Die Anaesthesiologie最新文献

{"title":"[Regression analysis to calculate the time point of ROSC-A feasibility study].","authors":"André Luckscheiter, W Zink, M Thiel, V Schneider-Lindner","doi":"10.1007/s00101-026-01648-4","DOIUrl":"10.1007/s00101-026-01648-4","url":null,"abstract":"<p><strong>Background: </strong>A regression model to estimate the duration from the onset of resuscitation efforts to the return of spontaneous circulation (ROSC) could help improving both resuscitation care and the quality control of registries. This study aims to evaluate the prediction accuracy and to identify challenges for future model development.</p><p><strong>Method: </strong>Regression models based on M5P, random forest (RF) algorithms and a linear regression (LR) modified using M5P were retrospectively developed using a Belgian cohort of 84 individuals in whom ROSC was achieved. Model performance was assessed using quality metrics, such as the correlation coefficient (CC), coefficient of determination (R²), and root mean square error (RMSE) in a cross-validation approach.</p><p><strong>Results: </strong>In the cohort 61.9% were male with a mean age of 65.7 years. A shockable rhythm was present in 27.7% of cases and the bystander cardiopulmonary resuscitation (CPR) rate was 48.2%. The no-flow time averaged 5.13 min. The mean time from CPR onset to first defibrillation was 7.81 min and to first medication administration 11.31 min. The ROSC occurred after an average of 16.8 min, the LR showed the highest correlation (0.73, 95% confidence interval, CI 0.72-0.74) and R² (0.53 [0.52-0.55]) along with the lowest RMSE (6.76 min [6.63-6.90]). The M5P yielded similar not significantly different values (CC 0.72 [0.70-0.73], R² 0.52 [0.50-0.53], RMSE 6.84 min [6.69-6.99]). In contrast, RF performed significantly worse (CC 0.62 [0.61-0.63], R² 0.38 [0.37-0.40], RMSE 7.89 min [7.82-7.96], all p < 0.01). Only LR showed no significant difference between predicted and actual values in terms of mean (p = 0.75) and variance (p = 0.15). The proportion of potentially prematurely terminated resuscitation attempts, defined as cases with actual ROSC occurring later than predicted ROSC plus RMSE, ranged from 13% (M5P) to 18% (LR).</p><p><strong>Conclusion: </strong>The duration from the start of CPR to ROSC appears to be a process that is suitable for modelling with machine learning algorithms. At this early stage of development, the individual regression models did not demonstrate sufficient validity possibly due to low sample size and simplified data structure; however, the findings indicated potential for an application as a quality assurance tool to compare actual vs. predicted time to ROSC. Therefore, to increase the robustness the results require further evaluation in a larger cohort with additional variables and improved data quality based on the Utstein criteria.</p>","PeriodicalId":72805,"journal":{"name":"Die Anaesthesiologie","volume":" ","pages":"231-241"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13167895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146088243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A 4-year-old girl with traumatic carotid artery dissection and subsequent infarction of the middle cerebral artery].","authors":"Thorsten Walter, Mareike Schimmel, Stefan Siegert, Lars Behrens","doi":"10.1007/s00101-025-01634-2","DOIUrl":"10.1007/s00101-025-01634-2","url":null,"abstract":"","PeriodicalId":72805,"journal":{"name":"Die Anaesthesiologie","volume":" ","pages":"252-255"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Desfluran – unverzichtbar oder obsolet?","authors":"Florian Gerheuser, Daniel Bolkenius, Stephanie Snyder-Ramos, Maika Berek, Susanne Koch, Theresa Krüger, Sebastian Gibb, Katja Nickel","doi":"10.1007/s00101-026-01675-1","DOIUrl":"10.1007/s00101-026-01675-1","url":null,"abstract":"","PeriodicalId":72805,"journal":{"name":"Die Anaesthesiologie","volume":" ","pages":"263-264"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147534580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Precision immunotherapy improves organ dysfunction in sepsis].","authors":"Lennart Wild, Christian Bode","doi":"10.1007/s00101-026-01644-8","DOIUrl":"10.1007/s00101-026-01644-8","url":null,"abstract":"","PeriodicalId":72805,"journal":{"name":"Die Anaesthesiologie","volume":" ","pages":"282-283"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146013438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seine Meinung (angesichts klimawissenschaftlicher Daten) zu ändern, ist auch eine Form von Freiheit: Klimametriken ersetzen keine klinische Abwägung!","authors":"Peter Kranke, Robert Kleinberg, Patrick Meybohm, Beverly Philip, Laurentiu Marin, Kai Zacharowski","doi":"10.1007/s00101-026-01674-2","DOIUrl":"10.1007/s00101-026-01674-2","url":null,"abstract":"","PeriodicalId":72805,"journal":{"name":"Die Anaesthesiologie","volume":" ","pages":"265-267"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kontrastmittel und AKI : Von der Kausalitätsfrage zum Risikomanagement.","authors":"Melanie Meersch-Dini, Detlef Kindgen-Milles","doi":"10.1007/s00101-026-01665-3","DOIUrl":"10.1007/s00101-026-01665-3","url":null,"abstract":"","PeriodicalId":72805,"journal":{"name":"Die Anaesthesiologie","volume":" ","pages":"223-224"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147437793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Publish well in anesthesiology: Quality standards and dealing with predatory journals].","authors":"Theresa Tenge, Aileen Hill, David Radke, Götz Schmidt, Justus Student, Laura Borgstedt, Rene M Pembele, Richard-Felix Kraus, Sebastian Roth, Martin Scharffenberg","doi":"10.1007/s00101-026-01656-4","DOIUrl":"10.1007/s00101-026-01656-4","url":null,"abstract":"","PeriodicalId":72805,"journal":{"name":"Die Anaesthesiologie","volume":" ","pages":"256-262"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13043557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prof. Dr. Dr. h.c. Klaus Peter – Anästhesiologe, Wissenschaftler, Hochschullehrer und Herausgeber aus Leidenschaft.","authors":"Bernhard Zwißler, Rolf Rossaint","doi":"10.1007/s00101-026-01673-3","DOIUrl":"10.1007/s00101-026-01673-3","url":null,"abstract":"","PeriodicalId":72805,"journal":{"name":"Die Anaesthesiologie","volume":" ","pages":"221-222"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147492195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The PHOENICS study: current evidence on the use of hydroxyethyl starch].","authors":"Daniel Chappell, Matthias Jacob","doi":"10.1007/s00101-026-01651-9","DOIUrl":"10.1007/s00101-026-01651-9","url":null,"abstract":"","PeriodicalId":72805,"journal":{"name":"Die Anaesthesiologie","volume":" ","pages":"284-286"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of pericapsular nerve group block on postoperative cognitive function in older patients undergoing total hip arthroplasty.","authors":"Gokhan Erdem, Burak Nalbant, Fatma Kavak Akelma, Enes Sağlam, Dilara Erdem, Ayşe Lafçı","doi":"10.1007/s00101-026-01654-6","DOIUrl":"10.1007/s00101-026-01654-6","url":null,"abstract":"<p><strong>Purpose: </strong>Postoperative cognitive dysfunction (POCD) is common in older patients undergoing orthopedic surgery and may hinder clinical recovery. This prospective study evaluated whether a preoperative pericapsular nerve group (PENG) block reduces POCD incidence in patients undergoing total hip arthroplasty (THA).</p><p><strong>Methods: </strong>This prospective, randomized, double-blind study included older patients scheduled for elective THA under spinal anesthesia. Patients were randomized into 2 groups: PENG (group P) and control (group C). Group P underwent an ultrasound-guided PENG block containing 20 mL of 0.25% bupivacaine, while group C received a sham block. Cognitive performance was evaluated using the telephone version of the Mini-Mental State Examination (T-MMSE) preoperatively and on postoperative days 7, 30 and 90. We evaluated postoperative pain using the numerical rating scale (NRS) and recorded opioid consumption, time to mobilization, hospital stay duration, neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR).</p><p><strong>Results: </strong>The final analysis included 84 patients (41 in group P and 43 in group C). There were no significant differences in demographic characteristics or intraoperative data between the groups (p > 0.05). The incidence of POCD on postoperative day 7 was lower in the PENG group (14.6% vs. 37.2%; p < 0.05). In the first 24h postoperatively group P reported significantly lower pain scores and opioid use (p < 0.001), were mobilized earlier and discharged sooner (p < 0.001). The NLR and PLR were lower in the PENG group at 24 and 48h postoperatively (p < 0.05).</p><p><strong>Conclusion: </strong>Preoperative PENG block may preserve early postoperative cognitive function in THA patients, through improved analgesia, reduced opioid consumption, attenuation of systemic inflammation, early mobilization and shorter hospital stay.</p>","PeriodicalId":72805,"journal":{"name":"Die Anaesthesiologie","volume":" ","pages":"242-251"},"PeriodicalIF":1.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146260088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}