Epigenetics communications最新文献

{"title":"In medio stat virtus? A reply to Dupras.","authors":"Luca Chiapperino, Francesco Paneni","doi":"10.1186/s43682-023-00017-1","DOIUrl":"10.1186/s43682-023-00017-1","url":null,"abstract":"","PeriodicalId":72947,"journal":{"name":"Epigenetics communications","volume":" ","pages":"5"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11116170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44836211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Walk on the wild side: a response to Zaina.","authors":"Luca Chiapperino, Francesco Paneni","doi":"10.1186/s43682-023-00019-z","DOIUrl":"10.1186/s43682-023-00019-z","url":null,"abstract":"","PeriodicalId":72947,"journal":{"name":"Epigenetics communications","volume":" ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11116241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45493844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"‘Epigenetics and Society’: a forum for the theoretical, ethical and societal appraisal of a burgeoning science","authors":"Luca Chiapperino, E. Bunnik, Gerard J. van den Berg","doi":"10.1186/s43682-022-00013-x","DOIUrl":"https://doi.org/10.1186/s43682-022-00013-x","url":null,"abstract":"","PeriodicalId":72947,"journal":{"name":"Epigenetics communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47294416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leukocyte-specific DNA methylation biomarkers and their implication for pathological epigenetic analysis","authors":"M. J. Dunnet, O. Ortega-Recalde, S. A. Waters, R. Weeks, I. Morison, T. Hore","doi":"10.1186/s43682-022-00011-z","DOIUrl":"https://doi.org/10.1186/s43682-022-00011-z","url":null,"abstract":"","PeriodicalId":72947,"journal":{"name":"Epigenetics communications","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42140944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking and colorectal cancer survival in relation to tumor LINE-1 methylation levels: a prospective cohort study","authors":"J. Kishikawa, T. Ugai, K. Fujiyoshi, Yang Chen, K. Haruki, Li Liu, K. Arima, Naohiko Akimoto, Tsuyoshi Hamada, K. Inamura, K. Kosumi, Tyler S. Twombly, Shanshan Shi, M. Lau, C. Du, Peilong Li, Chunguang Guo, J. Väyrynen, Sara A. Väyrynen, Simeng Gu, M. Song, Xuehong Zhang, Guanghai Dai, M. Giannakis, David A. Drew, A. Chan, C. Fuchs, J. Meyerhardt, Reiko Nishihara, J. Nowak, S. Ogino, K. Wu","doi":"10.1186/s43682-022-00012-y","DOIUrl":"https://doi.org/10.1186/s43682-022-00012-y","url":null,"abstract":"","PeriodicalId":72947,"journal":{"name":"Epigenetics communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42854879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential DNA methylation biomarkers for the detection of clear cell renal cell carcinoma identified by a whole blood-based epigenome-wide association study","authors":"Hideki Ohmomo, Shohei Komaki, Y. Sutoh, Tsuyoshi Hachiya, Kanako Ono, Eri Arai, H. Fujimoto, Teruhiko Yoshida, Y. Kanai, K. Asahi, Makoto Sasaki, A. Shimizu","doi":"10.1186/s43682-022-00009-7","DOIUrl":"https://doi.org/10.1186/s43682-022-00009-7","url":null,"abstract":"","PeriodicalId":72947,"journal":{"name":"Epigenetics communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49459694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and cardio-metabolic risk profiles of DNA methylation clocks among adults in south-central Côte d’Ivoire","authors":"Dafne N Sanchez, A. Jeong, Clémence Essé, F. Bassa, S. Koné, F. Acka, Véronique Laubhouet-Koffi, D. Kouassi, J. Utzinger, E. N'Goran, B. Bonfoh, M. Imboden, J. Holloway, Ikenna C. Eze","doi":"10.1186/s43682-022-00008-8","DOIUrl":"https://doi.org/10.1186/s43682-022-00008-8","url":null,"abstract":"","PeriodicalId":72947,"journal":{"name":"Epigenetics communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44934460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of the Illumina EPIC Array for Optimal Applications in Epigenetic Research Targeting Diverse Human Populations.","authors":"Zhou Zhang,&nbsp;Chang Zeng,&nbsp;Wei Zhang","doi":"10.1186/s43682-022-00015-9","DOIUrl":"https://doi.org/10.1186/s43682-022-00015-9","url":null,"abstract":"<p><p>The Illumina EPIC array is widely used for high-throughput profiling of DNA cytosine modifications in human samples, covering more than 850,000 modification sites across various genomic features. The application of this platform is expected to provide novel insights into the epigenetic contribution to human complex traits and diseases. Considering the diverse inter-population genetic and epigenetic variation, it will benefit the research community with a comprehensive characterization of this platform for its applicability to major global populations. Specifically, we mapped 866,836 CpG probes from the EPIC array to the human genome reference. We detected 91,034 CpG probes that did not align reliably to the human genome reference. In addition, 21,256 CpG probes were found to ambiguously map to multiple loci in the human genome, and 448 probes showing inaccurate genomic information from the original Illumina annotations. We further characterized those uniquely mapped CpG probes in terms of whether they contained common genetic variants, i.e., single nucleotide polymorphisms (SNPs), in major global populations, by utilizing the 1000 Genomes Project data. A list of optimal CpG probes on the EPIC array was generated for major global populations, with the aim of providing a resource to facilitate future studies of diverse human populations. In conclusion, our analysis indicated that studies of diverse human populations using the EPIC array would be benefited by taking into account of the technical features of this platform.</p>","PeriodicalId":72947,"journal":{"name":"Epigenetics communications","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9718568/pdf/nihms-1850286.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35208502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing understanding of maternal age: correlating epigenetic clocks in blood and myometrium.","authors":"Elise N Erickson,&nbsp;Anna K Knight,&nbsp;Alicia K Smith,&nbsp;Leslie Myatt","doi":"10.1186/s43682-022-00010-0","DOIUrl":"https://doi.org/10.1186/s43682-022-00010-0","url":null,"abstract":"<p><strong>Background: </strong>Advanced maternal age is currently a term defined by chronological age. However, a group of biomarkers known as epigenetic clocks, which can predict morbidity and mortality, has been used to estimate measures of biological aging. Uterine myometrial function during the process of parturition may be influenced by aging, as labor dystocia, unplanned intrapartum cesarean birth, and postpartum hemorrhage are more common in older individuals. The purpose of this study was to evaluate the use of epigenetic clocks in maternal myometrium and blood for predicting age and to evaluate the correlation of epigenetic age between the tissues.</p><p><strong>Results: </strong>We compared epigenetic age in blood and myometrial samples provided by women undergoing planned cesarean birth at term gestation. Chronological age ranged from 20 to 50 with a median (IQR) age of 35.5(8) years. The MethylationEPIC BeadChip was used to obtain DNA methylation data, and then epigenetic age was calculated using the Horvath, Hannum, GrimAge, and PhenoAge clocks. Spearman correlations of epigenetic age with chronological age were calculated. We tested the relationship of epigenetic age in maternal blood to epigenetic age in myometrium. Age acceleration, for each clock, was also correlated between tissues. Twenty-seven participants provided samples, and 21 matched specimens were included in the final analysis after quality control. Spearman correlation between maternal chronological age and epigenetic age were significant in three of the four clocks (pan-tissue Horvath, Hannum, and GrimAge), for both myometrium and blood samples. Correlations between blood epigenetic age and maternal age ranged from 0.72 to 0.87 (all <i>p</i> < 0.001). Correlations between myometrial epigenetic age and maternal age were also significant (0.62-0.70, <i>p</i> = 0.002), though lower than correlations seen in blood. Maternal blood epigenetic age also correlated with epigenetic age in myometrium with each of these three clocks 0.60 (<i>p</i> = 0.004, Horvath), 0.63 (<i>p</i> = 0.003, Hannum), and 0.80 (<i>p</i> < 0.001, GrimAge). GrimAge age acceleration had the highest correlation between tissues among the clocks (0.49, <i>p</i> = 0.02).</p><p><strong>Conclusions: </strong>Given the limited sample, this study provides insight into the potential use of epigenetic age derived from blood as a proxy for myometrial epigenetic age, which may be a useful biomarker in estimating myometrial biological age in relationship to myometrial dysfunction. GrimAge outperformed the other tested clocks in terms of concordance of epigenetic age and age acceleration between tissues; however, the Horvath and Hannum clocks may be useful depending on the outcome of interest in pregnancy.</p>","PeriodicalId":72947,"journal":{"name":"Epigenetics communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9432845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40344041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term aspirin use and epigenetic mitotic clocks for cancer risk prediction: findings in healthy colon mucosa and recommendations for future epigenetic aging studies","authors":"J. Nwanaji-Enwerem, Chijioke Nze, Andres Cardenas","doi":"10.1186/s43682-021-00004-4","DOIUrl":"https://doi.org/10.1186/s43682-021-00004-4","url":null,"abstract":"","PeriodicalId":72947,"journal":{"name":"Epigenetics communications","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44851162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}