Frontiers in tropical diseases最新文献

{"title":"Recent advances in the clinical development of antifungal vaccines: a narrative review","authors":"Das Alapan, Ojha Bisweswar, Sarkar Prasenjit, Das Prasanjit, Bandyopadhyay Arkapal","doi":"10.3389/fitd.2024.1446477","DOIUrl":"https://doi.org/10.3389/fitd.2024.1446477","url":null,"abstract":"Vaccine development tools for fungal infections are undergoing transformation where newer technologies like nanotechnology and bioinformatics are used to create new and improved vaccine candidates. Immunocompromised individuals and those with multiple chronic conditions are especially vulnerable to invasive fungal infections. These patients are at increased risk of developing widespread infections and experiencing poor health outcomes. Current management of fungal infections is associated with diagnostic challenges, side effects, and resistance. Vaccination is an effective strategy to prevent infections and boost immunity. Despite the significant burden of fungal disease, there are currently no licensed fungal vaccines available. This review is focused on various vaccine development strategies, including whole-cell, subunit, and nucleic acid-based vaccines. Various challenges like safety concerns, weak and nonspecific immune response, ideal adjuvants, and the need for improved drug delivery systems are also highlighted in this review. Sustained antigenic response, addressing host immune response variability, and eliciting persistent predictable immune response are crucial for vaccine development. Standardized protocols and robust preclinical studies are essential for the clinical development of potential vaccine candidates. Exploring novel targets using advanced technologies like bioinformatics, nanotechnology, and reverse vaccinology are being rapidly explored.","PeriodicalId":73112,"journal":{"name":"Frontiers in tropical diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141926008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustaining success through strategies for post-elimination management of neglected tropical diseases in African Union Member States","authors":"Nafiisah Chotun, Julian Eaton, Ifeoma Ajegbo Anagbogu, H. Tesfahunei, Sheila Shawa, Carol Karutu, Akeem Bolarinwa, Abdulaziz Mohammed","doi":"10.3389/fitd.2024.1421522","DOIUrl":"https://doi.org/10.3389/fitd.2024.1421522","url":null,"abstract":"The elimination of Neglected Tropical Diseases (NTDs) has seen significant progress, with 22 African Union Member States having successfully eliminated at least one NTD. However, post-elimination management of NTDs remains a challenge. This article provides important insights into the challenges faced by African Union Member States after eliminating NTDs, including potential financial support withdrawal and risk of disease reemergence. We also discuss comprehensive strategies for post-elimination management, emphasising the importance of robust surveillance systems, capacity building, community engagement, and the integration of mental health services. We also advocate for a multisectoral approach to sustain elimination gains, aligning with global and regional health strategies. Our analysis underscores the necessity of continuous innovation in surveillance, the critical role of community health workers, the integration of NTD post-elimination management into broader health and development frameworks such as Universal Healthcare Coverage, and the need for innovative financing and partnerships to ensure the long-term success of NTD elimination efforts.","PeriodicalId":73112,"journal":{"name":"Frontiers in tropical diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141926472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biobanking for tropical health: leveraging collaborative initiatives in the Lusophone world","authors":"A. P. Arez, Aline Souto, Manuela da Silva, C. R. S. do Nascimento, Isabel Couto, Silvana Belo, Nelson Lima","doi":"10.3389/fitd.2024.1438842","DOIUrl":"https://doi.org/10.3389/fitd.2024.1438842","url":null,"abstract":"Biological collections and biobanks are essential for scientific research and innovation, supporting various scientific fields such as health sciences, biotechnology, food and agriculture. They preserve and provide diverse organisms, biological materials and their associated data, enabling the study of biodiversity, diseases, and their evolution and ecological functions. These collections are crucial for addressing global challenges like biodiversity loss, sustainable food and feed production, and human health, including understanding variations in pathogenic and etiologic agents over time. Biobanks support the development of new therapies, biomarkers, and diagnostic tests while promoting equitable benefit sharing from genetic resource utilization and developing and implementing international standards, crucial for improving research reliability and reproducibility. Collaborative networks enhance biobank operation by organizing data, exchanging biological material and facilitating trans-biobank studies and protocols standardization/harmonization. The establishment of the Lusophone Network of Biobanks and Biological Collections is a significant step toward promoting collaboration, capacity building and capacity development among Portuguese-speaking countries, many of them dealing with tropical health issues, facilitating knowledge exchange and resource sharing for scientific advancement on a global scale.","PeriodicalId":73112,"journal":{"name":"Frontiers in tropical diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141925618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scabies: current knowledge and future directions","authors":"Elke Mitchell, Miranda Wallace, Justine Marshall, Margot Whitfeld, Lucia Romani","doi":"10.3389/fitd.2024.1429266","DOIUrl":"https://doi.org/10.3389/fitd.2024.1429266","url":null,"abstract":"Scabies is a global public health issue, with approximately 455 million new cases worldwide each year. Scabies is a parasitic skin disease caused by infestation with the mite Sarcoptes scabiei var. hominis that can lead to secondary skin infections such as impetigo. In 2017, scabies was added to the World Health Organization’s list of neglected tropical diseases renewing calls for effective management and control of the disease. Mass drug administration has emerged as an effective strategy to control scabies, especially in highly endemic settings. In this review, we detail scabies epidemiology and risk factors, clinical characteristics and diagnosis, as well as control options, and future areas for scabies research.","PeriodicalId":73112,"journal":{"name":"Frontiers in tropical diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141811421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural occurrence of Wolbachia in Anopheles sp. and Aedes aegypti populations could compromise the success of vector control strategies","authors":"O. Gnankiné, R. Dabiré","doi":"10.3389/fitd.2024.1329015","DOIUrl":"https://doi.org/10.3389/fitd.2024.1329015","url":null,"abstract":"Wolbachia is a maternally inherited bacterium commonly detected in approximately 50% of arthropod species, including mosquito vector species. Wolbachia species have been detected in different mosquito vectors, but in most malaria vectors, their occurrence in natural populations were reported 10 years ago. Aedes aegypti, the main vector of dengue virus, is generally uninfected by Wolbachia, and records of infection are rare and only include a few populations. This bacterium impacts the biology, ecology, and evolution of vector populations. Wolbachia has attracted considerable interest because of its role in reducing disease transmission. Moreover, this bacterium is known to manipulate insect reproduction by inducing cytoplasmic incompatibility (CI), thus providing new avenues for vector control strategies. Interestingly, wMel or wAlbB Wolbachia infections in Aedes populations exhibit a stable high frequency in most areas and contribute to the reduction of local dengue transmission. In natural populations of Anopheles, although Wolbachia was found, little is known about its role and effect on Plasmodium. If the incompatible insect technique (IIT) and population replacement strategy resulted in significant decreases in the dengue transmission in endemic countries such as the USA, Taiwan, Australia, and Brazil, natural Wolbachia detection in mosquitoes may pose a threat to these vector control strategies, raising the following question: “Does the natural occurrence of Wolbachia in Anopheles sp. and Ae. aegypti populations compromise the success of vector control strategies? This review presents recent achievements of Wolbachia in natural Anopheles and Ae. aegypti populations in terms of prevalence and provides guidelines for the development of Wolbachia-based vector control.","PeriodicalId":73112,"journal":{"name":"Frontiers in tropical diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141816687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting malaria hyper endemic zones in West Africa using a regional scale dynamical malaria model","authors":"E. Olaniyan, A. Tompkins, Cyril Caminade","doi":"10.3389/fitd.2024.1322502","DOIUrl":"https://doi.org/10.3389/fitd.2024.1322502","url":null,"abstract":"Due to the continuing large number of malaria-related deaths in tropical Africa, the need to develop a robust Malaria Early Warning System (MEWS) for effective action is growing to guide cost-effective implementation of interventions. This study employs a two-stage hierarchical evaluation technique to evaluate the ability of the VECTRI malaria model to simulate malaria dynamics at seasonal time scale (1 - 7 months) over Nigeria and West Africa. Two sets of malaria simulations are considered. The first set is based on VECTRI simulations driven by observed rainfall and temperature datasets (hereafter referred to as control run). The second is based on malaria simulations driven by the European Centre for Medium-Range Weather Forecasting (ECMWF) System5 ensemble seasonal forecasting system (hereafter referred to as Forecast run). Different metrics are employed to assess the skill of the VECTRI malaria model. Results based on the control run indicate that the model can reproduce hyper-endemic zones and the evolution of malaria cases, particularly the observed increase in cases with decreasing population density. Despite having significant biases and low correlation, the model successfully predicts annual anomalies in malaria cases across Nigeria, particularly in the savannah region that experience large malaria burden. Annual correlations between the VECTRI Forecast run and the VECTRI Control run are relatively low at all lead times (LT) and for each start date (SD) across West Africa, although correlation generally increases from the Gulf of Guinea to the Sahel. Despite low correlations, the Rank Probability Skill Score (RPSS) reveals that the model has a statistically significant skill in predicting malaria occurrences across all categories of malaria cases, regardless of start date or lead time. While the Guinea Forest has the strongest RPSS, the increase or decrease in skill from the first to seventh lead time varies significantly across the region. In addition, the VECTRI malaria model has a good ability to discriminate variability in malaria cases across all regions, with an average Area Under the Relative Operating Characteristics (ROC) Curve (AUC) of approximately 0.62. Our findings suggest that the VECTRI malaria model could be used as a reliable Malaria Early Warning System (MEWS), particularly for identifying malaria hyper-endemic zones in West Africa at seasonal time scale.","PeriodicalId":73112,"journal":{"name":"Frontiers in tropical diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141641098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verification of the reactivity of immunoglobulins in dried blood spots collected for onchocerciasis sero-surveillance by an Escherichia coli ELISA","authors":"H. Hassan, Kristi Miley, T. Unnasch","doi":"10.3389/fitd.2024.1419166","DOIUrl":"https://doi.org/10.3389/fitd.2024.1419166","url":null,"abstract":"The World Health Organization guidelines for verification of onchocerciasis elimination include demonstrating that the prevalence of exposure to the parasite in individuals born since transmission was interrupted needs to be less than 0.1%. The guidelines recommend using seropositivity to an Onchocerca volvulus specific antigen (Ov16) for this purpose. Ov16 seropositivity has most often been assessed using the Ov16 ELISA assay. Currently, the Ov16 ELISA assay includes internal positive and negative controls to monitor for proper assay performance but does not control for the quality of the dried blood spots (DBS) being tested. Previous studies have reported a high prevalence of antibodies recognizing Escherichia coli in children. Through the development of an ELISA assay to detect antibodies recognizing E. coli, a common commensal in humans, DBS may be prescreened for quality assurance prior to testing for Ov16. Results demonstrated antibodies to E. coli were detected in 100% of randomly selected serum samples collected from O. volvulus infected individuals residing in an onchocerciasis hyperendemic area. Furthermore, when DBS were improperly stored, the E. coli antibodies were found to decay over a period of one week, while remaining unchanged over the same period in properly stored samples. Similarly, E. coli antibodies were detected in 100% of a batch of field collected properly stored DBS, while being present only in 5% of a batch of improperly stored spots. This study demonstrates the value of E. coli ELISA for DBS quality control testing and validation of proper storage of collections of DBS for the Ov16 ELISA.","PeriodicalId":73112,"journal":{"name":"Frontiers in tropical diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141660351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Latest advances in the biological control of vectors of human tropical diseases","authors":"Juan Venegas, Slavica Vaselek, M. Yasnot","doi":"10.3389/fitd.2024.1430944","DOIUrl":"https://doi.org/10.3389/fitd.2024.1430944","url":null,"abstract":"","PeriodicalId":73112,"journal":{"name":"Frontiers in tropical diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disease X in the Tropics, preventing the next pandemic: how to accelerate spillover prevention and vaccine preparedness?","authors":"C. Possas, Ernesto T. A. Marques, Suresh V. Kuchipudi, Prashant Kumar, Jerome H. Kim, Akira Homma","doi":"10.3389/fitd.2024.1417065","DOIUrl":"https://doi.org/10.3389/fitd.2024.1417065","url":null,"abstract":"","PeriodicalId":73112,"journal":{"name":"Frontiers in tropical diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141677511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in the diagnosis and control of female genital schistosomiasis in sub-Saharan Africa: an exemplar case report associated with mixed and putative hybrid schistosome infection in Nsanje District, Southern Malawi","authors":"S. Kayuni, Lucas J. Cunningham, Dingase Kumwenda, Bright Mainga, D. Lally, P. Chammudzi, D. Kapira, G. Namacha, Bessie Ntaba, Alice Chisale, Tereza Nchembe, Luis Kinley, Ephraim Chibwana, A. Juhász, Sam Jones, J. Archer, P. Makaula, John Chiphwanya, E. J. LaCourse, J. Musaya, J. R. Stothard","doi":"10.3389/fitd.2024.1354119","DOIUrl":"https://doi.org/10.3389/fitd.2024.1354119","url":null,"abstract":"Female genital schistosomiasis (FGS) remains an often overlooked chronic complication of urogenital schistosomiasis in adolescent girls and women. Moreover, the role of zoonotic or hybrid schistosome infection(s) is poorly appreciated, but is increasingly becoming an emerging public health concern in sub-Saharan Africa. In Southern Malawi, during the “Hybridization in UroGenital Schistosomiasis (HUGS)” study visit, we describe the case of a 33-year-old woman with suspected FGS who partook in a detailed external assessment with internal cervical examination using a portable colposcope. She provided several biological samples for analysis with traditional and molecular parasitological methods—urine, cervicovaginal lavage (CVL), cervical swabs, and external mass and cervical biopsies—alongside provision of detailed demographic information after a thorough medical history questionnaire and an in-depth interview. These samples were screened for the presence of Schistosoma ova on microscopy and DNA genotyping using a novel real-time PCR assay in parallel to pre-published probe-based PCR assays capable of identifying and discriminating up to six named Schistosoma species. A further molecular screen of sexually transmitted infections (STIs) including Trichomonas vaginalis, Chlamydia spp., and human papilloma virus (HPV) was conducted on her genital swab and CVL. Overt FGS was diagnosed on clinical colposcopy alongside inspection of the cervical biopsy by microscopy, real-time PCR, and histopathology. The urine filtration, microscopy and real-time PCR of the CVL and swab were negative. This evidences the typical diagnostic challenge, and cases such as this will pose an unmet need in satisfactory patient management. In addition to Schistosoma haematobium, the presence of the zoonotic species Schistosoma mattheei and concurrent STIs raise questions as to the long-term effectiveness of the current control strategies of the National Control Programme to eliminate schistosomiasis as a public health problem. Improved availability of and regular accessibility to praziquantel treatment for women at risk such as this are urgently needed. Furthermore, targeted health education, increased community awareness, and dovetailing of synergistic activities and strategies with other health stakeholders such as those in sexual and reproductive health, as well as HIV/AIDS programs in the Ministry of Health, are needed here and in neighboring countries.","PeriodicalId":73112,"journal":{"name":"Frontiers in tropical diseases","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141359106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}