Current tissue microenvironment reports最新文献_第4页

Modeling the Response of Heart Muscle to Mechanical Stimulation In Vitro 模拟心肌对体外机械刺激的反应

Current tissue microenvironment reports Pub Date : 2020-09-01 DOI: 10.1007/s43152-020-00007-8

Jingxuan Guo, Nathaniel Huebsch

引用次数: 0

Modulating microenvironments for treating glioblastoma. 调节微环境治疗胶质母细胞瘤。

Current tissue microenvironment reports Pub Date : 2020-09-01 Epub Date: 2020-08-13 DOI: 10.1007/s43152-020-00010-z

LaDeidra Monet Roberts, Jennifer Munson

{"title":"Modulating microenvironments for treating glioblastoma.","authors":"LaDeidra Monet Roberts, Jennifer Munson","doi":"10.1007/s43152-020-00010-z","DOIUrl":"https://doi.org/10.1007/s43152-020-00010-z","url":null,"abstract":"Purpose of review: This review focuses on the development and progression of glioblastoma through the brain and glioma microenvironment. Specifically we highlight how the tumor microenvironment contributes to the hallmarks of cancer in hopes of offering novel therapeutic options and tools to target this microenvironment.Recent findings: The hallmarks of cancer, which represent elements of cancers that contribute to the disease's malignancy, yet elements within the brain tumor microenvironment, such as other cellular types as well as biochemical and biophysical cues that can each uniquely affect tumor cells, have not been well-described in this context and serve as potential targets for modulation.Summary: Here, we highlight how the brain tumor microenvironment contributes to the progression and therapeutic response of tumor cells. Specifically, we examine these contributions through the lens of Hanahan & Weinberg's Hallmarks of Cancer in order to identify potential novel targets within the brain that may offer a means to treat brain cancers, including the deadliest brain cancer, glioblastoma.","PeriodicalId":72757,"journal":{"name":"Current tissue microenvironment reports","volume":" ","pages":"99-111"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s43152-020-00010-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38555361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Pericytes in Vascular Development. 维管发育中的周细胞。

Current tissue microenvironment reports Pub Date : 2020-09-01 Epub Date: 2020-07-02 DOI: 10.1007/s43152-020-00014-9

Laura Beth Payne, Maruf Hoque, Clifton Houk, Jordan Darden, John C Chappell

引用次数: 9

CRISPR/Cas9 in Male Factor Infertility CRISPR/Cas9在男性因素不育中的作用

Current tissue microenvironment reports Pub Date : 2020-09-01 DOI: 10.1007/s43152-020-00011-y

D. Cinà, Drew Phillips, R. Flannigan

引用次数: 1

Using tools in mechanobiology to repair tendons. 使用机械生物学工具修复肌腱。

Current tissue microenvironment reports Pub Date : 2020-06-01 Epub Date: 2021-03-31 DOI: 10.1007/s43152-020-00005-w

Connor C Leek, Jaclyn M Soulas, Anna Lia Sullivan, Megan L Killian

{"title":"Using tools in mechanobiology to repair tendons.","authors":"Connor C Leek, Jaclyn M Soulas, Anna Lia Sullivan, Megan L Killian","doi":"10.1007/s43152-020-00005-w","DOIUrl":"https://doi.org/10.1007/s43152-020-00005-w","url":null,"abstract":"Purpose of review: The purpose of this review is to describe the mechanobiological mechanisms of tendon repair as well as outline current and emerging tools in mechanobiology that might be useful for improving tendon healing and regeneration. Over 30 million musculoskeletal injuries are reported in the US per year and nearly 50% involve soft tissue injuries to tendons and ligaments. Yet current therapeutic strategies for treating tendon injuries are not always successful in regenerating and returning function of the healing tendon.Recent findings: The use of rehabilitative strategies to control the motion and transmission of mechanical loads to repairing tendons following surgical reattachment is beneficial for some, but not all, tendon repairs. Scaffolds that are designed to recapitulate properties of developing tissues show potential to guide the mechanical and biological healing of tendon following rupture. The incorporation of biomaterials to control alignment and reintegration, as well as promote scar-less healing, are also promising. Improving our understanding of damage thresholds for resident cells and how these cells respond to bioelectrical cues may offer promising steps forward in the field of tendon regeneration.Summary: The field of orthopaedics continues to advance and improve with the development of regenerative approaches for musculoskeletal injuries, especially for tendon, and deeper exploration in this area will lead to improved clinical outcomes.","PeriodicalId":72757,"journal":{"name":"Current tissue microenvironment reports","volume":"1 2","pages":"31-40"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s43152-020-00005-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25372926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Recent Advancements in Engineering Strategies for Manipulating Neural Stem Cell Behavior. 操纵神经干细胞行为的工程策略的最新进展。

Current tissue microenvironment reports Pub Date : 2020-06-01 Epub Date: 2020-04-03 DOI: 10.1007/s43152-020-00003-y

Brian J O'Grady, Ethan S Lippmann

{"title":"Recent Advancements in Engineering Strategies for Manipulating Neural Stem Cell Behavior.","authors":"Brian J O'Grady, Ethan S Lippmann","doi":"10.1007/s43152-020-00003-y","DOIUrl":"https://doi.org/10.1007/s43152-020-00003-y","url":null,"abstract":"Purpose of review: Stem cells are exquisitely sensitive to biophysical and biochemical cues within the native microenvironment. This review focuses on emerging strategies to manipulate neural cell behavior using these influences in three-dimensional (3D) culture systems.Recent findings: Traditional systems for neural cell differentiation typically produce heterogeneous populations with limited diversity rather than the complex, organized tissue structures observed in vivo. Advancements in developing engineering tools to direct neural cell fates can enable new applications in basic research, disease modeling, and regenerative medicine.Summary: This review article highlights engineering strategies that facilitate controlled presentation of biophysical and biochemical cues to guide differentiation and impart desired phenotypes on neural cell populations. Specific highlighted examples include engineered biomaterials and microfluidic platforms for spatiotemporal control over the presentation of morphogen gradients.","PeriodicalId":72757,"journal":{"name":"Current tissue microenvironment reports","volume":"1 2","pages":"41-47"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s43152-020-00003-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25502122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Innovative Nanotechnological Formulations to Reach the Hepatic Stellate Cell 触及肝星状细胞的创新纳米技术配方

Current tissue microenvironment reports Pub Date : 2020-06-01 DOI: 10.1007/s43152-020-00004-x

K. Poelstra

引用次数: 0

The Role of Spinal Cord CX3CL1/CX3CR1 Signalling in Chronic Pain 脊髓 CX3CL1/CX3CR1 信号在慢性疼痛中的作用

Current tissue microenvironment reports Pub Date : 2020-06-01 DOI: 10.1007/s43152-020-00006-9

Karli Montague-Cardoso, Petra Mrózková, M. Malcangio

引用次数: 0

Therapeutic Targeting of Hepatic Macrophages 肝巨噬细胞的治疗靶向性

Current tissue microenvironment reports Pub Date : 2020-04-24 DOI: 10.1007/s43152-020-00008-7

H. Nijland, R. Bansal

引用次数: 0

Strategies for Peripheral Nerve Repair. 周围神经修复策略

Current tissue microenvironment reports Pub Date : 2020-01-01 Epub Date: 2020-04-21 DOI: 10.1007/s43152-020-00002-z

Matthew Wilcox, Holly Gregory, Rebecca Powell, Tom J Quick, James B Phillips

{"title":"Strategies for Peripheral Nerve Repair.","authors":"Matthew Wilcox, Holly Gregory, Rebecca Powell, Tom J Quick, James B Phillips","doi":"10.1007/s43152-020-00002-z","DOIUrl":"10.1007/s43152-020-00002-z","url":null,"abstract":"Purpose of review: This review focuses on biomechanical and cellular considerations required for development of biomaterials and engineered tissues suitable for implantation following PNI, as well as translational requirements relating to outcome measurements for testing success in patients.Recent findings: Therapies that incorporate multiple aspects of the regenerative environment are likely to be key to improving therapies for nerve regeneration. This represents a complex challenge when considering the diversity of biological, chemical and mechanical factors involved. In addition, clinical outcome measures following peripheral nerve repair which are sensitive and responsive to changes in the tissue microenvironment following neural injury and regeneration are required.Summary: Effective new therapies for the treatment of PNI are likely to include engineered tissues and biomaterials able to evoke a tissue microenvironment that incorporates both biochemical and mechanical features supportive to regeneration. Translational development of these technologies towards clinical use in humans drives a concomitant need for improved clinical measures to quantify nerve regeneration.","PeriodicalId":72757,"journal":{"name":"Current tissue microenvironment reports","volume":"1 2","pages":"49-59"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7749870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38767416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0