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Acta Universitatis Carolinae. Medica. Monographia最新文献

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Bone metastases of thyroid cancer biological behaviour and therapeutic possibilities. 甲状腺癌骨转移的生物学行为和治疗可能性。
Acta Universitatis Carolinae. Medica. Monographia Pub Date : 1978-01-01
J Nĕmec, V Zamrazil, D Pohunková, Z Matĕjovský, J Soumar, V Zeman, S Röhling, F Holík, J Bednár
{"title":"Bone metastases of thyroid cancer biological behaviour and therapeutic possibilities.","authors":"J Nĕmec, V Zamrazil, D Pohunková, Z Matĕjovský, J Soumar, V Zeman, S Röhling, F Holík, J Bednár","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7272,"journal":{"name":"Acta Universitatis Carolinae. Medica. Monographia","volume":" 83","pages":"7-106"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11584515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular changes in infectious diseases. 传染病中的心血管变化。
Acta Universitatis Carolinae. Medica. Monographia Pub Date : 1978-01-01
J Tesarová-Mágrová
{"title":"Cardiovascular changes in infectious diseases.","authors":"J Tesarová-Mágrová","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7272,"journal":{"name":"Acta Universitatis Carolinae. Medica. Monographia","volume":" 84","pages":"1-132"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11594716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adaptation of the central nervous system to oxygen deficiency during ontogenesis. 个体形成过程中中枢神经系统对缺氧的适应。
Acta Universitatis Carolinae. Medica. Monographia Pub Date : 1978-01-01
S Trojan
{"title":"Adaptation of the central nervous system to oxygen deficiency during ontogenesis.","authors":"S Trojan","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7272,"journal":{"name":"Acta Universitatis Carolinae. Medica. Monographia","volume":" 85","pages":"5-180"},"PeriodicalIF":0.0,"publicationDate":"1978-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11753078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of a new synthetic substrate, Nalpha-tosyl-L-arginine-P-nitroanilide (TAPA), for determining trypsin activity in the duodenal contents. 利用一种新的合成底物，α - toyl - l-精氨酸-对硝基苯胺(TAPA)，测定十二指肠内容物中胰蛋白酶的活性。
Acta Universitatis Carolinae. Medica. Monographia Pub Date : 1977-01-01
F Malis, E Kasafírek, P Fric, M Josífko
{"title":"Use of a new synthetic substrate, Nalpha-tosyl-L-arginine-P-nitroanilide (TAPA), for determining trypsin activity in the duodenal contents.","authors":"F Malis,&nbsp;E Kasafírek,&nbsp;P Fric,&nbsp;M Josífko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The newly synthesized chromogenic substrate Nalpha-tosyl-L-arginine-p-nitroanilide (TAPA) was used to determine the trypsin activity (as the concentration and output in 20-min samples) of the duodenal contents before and after hormonal stimulation with cholecystokinin-pancreozymin (CPZ) and secretin (S). The results were compared with those obtained by means of Nalpha-benzoyl-D,L-arginine-p-nitroanilide (BAPA) and the Nalpha-tosyl-L-arginine methylester (TAME). The synthetic substrates were compared in 17 subjects with normal and in 8 subjects with pathological CPZ-S test values. A high degree of correlation was found in every case between the values obtained by means of the given substrates and it actually proved possible to determine the conversion coefficients for the trypsin concentration (BAPA = 1.306 TAPA, TAME = 0.509 TAPA) and for trypsin output (BAPA = 1.306 TAPA, TAME = 0.535 TAPA). The results demonstrate the usefulness of our new chromogenic substrate TAPA, which is more readily available and cheaper than BAPA and TAME for determining trypsin activity in biological material.</p>","PeriodicalId":7272,"journal":{"name":"Acta Universitatis Carolinae. Medica. Monographia","volume":" 79 Pt 3","pages":"131-8"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11817963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of the most frequent congenital amino acid enzymopathies by multiple screening. 多重筛选检测最常见的先天性氨基酸酶病。
Acta Universitatis Carolinae. Medica. Monographia Pub Date : 1977-01-01
J Homolka, J Hyánek
{"title":"Detection of the most frequent congenital amino acid enzymopathies by multiple screening.","authors":"J Homolka,&nbsp;J Hyánek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The lecture submits a survey of the most frequent primary congenital disorders of amino acid metabolism and discusses their diagnostic significance for clinical biochemistry, paediatrics and antenatal medicine. The results of multiple chromatographic screening of these diseases, which has been carried out systematically since 1961, are commented on. It was demonstrated that all congenital disorders of amino acid metabolism can be found in the Czechoslovak population, provided that they are systematically diagnosed. The incidence of individual diseases in series of healthy and mentally retarded children belonging to different age groups is shown in the relevant tables.</p>","PeriodicalId":7272,"journal":{"name":"Acta Universitatis Carolinae. Medica. Monographia","volume":" 79 Pt 3","pages":"5-13"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11817971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digestive enzymes of the mucosa of the small intestine and trypsin and chymotrypsin proteolytic activity of the intestinal contents of germ-free, monocontaminated and conventional rabbits. 无菌家兔、单污染家兔和普通家兔小肠黏膜消化酶及肠道内容物胰蛋白酶和凝乳胰蛋白酶蛋白水解活性的研究。
Acta Universitatis Carolinae. Medica. Monographia Pub Date : 1977-01-01
F Maliś, P Fric, R Stépánková, J Kruml
{"title":"Digestive enzymes of the mucosa of the small intestine and trypsin and chymotrypsin proteolytic activity of the intestinal contents of germ-free, monocontaminated and conventional rabbits.","authors":"F Maliś,&nbsp;P Fric,&nbsp;R Stépánková,&nbsp;J Kruml","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The activity of the membrane-bound enzymes of the microvillous zone of the entreocytes (maltase, sucrase, trehalase, lactase, cellobiase, alkaline phosphatase and leucylaminopeptidase) was studied in mucosal smears from the proximal jejunum, ileum, caecum and sigmoid flexure in a group of control (C) (8) and germ-free (GF) (7) rabbits. The trypsin and chymotrypsin activity of the contents of the ileum, caecum and sigmoid flexure was studied in 6 C, 5 GF and 5 monocontaminated (MC) rabbits. In summing up it can be stated that the individual membrane-bound enzymes have a different gradient in the various intestinal segments of C and GF rabbits and that they differ reciprocally in character. The maximum statistically significant differences between GF and C rabbits were found in the ileum; in the jejunum they were somewhat smaller and in the caecum smaller still (in this localization the difference was C versus GF). Striking differences in the proportion of the individual disaccharidases were found inthe jejunum and ileum of C rabbits compared with GF rabbits, in which, in both these segments of small intestine the relationship maltase greater than sucrase greater than trehalase greater than lactase was preserved. The proteolytic activity of the intestinal contents likewise had a different gradient character in C, MC and GF rabbits. The maximum activities (especially trypsin) were found in MC animals. The microbial flora is one of the factors regulating the enzymatic activities of the microvillous zone of the enterocytes and it also significantly influences the proteolytic activity of the intestinal contents. This influence is particularly marked in the distal part of the alimentary tube.</p>","PeriodicalId":7272,"journal":{"name":"Acta Universitatis Carolinae. Medica. Monographia","volume":" 77 Pt 1","pages":"119-23"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11564595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypertyrosinaemia. Hypertyrosinaemia.
Acta Universitatis Carolinae. Medica. Monographia Pub Date : 1977-01-01
J Hyánek, J Holub, M Stechovská, J Hoza, M Simková, P Karger, A Valík, V Kunová
{"title":"Hypertyrosinaemia.","authors":"J Hyánek,&nbsp;J Holub,&nbsp;M Stechovská,&nbsp;J Hoza,&nbsp;M Simková,&nbsp;P Karger,&nbsp;A Valík,&nbsp;V Kunová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Screening tests of tyrosine levels in the newborn population showed that an elevated blood tyrosine level is the second commonest, and diagnostically the most serious, problem of neonatal age. Almost 1% of all newborn infants have a raised tyrosine level. The classic form of tyrosinosis and secondary hypertyrosinaemia in particular must be differentiated from benign, transitory forms. Methods for a differential diagnosis after loading the organism with ascorbic acid, pyridoxine or folic acid have been described. L-tyrosine tolerance tests proved ineffective. The results of the dietary treatment of transitory and classic forms of hypertyrosinaemia, using phenylalanine- and tyrosine-free hydrolysates, are described. The incidence of these diseases at different ages is shown in a table. Study of psychomotric development shows that untreated children do not display a subnormal IQ until they are of pre-school or school age.</p>","PeriodicalId":7272,"journal":{"name":"Acta Universitatis Carolinae. Medica. Monographia","volume":" 79 Pt 3","pages":"31-8"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11817968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Source and significance of serum alkaline phosphatases in diseases of the locomotor system. 血清碱性磷酸酶在运动系统疾病中的来源及意义。
Acta Universitatis Carolinae. Medica. Monographia Pub Date : 1977-01-01
J Stĕpán, J Stĕpán, A Susta
{"title":"Source and significance of serum alkaline phosphatases in diseases of the locomotor system.","authors":"J Stĕpán,&nbsp;J Stĕpán,&nbsp;A Susta","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A group of 292 patients with diseases of the locomotor system was examined. Elevated activity of the liver isoenzyme of serum alkaline phosphatase was found in rheumatoid arthritis. Evaluation of the alkaline phosphatase isoenzyme in these states is especially important for studying nonspecific irritation of the liver tissue as a result of long-term therapy. Significantly elevated bone isoenzyme activity was found in Paget's disease, ankylosing spondylitis and osteoporomalacia, gout, the hyperuricaemic syndrome and some osteoarthroses. In these states, study of the alkaline phosphatase isoenzymes is of particular significance in evaluation of the development of metabolic bone changes. An association between elevated bone and intestinal isoenzyme activity was found. The diagnostic value of the determination of serum alkaline phosphatase is multiplied if the isoenzymes are also evaluated.</p>","PeriodicalId":7272,"journal":{"name":"Acta Universitatis Carolinae. Medica. Monographia","volume":" 78 Pt 2","pages":"81-7"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11818071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alkaline phosphatases in neoplastic diseases. 肿瘤疾病中的碱性磷酸酶。
Acta Universitatis Carolinae. Medica. Monographia Pub Date : 1977-01-01
J Stĕpán, F Macholda, B Konopásek, V Zizkovský, V Bek, V Kordac
{"title":"Alkaline phosphatases in neoplastic diseases.","authors":"J Stĕpán,&nbsp;F Macholda,&nbsp;B Konopásek,&nbsp;V Zizkovský,&nbsp;V Bek,&nbsp;V Kordac","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results of determination of the activity of the liver and bone serum alkaline phosphatase isoenzyme were in complete agreement with the clinical, laboratory and gamma-radiographic findings in all 62 examined patients with neoplastic liver metastases and with the same findings in 36 out of 38 patients with bone metastases. Determination of the bone isoenzyme concurred with the radionuclear findings in 27 out of 30 patients. Thermostable serum alkaline phosphatase variants were evaluated in 136 patients. They were found in 8 out of 40 patients with a lung carcinoma and in 8 out of 13 with a primary hepatocellular carcinoma. The findings were correlated with the presence of alpha-1 fetoprotein in the serum. A thermostable variant corresponding to the Nagao isoenzyme was evaluated biochemically in a patient with a stomach carcinoma.</p>","PeriodicalId":7272,"journal":{"name":"Acta Universitatis Carolinae. Medica. Monographia","volume":" 78 Pt 2","pages":"131-7"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11818175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipoprotein lipase and postheparin esterase activity in primary hyperlipoproteinaemia type IV and V. 原发性高脂蛋白血症IV型和V型的脂蛋白脂肪酶和肝素后酯酶活性。
Acta Universitatis Carolinae. Medica. Monographia Pub Date : 1977-01-01
L Kucerová, E Fabian, J Fabianová
{"title":"Lipoprotein lipase and postheparin esterase activity in primary hyperlipoproteinaemia type IV and V.","authors":"L Kucerová,&nbsp;E Fabian,&nbsp;J Fabianová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a study of the aetiopathogenesis of primary hyperlipoproteinaemias, which has not yet been elucidated, we paid attention to the heparin-activated lipolytic enzymes. Lipoprotein lipase (LPL) and postheparin esterase (PHE) activity was determined in 35 patients with primary hyperlipoproteinaemia (HLP) type IV (average age 50 years), 28 with type V (average age 48 years) and 2 with type III (57 and 62 years). Since PHE activity is correlated to sex and in women also to age, these factors had to be taken into account. The average activity values for the given enzymes in the patients group did not differ from the results in the control group. From these enzymes activities we tried to analyse the findings in individual cases in which the values were lower or higher than the control group range. The low PHE activity in some patients with type IV and V was evidently secondary and due to hepatobiliary disorder (most frequently liver steatosis). The simultaneous elevation of LPL and PHE activity in type IV and V patients with a high serum lipoprotein concentration shows that the response of patients with extreme HLP to heparin is more pronounced. The low PHE activity in type III (tested in only 2 patients) could possibly indicate the liver disorder on which this metabolic disease may be based.</p>","PeriodicalId":7272,"journal":{"name":"Acta Universitatis Carolinae. Medica. Monographia","volume":" 78 Pt 2","pages":"71-4"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11425317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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