Frontiers in stroke最新文献

{"title":"A single-blind randomized trial on the efficacy of telerehabilitation in post-stroke cognitive impairment. CIPS-TER study: rationale, design and methodology.","authors":"Eleonora Barucci, Arianna Cavaliere, Eleonora Pavan, Benedetta Formelli, Francesca Cecchi, Cristina Polito, Giulia Salti, Filippo Fratini, Costanza Parenti, Francesca Pescini, Giacomo Redi, Marzia Baldereschi, Antonio Di Carlo, Emilia Salvadori, Anna Poggesi","doi":"10.3389/fstro.2025.1609541","DOIUrl":"10.3389/fstro.2025.1609541","url":null,"abstract":"<p><strong>Background and aims: </strong>Cognitive impairment (CI) after stroke is still a neglected consequence compared to other neurological deficits for which rehabilitation pathways are routinely available. Cognitive teleRehabilitation (CTR) represents an emerging approach that has the potential to reduce healthcare costs and potentially reaching many patients. By means of a randomized controlled trial, the aims are to investigate the prevalence of cognitive impairment after stroke and the efficacy of a CTR program in: (a) reducing the risk of CI 6 months after stroke; (b) generalizability of the cognitive training to real life; (c) impact on cognitive performances. In the treated group, feasibility, adherence and appreciation of the CTR will also be evaluated.</p><p><strong>Methods and outcomes: </strong>The CIPS-TER study is a 2-year prospective, single-blind, randomized clinical trial. One hundred patients with ischemic or hemorrhagic stroke will be enrolled in the study, within 5-21 days after onset, and randomized to treatment or standard care. The CTR program will consist of up to 40 h (8 weeks) of individual treatment based on memory, attention, executive functions, and visuospatial tasks to be autonomously performed with a tablet. The study outcomes will be evaluated at 6-month follow-up visit and will include the diagnosis of cognitive impairment, activities of daily living, quality of life, changes in frailty status and cognitive efficiency.</p><p><strong>Conclusions: </strong>CIPS-TER study will expand our knowledge on the potential effect of cognitive rehabilitation on future cognitive and functional decline after stroke.</p>","PeriodicalId":73108,"journal":{"name":"Frontiers in stroke","volume":"4 ","pages":"1609541"},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of risk factors for myocardial injury in acute ischemic stroke with diabetes mellitus: a retrospective cohort study on stroke-heart syndrome.","authors":"Huijuan Pu, Yumin Wang, Guoping Zhao, Binbing Shi, Ni An, Changxi Zhang, Jie Liu, Wanling Wu, Hong Zhu, Lei Li, Defeng Pan","doi":"10.3389/fstro.2025.1617937","DOIUrl":"10.3389/fstro.2025.1617937","url":null,"abstract":"<p><strong>Background: </strong>Ischemic stroke (IS) causes significant death and disability. Stroke-Heart Syndrome (SHS) involves cardiovascular complications, worsening outcomes. Diabetes mellitus (DM) increases the risk of myocardial injury following IS. This study explores risk factors for myocardial injury in acute ischemic stroke (AIS) with DM patients to improve early identification and prevention.</p><p><strong>Methods: </strong>This is a retrospective cohort study. Inclusion criteria: neuroimaging-confirmed AIS, admission within 72 h, and measured cardiac troponinT (cTnT) levels. Exclusion criteria included acute hemorrhagic stroke, other cTnT elevation causes, severe organ failure, infections, malignancies, and missing data. Logistic and LASSO regression analyses identified independent risk factors for myocardial injury.</p><p><strong>Results: </strong>Myocardial injury occurred in 194 patients. Independent risk factors identified were coronary heart disease (CHD), insular cortex lesions, peak brain natriuretic peptide precursor (peak NT-proBNP), C-reactive protein (CRP), and higher National Institutes of Health Stroke Scale (NIHSS) scores. These factors were significantly associated with myocardial injury and ROC analysis showed that the AUC for CHD was 0.621, the AUC for insular cortex lesions was 0.648, the AUC for NIHSS score was 0.726, the AUC for peak NT-proBNP was 0.816 and the AUC for CRP was 0.764. Subgroup analysis suggested that reperfusion therapy was associated with increased myocardial injury risk in various patient subgroups.</p><p><strong>Conclusion: </strong>CHD, insular cortex lesions, peak NT-proBNP and CRP levels, and higher stroke severity (NIHSS score) are significant risk factors for myocardial injury in AIS patients with DM.</p>","PeriodicalId":73108,"journal":{"name":"Frontiers in stroke","volume":"4 ","pages":"1617937"},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ischemic stroke and hyperintense plaques detected by high-resolution vessel wall MRI in Japanese patients with intracranial atherosclerotic disease.","authors":"Naoki Takayama, Takakuni Maki, Yasutaka Fushimi, Masakazu Okawa, Yohei Mineharu, Kiyofumi Yamada, Tao Yang, Yu Yamamoto, Keita Suzuki, Ken Yasuda, John Grinstead, Sinyeob Ahn, Riki Matsumoto, Yoshiki Arakawa, Kazumichi Yoshida","doi":"10.3389/fstro.2025.1610666","DOIUrl":"10.3389/fstro.2025.1610666","url":null,"abstract":"<p><strong>Background: </strong>Conventional MRI sequences are insufficient for the detailed depiction of intracranial atherosclerotic disease (ICAD) plaques. The aim of this study was to investigate the association between ischemic events and intracranial atherosclerotic plaque characteristics using a high-resolution T1-weighted black-blood MRI technique (DANTE T1-SPACE) in the anterior circulation in the Japanese population.</p><p><strong>Methods: </strong>Patients with a total of 108 lesions causing ≥40% stenosis on the C1-5 segments of the intracranial internal carotid artery (ICA) or M1 segment of the middle cerebral artery (MCA) were included. Hyperintense plaques (HIPs) were defined as plaques with a spot of signal intensity (SI) higher than 1.5-fold SI of the ipsilateral temporal muscle on DANTE T1-SPACE. The vessel wall lesions were divided into symptomatic and asymptomatic groups. The lesions in the symptomatic group were classified as artery-to-artery embolism, hemodynamic infarction, cardiac embolism, undetermined and transient ischemic attack (TIA).</p><p><strong>Results: </strong>Among the 108 plaques, 19 were symptomatic and 89 were asymptomatic. The percentage of HIPs in the symptomatic group was significantly higher than in the asymptomatic group (57.9% vs. 24.7%, <i>p</i> = 0.01). In the symptomatic group, the proportion of HIPs in the A-to-A embolism subgroup was higher than in the other subgroups.</p><p><strong>Conclusions: </strong>DANTE T1-SPACE may aid in the identification of intracranial plaques with imaging characteristics suggestive of increased stroke risk, particularly hyperintensity potentially reflecting intraplaque hemorrhage.</p>","PeriodicalId":73108,"journal":{"name":"Frontiers in stroke","volume":"4 ","pages":"1610666"},"PeriodicalIF":0.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802711/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of Heads Up testing on thrombectomy for acute ischemic stroke.","authors":"Mallory Blackwood, Charles Beaman, Latisha Sharma, David S Liebeskind","doi":"10.3389/fstro.2025.1612019","DOIUrl":"10.3389/fstro.2025.1612019","url":null,"abstract":"<p><p>The Heads Up test, initially described in 2017, offers a potential tool for assessing likelihood of collateral failure in patients with acute large vessel occlusion (LVO) but low or resolving NIH who may become candidates for mechanical thrombectomy (MT). By raising the head of bed and performing serial exams (Heads Up test), detection of early symptomatic worsening may indicate vulnerability of collateral blood supply. The present study aims to examine the practical applications and outcomes of the Heads Up test in one institution over 9 years by analyzing 15 consecutive cases of documented Heads Up testing. Our findings suggest that the Heads Up test can provide valuable guidance in treatment decisions, but further data is needed to refine its criteria and applicability in the evolving neurointerventional practice.</p>","PeriodicalId":73108,"journal":{"name":"Frontiers in stroke","volume":"4 ","pages":"1612019"},"PeriodicalIF":0.0,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astrocyte to neuron reprogramming with NeuroD1 for repair in canine stroke.","authors":"Isaac H Clark, Zachary Roushdy, Dilmareth Natera-Rodriguez, Kevin Sun, Olivia Erlanson, Shaimaa Khedr, Walter C Low, Andrew W Grande","doi":"10.3389/fstro.2025.1602076","DOIUrl":"10.3389/fstro.2025.1602076","url":null,"abstract":"<p><p>Stroke affects hundreds of thousands of people each year and leads to neuronal damage and often long term disabilities. This study served as an exploratory study investigating astrocyte to neuron reprogramming as a potential treatment for ischemic stroke using a canine model to assess anatomical and functional recovery. The study's exploratory nature involved a small sample size, precluding statistically significant conclusions. For treatment, an adeno associated viral (AAV) vector was constructed such that it would target astrocytes and allow expression of NeuroD1 for the intent of reprogramming them into neurons. Animals were analyzed anatomically using MRI scanning, behaviorally with neurological severity score testing, and cellularly with immunohistochemistry staining. Behaviorally, treated animals recovered more rapidly and to a greater extent than controls; anatomically, treated animals also showed much less ventricle enlargement post stroke; and on the cellular level, treated animals showed a decreased level of astrocyte and microglial activation. These findings suggest that NeuroD1-mediated astrocyte reprogramming may reduce neuroinflammation and enhance functional recovery in ischemic stroke, warranting further exploration of this therapeutic approach.</p>","PeriodicalId":73108,"journal":{"name":"Frontiers in stroke","volume":"4 ","pages":"1602076"},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is delirium after stroke associated with dysregulation of hypothalamic pituitary axis?","authors":"Amanda J Barugh, Alasdair M J MacLullich, Susan S Shenkin, Michael Allerhand, Gillian E Mead","doi":"10.3389/fstro.2025.1584571","DOIUrl":"10.3389/fstro.2025.1584571","url":null,"abstract":"<p><p>Delirium after stroke is a serious condition associated with worse long-term cognition. However, the mechanism of delirium is not well understood. The aberrant stress response has been postulated as a mechanism for delirium.</p><p><strong>Aim: </strong>to explore the relationship between cortisol dysregulation and delirium over the first year after stroke in a prospective cohort study of patients admitted to an acute stroke unit.</p><p><strong>Methods: </strong>consecutive patients admitted to an acute stroke unit over a 1 year period were identified and recruited if they were aged age ≥ 60 years and not taking steroids. Patients with incapacity were included if proxy consent could be obtained. Baseline data included stroke severity, cognition, illness severity, and pre-stroke cognition. Patients were assessed at 1, 3, 5, 7, 14, 21, 28 days, 4 months and 12 months for delirium. Salivary samples were taken morning and evening for cortisol analysis.</p><p><strong>Results: </strong>of the 831 patients screened, 304 met inclusion criteria and of these 95 agreed to participant. Twenty-six (27%) had delirium at some point during the 12 months follow-up. Delirium was associated with increasing age (mean age 83.5 years vs. 74 years, <i>p</i> < 0.001), being female (62% vs. 23%, <i>p</i> = 0.013), not independent in pre-stroke activities of daily living (35% vs. 33%), higher IQCODE score median 3.56 vs. 3.19), worse stroke severity (median National Institute of Stroke Scale 5 vs. 8.5) <i>p</i> = 0.009) and having had a total anterior circulation stroke (<i>p</i> < 0.001). Univariable analyses identified several associations between delirium and cortisol in the first 28 days but not at 4 or 12 months. However, on multivariable analyses there were no significant associations between delirium and cortisol at any time point, e.g., odds ratio for median 9 am cortisol 0.95 (95% CI 0.89 to 1.01, <i>p</i> = 0.08).</p><p><strong>Conclusion: </strong>there was no independent association between delirium and cortisol dysregulation after stroke. If an association does exist, it is likely to be small.</p>","PeriodicalId":73108,"journal":{"name":"Frontiers in stroke","volume":"4 ","pages":"1584571"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing Africa's stroke workforce to address the stroke burden: a proposal from the African's stroke organization's educational and training committee.","authors":"Paul Bolaji, Ebenezer Ad Adams, Rufus Akinyemi, Mayowa Owolabi, Foad Abd-Allah","doi":"10.3389/fstro.2025.1611194","DOIUrl":"10.3389/fstro.2025.1611194","url":null,"abstract":"<p><p>Stroke is the second leading cause of death and disability in Africa, disproportionately affecting individuals in their most productive years and placing an immense socio-economic burden on families and healthcare systems. Despite the growing stroke burden, Africa faces a severe shortage of trained stroke specialists, with only three neurologists per 10 million people compared to up to 900 per 10 million in high-income countries. This gap has led to inadequate acute management, limited rehabilitation services, and poor long-term outcomes. To address this crisis, the African Stroke Organization (ASO) established an Education and Training Committee focused on developing a structured stroke education framework. This proposal outlines ASO's strategic initiatives to build stroke care capacity through research, professional training, service development, and advocacy. By implementing a comprehensive stroke education program-including online courses, hands-on workshops, conference-based training, and a future summer school, ASO aims to train 5,000 by 2030. Through this initiative, ASO seeks to empower African healthcare professionals, reduce disparities in stroke care, and ultimately improve stroke outcomes across the continent. This proposal presents the rationale, objectives, and implementation strategies for the ASO Stroke Education Program and calls for international collaboration to support this critical effort.</p>","PeriodicalId":73108,"journal":{"name":"Frontiers in stroke","volume":"4 ","pages":"1611194"},"PeriodicalIF":1.2,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-year post-stroke outcomes in urban North-western Tanzania.","authors":"Joshua Ngimbwa, Goodluck Nchasi, Innocent Kitandu Paul, Anna Kasala, Lilian Andrew Mwamba, Sospeter Berling, Matilda K Basinda, Gladness Xavier, Benjamin Andrew, Akili Mawazo, Dorice Lucas, Karim Mahawish, Ladius Rudovick, Bahati Wajanga, Robert Peck, Sarah Shali Matuja","doi":"10.3389/fstro.2025.1593092","DOIUrl":"10.3389/fstro.2025.1593092","url":null,"abstract":"<p><strong>Background: </strong>stroke is one of the leading causes of death and disability globally. Despite advancements in acute stroke care, long-term outcomes have not been extensively studied in Tanzania. This study aimed to investigate the long-term post-stroke outcomes among adults admitted with stroke to a large tertiary hospital in northwestern Tanzania.</p><p><strong>Methods: </strong>adults (≥18 years) with stroke who were enrolled in the Lake Zone Stroke Registry Study (LZSS) at Bugando Medical Center between March 2020 and October 2021 were prospectively followed up until October 2024. Stroke diagnosis and classification were confirmed using brain imaging, and baseline stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS). Data on case fatality were collected using the modified Rankin Scale along with information on secondary stroke prevention. The Kaplan-Meier analysis was used to describe survival, and the Cox regression model was used to examine independent factors associated with fatality.</p><p><strong>Results: </strong>the study included 301 adults, with a mean age of 65.5 ± 14 years, of whom 51% (153/301) were female and 68% (205/301) had ischemic strokes. Case fatality rates were 42.9% (98/228) at 1 year, 75.9% (173/228) at 2 years, and 96.5% (220/228) at 3 years. Independent factors associated with fatality were severe stroke (adjusted hazard ratio (aHR) 7.9, 95% CI [2.3, 27.4], <i>p</i> = 0.001), moderate to severe stroke (aHR 4.6, 95% CI [1.3, 16.1], <i>p</i> = 0.017), a lack of health insurance coverage (aHR 3.7, 95% CI [1.9, 6.8], <i>p</i> < 0.001), and previous stroke (aHR 3.3, 95% CI [1.3, 8.3], <i>p</i> = 0.01). Attendance rates of follow-up clinics and physiotherapy among survivors were 28.6% (86/301) and 8.6% (26/301), respectively. Among stroke survivors with hypertension and diabetes, 32% (83/257) and 41% (20/49) were adherent to antihypertensive and diabetic medications, respectively.</p><p><strong>Conclusion: </strong>this study highlights the high long-term case fatality rates among adults with stroke in northwestern Tanzania, with stroke severity, a lack of health insurance, and previous strokes being key factors associated with fatality. Low attendance rates at follow-up clinics and poor adherence to medications among survivors of stroke with hypertension and diabetes underline the importance of strengthening post-stroke care systems, including health insurance coverage, to improve survival and quality of life.</p>","PeriodicalId":73108,"journal":{"name":"Frontiers in stroke","volume":"4 ","pages":"1593092"},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802649/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved functional outcomes and cost benefits of door-to-needle time under 30 min in acute ischemic stroke: an observational study.","authors":"Jia Dong James Wang, Ying-Qiu Dong, Joshua Y P Yeo, Kevin Soon Hwee Teo, Shiyang Ng, Mingxue Jing, Bernard P L Chan, Leonard L L Yeo, Magdalene L J Chia, Louis Widjaja, Lily Y H Wong, Pamela Lim, Shikha Kumari, Diarmuid Murphy, Hock-Luen Teoh, Benjamin Y Q Tan","doi":"10.3389/fstro.2025.1583875","DOIUrl":"10.3389/fstro.2025.1583875","url":null,"abstract":"<p><strong>Introduction: </strong>Intravenous thrombolysis (IVT) is cornerstone of acute ischemic stroke(AIS) recanalization therapy. Clinical guidelines advocate achieving Door-to-Needle (DTN) time of 60 min or less, with recent evidence highlighting clinical advantages of even shorter DTN times. However, economic implications of reducing DTN time are less well-studied. This study aims to assess shorter DTN targets impact on clinical outcomes and healthcare costs.</p><p><strong>Methods: </strong>This observational cohort study included consecutive patients with AIS treated with IVT in a comprehensive stroke center from January 2017 to December 2023. Patients were stratified by DTN time into 4 groups: ≤ 30, 31-45, 46-60, and >60 min. Multivariate linear and logistic regressions were performed to evaluate impact of DTN time on functional and financial outcomes, including modified Rankin's Score (mRS) at 3-months post-AIS, length-of-stay (LoS), total hospitalization cost, symptomatic intracerebral hemorrhage (SICH) and inpatient mortality.</p><p><strong>Results: </strong>1,146 patients (62.0% male) with mean age of 68.6 years were included. Overall, 47.6% of patients achieved a mRS of 0-2 at 3 months after AIS. Patients with DTN time of ≤ 30 min demonstrated higher odds of achieving mRS 0-2 at 3 months (OR 2.35, 95% CI 1.26-4.39) compared to DTN time of ≥60 min. They also experienced 4-day shorter length of stay (LoS) until rehabilitation (<i>p</i> = 0.005) and 22.7% reduction in total hospitalization costs (<i>p</i> = 0.004).</p><p><strong>Conclusions: </strong>This study suggests that DTN time of ≤ 30 min is associated with improved functional outcomes and significant cost benefits, supporting consideration of this more aggressive target for acute stroke units. Further research is needed to assess feasibility and broader impact of implementing a 30-min DTN goal in routine clinical practice.</p>","PeriodicalId":73108,"journal":{"name":"Frontiers in stroke","volume":"4 ","pages":"1583875"},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145992197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Mechanical thrombectomy using stent retriever devices in deep cerebral venous thrombosis: illustrative cases.","authors":"Álvaro Martínez-Martín, Francisco Hernández-Fernández, Juan David Molina-Nuevo, Blanca Serrano Serrano, Tomás Segura","doi":"10.3389/fstro.2025.1568841","DOIUrl":"10.3389/fstro.2025.1568841","url":null,"abstract":"<p><strong>Background: </strong>Treatment of cerebral venous thrombosis has traditionally been based on anticoagulant therapy. However, in certain circumstances, such as deep cerebral venous thrombosis, anticoagulation may be insufficient, so endovascular treatment by mechanical thrombectomy has been used for some years. There is currently no clear indication of which device is the gold standard in the endovascular treatment of cerebral venous thrombosis, although stent retriever devices are the most commonly used.</p><p><strong>Case presentation: </strong>We describe two cases of deep cerebral venous thrombosis refractory to anticoagulant treatment treated by mechanical thrombectomy with stent retriever devices, one of which has not been described to date as being used in the treatment of cerebral venous thrombosis (Tiger XL^®).</p><p><strong>Conclusions: </strong>Some situations in like deep cerebral venous thrombosis may require endovascular treatment with mechanical thrombectomy if anticoagulation fails, with increasing evidence that it improves vital and functional prognosis.</p>","PeriodicalId":73108,"journal":{"name":"Frontiers in stroke","volume":"4 ","pages":"1568841"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}