Frontiers in biomaterials science最新文献_第3页

Nanomedicine and regulatory science: the challenges in Africa 纳米医学和管理科学:非洲的挑战

Frontiers in biomaterials science Pub Date : 2023-11-08 DOI: 10.3389/fbiom.2023.1184662

N. Z. Nyazema, J. T. Chanyandura, P. O. Kumar

{"title":"Nanomedicine and regulatory science: the challenges in Africa","authors":"N. Z. Nyazema, J. T. Chanyandura, P. O. Kumar","doi":"10.3389/fbiom.2023.1184662","DOIUrl":"https://doi.org/10.3389/fbiom.2023.1184662","url":null,"abstract":"The integrated approach in the development of nanotechnology is allowing its introduction into multiple fields, including pharmaceutical research, in which there are now several medicines containing nanomaterials or at least making nano-based claims. As a result of increasing research in nanotechnology, pre-existing medicines have been reformulated, and new medicines have been developed. This has brought challenges to the current regulatory frameworks in Europe and the United States. These regulatory agencies are known to be stringent because they have both the human capacity and skills and conducive policies and the landscape to manage new technology, unlike the agencies in most African countries. Because the European Medicines Agency (EMA) and the US Food and Drug Administration (FDA) have embraced regulatory science (RS) as a means of proactive analysis of regulatory principles, those agencies will be able to address nanomedicine challenges in a straightforward manner. African countries currently do not have a harmonized regulatory framework because different national regulatory authorities are at different levels of development. The pharmaceutical sector in Africa is facing many challenges, including the non-existence of research and development partnerships between industry, universities, and research institutions that foster nanomedicine development. Now that the African Medicine Agency (AMA) is in place, Africa should see the rapid implementation of the AU Model Law on Medical Products Regulation that will assist in putting in place capacity-building programs in nanomedicine RS.","PeriodicalId":73067,"journal":{"name":"Frontiers in biomaterials science","volume":"46 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo validation of a mechanically adaptive microfluidic intracortical device as a platform for sustained local drug delivery 机械自适应微流体皮质内装置作为持续局部药物递送平台的体内验证

Frontiers in biomaterials science Pub Date : 2023-10-17 DOI: 10.3389/fbiom.2023.1279367

Youjoung Kim, Lindsey N. Druschel, Natalie Mueller, Danielle Sarno, Kaela Gisser, Allison Hess-Dunning, Jeffrey R. Capadona

{"title":"In vivo validation of a mechanically adaptive microfluidic intracortical device as a platform for sustained local drug delivery","authors":"Youjoung Kim, Lindsey N. Druschel, Natalie Mueller, Danielle Sarno, Kaela Gisser, Allison Hess-Dunning, Jeffrey R. Capadona","doi":"10.3389/fbiom.2023.1279367","DOIUrl":"https://doi.org/10.3389/fbiom.2023.1279367","url":null,"abstract":"Introduction: Intracortical microelectrodes (IME) are vital to properly functioning brain-computer interfacing (BCI). However, the recording electrodes have shown a steady decline in performance after implantation, mainly due to chronic inflammation. Compliant materials have been explored to decrease differential strain resulting in lower neural inflammation. We have previously developed a fabrication method for creating mechanically adaptive microfluidic probes made of a cellulose nanocrystal (CNC) polymer nanocomposite material that can become compliant after implantation. Here, we hypothesized that our device, would have a similar tissue response to the industry standard, allowing drug delivery therapeutics to improve neural inflammation in the future. Methods: RNA expression analysis was performed to determine the extent of neural inflammation and oxidative stress in response to the device compared to controls and to naïve shame tissue. Results: Results presented for both four- and eight-weeks post-implantations suggest that our device offers a promising platform technology that can be used to deliver therapeutic strategies to improve IME performance.","PeriodicalId":73067,"journal":{"name":"Frontiers in biomaterials science","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135994915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling hierarchical patterning of biomaterial inks with 3D microfluidic-assisted spinning: a paradigm shift in bioprinting technologies 用三维微流体辅助纺丝揭开生物材料墨水的分层图案:生物打印技术的范式转变

Frontiers in biomaterials science Pub Date : 2023-10-17 DOI: 10.3389/fbiom.2023.1279061

Sajad Mohammadi, Gianluca Cidonio

{"title":"Unravelling hierarchical patterning of biomaterial inks with 3D microfluidic-assisted spinning: a paradigm shift in bioprinting technologies","authors":"Sajad Mohammadi, Gianluca Cidonio","doi":"10.3389/fbiom.2023.1279061","DOIUrl":"https://doi.org/10.3389/fbiom.2023.1279061","url":null,"abstract":"For decades, 3D bioprinting has offered a revolutionising approach to combine living cells and biomaterials to engineer complex, yet functional constructs. However, traditional 3D bioprinting platforms fall short of the ability to pattern complex gradients of biomaterials, cells, and ultimately bio-physical properties to drive tissue formation and regeneration. Recently, 3D microfluidic-assisted bioprinting (3DMB) has risen as a new hybrid approach for the fabrication of physiologically relevant tissues, adopting a microfluidic chip as functional printhead to achieve hierarchical patterning of bioinks and precise control over the microscale architecture of printed constructs, enabling the creation of multi-layered tissues. This review explores recent advancements in graded biomaterial patterning using microfluidic-assisted spinning and novel 3D bioprinting technologies. The physiological hierarchical arrangement of human tissues and the crucial role of biomaterials in achieving ordered assembly is hereby discussed. Lastly, the integration of microfluidic-assisted techniques with new bioprinting platforms is highlighted, examining the latest advancements in tissue regeneration and disease modelling.","PeriodicalId":73067,"journal":{"name":"Frontiers in biomaterials science","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135992600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ion—modified optimization of smart scaffolds in bone tissue regeneration 离子修饰优化骨组织再生智能支架

Frontiers in biomaterials science Pub Date : 2023-10-11 DOI: 10.3389/fbiom.2023.1289382

Yashas Basavarajappa

引用次数: 0

Injectable hydrogel with immobilized BMP-2 mimetic peptide for local bone regeneration. 含固定 BMP-2 拟态肽的可注射水凝胶，用于局部骨再生。

Frontiers in biomaterials science Pub Date : 2022-01-01 Epub Date: 2022-07-22 DOI: 10.3389/fbiom.2022.948493

Kirstene A Gultian, Roshni Gandhi, Kayla DeCesari, Vineeth Romiyo, Emily P Kleinbart, Kelsey Martin, Pietro M Gentile, Tae Won B Kim, Sebastián L Vega

{"title":"Injectable hydrogel with immobilized BMP-2 mimetic peptide for local bone regeneration.","authors":"Kirstene A Gultian, Roshni Gandhi, Kayla DeCesari, Vineeth Romiyo, Emily P Kleinbart, Kelsey Martin, Pietro M Gentile, Tae Won B Kim, Sebastián L Vega","doi":"10.3389/fbiom.2022.948493","DOIUrl":"10.3389/fbiom.2022.948493","url":null,"abstract":"<p><p>Osteoporosis is a disease characterized by a decrease in bone mineral density, thereby increasing the risk of sustaining a fragility fracture. Most medical therapies are systemic and do not restore bone in areas of need, leading to undesirable side effects. Injectable hydrogels can locally deliver therapeutics with spatial precision, and this study reports the development of an injectable hydrogel containing a peptide mimic of bone morphogenetic protein-2 (BMP-2). To create injectable hydrogels, hyaluronic acid was modified with norbornene (HANor) or tetrazine (HATet) which upon mixing click into covalently crosslinked Nor-Tet hydrogels. By modifying HANor macromers with methacrylates (Me), thiolated BMP-2 mimetic peptides were immobilized to HANor via a Michael addition reaction, and coupling was confirmed with 1H NMR spectroscopy. BMP-2 peptides presented in soluble and immobilized form increased alkaline phosphatase (ALP) expression in MSCs cultured on 2D and encapsulated in 3D Nor-Tet hydrogels. Injection of bioactive Nor-Tet hydrogels into hollow intramedullary canals of Lewis rat femurs showed a local increase in trabecular bone density as determined by micro-CT imaging. The presented work shows that injectable hydrogels with immobilized BMP-2 peptides are a promising biomaterial for the local regeneration of bone tissue and for the potential local treatment of osteoporosis.</p>","PeriodicalId":73067,"journal":{"name":"Frontiers in biomaterials science","volume":"1 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e5/45/nihms-1878265.PMC10120851.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9392531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-Inspired Materials 仿生材料

Frontiers in biomaterials science Pub Date : 2019-04-10 DOI: 10.2174/97898114068981190601

U. T. Bezerra, H. S. Ferreira, N. P. Barbosa, A. Manzano-Ramírez, A. Nobrega, Benedikt Demmert, Corinna F. Böhm, Eng. Kai Li, Eng. Piet Stroeven, G. Rzevski, Jose Augusto Gomes Neto, J. L. R. Araiza, K. Ghavami, Mario Villalón, M. Phocas, Martina Schüßler, Niki Georgiou, O. Kontovourkis, Sandra Patricia Reyes Ortiz, S. Wolf, Theofilo Barreto Moreira Oliveira, V. Stabnikov, V. Ivanov

引用次数: 0

Bio-inspired Design with Bamboo 竹子的仿生设计

Frontiers in biomaterials science Pub Date : 2019-04-10 DOI: 10.2174/9789811406898119060009

N. P. Barbosa, Jose Augusto Gomes Neto, Sandra Patricia Reyes Ortiz, K. Ghavami

引用次数: 0

Bio-Pulse Oscillations Driven Design of Kinetic Structures 生物脉冲振荡驱动的动力结构设计

Frontiers in biomaterials science Pub Date : 2019-04-10 DOI: 10.2174/9789811406898119060003

M. Phocas, O. Kontovourkis, Niki Georgiou

引用次数: 0

Sustainable and Safe Construction Biomaterials: Biocements and Biogrouts 可持续和安全的建筑生物材料:生物水泥和生物灌浆

Frontiers in biomaterials science Pub Date : 2019-04-10 DOI: 10.2174/9789811406898119060011

V. Ivanov, V. Stabnikov

引用次数: 3

Interaction Between Natural Fibres and Synthetic Polymers 天然纤维与合成聚合物的相互作用

Frontiers in biomaterials science Pub Date : 2019-04-10 DOI: 10.2174/9789811406898119060012

A. Manzano-Ramírez, Mario Villalón, J. L. R. Araiza

引用次数: 0