{"title":"Hyperammonemia Syndrome Due to Ureaplasma and Mycoplasma Infections in Solid Organ Transplant Recipients: Treatment and Prophylaxis Strategies","authors":"Ashley H. Barnes, K. Saharia, Katya Prakash","doi":"10.1007/s40506-023-00265-8","DOIUrl":"https://doi.org/10.1007/s40506-023-00265-8","url":null,"abstract":"","PeriodicalId":72759,"journal":{"name":"Current treatment options in infectious diseases","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44721903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Looking at Sepsis in Patients with Terminal Illnesses","authors":"P. Daniels, Meera Pahuja","doi":"10.1007/s40506-023-00264-9","DOIUrl":"https://doi.org/10.1007/s40506-023-00264-9","url":null,"abstract":"","PeriodicalId":72759,"journal":{"name":"Current treatment options in infectious diseases","volume":"15 1","pages":"53 - 60"},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48089336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Theodora Germanopoulou, Angela Ishak, E. Hardy, Jennie E. Johnson, E. Mylonakis
{"title":"Listeriosis in Pregnancy","authors":"Theodora Germanopoulou, Angela Ishak, E. Hardy, Jennie E. Johnson, E. Mylonakis","doi":"10.1007/s40506-023-00262-x","DOIUrl":"https://doi.org/10.1007/s40506-023-00262-x","url":null,"abstract":"","PeriodicalId":72759,"journal":{"name":"Current treatment options in infectious diseases","volume":"15 1","pages":"14-25"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42801215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Challenges in the Hospital Water System and Innovations to Prevent Healthcare-Associated Infections","authors":"Erin B Gettler, Becky A. Smith, Sarah S. Lewis","doi":"10.1007/s40506-023-00261-y","DOIUrl":"https://doi.org/10.1007/s40506-023-00261-y","url":null,"abstract":"","PeriodicalId":72759,"journal":{"name":"Current treatment options in infectious diseases","volume":"15 1","pages":"1 - 13"},"PeriodicalIF":0.0,"publicationDate":"2023-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49127280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Monica Palanichamy Kala, Ashley L St John, Abhay P S Rathore
{"title":"Dengue: Update on Clinically Relevant Therapeutic Strategies and Vaccines.","authors":"Monica Palanichamy Kala, Ashley L St John, Abhay P S Rathore","doi":"10.1007/s40506-023-00263-w","DOIUrl":"https://doi.org/10.1007/s40506-023-00263-w","url":null,"abstract":"<p><p>Dengue viruses (DENV) continue to circulate worldwide, resulting in a significant burden on human health. There are four antigenically distinct serotypes of DENV, an infection of which could result in a potentially life-threatening disease. Current treatment options are limited and rely on supportive care. Although one dengue vaccine is approved for dengue-immune individuals and has modest efficacy, there is still a need for therapeutics and vaccines that can reduce dengue morbidities and lower the infection burden. There have been recent advances in the development of promising drugs for the treatment of dengue. These include direct antivirals that can reduce virus replication as well as host-targeted drugs for reducing inflammation and/or vascular pathologies. There are also new vaccine candidates that are being evaluated for their safety and efficacy in preventing dengue disease. This review highlights nuances in the current standard-of-care treatment of dengue. We also discuss emerging treatment options, therapeutic drugs, and vaccines that are currently being pursued at various stages of preclinical and clinical development.</p>","PeriodicalId":72759,"journal":{"name":"Current treatment options in infectious diseases","volume":"15 2","pages":"27-52"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10111087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9386604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashley H. Barnes, Christopher K Smith, Aditee Dash, Akira A. Shishido
{"title":"Mpox: Special Considerations in the Immunocompromised Host","authors":"Ashley H. Barnes, Christopher K Smith, Aditee Dash, Akira A. Shishido","doi":"10.1007/s40506-022-00260-5","DOIUrl":"https://doi.org/10.1007/s40506-022-00260-5","url":null,"abstract":"","PeriodicalId":72759,"journal":{"name":"Current treatment options in infectious diseases","volume":"1 1","pages":"1-24"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45331959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Case Report and Review of Management of HIV/HCV Coinfection After Treatment Failure","authors":"P. Mathur, S. Kottilil, E. Wilson","doi":"10.1007/s40506-022-00259-y","DOIUrl":"https://doi.org/10.1007/s40506-022-00259-y","url":null,"abstract":"","PeriodicalId":72759,"journal":{"name":"Current treatment options in infectious diseases","volume":"14 1","pages":"35 - 42"},"PeriodicalIF":0.0,"publicationDate":"2022-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49198660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
James Hunter Fly, Seerat Kapoor, Kelly Bobo, Jeremy S Stultz
{"title":"Updates in the Pharmacologic Prophylaxis and Treatment of Invasive Candidiasis in the Pediatric and Neonatal Intensive Care Units: Updates in the Pharmacologic Prophylaxis.","authors":"James Hunter Fly, Seerat Kapoor, Kelly Bobo, Jeremy S Stultz","doi":"10.1007/s40506-022-00258-z","DOIUrl":"https://doi.org/10.1007/s40506-022-00258-z","url":null,"abstract":"<p><strong>Purpose of review: </strong>The goal of this review was to provide an update on the prevention and treatment options for invasive candidiasis (IC) in the neonatal intensive care unit (NICU) and pediatric intensive care unit (PICU).</p><p><strong>Recent findings: </strong>Studies have further validated the use of fluconazole for IC prophylaxis among high-risk patients in the NICU. It remains unclear if prophylaxis leads to resistance development and the ideal dosage regimen is still not clear. Recent studies have been published comparing caspofungin and micafungin to amphotericin B and illustrated similar efficacy outcomes in the NICU. Micafungin now has approval from the United States Food and Drug Administration (FDA) for use in infants < 4 months of age. Prophylactic strategies in the PICU could include zinc and vitamin D. Anidulafungin has recent non-comparative data supporting use in pediatric patients older than 1 month of age and also has a recent FDA approval for use in children 1 month of age and older.</p><p><strong>Summary: </strong>Fluconazole prophylaxis remains a reasonable strategy in select NICU patients, although further analyses of resistance and the optimal dosage regimen are needed. Echinocandins are potential therapeutic options for non-meningitis or urinary tract infections in both the neonatal and pediatric population.</p>","PeriodicalId":72759,"journal":{"name":"Current treatment options in infectious diseases","volume":"14 2","pages":"15-34"},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9629810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40664036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Franklin Mikell, William M. Wooten, S. Manandhar, J. Emberger
{"title":"Global Travel and Antimicrobial Resistance: a Challenge for Stewardship","authors":"Franklin Mikell, William M. Wooten, S. Manandhar, J. Emberger","doi":"10.1007/s40506-021-00257-6","DOIUrl":"https://doi.org/10.1007/s40506-021-00257-6","url":null,"abstract":"","PeriodicalId":72759,"journal":{"name":"Current treatment options in infectious diseases","volume":"14 1","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2022-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42624332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}