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Management of Lithium Dosing Around Delivery: An Observational Study. 分娩前后的锂剂量管理:观察研究
Focus (American Psychiatric Publishing) Pub Date : 2024-01-01 Epub Date: 2024-01-12 DOI: 10.1176/appi.focus.23021031
Nina M Molenaar, Eline M P Poels, Thalia Robakis, Richard Wesseloo, Veerle Bergink
{"title":"Management of Lithium Dosing Around Delivery: An Observational Study.","authors":"Nina M Molenaar, Eline M P Poels, Thalia Robakis, Richard Wesseloo, Veerle Bergink","doi":"10.1176/appi.focus.23021031","DOIUrl":"10.1176/appi.focus.23021031","url":null,"abstract":"<p><strong>Objectives: </strong>Recommendations on lithium dosing around delivery vary, with several guidelines suggesting that lithium should be discontinued prior to delivery. We aimed to evaluate the validity of these recommendations by investigating 1) maternal lithium blood level changes following delivery, and 2) the association between neonatal lithium blood levels at delivery and neonatal outcomes.</p><p><strong>Methods: </strong>In this retrospective observational cohort study, we included women with at least one lithium blood level measurement during the final week of pregnancy and the first postpartum week. For aim 2, we included a subcohort of women with neonates for whom neonatal lithium blood levels (obtained from the umbilical cord or a neonatal vein puncture within 24 hours of delivery) were available.</p><p><strong>Results: </strong>There were a total of 233 maternal lithium blood level measurements; 55 (23.6%) in the week before delivery and 178 (76.4%) in the week after. There was no association between time and lithium blood level/dose ratio (Pearson correlation coefficient -0.03, <i>P</i> = .63). Additionally, we included a total of 29 neonates for whom a lithium measurement was performed within 24 hours postpartum. Maternal and neonatal lithium blood levels were strongly correlated. We observed no associations between neonatal lithium blood levels at delivery and neonatal outcomes.</p><p><strong>Conclusion: </strong>Based on our findings, we do not recommend lowering the dosage or discontinuation of lithium prior to delivery. Stable dosing can prevent subtherapeutic lithium serum levels, which is especially important in the postpartum period when relapse risks are highest.Appeared originally in <i>Bipolar Disord 2021; 23:49-54</i>.</p>","PeriodicalId":73036,"journal":{"name":"Focus (American Psychiatric Publishing)","volume":"22 1","pages":"120-125"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opioid Use Disorder Documented at Delivery Hospitalization-United States, 1999-2014. 1999-2014 年美国分娩住院时记录的阿片类药物使用障碍。
Focus (American Psychiatric Publishing) Pub Date : 2024-01-01 Epub Date: 2024-01-12 DOI: 10.1176/appi.focus.23021030
Sarah C Haight, Jean Y Ko, Van T Tong, Michele K Bohm, William M Callaghan
{"title":"Opioid Use Disorder Documented at Delivery Hospitalization-United States, 1999-2014.","authors":"Sarah C Haight, Jean Y Ko, Van T Tong, Michele K Bohm, William M Callaghan","doi":"10.1176/appi.focus.23021030","DOIUrl":"10.1176/appi.focus.23021030","url":null,"abstract":"","PeriodicalId":73036,"journal":{"name":"Focus (American Psychiatric Publishing)","volume":"22 1","pages":"126-130"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postpartum Psychosis: A Proposed Treatment Algorithm. 产后精神病:建议的治疗算法。
Focus (American Psychiatric Publishing) Pub Date : 2024-01-01 Epub Date: 2024-01-12 DOI: 10.1176/appi.focus.23021033
Chaitra Jairaj, Gertrude Seneviratne, Veerle Bergink, Iris E Sommer, Paola Dazzan
{"title":"Postpartum Psychosis: A Proposed Treatment Algorithm.","authors":"Chaitra Jairaj, Gertrude Seneviratne, Veerle Bergink, Iris E Sommer, Paola Dazzan","doi":"10.1176/appi.focus.23021033","DOIUrl":"10.1176/appi.focus.23021033","url":null,"abstract":"<p><strong>Background: </strong>Postpartum psychosis (PPP) is a psychiatric emergency that generally warrants acute inpatient care. PPP is marked by the sudden onset of affective and psychotic symptoms with a rapid deterioration in mental state. Evidence suggests that PPP is a discrete disorder on the bipolar disorder spectrum with a distinct treatment profile and prognosis.</p><p><strong>Methods: </strong>We conducted a PubMed database search for various terms involving PPP and its treatment and included peer-reviewed articles published in English.</p><p><strong>Objective: </strong>To provide a treatment algorithm for the management of PPP based on available evidence.</p><p><strong>Results: </strong>Pharmacological therapy is the mainstay of PPP management in the acute phase. Evidence points to a combination of antipsychotics and lithium in the acute treatment of PPP. Electroconvulsive therapy can offer a rapid treatment response where required. Lithium appears to have the best evidence for relapse prevention and prophylaxis in PPP. Psychoeducation is essential and psychosocial interventions used in bipolar disorder may be effective in PPP.</p><p><strong>Conclusion: </strong>Early detection and prompt treatment with antipsychotics and lithium, followed by maintenance treatment with lithium, is associated with a favourable prognosis in PPP.Reprinted from <i>J Psychopharmacol 2023; 37:960-970</i>, with permission from Sage Journals. Copyright © 2023.</p>","PeriodicalId":73036,"journal":{"name":"Focus (American Psychiatric Publishing)","volume":"22 1","pages":"131-142"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Premenstrual Dysphoric Disorder: A Scoping Review. 经前期情感障碍的管理:范围综述》。
Focus (American Psychiatric Publishing) Pub Date : 2024-01-01 Epub Date: 2024-01-12 DOI: 10.1176/appi.focus.23021035
Sara V Carlini, Teresa Lanza di Scalea, Stephanie Trentacoste McNally, Janice Lester, Kristina M Deligiannidis
{"title":"Management of Premenstrual Dysphoric Disorder: A Scoping Review.","authors":"Sara V Carlini, Teresa Lanza di Scalea, Stephanie Trentacoste McNally, Janice Lester, Kristina M Deligiannidis","doi":"10.1176/appi.focus.23021035","DOIUrl":"10.1176/appi.focus.23021035","url":null,"abstract":"<p><p>Premenstrual dysphoric disorder (PMDD) and premenstrual syndrome (PMS) refer to physical, cognitive, or affective symptoms that arise in the late luteal phase and remit with menses. The present work is a clinically focused scoping review of the last twenty years of research on treatment for these disorders. A search of key terms using the PubMed/Medline, the Cochrane Library, Embase, and Web of Science databases was performed, and 194 studies of adult women met initial inclusion criteria for review. Research studies concerning medications, pharmacological and non-pharmacological complementary and alternative medicine treatments, and surgical interventions with the most available evidence were appraised and summarized. The most high-quality evidence can be found for the use of selective serotonin reuptake inhibitors (SSRIs) and combined oral contraceptives (COCs), with gonadotropin releasing hormone (GnRH) agonists and surgical interventions showing efficacy for refractory cases. While there is some evidence of the efficacy of alternative and complementary medicine treatments such as nutraceuticals, acupuncture, and yoga, variability in quality and methods of studies must be taken into account. Reprinted from <i>Int J Womens Health 2022; 14:1783-1801,</i> with permission from Dove Medical Press Ltd. Copyright © 2022.</p>","PeriodicalId":73036,"journal":{"name":"Focus (American Psychiatric Publishing)","volume":"22 1","pages":"81-96"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bridging the Gap: Integrating Awareness of Polycystic Ovary Syndrome Into Mental Health Practice. 缩小差距:将对多囊卵巢综合症的认识融入心理健康实践。
Focus (American Psychiatric Publishing) Pub Date : 2024-01-01 Epub Date: 2024-01-12 DOI: 10.1176/appi.focus.20230024
Lindsay R Standeven, Annie Ho, Liisa Hantsoo
{"title":"Bridging the Gap: Integrating Awareness of Polycystic Ovary Syndrome Into Mental Health Practice.","authors":"Lindsay R Standeven, Annie Ho, Liisa Hantsoo","doi":"10.1176/appi.focus.20230024","DOIUrl":"10.1176/appi.focus.20230024","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. Individuals with PCOS report reduced quality of life compared with those without PCOS, with possible contributing factors including infertility, hirsutism, irregular menses, and weight gain. Recent literature also supports increased associations between PCOS and co-occurring psychiatric conditions, particularly depression, anxiety, bipolar disorder, and eating disorders. It is concerning that a higher prevalence of suicidal ideation has been observed in individuals with PCOS. Given the high rates of psychiatric burden among those with PCOS, psychiatric care providers are well suited to be on the front lines of screening for psychiatric symptoms as well as initiating treatment. Current interventions include lifestyle changes (improving exercise and nutrition), pharmacological treatments (e.g., insulin-sensitizing agents, oral contraceptives, and psychotropic drugs), and psychotherapeutic interventions (e.g., cognitive-behavioral therapy and mindfulness-based therapy). This review provides an overview of recent research on the prevalence of comorbid psychiatric conditions, a foundation in PCOS-specific symptom screening and diagnosis, and an overview of treatments for psychiatric symptoms among individuals with PCOS.</p>","PeriodicalId":73036,"journal":{"name":"Focus (American Psychiatric Publishing)","volume":"22 1","pages":"53-62"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Depression in Polycystic Ovary Syndrome: Focusing on Pathogenesis and Treatment. 多囊卵巢综合征中的抑郁症:关注发病机制和治疗。
Focus (American Psychiatric Publishing) Pub Date : 2024-01-01 Epub Date: 2024-01-12 DOI: 10.1176/appi.focus.23021032
Liwei Xing, Jinlong Xu, Yuanyuan Wei, Yang Chen, Haina Zhuang, Wei Tang, Shun Yu, Junbao Zhang, Guochen Yin, Ruirui Wang, Rong Zhao, Dongdong Qin
{"title":"Depression in Polycystic Ovary Syndrome: Focusing on Pathogenesis and Treatment.","authors":"Liwei Xing, Jinlong Xu, Yuanyuan Wei, Yang Chen, Haina Zhuang, Wei Tang, Shun Yu, Junbao Zhang, Guochen Yin, Ruirui Wang, Rong Zhao, Dongdong Qin","doi":"10.1176/appi.focus.23021032","DOIUrl":"10.1176/appi.focus.23021032","url":null,"abstract":"<p><p>Polycystic ovary syndrome (PCOS) is one of the most prevalent gynecological endocrine conditions affecting reproductive women. It can feature a variety of symptoms, such as obesity, insulin resistance, skin conditions, and infertility. Women with PCOS are susceptible to illnesses including mood disorders, diabetes, hypertension, and dyslipidemia. Among them, depression is the most common in PCOS and has a detrimental effect on quality of life. Depression may occasionally develop due to the pathological traits of PCOS, but its exact pathogenesis in PCOS have eluded researchers to date. Therefore, there is an urgent need to explore the pathogenesis and treatments of depression in PCOS. The present review discusses the epidemiology of depression in PCOS, potential pathogenic mechanisms underlying PCOS and depression, as well as some potential factors causing depression in PCOS, including obesity, insulin resistance, hyperandrogenism, inflammation, and infertility. Meanwhile, some common treatment strategies for depression in PCOS, such as lifestyle intervention, acupuncture, oral contraceptive pills, psychological intervention, and insulin-sensitizer, are also reviewed. To fully understand the pathogenesis and treatment of depression in PCOS, a need remains for future large-scale multi-center randomized controlled trials and in-depth mechanism studies. Appeared originally in <i>Front Psychiatry 2022; 13:1001484</i>.</p>","PeriodicalId":73036,"journal":{"name":"Focus (American Psychiatric Publishing)","volume":"22 1","pages":"109-119"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11058923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Traumatic Stress Symptoms During the Acute Posttrauma Period. 创伤后急性期创伤应激症状评估。
Focus (American Psychiatric Publishing) Pub Date : 2023-07-01 Epub Date: 2023-06-28 DOI: 10.1176/appi.focus.20230001
Zoe M F Brier, Johanna E Hidalgo, Hannah C Espeleta, Tatiana Davidson, Kenneth J Ruggiero, Matthew Price
{"title":"Assessment of Traumatic Stress Symptoms During the Acute Posttrauma Period.","authors":"Zoe M F Brier, Johanna E Hidalgo, Hannah C Espeleta, Tatiana Davidson, Kenneth J Ruggiero, Matthew Price","doi":"10.1176/appi.focus.20230001","DOIUrl":"10.1176/appi.focus.20230001","url":null,"abstract":"<p><p>A substantial majority of adults in the United States will experience a potentially traumatic event (PTE) in their lifetime. A considerable proportion of those individuals will go on to develop posttraumatic stress disorder (PTSD). Distinguishing between those who will develop PTSD and those who will recover, however, remains as a challenge to the field. Recent work has pointed to the increased potential of identifying individuals at greatest risk for PTSD through repeated assessment during the acute posttrauma period, the 30-day period after the PTE. Obtaining the necessary data during this period, however, has proven to be a challenge. Technological innovations such as personal mobile devices and wearable passive sensors have given the field new tools to capture nuanced in vivo changes indicative of recovery or nonrecovery. Despite their potential, there are numerous points for clinicians and research teams to consider when implementing these technologies into acute posttrauma care. The limitations of this work and considerations for future research in the use of technology during the acute posttrauma period are discussed.</p>","PeriodicalId":73036,"journal":{"name":"Focus (American Psychiatric Publishing)","volume":"21 3","pages":"239-246"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10178725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethical and Legal Aspects of Trauma Evaluation. 创伤评估的伦理与法律问题。
Focus (American Psychiatric Publishing) Pub Date : 2023-07-01 Epub Date: 2023-06-28 DOI: 10.1176/appi.focus.20230005
Jacob M Appel
{"title":"Ethical and Legal Aspects of Trauma Evaluation.","authors":"Jacob M Appel","doi":"10.1176/appi.focus.20230005","DOIUrl":"10.1176/appi.focus.20230005","url":null,"abstract":"","PeriodicalId":73036,"journal":{"name":"Focus (American Psychiatric Publishing)","volume":"21 3","pages":"281-285"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10178717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of MDMA-Assisted Therapy for Posttraumatic Stress Disorder. 回顾治疗创伤后应激障碍的摇头丸辅助疗法。
Focus (American Psychiatric Publishing) Pub Date : 2023-07-01 Epub Date: 2023-06-28 DOI: 10.1176/appi.focus.20220088
Benjamin R Lewis, Kevin Byrne
{"title":"A Review of MDMA-Assisted Therapy for Posttraumatic Stress Disorder.","authors":"Benjamin R Lewis, Kevin Byrne","doi":"10.1176/appi.focus.20220088","DOIUrl":"10.1176/appi.focus.20220088","url":null,"abstract":"<p><p>Posttraumatic stress disorder (PTSD) is a common chronic and disabling psychiatric disorder that may develop after exposure to a traumatic life event. There are existing evidence-based psychotherapies and pharmacotherapies for PTSD; however, these treatments have significant limitations. 3,4-methylenedioxymethamphetamine (MDMA) was granted \"breakthrough therapy\" status by the U.S. Food and Drug Administration (FDA) in 2017 for the treatment of PTSD in conjunction with psychotherapy after preliminary Phase II results. This treatment is currently being investigated in Phase III trials with anticipated FDA approval of MDMA-assisted psychotherapy for PTSD in late 2023. This article reviews the evidence base for MDMA-assisted psychotherapy for PTSD, pharmacology and the proposed causal mechanisms of MDMA, risks and limitations of the current evidence, and challenges and future directions for the field.</p>","PeriodicalId":73036,"journal":{"name":"Focus (American Psychiatric Publishing)","volume":"21 3","pages":"247-256"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316220/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9801540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Horizons in the Assessment and Treatment of Posttraumatic Stress Disorder. 创伤后应激障碍评估和治疗的新视野。
Focus (American Psychiatric Publishing) Pub Date : 2023-07-01 Epub Date: 2023-06-28 DOI: 10.1176/appi.focus.20230013
Negar Fani
{"title":"New Horizons in the Assessment and Treatment of Posttraumatic Stress Disorder.","authors":"Negar Fani","doi":"10.1176/appi.focus.20230013","DOIUrl":"10.1176/appi.focus.20230013","url":null,"abstract":"","PeriodicalId":73036,"journal":{"name":"Focus (American Psychiatric Publishing)","volume":"21 3","pages":"237-238"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10316212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10178722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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