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Current problems in clinical biochemistry最新文献

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Genetically abnormal fibrinogens--strategies for structure elucidation, including fibrinopeptide analysis. 基因异常纤维蛋白原——结构解析策略，包括纤维蛋白肽分析。
Current problems in clinical biochemistry Pub Date : 1984-01-01
A Henschen, M Kehl, C Southan
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引用次数: 0
Function of pulmonary alveolar macrophage fibronectin. 肺泡巨噬细胞纤维连接蛋白的功能。
Current problems in clinical biochemistry Pub Date : 1983-01-01
B Villiger
{"title":"Function of pulmonary alveolar macrophage fibronectin.","authors":"B Villiger","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72742,"journal":{"name":"Current problems in clinical biochemistry","volume":"13 ","pages":"190-201"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17421118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Contractile proteins of the lung. 肺的收缩蛋白。
Current problems in clinical biochemistry Pub Date : 1983-01-01
R B Low, J Woodcock-Mitchell, P M Absher, J N Evans, K B Adler
{"title":"Contractile proteins of the lung.","authors":"R B Low, J Woodcock-Mitchell, P M Absher, J N Evans, K B Adler","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72742,"journal":{"name":"Current problems in clinical biochemistry","volume":"13 ","pages":"149-56"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17708561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microbicidal mechanisms of macrophages. 巨噬细胞的杀微生物机制。
Current problems in clinical biochemistry Pub Date : 1983-01-01
J Mauël
{"title":"Microbicidal mechanisms of macrophages.","authors":"J Mauël","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72742,"journal":{"name":"Current problems in clinical biochemistry","volume":"13 ","pages":"180-9"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17708563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The genetics of Type 1 (insulin-dependent) diabetes. 1型(胰岛素依赖型)糖尿病的遗传学。
Current problems in clinical biochemistry Pub Date : 1983-01-01
A G Cudworth, E Wolf
{"title":"The genetics of Type 1 (insulin-dependent) diabetes.","authors":"A G Cudworth,&nbsp;E Wolf","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The major genetic susceptibility to Type 1 (insulin-dependent) diabetes is determined by genes within the HLA region located on the short arm of chromosome 6. Ninety-seven percent of Type 1 diabetic patients belonging to the Barts-Windsor family study possess either DR3 or DR4 and about 50% possess both these antigens. This excess of DR3, DR4 heterozygosity can be best explained by postulating two different susceptibility genes which react in an interactive way. No increase in DR3 or DR4 homozygosity is found, nor is there an increase in recombination frequency in these families. Linkage disequilibrium between certain B and DR antigens differs in \"diabetic\" compared to \"non-diabetic\" haplotypes. In families with two or more Type 1 diabetic children, the affected siblings are with rare exception either HLA identical or haplo-identical. The results from the prospective Barts-Windsor family study indicate that complement fixing islet cell antibodies are a good marker of on-going immune destruction in the pancreatic islets. There is also a high prevalence of antibodies reacting with certain cells in the pituitary gland in newly diagnosed cases and their unaffected first degree relatives. A possible explanation is that a common virus may be acting to produce damage in several endocrine tissues. The Barts-Windsor family study was initiated in 1978 by the late Andrew Cudworth as a prospective family study to investigate the genetic, immunological and environmental factors involved in Type 1 (insulin-dependent) diabetes. About 200 families with a Type 1 diabetic child and at least one other unaffected sibling under the age of 20 years were ascertained from a defined geographical area of approximately 1500 square km, centered around Windsor, East Berkshire, UK. These families are visited every 3 to 4 months and are regularly screened for autoantibodies, in particular islet cell antibodies, and for viral antibodies and they have all been HLA-A, B, C genotyped. A large proportion have also been genotyped for HLA-DR and for the complement factors Bf, C2 and C4, which are coded by genes within the HLA-region.</p>","PeriodicalId":72742,"journal":{"name":"Current problems in clinical biochemistry","volume":"12 ","pages":"45-64"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17478460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Viruses in the pathogenesis of type I diabetes. 病毒在I型糖尿病发病机制中的作用。
Current problems in clinical biochemistry Pub Date : 1983-01-01
J W Yoon
{"title":"Viruses in the pathogenesis of type I diabetes.","authors":"J W Yoon","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72742,"journal":{"name":"Current problems in clinical biochemistry","volume":"12 ","pages":"11-44"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17378427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of islet cell antibodies in the pathogenesis of type I diabetes. 胰岛细胞抗体在1型糖尿病发病机制中的作用。
Current problems in clinical biochemistry Pub Date : 1983-01-01
C H Brogren, S Baekkeskov, T Dyrberg, A Lernmark, B Marner, J Nerup, G K Papadopoulos
{"title":"Role of islet cell antibodies in the pathogenesis of type I diabetes.","authors":"C H Brogren,&nbsp;S Baekkeskov,&nbsp;T Dyrberg,&nbsp;A Lernmark,&nbsp;B Marner,&nbsp;J Nerup,&nbsp;G K Papadopoulos","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72742,"journal":{"name":"Current problems in clinical biochemistry","volume":"12 ","pages":"65-85"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17421116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alveolar type II epithelial cells in primary culture. 原代培养的肺泡II型上皮细胞。
Current problems in clinical biochemistry Pub Date : 1983-01-01
R J Mason, C C Leslie, D R Voelker
{"title":"Alveolar type II epithelial cells in primary culture.","authors":"R J Mason,&nbsp;C C Leslie,&nbsp;D R Voelker","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72742,"journal":{"name":"Current problems in clinical biochemistry","volume":"13 ","pages":"24-34"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17421119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular components of the alveolar unit. 肺泡单位的细胞成分。
Current problems in clinical biochemistry Pub Date : 1983-01-01
P H Burri
{"title":"Cellular components of the alveolar unit.","authors":"P H Burri","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72742,"journal":{"name":"Current problems in clinical biochemistry","volume":"13 ","pages":"11-22"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17709584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early intervention in insulin-dependent diabetes mellitus. 胰岛素依赖型糖尿病的早期干预。
Current problems in clinical biochemistry Pub Date : 1983-01-01
G F Cahill
{"title":"Early intervention in insulin-dependent diabetes mellitus.","authors":"G F Cahill","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":72742,"journal":{"name":"Current problems in clinical biochemistry","volume":"12 ","pages":"108-18"},"PeriodicalIF":0.0,"publicationDate":"1983-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17478459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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