Clinical research communications最新文献_第2页

Personalized medicine approach to osteoporosis management in women: integrating genetics, pharmacogenomics, and precision treatments 女性骨质疏松症管理的个性化医学方法:整合遗传学、药物基因组学和精确治疗

Clinical research communications Pub Date : 2023-01-01 DOI: 10.53388/crc2023018

Seyi Samson Enitan, Esther Ngozi Adejumo, John Osaigbovoh Imaralu, Ayodele Ademola Adelakun, Oluwakemi Anike Ladipo, Comfort Bosede Enitan

{"title":"Personalized medicine approach to osteoporosis management in women: integrating genetics, pharmacogenomics, and precision treatments","authors":"Seyi Samson Enitan, Esther Ngozi Adejumo, John Osaigbovoh Imaralu, Ayodele Ademola Adelakun, Oluwakemi Anike Ladipo, Comfort Bosede Enitan","doi":"10.53388/crc2023018","DOIUrl":"https://doi.org/10.53388/crc2023018","url":null,"abstract":"Osteoporosis has emerged as a significant health issue among postmenopausal women. Addressing this concern necessitates a multifaceted approach encompassing genetics, pharmacogenomics, bone turnover markers, lifestyle factors, concurrent medical conditions, biomarkers, and advanced imaging techniques. Nonetheless, challenges in terms of cost-effectiveness and ethical considerations do exist. Fortunately, the convergence of technological progress and research endeavors offers a promising trajectory. The integration of genetic testing and pharmacogenomics into clinical practice holds substantial potential. This integration empowers healthcare professionals to forecast treatment responses and pinpoint individuals with elevated susceptibility, thereby enabling the implementation of tailored and efficacious interventions that optimize outcomes – personalized medicine. Given the intricate nature of osteoporosis, personalized strategies stand to greatly benefit women grappling with this condition. Further research and collaborative efforts are imperative to propel advancements within this domain, paving the way for further breakthroughs.","PeriodicalId":72626,"journal":{"name":"Clinical research communications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70804340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

How to select gastric cancer patients suitable for immunotherapy? 如何选择适合免疫治疗的胃癌患者?

Clinical research communications Pub Date : 2023-01-01 DOI: 10.53388/crc2023021

Ling-Ling Yu, Guo-Jun Zhang, Bao Zhang, Hai-Yue Yu, Guo-Liang Zheng

引用次数: 0

Meta analysis on the effectiveness of auricular therapy combined with modern medicine in the treatment of depression/anxiety disorders in maintenance hemodialysis patients 耳穴疗法联合现代医学治疗维持性血液透析患者抑郁/焦虑障碍疗效的Meta分析

Clinical research communications Pub Date : 2023-01-01 DOI: 10.53388/crc2023009

Yang Liu, Luo Guo, N. Hao

引用次数: 0

Chromoblastomycosis: a tropical – subtropical fungal disease with pathognomonic features not to be neglected in a global health scenario 嗜铬菌病:热带-亚热带真菌疾病的病理特征，在全球健康的情况下不容忽视

Clinical research communications Pub Date : 2023-01-01 DOI: 10.53388/crc2023001

L. Defendi, G. Morgantetti, Guilherme Alencar de Medeiros, M. Balancin

引用次数: 0

Different strategies for ultra-early reperfusion therapy in anterior circulation acute ischemic stroke safety and effectiveness of the comparative observation 不同策略超早期再灌注治疗急性缺血性脑卒中前循环的安全性和有效性比较观察

Clinical research communications Pub Date : 2023-01-01 DOI: 10.53388/crc2023011

Wenhao Zhou, Lu-Xing Yang, Yanchao Huo, Meng Geng, Mengye Zhang, Chuan-Hui Li, N. Shang, Yao-ming Xu

引用次数: 0

Junctional epidermolysis bullosa in children: an overview 儿童大疱性结缔组织表皮松解症:综述

Clinical research communications Pub Date : 2023-01-01 DOI: 10.53388/crc2023002

S. Namboothiri

引用次数: 0

Application of integrated traditional Chinese and Western medicine in the treatment of juvenile localized scleroderma with skin ulcer: a case report 中西医结合治疗小儿局限性硬皮病并发皮肤溃疡1例

Clinical research communications Pub Date : 2023-01-01 DOI: 10.53388/crc2023016

Jia-Qian Zhang, Xiao-Han Wang, Wenjing Tu, Li-Ming Chen, Q. Kong, Yin-Huan Zhao

{"title":"Application of integrated traditional Chinese and Western medicine in the treatment of juvenile localized scleroderma with skin ulcer: a case report","authors":"Jia-Qian Zhang, Xiao-Han Wang, Wenjing Tu, Li-Ming Chen, Q. Kong, Yin-Huan Zhao","doi":"10.53388/crc2023016","DOIUrl":"https://doi.org/10.53388/crc2023016","url":null,"abstract":"Background: Juvenile Localized Scleroderma (JLS) is a rare pediatric rheumatic disease characterized by inflammation and skin sclerosis. The side effect of consensus-recommended medications and the risk of disability posed challenges to the JLS treatment. We intend to demonstrate the potential of traditional Chinese medicine in treating JLS with skin ulcers and reducing the dose of glucocorticoid. Method: Here we report a case of a 13-year-old male with JLS who took oral methotrexate tablets of 10 mg/week and methylprednisolone of 6 mg/day for over six months without significant effect and suffered from skin ulcers on the dorsal feet one month after drug cessation. Subsequently, the patient was treated with integrated traditional Chinese and Western medicine of low-dose glucocorticosteroid, adjusted Shenqi Huoxue formula and Jinshe Xiaoyan formula, etc. Results: After integrated treatment, the patient’s dorsal feet ulcers healed and the skin sclerosis and hyperpigmentation improved significantly. Conclusions: This case report suggests that integrated traditional Chinese and Western medicine can be used as an effective treatment for JLS.","PeriodicalId":72626,"journal":{"name":"Clinical research communications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70804664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Report of a case of neuromyelitis optica spectrum disease with symptomatic epilepsy 视神经脊髓炎伴症状性癫痫1例报告

Clinical research communications Pub Date : 2023-01-01 DOI: 10.53388/crc2023013

C. Fang, Xiu-Li Wang, W. Di, T. Liu, Lei Wen, Na Liu, Fuping Shi

引用次数: 0

Life-threatening delayed mediastinal and subcutaneous emphysema after general anesthesia in a rheumatoid arthritis patient: a case report 类风湿性关节炎患者全身麻醉后出现危及生命的迟发性纵隔及皮下肺气肿1例

Clinical research communications Pub Date : 2023-01-01 DOI: 10.53388/crc2023019

Ke-Qiang He, Jingyi Wu, Bin Hu, Ji Yuan, Chao-Liang Tang

{"title":"Life-threatening delayed mediastinal and subcutaneous emphysema after general anesthesia in a rheumatoid arthritis patient: a case report","authors":"Ke-Qiang He, Jingyi Wu, Bin Hu, Ji Yuan, Chao-Liang Tang","doi":"10.53388/crc2023019","DOIUrl":"https://doi.org/10.53388/crc2023019","url":null,"abstract":"Background: Delayed mediastinal emphysema with subcutaneous emphysema after extubation is rarely reported in current literature. Symptomatic treatment is considered effective for management. Case presentation: We report a case of a 56-year-old female with longstanding rheumatoid arthritis under corticosteroid therapy who developed mediastinal emphysema with subcutaneous emphysema 2 days after recovering from general anesthesia for orthopedic surgery treating a femoral neck fracture. The patient received aggressive subcutaneous decompression and symptomatic management. Results: The patient’s condition improved after treatment. Based on computed tomography scan results, we hypothesize that the longstanding rheumatoid arthritis may have resulted in fragile lung tissue. Violent postoperative coughing likely caused rupture of small airways, leading to mediastinal emphysema. Conclusions: It is crucial to preoperatively assess the risk of airway injury in high-risk patients with longstanding rheumatoid arthritis. Delayed postoperative mediastinal emphysema should be carefully evaluated and managed aggressively to avoid exacerbation or life-threatening scenarios. Further research is warranted to elucidate the pathology and guide perioperative management in these patients.","PeriodicalId":72626,"journal":{"name":"Clinical research communications","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70804385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An update on common inherited thrombophilic conditions 常见遗传性血栓病的最新进展

Clinical research communications Pub Date : 2023-01-01 DOI: 10.53388/crc2023022

Giuseppe Lippi

引用次数: 0