Endocrines最新文献_第6页

Pregnancy and Type 2 Diabetes: Unmet Goals 妊娠和2型糖尿病：尚未实现的目标

Endocrines Pub Date : 2023-05-12 DOI: 10.3390/endocrines4020028

M. Dalfrà, S. Burlina, A. Lapolla

引用次数: 0

The Androgen Regulation of Matrix Metalloproteases in Prostate Cancer and Its Related Tumor Microenvironment 基质金属蛋白酶在前列腺癌症及其相关肿瘤微环境中的雄激素调节

Endocrines Pub Date : 2023-05-09 DOI: 10.3390/endocrines4020027

Carmela Sorrentino, Rosa D’Angiolo, Giulia Gentile, P. Giovannelli, B. Perillo, A. Migliaccio, G. Castoria, M. Di Donato

{"title":"The Androgen Regulation of Matrix Metalloproteases in Prostate Cancer and Its Related Tumor Microenvironment","authors":"Carmela Sorrentino, Rosa D’Angiolo, Giulia Gentile, P. Giovannelli, B. Perillo, A. Migliaccio, G. Castoria, M. Di Donato","doi":"10.3390/endocrines4020027","DOIUrl":"https://doi.org/10.3390/endocrines4020027","url":null,"abstract":"Prostate cancer represents the most common type of cancer among males and the second leading cause of cancer death in men in Western society. In most cases (~70%), PC has a slow and symptom-free growth, whereas it is more aggressive in the remaining patients. Current PC therapies prevalently target the proliferative function of the androgen receptor and may only be effective within short periods, beyond which the disease will progress to metastatic and castration-resistant phenotype. Preclinical and clinical studies are aimed at investigating the molecular basis for prostate cancer spreading. Although considerable efforts have been made to dissect the programs that foster prostate cancer spreading, few biomarkers predictive of metastatic phenotype have yet been identified and few therapeutic options are available for treatment of the metastatic disease. In the present paper, we will discuss innovative aspects of prostate cancer biology, which impinge on the role of cancer-associated fibroblasts and the released matrix metalloproteinases in the disease progression. Investigating these aspects might allow the discovery of clinically actionable biomarkers to target in the advanced stages of prostate cancer.","PeriodicalId":72908,"journal":{"name":"Endocrines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49591928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into the Mechanism of Action of Helianthus annuus (Sunflower) Seed Essential Oil in the Management of Type-2 Diabetes Mellitus Using Network Pharmacology and Molecular Docking Approaches 利用网络药理学和分子对接方法深入探讨向日葵籽精油治疗2型糖尿病的作用机制

Endocrines Pub Date : 2023-05-02 DOI: 10.3390/endocrines4020026

Athika Rampadarath, F. Balogun, S. Sabiu

{"title":"Insights into the Mechanism of Action of Helianthus annuus (Sunflower) Seed Essential Oil in the Management of Type-2 Diabetes Mellitus Using Network Pharmacology and Molecular Docking Approaches","authors":"Athika Rampadarath, F. Balogun, S. Sabiu","doi":"10.3390/endocrines4020026","DOIUrl":"https://doi.org/10.3390/endocrines4020026","url":null,"abstract":"Type-2 diabetes mellitus (T2D) is one of the leading non-communicable diseases of global concern. Knowing the exact mechanism of action of available antidiabetic agents, particularly natural products, may assist in providing effective therapeutic solutions. The antidiabetic action of Helianthus annuus (sunflower) seed has been established; however, the molecular mechanism of action, especially the essential oil, is lacking. The study explored network pharmacology and molecular docking studies to determine the active phytoconstituents, signaling pathways, and probable therapeutic targets to determine the antidiabetic potential of sunflower seed essential oil. Preliminary analysis established 23 target genes with 15 phytoconstituents involved in T2D which all passed Lipinski’s rule of five with no violation. Three pathways were proposed by KEGG analysis as therapeutic targets for T2D development with PPAR as the major route affecting PPARA, FABP4, PPARD, PPARG, and CPT2 genes. Molecular docking investigation confirmed the effectiveness of active SSEO compounds against the identified genes (targets) and established phylloquinone, linoleic acid, tricosylic acid, and lignoceric acid as the probable drug candidates that could offer laudable therapeutic effects in an effort towards T2D management. Thereby, we present an insight toward understanding the mechanism of the antidiabetic action of sunflower seeds via the stimulation of glucose to enhance insulin release.","PeriodicalId":72908,"journal":{"name":"Endocrines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45376319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

High-Intensity Interval Cycling and Running Yield a Similar Myokine and Osteokine Response in Young Adult Females 在年轻成年女性中，高强度间歇骑行和跑步产生相似的肌因子和骨因子反应

Endocrines Pub Date : 2023-05-01 DOI: 10.3390/endocrines4020025

G. Borzooeian, Steven Kottaras, R. Kouvelioti, M. Bell, W. Ward, E. Tsiani, P. Klentrou

{"title":"High-Intensity Interval Cycling and Running Yield a Similar Myokine and Osteokine Response in Young Adult Females","authors":"G. Borzooeian, Steven Kottaras, R. Kouvelioti, M. Bell, W. Ward, E. Tsiani, P. Klentrou","doi":"10.3390/endocrines4020025","DOIUrl":"https://doi.org/10.3390/endocrines4020025","url":null,"abstract":"Background: The differential responses of the myokine irisin, in combination with changes in markers and regulators of bone remodeling to high-intensity interval exercise of high and low impact, were examined in 18 young adult females (22.5 ± 2.7 years). Methods: Participants performed two high-intensity interval exercise trials in random order: running on a treadmill and cycling on a cycle ergometer. Trials consisted of eight 1 min running or cycling intervals at ≥ 90% of maximal heart rate, separated by 1 min passive recovery intervals. Blood samples were collected at rest (pre-exercise) and 5 min, 1 h, and 24 h following each exercise trial. Irisin, osteocalcin, sclerostin, osteoprotegerin (OPG), receptor activator nuclear factor kappa-β ligand (RANKL), and parathyroid hormone (PTH) were analyzed in serum, with post-exercise concentrations being corrected for exercise-induced changes in plasma volume. Results: Irisin was elevated 24 h post-exercise compared to its resting values in both trials (20%, p < 0.05) and was higher after cycling compared to running (exercise mode effect, p < 0.05) with no interaction. Osteocalcin, sclerostin, PTH, and RANKL increased from pre- to 5 min post-exercise (18%, 37%, 83%, and 33%, respectively, p < 0.05), returning to baseline levels in 1 h, with no trial or interaction effects. OPG showed a time effect (p < 0.05), reflecting an overall increase at 5 min and 1 h post-exercise, which was not significant after the Bonferroni adjustment. Conclusions: In young adult females, high-intensity interval exercise induced an immediate response in markers and regulators of bone remodeling and a later response in irisin concentrations, which was independent of the gravitational impact.","PeriodicalId":72908,"journal":{"name":"Endocrines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42005410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Promising Role of Self-Compassion in Managing Type 1 Diabetes 自我同情在治疗1型糖尿病中的重要作用

Endocrines Pub Date : 2023-04-26 DOI: 10.3390/endocrines4020024

Chloe Kaelberer, M. Tanenbaum

引用次数: 0

Potential Effects of Oral Isotretinoin on Growth Plate and Height 口服异维甲酸对生长板和身高的潜在影响

Endocrines Pub Date : 2023-04-07 DOI: 10.3390/endocrines4020023

A. Cardoso-Demartini, C. Boguszewski, Margaret C. S. Boguszewski

引用次数: 0

Detection of Metabolic Syndrome Using Insulin Resistance Indexes: A Cross-Sectional Observational Cohort Study 应用胰岛素抵抗指数检测代谢综合征的横断面观察队列研究

Endocrines Pub Date : 2023-04-03 DOI: 10.3390/endocrines4020021

Lucas Fornari Laurindo, Giulia Minniti, Ricardo José Tofano, K. Quesada, Eduardo Federighi Baisi Chagas, Sandra Maria Barbalho

{"title":"Detection of Metabolic Syndrome Using Insulin Resistance Indexes: A Cross-Sectional Observational Cohort Study","authors":"Lucas Fornari Laurindo, Giulia Minniti, Ricardo José Tofano, K. Quesada, Eduardo Federighi Baisi Chagas, Sandra Maria Barbalho","doi":"10.3390/endocrines4020021","DOIUrl":"https://doi.org/10.3390/endocrines4020021","url":null,"abstract":"Insulin resistance (IR) is considered cardinal to the pathophysiology of metabolic syndrome (MetS). Previously, several simple indexes of IR calculated from biochemical and anthropometric variables have been proposed. However, these indexes are population-dependent; therefore, further studies on a global scale are necessary. The present study assessed the diagnostic accuracy of eight IR indicators, namely, METS-IR, TG-HDL-c, TyG, TyG-BMI, TyG-NC, TyG-NHtR, TyG-WC, and TyG-WHtR, in indicating MetS among a Brazilian population. For this, 268 patients (152 men and 116 women, 53–59 years of age) were included in the study, out of which 111 were diagnosed with MetS according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III). All indexes achieved significant accuracy, with TyG-WC (0.849 (0.800–0.889)), TyG (0.837 (0.787–0.879)), and TG-HDL-c (0.817 (0.765–0.861)) having the highest area under the curve (AUC). Further, the most heightened diagnostic sensitivities were observed for TG-HDL-c (90.99%), TyG-WC (89.19%), and TyG-NC (84.68%), whereas the highest diagnostic specificities were noted for TyG (73.89%), TyG-WHtR (72.61%), and TyG-WC (66.88%). Thus, TyG-WC, TyG, and TG-HDL-c reached the greatest AUC values in our analyses, making them useful diagnostic indicators of MetS, and crucial for patients’ clinical management.","PeriodicalId":72908,"journal":{"name":"Endocrines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43550476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Insights into Androgen Receptor Action in Lung Cancer 雄激素受体在癌症中的作用

Endocrines Pub Date : 2023-04-03 DOI: 10.3390/endocrines4020022

Darko Durovski, Milica Jankovic, S. Prekovic

引用次数: 2

Alzheimer’s Disease and Premature Ovarian Insufficiency 阿尔茨海默病与卵巢早衰

Endocrines Pub Date : 2023-04-01 DOI: 10.3390/endocrines4020020

S. Vujović, M. Ivović, M. Tančić Gajić, L. Marina, Svetlana Jovičić, Natalija Pavlović, Milena Erić Jovicić

{"title":"Alzheimer’s Disease and Premature Ovarian Insufficiency","authors":"S. Vujović, M. Ivović, M. Tančić Gajić, L. Marina, Svetlana Jovičić, Natalija Pavlović, Milena Erić Jovicić","doi":"10.3390/endocrines4020020","DOIUrl":"https://doi.org/10.3390/endocrines4020020","url":null,"abstract":"Estradiol promotes neuronal growth, transmission, survival, myelinization, plasticity, synaptogenesis, and dendritic branching and it improves cognitive function. Alzheimer’s disease (AD) is characterized by amyloid plaques, neurofibrillary tangles, and the loss of neuronal connection in the brain. Genomic analysis has concluded that hypoestrogenism influences the APOE gene and increases the risk of AD. Premature ovarian insufficiency (POI) is defined as oligo/amenorrhea in women below 40 years of age, low estradiol, and high-gonadotropin levels. Early symptoms and signs of POI must be detected in time in order to prevent subsequent complications, such as Alzheimer’s disease. Meta-analysis has shown favorable effects of estrogen in preventing Alzheimer’s. We measured some of the typical markers of AD in women with POI such as interleukin 6 (IL-6), interleukin 8 (IL-8), tissue necrosis factor α (TNFα), TAU1, TREM2, and amyloid precursor proteins (APP). While FSH, LH, and IL-8 were significantly higher in POI group, compared to controls, testosterone and DHEAS were lower. A significant decrease in IL-6 was found in the POI group during a 6-month therapy, as well as an increase in amyloid precursor proteins. CONCLUSION: Neurological complications of POI, such as declining short-term memory, cognitive function, and dementia, have to be promptly stopped by initiating estro-progestogen therapy in POI. A long-term continuation of the therapy would be strongly advised.","PeriodicalId":72908,"journal":{"name":"Endocrines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46326317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Ketone Bodies in Various Animal Models of Kidney Disease 酮体在各种肾脏疾病动物模型中的作用

Endocrines Pub Date : 2023-03-16 DOI: 10.3390/endocrines4010019

Haoxin Liu, Liang-Jun Yan

{"title":"The Role of Ketone Bodies in Various Animal Models of Kidney Disease","authors":"Haoxin Liu, Liang-Jun Yan","doi":"10.3390/endocrines4010019","DOIUrl":"https://doi.org/10.3390/endocrines4010019","url":null,"abstract":"The kidney is a vital organ that carries out significant metabolic functions in our body. Due to the complexity of its role, the kidney is also susceptible to many disease conditions, such as acute kidney injury (AKI) and chronic kidney disease (CKD). Despite the prevalence and our increased understanding of the pathophysiology of both AKI and CKD as well as the transition of AKI to CKD, no well-established therapeutics have been applied clinically to these conditions, rendering an urgent need for a novel potential therapeutic target to be developed. In this article, we reviewed the function of ketone bodies in some common kidney conditions, such as drug-induced nephrotoxicity, ischemia and reperfusion injury, fibrosis development, diabetic kidney disease, kidney aging, hypertension, and CKD progression. All the selected studies reviewed were performed in animal models by primarily utilizing rodents, which also provide invaluable sources for future clinical applications. Ketone bodies have shown significant renal protective properties via attenuation of oxidative stress, increased expression of anti-inflammatory proteins, gene regulation, and a reduction of apoptosis of renal cells. A physiological level of ketone bodies could be achieved by fasting, a ketogenic diet, and an exogenous ketone supplement. Finally, the limitations of the long-term ketogenic diet were also discussed.","PeriodicalId":72908,"journal":{"name":"Endocrines","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44394386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0