European journal of respiratory medicine最新文献_第2页

Safety and Efficacy of Nebulised Anti-Inflammatory Solution of Alkaline Hypertonic Ibuprofen (AHI) for Treatment of SARS-Cov-2 Infection: A Compassionate Study with a Comparator Arms 碱性高渗布洛芬(AHI)雾化抗炎液治疗SARS-Cov-2感染的安全性和有效性:一项比较组的同情性研究

European journal of respiratory medicine Pub Date : 2022-01-01 DOI: 10.31488/ejrm.132

引用次数: 0

The Effect of Nasal High Flow Therapy on Minute Ventilation in Chronic Obstructive Pulmonary Disease. 鼻高流量治疗对慢性阻塞性肺疾病分分钟通气的影响。

European journal of respiratory medicine Pub Date : 2021-04-01 DOI: 10.31488/ejrm.113

M O Sowho, P Galiatsatos, M Guzman, N N Hansel, J C Jun, E R Neptune, P Biselli, J P Kirkness

{"title":"The Effect of Nasal High Flow Therapy on Minute Ventilation in Chronic Obstructive Pulmonary Disease.","authors":"M O Sowho, P Galiatsatos, M Guzman, N N Hansel, J C Jun, E R Neptune, P Biselli, J P Kirkness","doi":"10.31488/ejrm.113","DOIUrl":"https://doi.org/10.31488/ejrm.113","url":null,"abstract":"Introduction: Nasal high-flow therapy (HFT) has been shown to improve daytime breathing mechanics in healthy adults as well as the lung function and quality of life in chronic obstructive pulmonary disease (COPD) patients.Method: We hypothesized that improved breathing mechanics with HFT may further reduce minute ventilation (i.e. decreased work of breathing) during sleep in patients with COPD. In COPD participants we examined the dose effect of HFT (within night randomization of HFT level; 0, 10, 20 and 30L/min) on minute ventilation, oxyhemaglobin saturation and transcutaneous carbon dioxide during wake and sleep. We assessed overnight polysomnography with and without HFT on two separate nights. Paired t-tests were used to compare overnight sleep quality with and without HFT. The association between ventilatory variables and HFT level was assessed using regression analysis.Results: During sleep, HFT decreased minute ventilation by 0.63±0.02L/min per 10L/min nasal airflow by reducing tidal volume (37±6mL per 10L/min; p<0.001) without affecting respiratory rate (p=0.9) or arterial CO2 (p=0.7). In contrast, during wakefulness reductions in minute ventilation (0.85±0.04L/min per 10L/min) was due to respiratory rate reduction along with prolongation in expiratory time.Conclusion: The reduction in minute ventilation is greater with higher dead-space volumes (r=0.50; p<0.02) and during wakefulness suggesting that ventilatory responses to HFT are mediated through a reduction in dead-space ventilation. The reduction in ventilation in response to HFT is large enough to reduce respiratory loads. Reducing respiratory loads may avert muscle fatigue, preserve respiratory function, or prevent development of respiratory failure.","PeriodicalId":72981,"journal":{"name":"European journal of respiratory medicine","volume":"3 1","pages":"172-177"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9428779/pdf/nihms-1831282.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9340472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inspiratory Muscle Training with an Electronic Device to Facilitate Weaning Ventilatory of a Patient with COVID-19 使用电子设备进行吸气肌训练以促进COVID-19患者的脱机通气

European journal of respiratory medicine Pub Date : 2021-01-01 DOI: 10.31488/ejrm.111

引用次数: 0

Evidence-Based Practice for Care of Preterm Infants Receiving Non-Invasive Ventilation (Clinical Trials identifier: NCT04165382) 无创通气早产儿护理的循证实践(临床试验编号:NCT04165382)

European journal of respiratory medicine Pub Date : 2021-01-01 DOI: 10.31488/ejrm.110

引用次数: 0

Current State and Understanding of Methamphetamine-associated Pulmonary Arterial Hypertension 甲基苯丙胺相关性肺动脉高压的现状与认识

European journal of respiratory medicine Pub Date : 2021-01-01 DOI: 10.31488/ejrm.112

Raymond Xu, Susan X. Zhao

引用次数: 1

Crazy-Paving Pattern: A Rare Case of Autoimmune Pulmonary Alveolar Proteinosis (PAP) with Positive Anti-GM-CSF Antibody Following Cryptococcal Infection in an otherwise Healthy Individual and Review of Literature 疯狂铺路模式:一例罕见的自身免疫性肺泡蛋白沉积症(PAP)在隐球菌感染后出现抗gm - csf抗体阳性并文献复习

European journal of respiratory medicine Pub Date : 2021-01-01 DOI: 10.31488/ejrm.116

引用次数: 0

The Use of End-Tidal CO2 as a Screening Tool in Patients with Pulmonary Embolism 末潮CO2作为肺栓塞患者筛查工具的应用

European journal of respiratory medicine Pub Date : 2021-01-01 DOI: 10.31488/ejrm.117

引用次数: 0

Use of Noninvasive Positive-Pressure Ventilation to Prevent Extubation Failure: A Concise Review 使用无创正压通气预防拔管失败:简要回顾

European journal of respiratory medicine Pub Date : 2021-01-01 DOI: 10.31488/ejrm.120

引用次数: 0

Evolution of a Pivotal Clinical Study to Evaluate Extracorporeal Photopheresis for Refractory Bronchiolitis Obliterans 评价难治性闭塞性细支气管炎体外光变性的关键临床研究进展

European journal of respiratory medicine Pub Date : 2021-01-01 DOI: 10.31488/ejrm.114

引用次数: 0

Inhalation of Sodium Pyruvate to Reduce the Symptoms and Severity of Respiratory Diseases Including COVID-19, Long COVID, and Pulmonary Fibrosis 吸入丙酮酸钠减轻COVID-19、长COVID和肺纤维化等呼吸系统疾病的症状和严重程度

European journal of respiratory medicine Pub Date : 2021-01-01 DOI: 10.31488/ejrm.121

Christopher R. Lupfer, Riley A Nadler, Ronald Amen, Alain Martin

{"title":"Inhalation of Sodium Pyruvate to Reduce the Symptoms and Severity of Respiratory Diseases Including COVID-19, Long COVID, and Pulmonary Fibrosis","authors":"Christopher R. Lupfer, Riley A Nadler, Ronald Amen, Alain Martin","doi":"10.31488/ejrm.121","DOIUrl":"https://doi.org/10.31488/ejrm.121","url":null,"abstract":"Background: To combat the continuing COVID-19 pandemic, and to treat the symptoms in Long COVID patients safe, effective, and inexpensive treatments are needed. Patients recovering from severe COVID-19 are at serious risk of de veloping pulmonary fibrosis. Conversely, patients with pulmonary fibrosis have an increased risk and susceptibility to COVID-19 infection, demonstrating the need to treat both. Design: Three separate clinical trials were conducted 1) in COVID-19 infected patients, 2) in Long COVID patients, and 3) in patients with Pulmonary Fibrosis to determine the effi cacy of N115, a sodium pyruvate based nasal spray. Patient symptoms, vital signs and respiratory function were evaluated compared to a placebo control or a no treatment baseline control. Findings: During active COVID-19 infection, N115 de creased viral titers and produced a significant improvement over saline in coughing/sneezing and fatigue. In Long COVID patients, N115 significantly reduced headache, coughing/sneezing and increased SaO2 levels (decreased hypoxemia) and improved breathing (dyspnea). In patients with Pulmonary Fibrosis, there was a significant improvement in all lung func -tions, compared to baseline, as determined by changes in SaO2, FVC, FEV1, PEF, and FEV1/FVC ratio. Conclusions: N115 is safe and effective at reducing symptoms of active COVID-19 infection and improves disease condition in Long COVID patients. Furthermore, N115 significantly improves lung function in Pulmonary Fibrosis patients. As COVID-19 and Pulmonary Fibrosis are associated with each other, our clinical research demonstrates that N115 is a promising treat ment for both and adds to the current 19 human clinical trials where N115 has shown efficacy in thousands of patients, regardless of the etiology of the lung disease (COPD, CF, allergic rhinitis, sinusitis, the flu, COVID-19 infected patients, Long COVID and patients with Fibrosis).","PeriodicalId":72981,"journal":{"name":"European journal of respiratory medicine","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82037293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3