Endocrinology, diabetes and metabolism journal最新文献

{"title":"Empowering Young Researchers: Searching for What to Say to Young People to Avoid Becoming Obese","authors":"","doi":"10.31038/edmj.2023713","DOIUrl":"https://doi.org/10.31038/edmj.2023713","url":null,"abstract":"71 US respondents, ages 14-19, evaluated phrases about what to do to avoid overeating. The phrases were selected by two student researchers, one in middle school, one in elementary school, using artificial intelligence. The phrases were combined according an underlying experimental design, creating 24 vignettes, with each of the 71 respondents evaluating a unique set of vignettes, rating each vignette on ‘for me versus not for me’. Clustering reveal three clearly different mind-sets about what is most relevant to the respondent; Mind-Set 1 focuses on exercise, Mind-Set 2 focuses on eating healthfully, Mind-Set 3 focuses on parental responsibility. The three mind-sets emerged clearly and dramatically, even though the respondents evaluated combinations of messages, some relevant, some not relevant.","PeriodicalId":72911,"journal":{"name":"Endocrinology, diabetes and metabolism journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69508877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fractures after Initiation of a Drug Holiday in a Real- Life Setting","authors":"Michael Morkos, Sanford Baim, Alessandra Casagrande, Paul Mahrous, Muriel Tania L Go, Hasan Husni, Mirette Hanna, Sara Bedrose, Dingfeng Li","doi":"10.31038/edmj.2023712","DOIUrl":"https://doi.org/10.31038/edmj.2023712","url":null,"abstract":"Purpose: We aimed to assess the fracture rate in patients who were placed on a drug holiday (DH) after minimum adequate therapy versus those who continued therapy (CT) in a real-life setting. Methods: This is a retrospective cohort study conducted in a tertiary academic center. Inclusion criteria involved osteoporotic adults who received minimum adequate bisphosphonate therapy (≥ 3 years), otherwise, patients were excluded. Results: Of 1,814 charts randomly selected and reviewed, 272 patients met the inclusion criteria. In our cohort, females were 90.9%, White 50.0%, and African American 40.5%. A DH was initiated in 119 patients (43.8%). In the CT versus DH cohorts, the mean duration of therapy was 6.0 ± 2.6 versus 5.7 ± 2.3 years, total duration of follow-up 6.9 ± 2.9 versus 7.8 ± 2.7 years, and fractures occurred in 11.7% versus 9.2% respectively, not statistically different. The mean duration of follow-up after starting DH was 2.5 ± 1.9 years. Upon risk stratification using FRAX scoring, in the high-risk cohort, fragility fractures occurred in 16.5% (n=22/133) of the CT group versus 13.5% (n=7/52) of the DH cohort (P=0.66). In the lower risk cohort based on FRAX scoring, fragility fractures occurred in 7.1% (n=10/131) of the CT group versus 6.0% (n=4/63) of the DH cohort (P=1.0). Conclusion: In our cohort, continued drug therapy did not provide additional fracture protective benefits beyond the minimum adequate duration of therapy. A drug holiday after three to five years of treatment may be considered after review of risk factors for future fracture.","PeriodicalId":72911,"journal":{"name":"Endocrinology, diabetes and metabolism journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45696059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalance and Risk Factors of Hypogonadism in Male Patients with Type 2 Diabetes in El Minya, Egypt","authors":"","doi":"10.31038/edmj.2023711","DOIUrl":"https://doi.org/10.31038/edmj.2023711","url":null,"abstract":"Background: Hypogonadism in adult men is a clinical and biochemical syndrome associated with low level of testosterone, which may adversely affect multiple organ functions and quality of life. It is closely related to the development of diabetes. This study was designed to determine the incidence of hypogonadism and related risk factors among men with type 2 diabetes (T2D). Patients and Methods: A total of 300 male patients diagnosed with T2D age from 30-70 years were enrolled in the study. Arabic version of the Androgen Deficiency in Aging Male (ADAM) questionnaire was employed to assess the androgen insufficiency in men. Hemoglobin A1c, FSH, LH, total and free testosterone, levels were measured by enzyme immunoassay. Results: T2D patients were divided into two groups: 48 (16%) patients with hypogonadism and 252 (84%) patients without hypogonadism. Multiple logistic regression analysis for factors affecting Hypogonadism among patients according to (total testosterone + ADAM +ve) versus those without hypogonadism it was found that age, random blood sugar, body mass index (BMI), Hb A1c are independent risk factors for the development of hypogonadism with odds ratio (0.95, 1, 1.1, 1.37) with p value (0.02, 0.03, 0. 03, 0.008) respectively. The ROC analysis of the accuracy of indices and cut off values for the studied total testosterone for predicting the hypogonadism according to total testosterone + ADAM score positive: The AUC was 0.98 «p-value <0.0001» with sensitivity 100% and specificity of 96.4% at Cut off value ≤ 12. Conclusion: Several risk factors of diabetes are associated closely with hypogonadism. Age, BMI, blood sugar, and Hb A1c are independent risk factors for the development of hypogonadism in male patients with T2D.","PeriodicalId":72911,"journal":{"name":"Endocrinology, diabetes and metabolism journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42157354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of Risks of Preeclampsia and Its Contributing Variables in Imo State","authors":"","doi":"10.31038/edmj.2022623","DOIUrl":"https://doi.org/10.31038/edmj.2022623","url":null,"abstract":"","PeriodicalId":72911,"journal":{"name":"Endocrinology, diabetes and metabolism journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47420948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myristolated Serotonin 2A Receptor Peptide Promotes Long-Lasting Blood Pressure-Lowering and Reno protection in Hypertensive Rat Species.","authors":"Mihal Grinberg,&nbsp;Mark B Zimering","doi":"10.31038/EDMJ.2022631","DOIUrl":"https://doi.org/10.31038/EDMJ.2022631","url":null,"abstract":"<p><strong>Aim: </strong>The aim of the present study was to test whether conjugation of a synthetic peptide corresponding to a fragment of the second extracellular domain of the human serotonin 2A receptor substantially alters the in vivo pharmacodynamic blood pressure-lowering profile of the peptide in different hypertensive rat strains.</p><p><strong>Methods: </strong>Sertuercept (SCLLADDN) was synthesized and modified using pegylation or myristolation. The two different peptide conjugates were tested in male Zucker diabetic fatty rats for acute and long-lasting blood pressure-lowering effects following single intraperitoneal administration. The myristolated Sertuercept was administered intraperitoneally to female Zucker fatty and male spontaneously hypertensive rats (SHR) and blood pressure was monitored either using tail cuff measurement (female Zucker) or by telemetry (SHR) rats. Plasma immunoglobulin G obtained by Protein G affinity chromatography in 25-week-old female Zucker or male spontaneously hypertensive rats was tested for binding to a linear synthetic peptide corresponding to the second extracellular loop of the serotonin 2A receptor. A cohort of male Zucker diabetic fatty rats was randomized to seven weeks of once-weekly myristolated Sertuercept or scrambled peptide (injections) and the kidneys were examined histologically for differences in total kidney lesions or fibrosis.</p><p><strong>Results: </strong>Pegylated Sertuercept promoted substantial blood pressure-lowering lasting approximately 30-48 hours in male Zucker diabetic fatty rats. Blood pressure-lowering following a single injection of Myristolated Sertuercept was much longer-lasting (6-11 days) and it was effective in male Zucker diabetic fatty rats, male spontaneously hypertensive rats and in a subset of hypertensive female Zucker fatty rats. Seven weeks' treatment with once-weekly Myristolated Sertuercept (2mg/kg) was associated with significantly fewer kidney lesions and less interstitial fibrosis compared to scrambled peptide in 25-week-old male Zucker diabetic fatty rats. Male spontaneously hypertensive rats (4 of 4 tested) harbored plasma IgG which bound significantly to serotonin 2A receptor peptide, and a subset of female Zucker fatty rats harboring IgG were responsive to blood pressure-lowering from the myristolated Sertuercept peptide.</p><p><strong>Summary: </strong>Myristolated-Sertuercept, an epitope-specific peptide comprised of a portion of second extracellular loop of the human serotonin 2A receptor was safe, well-tolerated and effectively lowered blood pressure for one week or longer in two different strains of male hypertensive rats. These data provide proof-of-concept that once-weekly systemic drug administration is feasible to achieve not only long-lasting hypertension control, but also substantial renoprotection.</p>","PeriodicalId":72911,"journal":{"name":"Endocrinology, diabetes and metabolism journal","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10010125/pdf/nihms-1867880.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9116215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Tuberculosis in Patients Visiting Massawa Hospital: Cross-Sectional Study, 2021","authors":"Berhe Tesfai, Mihreteab Abraham, Hailemichael Gebremariam, Abiel Abraham, Liwam Abraham, Fitsum Kibreab","doi":"10.31038/edmj.2022622","DOIUrl":"https://doi.org/10.31038/edmj.2022622","url":null,"abstract":"Background: Despite the availability of efficacious drugs, tuberculosis remains a major public health problem in low- and middle-income countries. This study was aimed to determine the prevalence of tuberculosis in Massawa Hospital, Eritrea. Methods: Laboratory and medical records of tuberculosis patients in Massawa Hospital were reviewed. All patients who did sputum exam by Xpert Gene from January 01, 2018 to May 1, 2021 in Massawa Hospital were enrolled in this study. Categorical variables were presented in percent, frequencies, Chi-square test, and odds ratio with 95% confidence interval. P value <0.05 was considered significant. Results: Sputum examination was done on 2178 patients and the prevalence of bacteriologically positive tuberculosis was 7%. Moreover, the prevalence of rifampicin resistant tuberculosis among the total tested and bacteriologically positive patients was 0.4% and 5.9% respectively. The main reason for sputum examination was presumptive diagnosis of tuberculosis (85.5%). Tuberculosis spondylitis (15.6%) and adenitis (13.6%) were found to be the most common types of extra pulmonary tuberculosis. The prevalence of tuberculosis in HIV patients was 5.2% and all started highly active antiretroviral therapy. Patients aged 15 to 24 years were having higher prevalence of tuberculosis (8.8%, 95%CI 0.68-4.72, OR-1.79). And, those from Ghelaelo subzone were having about two times higher prevalence of tuberculosis (9.9%, 95%CI 1.39-3.06, OR-2.06). Patients who had previous history of tuberculosis were having about five times higher prevalence of tuberculosis (27.5%, 95%CI 2.65-11.17. OR-5.4, p<0.001) and Rifampicin resistant tuberculosis (9.1%, p<0.002). Conclusion: The prevalence of tuberculosis and the multidrug resistant tuberculosis among the confirmed cases was comparatively increased than the average WHO estimates for Eritrea and similar to a study conducted in Nakfa subzone, Eritrea. The prevalence of tuberculosis in HIV patients was higher to the WHO estimates and previous studies in the country. Previous history of tuberculosis was significantly associated with the prevalence tuberculosis and multidrug resistant tuberculosis. Further prospective studies to evaluate the national prevalence of tuberculosis and rifampicin resistant tuberculosis are highly recommended.","PeriodicalId":72911,"journal":{"name":"Endocrinology, diabetes and metabolism journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49546078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Susceptibility of South Asians to Cardiometabolic Disease as a Result of Starvation Adaptation Exacerbated During the Colonial Famines","authors":"M. Syed, F. Deek, A. Shaikh","doi":"10.31038/edmj.2022621","DOIUrl":"https://doi.org/10.31038/edmj.2022621","url":null,"abstract":"South Asians, representing one quarter of the world’s population, have disproportionally high rates of obesity and cardiometabolic disease thus resulting an epidemic health crisis. This crisis could be the consequence of epigenetic effects exacerbated during the colonial-era famines resulting in a unique starvation-adapted physiology. Due to evolutionary mismatch in circumstances of abundance, this starvation-adapted physiology can become harmful. Evidence for this starvation adaptation in South Asians includes high body fat and unfavorable adipokines; low lean body mass; lower resting energy expenditure (compounded by lack of brown adipose tissue); greater insulin resistance and insulin response; exaggerated lipemic response to fat and sugar intake; less capacity to handle an overabundance of food; lower fat burning (oxidative capacity) and VO2max during aerobic exercise; and energy-conserving response to resistance exercise, as well as increased lipoprotein (a) levels. The Roma people, also of South Asian ancestry, may represent an interesting pre-colonial historical control. Physician and patient knowledge of this unique physiology in South Asians will promote a stronger physician-patient relationship and foster compliance with treatment.","PeriodicalId":72911,"journal":{"name":"Endocrinology, diabetes and metabolism journal","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43879948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ordinary People Thinking about What Emotional Issues Obesity Might Trigger: A Mind Genomics Cartography","authors":"H. Moskowitz","doi":"10.31038/edmj.2022613","DOIUrl":"https://doi.org/10.31038/edmj.2022613","url":null,"abstract":"107 respondents each evaluated 60 unique vignettes (combinations of two, three or four messages), dealing with descriptions of how a person with obesity might feel. The respondent rated each vignette on degree to which the vignette would provoke a feeling of ‘cannot deal with it’ (viz., strong anxiety). Deconstruction of the responses to the full set of 36 messages on a respondent-respondent basis revealed that two specific messages provoked the highest degree of anxiety; you believe that the food industry will work to help you find the right foods to eat and you just can’t control the eating. Substantial differences emerged for age, and for the location where anxiety might be experienced (e.g., while listening to music.). Clustering the 107 respondents into mind-sets, groups with different points of view, revealed three radically different group, based on the elements which drive anxiety: MS1 – Anxiety about acceptance by others; MS 2 – Anxiety when thinking about professional help; MS3 – Anxiety about helplessness and being out of control.","PeriodicalId":72911,"journal":{"name":"Endocrinology, diabetes and metabolism journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46776407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Serotonin 2A Receptor Autoantibodies Predict Rapid, Substantial Decline in Neurocognitive Performance in Older Adult Veterans with TBI.","authors":"Mark B Zimering,&nbsp;Mihal Grinberg,&nbsp;Catherine E Myers,&nbsp;Gideon Bahn","doi":"10.31038/edmj.2022614","DOIUrl":"https://doi.org/10.31038/edmj.2022614","url":null,"abstract":"<p><strong>Aim: </strong>Traumatic brain injury (TBI) was associated with increased plasma serotonin 2A receptor (5-HT2AR) autoantibodies in adults who experienced neurodegenerative complications. We tested whether the baseline presence of plasma serotonin 2A receptor (5-HT2AR) autoantibodies was a significant predictor of the two-year rate of cognitive decline in middle-aged and older adult TBI.</p><p><strong>Methods: </strong>Plasma from thirty-five middle-aged and older adult veterans (mean 65 years old) who had suffered traumatic brain injury was subjected to protein-A affinity chromatography. One-fortieth dilution of the resulting immunoglobulin (Ig) G fraction was tested for binding (in ELISA) to a linear synthetic peptide corresponding to the second extracellular loop region of the human 5-HT2A receptor. All available patients completed baseline and two-year follow-up neurocognitive tests of memory (St Louis University Mental Status), processing speed (Digit Symbol Substitution Test) and executive function (Trails-making Test, Part B). Change in cognitive performance was computed as (two-year - baseline) raw test score.</p><p><strong>Results: </strong>Eighteen patients completed both baseline and two-year follow up neurocognitive tests. TBI patients harboring plasma 5-HT2AR autoantibodies at the baseline examination (n=13) did not differ significantly in their baseline clinical characteristics (age, education level) compared to TBI patients lacking baseline plasma autoantibodies (n=5). Plasma serotonin 2AR antibody-positive patients experienced a significantly greater post-baseline decline in performance on the St Louis University Mental Status test (P=0.0118) and in the Digit Symbol Substitution Test (P=0.011), but not in Trails-making Part B (P=0.129) compared to serotonin 2AR antibody-negative patients. In multivariable linear regression analyses that adjusted for age, baseline presence of plasma 5-HT2AR autoantibody was a significant predictor of the two-year rate of decline in memory, and processing speed. Binding of plasma autoantibody to the serotonin 2A receptor peptide in the enzyme linked immunosorbent assay was also significantly higher (at 1/160th titer of the protein-A eluate= 1 μg/mL IgG) in TBI patients harboring <i>vs</i>. those not harboring baseline plasma 5-HT2AR autoantibodies.</p><p><strong>Conclusion: </strong>These data suggest that plasma 5-hydroxytryptamine 2A receptor autoantibodies which were increased in approximately two-thirds of middle-aged and older adults following traumatic brain injury predicts rapid and substantial declines in cognitive function (memory and processing speed), independent of age.</p>","PeriodicalId":72911,"journal":{"name":"Endocrinology, diabetes and metabolism journal","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9753318/pdf/nihms-1854953.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10762654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified Dachaihu Decoction Regulates FOXO3a Acetylation Activated Autophagy and Relieving Insulin Resistance in Obesity","authors":"Cong Long, Yang Gao, Xuke Han, Su-qin Li, Qiu Chen","doi":"10.31038/edmj.2021542","DOIUrl":"https://doi.org/10.31038/edmj.2021542","url":null,"abstract":"Background The previous studies of our research group indicate that the weakening of mitochondrial autophagy function is the key mechanism of obesity-induced insulin resistance, and Mitochondrial autophagy mediated by PINK1/Parkin pathway can reverse mitochondrial dysfunction. Recently, we found that FOXO3a, as an upstream regulator of PINK1, has been found to play a key role in regulating mitochondrial autophagy.However,FOXO3a is regulated by deacetylation. Objective To explore whether Modified Dachaihu Decoction can regulate liver mitochondrial autophagy mediated by the PINK1/Parkin signal pathway by regulating the expression of FOXO3a acetylation. Western blot showed that compared with the model control group, the expression of mitochondrial autophagy-related proteins and FOXO3a in the Modified Dachaihu Decoction group increased, and the expression of ace-FOXO3a decreased (P < 0.05). We speculate that in this experiment, Modified Dachaihu Decoction may regulate mitochondrial autophagy mediated by PINK1/ Parkin signal pathway by downregulating the expression of FOXO3a acetylation, to reduce Hepatic Insulin Resistance in Obesity.","PeriodicalId":72911,"journal":{"name":"Endocrinology, diabetes and metabolism journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48987611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}