-Directed-Therapy using ablative focal SBRT is effective in bridging the gap between the identification of early metastases and the initiation of palliative systemic therapy. It is a fast outpatient procedure yielding high rates of local control, free of significant toxicity and repeatable if necessary. ADT could be withheld for almost 3 years. Patients with predictors for worse outcome could be identified.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1738508"},"PeriodicalIF":1.7,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbes and benign prostatic hyperplasia: the role of dysbiosis.","authors":"Gordon Treacy, Katherine Dinan, Timothy G Dinan","doi":"10.3389/fruro.2026.1959570","DOIUrl":"https://doi.org/10.3389/fruro.2026.1959570","url":null,"abstract":"<p><p>Benign prostatic hyperplasia (BPH) is a common age-related condition characterized by stromal and epithelial proliferation within the prostate and is influenced by androgen signaling, ageing, obesity, metabolic dysfunction, and inflammation. Increasing interest has focused on whether the gut microbiota may contribute to these processes through a putative gut-prostate axis. The human gut contains a complex microbial ecosystem comprising thousands of bacterial species whose metabolites and immune-modulatory activities influence host physiology. Alterations in microbial composition and function have been associated with numerous chronic inflammatory and metabolic disorders. Emerging clinical and preclinical evidence suggests that gut dysbiosis may also be associated with prostate enlargement and lower urinary tract symptoms. Proposed mechanisms include altered production of short-chain fatty acids, impaired intestinal barrier integrity with increased lipopolysaccharide translocation, Toll-like receptor signaling, changes in tryptophan and serotonin metabolism, vagal pathways, and systemic cytokine-mediated inflammation. However, current evidence remains largely associative and mechanistic, with relatively few human studies directly linking alterations in the gut microbiota to BPH pathogenesis. This narrative review examines current evidence supporting the gut-prostate axis in BPH, evaluates potential biological mechanisms such as the vagus nerve and tryptophan, discusses dietary influences on microbiota composition, and highlights limitations in the existing literature together with priorities for future research and therapeutic development.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1959570"},"PeriodicalIF":1.7,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsatellite instability in penile cancer: comparative analysis of primary tumors and metastases.","authors":"Hadson Silva Araujo, Gustavo Ramos Teixeira, Ana Carolina Laus, Gustavo Noriz Berardinelli, Daniel D Almeida Preto, Rui Manuel Reis, Flavio Mavignier Cárcano","doi":"10.3389/fruro.2026.1908537","DOIUrl":"10.3389/fruro.2026.1908537","url":null,"abstract":"<p><strong>Background: </strong>Penile cancer (PeCA) presents high morbidity and mortality and is more prevalent in underdeveloped countries. The presence of nodal metastasis at diagnosis or as early recurrence carries a worse prognosis, making it important to determine whether clinically relevant biomarkers are maintained between primary tumors and corresponding lymph node metastases. We aim to describe the presence of DNA microsatellite instability (MSI) in primary PeCA tumors and locoregional lymph nodes affected by metastatic cells, as well as to assess HPV status through p16 expression.</p><p><strong>Methods: </strong>A total of 116 patients were comparatively evaluated between the primary tumor and lymph node metastases. The evaluation of p16 and mismatch repair proteins was done by immunohistochemistry, and MSI status was assessed using a hexa-plex marker by polymerase chain reaction, followed by fragment analysis.</p><p><strong>Results: </strong>All patients underwent a standard lymphadenectomy (inguinal or pelvic), with a pN0 frequency of 33.6%. MSI-H was found in three patients (2.6%), with correspondence between the presence of the biomarker in the primary tumors and the lymph node metastases. A second validation was performed using IHC for MMR, with MLH1/PMS2 loss in MSI-H cases. 22.8% of patients expressed p16 by immunohistochemistry. p16 positivity was associated with a 55% reduction in the risk of death. All MSI-H patients were p16 positive.</p><p><strong>Conclusion: </strong>MSI-H occurs in 2,6% of the sample and is associated predominantly with MLH1/PMS2 loss and p16 positivity. Together, these findings suggest potential interactions between HPV- associated carcinogenesis and genomic instability. Further prospective, biomarker-driven trials are warranted to define their prognostic and therapeutic relevance in PeCA.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1908537"},"PeriodicalIF":1.7,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13553218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148921959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Pseudo-prune belly syndrome after early fetal bladder decompression: implications for the pathogenesis of prune belly spectrum disorders.","authors":"Alberto Parente, Mercedes Fariñas, Monica Miño, Francisca Sonia Molina","doi":"10.3389/fruro.2026.1919700","DOIUrl":"10.3389/fruro.2026.1919700","url":null,"abstract":"<p><strong>Background: </strong>Prune Belly Syndrome (PBS) is a rare congenital disorder characterized by abdominal wall deficiency, urinary tract dilatation, and bilateral cryptorchidism. Its pathogenesis remains controversial, with both developmental and mechanical theories proposed. Whether early fetal decompression influences the phenotypic expression of PBS has not been established.</p><p><strong>Case presentation: </strong>We report a male fetus diagnosed at 12 weeks' gestation with severe megacystis and bilateral hydroureteronephrosis. A Somatex^® vesicoamniotic shunt was placed at 16 weeks because of progressive lower urinary tract obstruction. Prenatal follow-up demonstrated complete resolution of upper urinary tract dilatation and persistent bladder decompression throughout pregnancy. After birth, the patient presented bilateral cryptorchidism and mild abdominal wall weakness but preserved renal morphology and function. Voiding cystourethrography showed high-grade bilateral vesicoureteral reflux, and diagnostic cystoscopy excluded posterior urethral valves and urethral atresia, supporting the diagnosis of Pseudo-Prune Belly Syndrome (PPBS). At 6 months of follow-up, the patient remains asymptomatic, with no urinary tract infections, spontaneous bilateral testicular descent, stable abdominal wall weakness, normal renal growth, and preserved renal function.</p><p><strong>Conclusion: </strong>This case illustrates a favorable early outcome following prenatal vesicoamniotic shunting in a fetus with severe lower urinary tract obstruction who subsequently developed an attenuated phenotype consistent with PPBS. Although causality cannot be inferred from a single observation, these findings are consistent with the fetal outlet obstruction hypothesis and raise the possibility that early fetal decompression may influence phenotypic expression in selected patients. Further studies are required to clarify the role of prenatal intervention in the pathogenesis and clinical spectrum of PBS.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1919700"},"PeriodicalIF":1.7,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Urachal calculus with an atypical intravesical CT appearance and literature review.","authors":"Xingqiang Long, Yunli Zhi, Yinghe Zhou, Daoqi Wang, Haixiang Guo","doi":"10.3389/fruro.2026.1899074","DOIUrl":"10.3389/fruro.2026.1899074","url":null,"abstract":"<p><strong>Background: </strong>Urachal calculi are uncommon complications of urachal remnants. Their clinical and radiological appearances overlap with bladder calculi, vesicourachal diverticula, infected urachal cysts, and calcified urachal tumors, creating a potential diagnostic pitfall.</p><p><strong>Case description: </strong>A 54-year-old man presented with intermittent lower abdominal pain lasting more than six months without hematuria, dysuria, umbilical discharge, fever, or other lower urinary tract symptoms. Cystoscopy at a local hospital showed bladder inflammation but no stone. In our hospital, computed tomography demonstrated a 1.2 x 0.9 cm densely calcified lesion (approximately 1112 HU) at the junction of the bladder dome and anterior wall. The lesion appeared to lie within the bladder outline and initially mimicked a bladder diverticular calculus. Repeat cystoscopy at our institution identified a partially intravesical calculus with a component embedded in the urachal tract. The intravesical component was fragmented using a holmium laser, followed by laparoscopic partial cystectomy and en bloc excision of the urachal remnant and residual calculus. Histopathological examination showed an inflamed urachal remnant without intestinal metaplasia, dysplasia, or malignancy. The urinary catheter was removed after 2 days, and the patient was discharged after a 7-day hospitalization. Post-discharge recurrence could not be assessed because the patient was lost to follow-up.</p><p><strong>Conclusion: </strong>A midline calcification at the bladder dome should prompt consideration of a urachal origin even when it appears intravesical. Multiplanar CT assessment, systematic inspection of the bladder dome, and histological evaluation of the excised remnant are important for diagnosis and management.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1899074"},"PeriodicalIF":1.7,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13549815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relative Sertoli-cell FSH hyporesponsiveness as a potential contributor to sperm DNA fragmentation: a hypothesis-driven narrative review and proposal of the FERTILE framework.","authors":"Hussein Kandil","doi":"10.3389/fruro.2026.1915445","DOIUrl":"10.3389/fruro.2026.1915445","url":null,"abstract":"<p><strong>Background: </strong>Sperm DNA fragmentation (SDF) is associated with impaired fertility, adverse reproductive outcomes, and an increased risk of miscarriage. Although oxidative stress is considered the predominant contributor to SDF, accumulating evidence suggests that abnormalities arising during spermatogenesis may also influence sperm DNA integrity. However, whether relative Sertoli-cell FSH hyporesponsiveness contributes to SDF has not been directly investigated.</p><p><strong>Objective: </strong>To evaluate the biological plausibility that relative Sertoli-cell FSH hyporesponsiveness may contribute to SDF and to propose a multidimensional research framework for future biological investigation.</p><p><strong>Methods: </strong>A hypothesis-driven narrative review was conducted using experimental, translational, and clinical evidence addressing FSH signaling, Sertoli-cell biology, spermatogenesis, SDF, pharmacogenetics, and FSH-based therapeutic interventions. Relevant literature was identified through structured searches of PubMed, Scopus, and Embase up to June 1, 2026.</p><p><strong>Results: </strong>Available evidence suggests that circulating FSH concentrations may not accurately reflect effective intratesticular FSH action. Human associative studies, pharmacogenetic findings, and mechanistic experimental evidence collectively support the biological plausibility that inter-individual variation in effective FSH signaling may influence Sertoli-cell support of germ-cell maturation, chromatin remodeling, and cellular quality-control mechanisms. Although direct clinical evidence remains limited, these observations suggest that relative Sertoli-cell FSH hyporesponsiveness could contribute to defective chromatin packaging, persistence of DNA damage, and increased susceptibility to SDF in selected men. To facilitate future investigation of this hypothesis, the FERTILE framework is proposed as a seven-domain conceptual model integrating FSH and effective intratesticular signaling, endocrine markers, receptor and ligand genetics, testicular structure, inflammation and oxidative stress, lifestyle and environmental factors, and evaluation of DNA integrity.</p><p><strong>Conclusions: </strong>Relative Sertoli-cell FSH hyporesponsiveness represents a biologically plausible but currently unproven contributor to elevated SDF. The proposed FERTILE framework is intended as a conceptual research tool for biological stratification and hypothesis generation rather than a clinical decision-making instrument. Prospective studies incorporating endocrine profiling, pharmacogenetic characterization, standardized SDF assessment, and direct or validated surrogate measures of Sertoli-cell responsiveness are required to determine whether relative Sertoli-cell FSH hyporesponsiveness has independent clinical relevance for sperm DNA integrity and reproductive outcomes.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1915445"},"PeriodicalIF":1.7,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13547001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148907936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paratesticular myofibroblastic lesion in a prepubertal child: a case report of a rare spindle cell tumor with testis-sparing management.","authors":"Jeremy Sheiber, Jordan Nguyen, Michelle Smith, Manish Bajaj, Abhishek Seth, Pamela Ellsworth, Peter Y Cai","doi":"10.3389/fruro.2026.1866045","DOIUrl":"10.3389/fruro.2026.1866045","url":null,"abstract":"<p><p>Paratesticular tumors are uncommon in the pediatric population and can represent a wide range of benign and malignant pathologies. We report the case of an otherwise healthy 2-year-old boy who presented with an asymptomatic right scrotal mass. Serial scrotal ultrasounds demonstrated a stable, well-circumscribed extratesticular lesion adjacent to the epididymal head with internal vascularity and normal bilateral testicular architecture. Serum tumor markers, including alpha-fetoprotein, beta-human chorionic gonadotropin, and lactate dehydrogenase, were within normal limits. There was no family history of malignancy or urologic conditions. Given persistent diagnostic uncertainty, surgical exploration was performed. Intraoperatively, a firm paratesticular mass arising from the tunica albuginea was identified and excised with preservation of the testis. Frozen section analysis revealed bland spindle cells without malignant features, allowing for testis-sparing management. Permanent histopathology demonstrated a well-circumscribed spindle cell lesion within a loose collagenous stroma with dystrophic calcifications. Immunohistochemistry showed positivity for smooth muscle actin and negativity for desmin, myogenin, MyoD1, β-catenin, S100, and anaplastic lymphoma kinase (ALK), supporting a diagnosis of benign myofibroblastic lesion, such as fibrous pseudotumor, and excluding inflammatory myofibroblastic tumor. To our knowledge, this case represents one of the earliest presentations of a benign paratesticular myofibroblastic lesion. This case underscores the importance of considering rare benign spindle cell lesions in the differential of paratesticular lesions in young children and the use of intraoperative frozen section to facilitate testis-sparing surgery and avoid unnecessary orchiectomy through careful multidisciplinary evaluation.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1866045"},"PeriodicalIF":1.7,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13541473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urothelial carcinoma of the bladder with prostatic stromal invasion and early postoperative bone metastases: a case report.","authors":"Cheng Wang, Mengyun Wang, Yue He","doi":"10.3389/fruro.2026.1910163","DOIUrl":"10.3389/fruro.2026.1910163","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Prostatic involvement by bladder urothelial carcinoma is uncommon, and prostatic stromal invasion usually indicates aggressive tumor biology and poor prognosis. Such patients may present with prostatic enlargement or a mass at the bladder neck-prostate junction, while serum prostate-specific antigen (PSA) may remain within the normal range. This diagnostic overlap may lead to clinical confusion with benign prostatic hyperplasia or primary prostatic tumors.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Case presentation: &lt;/strong&gt;A 54-year-old man was admitted with urinary frequency, urgency, dysuria, and intermittent gross hematuria. Serum PSA on admission was 2.1 ng/mL. Imaging suggested a mass at the bladder neck-prostate junction with an indistinct boundary between the bladder and prostate. After transurethral resection of a bladder lesion, pathology and immunohistochemistry indicated high-grade invasive urothelial carcinoma. Tumor cells expressed CK20, GATA3, and p63, partially expressed CK7 and Uroplakin III, and were negative for PSA and NKX3.1. The patient subsequently underwent radical cystectomy, ileal conduit urinary diversion, and pelvic lymph-node dissection. Postoperative pathology revealed high-grade bladder urothelial carcinoma with invasion of the prostatic stroma and capsule, staged as pT4aN0M0, with lymphovascular invasion, perineural invasion, and a positive prostatic urethral margin. PD-L1 expression was low (TPS &lt;1%, IC &lt;1%), and HER2 was negative. Because no neoadjuvant systemic therapy had been given and the final pathology showed pT4a disease with a positive margin, adjuvant systemic therapy was recommended and initiated. The patient received only approximately one week of platinum-based chemotherapy plus immunotherapy; treatment was discontinued because of poor tolerance and substantial financial burden. Three months after surgery, the patient developed low back pain. Whole-body bone scintigraphy and SPECT/CT demonstrated multiple bone metastases involving the L2 and L4 vertebrae and posterior elements, bilateral iliac bones, the left acetabular rim, and the right inferior pubic ramus. He subsequently received denosumab combined with conformal intensity-modulated radiotherapy to vertebral metastatic lesions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;This case highlights that a normal PSA level does not exclude prostatic involvement by bladder-derived urothelial carcinoma. For patients with bladder neck or prostatic masses, especially those with normal PSA but imaging evidence of bladder-prostate junction involvement, an immunohistochemical panel including GATA3, CK7, CK20, p63, Uroplakin III, PSA, and NKX3.1 should be used early for differential diagnosis. Prostatic stromal invasion combined with lymphovascular invasion, perineural invasion, and a positive surgical margin may indicate highly aggressive disease and an increased risk of early distant metastasis, requiring intensified postoperative risk assessment, systemic treatme","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1910163"},"PeriodicalIF":1.7,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13541533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148898619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary leiomyomatosis and renal cell carcinoma: a case report and literature review.","authors":"Shuqi Zuo, Yafei Xue, Fei Wang, Honglin Guo, Min Cui, Xingbo Zhao, Xiaoyi Qi","doi":"10.3389/fruro.2026.1907141","DOIUrl":"10.3389/fruro.2026.1907141","url":null,"abstract":"<p><p>Hereditary leiomyomatosis and renal cell carcinoma (HLRCC), caused by germline <i>FH</i> mutations, is a rare autosomal dominant syndrome. This report details a 42-year-old woman with aggressive FH-deficient renal cell carcinoma (RCC) and multiple uterine leiomyomas. Radical nephrectomy and subsequent hysterectomy confirmed FH-deficient tumors via immunohistochemistry and genetic testing (<i>FH</i> c.1240A>G, p. Lys414Glu). Despite adjuvant immunotherapy and targeted therapy, rapid bone metastasis occurred postoperatively. This case highlights the aggressive nature of HLRCC-associated RCC, underscores challenges in therapeutic management, and emphasizes the necessity of early genetic testing and multidisciplinary surveillance to improve outcomes.</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1907141"},"PeriodicalIF":1.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13537973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Artificial intelligence and machine learning in neurogenic lower urinary tract dysfunction and spinal cord injury: current status, emerging technologies, and ethical perspectives.","authors":"","doi":"10.3389/fruro.2026.1962187","DOIUrl":"https://doi.org/10.3389/fruro.2026.1962187","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fruro.2026.1931923.].</p>","PeriodicalId":73113,"journal":{"name":"Frontiers in urology","volume":"6 ","pages":"1962187"},"PeriodicalIF":1.7,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13539415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}