Ci ji yi xue za zhi = Tzu-chi medical journal最新文献

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Corrigendum: An evaluation study on gamified online learning experiences and its acceptance among medical students. 更正:关于游戏化在线学习体验及其在医学生中接受程度的评估研究。
Ci ji yi xue za zhi = Tzu-chi medical journal Pub Date : 2019-09-12 eCollection Date: 2020-04-01 DOI: 10.4103/1016-3190.266816
{"title":"Corrigendum: An evaluation study on gamified online learning experiences and its acceptance among medical students.","authors":"","doi":"10.4103/1016-3190.266816","DOIUrl":"10.4103/1016-3190.266816","url":null,"abstract":"<p><p>[This corrects the article on p. 211 in vol. 32.].</p>","PeriodicalId":72593,"journal":{"name":"Ci ji yi xue za zhi = Tzu-chi medical journal","volume":"32 2","pages":"222"},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/2f/TCMJ-32-222.PMC7137372.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37815894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fostering 2nd-year medical students' reflective capacity: A biopsychosocial model course. 培养二年级医学生的反思能力:生物心理社会模式课程。
Ci ji yi xue za zhi = Tzu-chi medical journal Pub Date : 2019-09-12 eCollection Date: 2020-07-01 DOI: 10.4103/tcmj.tcmj_65_19
Hsuan Hung, Ling-Ling Kueh, Jun-Neng Roan, Jing-Jane Tsai
{"title":"Fostering 2<sup>nd</sup>-year medical students' reflective capacity: A biopsychosocial model course.","authors":"Hsuan Hung, Ling-Ling Kueh, Jun-Neng Roan, Jing-Jane Tsai","doi":"10.4103/tcmj.tcmj_65_19","DOIUrl":"10.4103/tcmj.tcmj_65_19","url":null,"abstract":"<p><strong>Objective: </strong>The biopsychosocial (BPS) model has been proposed to take into account the interaction of psychological and social factors in medical practice. Although some studies have explored its application in medical education, little has been evaluated about students' reflection in such courses. This study introduced a BPS model course and aimed to assess changes in students' reflective capacity resulting from this course.</p><p><strong>Materials and methods: </strong>Eighty-seven written reflections before and after the course were segmented, coded, and rated using the Reflection Evaluation for Learners' Enhanced Competencies Tool rubric, which contains six factors of reflective capacity, namely description of disease experience, presence, attending to emotions, description of conflict or disorienting dilemma, meaning making, and action.</p><p><strong>Results: </strong>After the BPS model course, the overall reflective capacity, as well as the \"Presence\" and \"Meaning making\" scores, increased, while scores for \"Attending to emotion\" decreased significantly. \"Description of disease experience,\" \"Description of conflict or disorienting dilemma,\" and \"Action\" showed no significant change.</p><p><strong>Conclusion: </strong>Pedagogical suggestions are discussed for a BPS model course with reflective training for young medical students.</p>","PeriodicalId":72593,"journal":{"name":"Ci ji yi xue za zhi = Tzu-chi medical journal","volume":" ","pages":"291-297"},"PeriodicalIF":0.0,"publicationDate":"2019-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/a2/TCMJ-32-291.PMC7485666.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38404216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of the antiplatelet and analgesic effects of dextromethorphan and its metabolites. 右美沙芬及其代谢物抗血小板和镇痛作用的机理。
Ci ji yi xue za zhi = Tzu-chi medical journal Pub Date : 2019-09-05 eCollection Date: 2020-04-01 DOI: 10.4103/tcmj.tcmj_48_19
Wen-Lin Su, Yu-Ya Weng, Wen-Hsin Huang, Hao-Ai Shui, Tz-Chong Chou
{"title":"Mechanisms of the antiplatelet and analgesic effects of dextromethorphan and its metabolites.","authors":"Wen-Lin Su, Yu-Ya Weng, Wen-Hsin Huang, Hao-Ai Shui, Tz-Chong Chou","doi":"10.4103/tcmj.tcmj_48_19","DOIUrl":"10.4103/tcmj.tcmj_48_19","url":null,"abstract":"<p><strong>Objective: </strong>In the present study, we investigated the effects of dextromethorphan (DM) and its metabolites, including dextrorphan (LK2), 3-methoxymorphinan (LK3), and 3-hydroxymorphinan (LK4), on platelet aggregation <i>in vitro</i> and the inflammatory pain caused by carrageenan in rats, and their underlying mechanisms.</p><p><strong>Materials and methods: </strong>Rabbit platelets were pretreated with DM or its metabolites to assess their effects on platelet aggregation and related target mediators. In addition, the analgesic activity and the underlying mechanisms of DM and LK3 were investigated in a carrageenan-evoked thermal hyperalgesia rat model.</p><p><strong>Results: </strong>The inhibitory potency of DM and its metabolites on platelet aggregation induced by arachidonic acid or collagen was LK3> DM > LK4>> LK2 as demonstrated by the half-maximal inhibitory concentration values. Moreover, the mechanisms of the antiplatelet effect of DM and LK3 may involve the inhibition of intracellular calcium mobilization, expression of platelet surface glycoprotein IIb/IIIa, the formation of thromboxane B<sub>2</sub>, and elevation of platelet membrane fluidity. DM and LK3 also exhibited analgesic effects on carrageenan-evoked thermal hyperalgesia by suppressing the production of pro-inflammatory cytokines, nitric oxide, prostaglandin E<sub>2</sub>, and neutrophil infiltration in inflammatory sites.</p><p><strong>Conclusion: </strong>DM and its metabolites, especially LK3, exhibit both antiplatelet and analgesic effects, and may, therefore, potentially ameliorate platelet hyperactivity and inflammatory-related diseases.</p>","PeriodicalId":72593,"journal":{"name":"Ci ji yi xue za zhi = Tzu-chi medical journal","volume":"32 2","pages":"154-161"},"PeriodicalIF":0.0,"publicationDate":"2019-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fc/f5/TCMJ-32-154.PMC7137376.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37815969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of hospice care on health-care costs for Taiwanese patients with cancer during their last month of life in 2004-2011: A trend analysis. 2004-2011 年临终关怀对台湾癌症患者生命最后一个月医疗费用的影响:趋势分析
Ci ji yi xue za zhi = Tzu-chi medical journal Pub Date : 2019-08-21 eCollection Date: 2020-07-01 DOI: 10.4103/tcmj.tcmj_90_19
Jui-Kun Chiang, Yee-Hsin Kao
{"title":"Effect of hospice care on health-care costs for Taiwanese patients with cancer during their last month of life in 2004-2011: A trend analysis.","authors":"Jui-Kun Chiang, Yee-Hsin Kao","doi":"10.4103/tcmj.tcmj_90_19","DOIUrl":"10.4103/tcmj.tcmj_90_19","url":null,"abstract":"<p><strong>Objective: </strong>End-of-life cancer care imposes a heavy financial burden on patients, their families, and their health insurers. The aim of this study was to explore the 8-year (2004-2011) trends in health-care costs for Taiwanese cancer decedents in their last month of life and, specifically, to assess the association of these trends with hospice care.</p><p><strong>Materials and methods: </strong>We conducted a population-based longitudinal study and analyzed data from Taiwan's National Health Insurance Research Database. The data consisted of not only claims information - costs of hospitalization and outpatient department visits - but also the associated patient characteristics, catastrophic illness status, hospice patient designation, and insurance system exit date (the proxy for death).</p><p><strong>Results: </strong>A total of 11,104 cancer decedents were enrolled, and 2144 (19.3%) of these patients received hospice care. The rate of hospice service use increased from 14.9% to 21.5% over 8 years. From 2004 to 2011, the mean health-care cost per day in the last month of life increased 8.2% (from US$93 ± $108 in 2004 to US$101 ± $110 in 2011; <i>P</i> = 0001). We compared three groups of patients who received hospice care for more than 1 month (long-H group), received hospice care for 30 days or less (short-H group), and did not receive hospice care (non-H group). Compared to non-H group, long-H group had a significantly lower mean health-care cost per day during their last month of life (US$85.7 ± 57.3 vs. US$102.4 ± 120) (<i>P</i> < 0001). Furthermore, compared to short-H and non-H groups, patients in the long-H group had lower probabilities of receiving chemotherapy and visiting the emergency department more than once. They also incurred lower health-care costs (US$77.1 ± 58.1 vs. US$92.2 ± 56.0 for short-H group and US$102.4 ± 120 for non-H group) (<i>P</i> < 0001).</p><p><strong>Conclusion: </strong>Health-care costs in the last month of life are increasing over time in Taiwan. Nonetheless, health-care costs for patients receiving hospice can be as much as 16.3% lower than patients not receiving hospice care. Patients receiving hospice care for more than 30 days also had lower health-care costs than those receiving care for <30 days.</p>","PeriodicalId":72593,"journal":{"name":"Ci ji yi xue za zhi = Tzu-chi medical journal","volume":" ","pages":"278-285"},"PeriodicalIF":0.0,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9e/95/TCMJ-32-278.PMC7485665.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38499154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision medicine in the diagnosis and treatment of male lower urinary tract symptoms suggestive of benign prostatic hyperplasia. 精准医学在诊断和治疗提示良性前列腺增生的男性下尿路症状中的应用。
Ci ji yi xue za zhi = Tzu-chi medical journal Pub Date : 2019-08-21 eCollection Date: 2020-01-01 DOI: 10.4103/tcmj.tcmj_107_19
Jing-Liang Chen, Yuan-Hong Jiang, Cheng-Ling Lee, Hann-Chorng Kuo
{"title":"Precision medicine in the diagnosis and treatment of male lower urinary tract symptoms suggestive of benign prostatic hyperplasia.","authors":"Jing-Liang Chen, Yuan-Hong Jiang, Cheng-Ling Lee, Hann-Chorng Kuo","doi":"10.4103/tcmj.tcmj_107_19","DOIUrl":"10.4103/tcmj.tcmj_107_19","url":null,"abstract":"<p><p>Male lower urinary tract symptoms (LUTSs) are highly prevalent in men and the incidence increases with aging. The pathophysiology of male LUTSs might be bladder outlet dysfunctions such as bladder neck (BN) dysfunction, benign prostatic obstruction, and poor relaxation of external sphincter and bladder dysfunctions such as detrusor overactivity (DO), detrusor underactivity, DO, and inadequate contractility. Male LUTSs include voiding and storage symptoms, and precision diagnosis should not be done based on the symptoms alone. Videourodynamic study provides a thorough look at the bladder and bladder outlet and can clearly demonstrate the underlying pathophysiology when the initial medication fails to relieve LUTS. Medical treatment should be given based on the underlying pathophysiology of LUTS, and surgical intervention to remove prostate should only be performed when a definite bladder outlet obstruction due to prostatic obstruction has been confirmed by invasive urodynamic study.</p>","PeriodicalId":72593,"journal":{"name":"Ci ji yi xue za zhi = Tzu-chi medical journal","volume":"32 1","pages":"5-13"},"PeriodicalIF":0.0,"publicationDate":"2019-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5d/bb/TCMJ-32-5.PMC7015008.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37687574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visualizing the effects of antibiotics on the mouse colonic mucus layer. 抗生素对小鼠结肠粘液层影响的可视化。
Ci ji yi xue za zhi = Tzu-chi medical journal Pub Date : 2019-08-20 eCollection Date: 2020-04-01 DOI: 10.4103/tcmj.tcmj_70_19
Chun-Yao Chen, Kai-Chieh Hsu, Hsuan-Yu Yeh, Han-Chen Ho
{"title":"Visualizing the effects of antibiotics on the mouse colonic mucus layer.","authors":"Chun-Yao Chen, Kai-Chieh Hsu, Hsuan-Yu Yeh, Han-Chen Ho","doi":"10.4103/tcmj.tcmj_70_19","DOIUrl":"10.4103/tcmj.tcmj_70_19","url":null,"abstract":"<p><strong>Objective: </strong>Mucus provides a protective barrier separating sensitive epithelial surfaces from the outside world. The mouse colonic mucus is organized as a bacteria-free inner layer and a bacteria-colonized outer layer. Antibiotic treatments are known to disturb gut microbiota, but their effect on the mucosal barrier is rarely discussed. The aim was to evaluate and visualize the impact of antibiotics on the colonic mucus and the microbial community.</p><p><strong>Materials and methods: </strong>Two sets of experiments were conducted. In the antibiotic experiment, mice orally ingested both streptomycin and bacitracin for 7 days. In the recovery experiment, mice were allowed to recover for 7 days without antibiotics after having received the 7-day antibiotic treatment. Mouse colons were isolated and divided into proximal, middle, and distal parts. Specimens were examined under a transmission electron microscope to identify morphological changes. The gut microbial community was evaluated by analyzing 16S rDNA sequences isolated from the different parts of the mouse colon.</p><p><strong>Results: </strong>The antibiotic-treated mice were physiologically normal. However, a significantly increased inner mucus layer in the proximal and middle colon and a dramatic decrease in bacterial numbers in the outer mucus layers were observed. The 16S rDNA compositions showed a similarity in the dominant taxa among different colon sections. While control mice had a diverse microbiota, antibiotic treatments effectively eliminated most of the bacteria, such that the community was dominated by only one genus (<i>Turicibacter</i> or <i>Staphylococcus</i>). Furthermore, following antibiotic withdrawal in treated mice, the thickness of the inner mucus layer returned to control levels, and the microbial community regained a more complex structure, dominated by <i>Firmicutes</i>, <i>Bacteroidetes</i>, and <i>Proteobacteria</i>.</p><p><strong>Conclusions: </strong>Our results indicated that antibiotic treatments not only disturbed the microbiota but also altered the structure of the mucus layer. After the withdrawal of antibiotics, the mucus layer was quickly regenerated within days, probably in response to microbial growth. The recolonization by gut inhabitants with diverse ecological roles, such as mucin-degraders and fermenters indicate that the gut ecosystem is functionally sound and highly resilient.</p>","PeriodicalId":72593,"journal":{"name":"Ci ji yi xue za zhi = Tzu-chi medical journal","volume":"32 2","pages":"145-153"},"PeriodicalIF":0.0,"publicationDate":"2019-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/0a/TCMJ-32-145.PMC7137371.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37817994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The pattern of problematic internet use and mental health-related internet use among psychiatric outpatients at a tertiary care center. 一家三级医疗中心的精神科门诊患者使用问题网络和与精神健康有关的网络的模式。
Ci ji yi xue za zhi = Tzu-chi medical journal Pub Date : 2019-08-14 eCollection Date: 2020-04-01 DOI: 10.4103/tcmj.tcmj_50_19
Yatan Pal Singh Balhara, Swarndeep Singh, Rachna Bhargava
{"title":"The pattern of problematic internet use and mental health-related internet use among psychiatric outpatients at a tertiary care center.","authors":"Yatan Pal Singh Balhara, Swarndeep Singh, Rachna Bhargava","doi":"10.4103/tcmj.tcmj_50_19","DOIUrl":"10.4103/tcmj.tcmj_50_19","url":null,"abstract":"<p><strong>Objective: </strong>There is scarce literature available on the pattern of problematic internet use (PIU) and use of internet for mental health help-seeking among adult patients with psychiatric disorders in South-East Asian countries. The present study aimed to understand the pattern of PIU among adult patients attending the outpatient psychiatry services at a tertiary care center in India. Further, it aimed to explore the use of internet for seeking mental health-related information or services among them.</p><p><strong>Materials and methods: </strong>This cross-sectional study recruited adult outpatients attending the outpatient psychiatry services following purposive sampling between June 2018 and December 2018. A semi-structured questionnaire was used to collect information regarding sociodemographic characteristics and internet use pattern of participants, including use of internet for various mental health-related purposes. The Generalized Problematic Internet Use Scale 2 (GPIUS-2) was used to assess the PIU. Statistical analysis was performed using SPSS version 23.0 software.</p><p><strong>Results: </strong>Among 155 study participants, 45 (29.03%) scored above 60 on GPIUS-2. Those with PIU were significantly younger, reported higher duration of daily internet use, and spent greater proportion of time online on activities related to social networking or social media than those with and without PIU. More than half of the participants reported internet use for seeking mental health-related information at least once in the past 1 month. There was no significant difference in the mental health-related internet use among adult patients with different psychiatric diagnoses, except for two situations. There was lesser use of internet for seeking information related to the symptoms of illness and various treatment modalities available among participants diagnosed with psychotic disorder. On the other hand, a greater use of internet for seeking information related to the symptoms of illness was reported by participants diagnosed with anxiety disorder.</p><p><strong>Conclusion: </strong>This study suggested that PIU is a frequently cooccurring condition among adult patients with primary psychiatric disorder. The importance of internet as a medium for seeking mental health information and services was observed among most of the study participants.</p>","PeriodicalId":72593,"journal":{"name":"Ci ji yi xue za zhi = Tzu-chi medical journal","volume":"32 2","pages":"198-204"},"PeriodicalIF":0.0,"publicationDate":"2019-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/09/da/TCMJ-32-198.PMC7137367.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37815976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of hydrogen peroxide-inducible clone-5 in tumor progression. 过氧化氢诱导的克隆-5在肿瘤进展中的作用
Ci ji yi xue za zhi = Tzu-chi medical journal Pub Date : 2019-08-02 eCollection Date: 2020-01-01 DOI: 10.4103/tcmj.tcmj_120_19
Wen-Sheng Wu
{"title":"The role of hydrogen peroxide-inducible clone-5 in tumor progression.","authors":"Wen-Sheng Wu","doi":"10.4103/tcmj.tcmj_120_19","DOIUrl":"10.4103/tcmj.tcmj_120_19","url":null,"abstract":"<p><p>The poor prognosis of cancers such as hepatocellular carcinoma is due to high recurrence rate mainly caused by metastasis. Target therapy aiming at critical signal molecules within these pathways is one of the promising strategies for the prevention of metastasis. Hydrogen peroxide-inducible clone-5 (Hic-5), which belongs to the paxillin superfamily, is emerging as a potential target along the metastatic signaling pathway. Hic-5 and paxillin share similar structural features; however, there are a lot of different biochemical properties between them, including tissue-specific distribution, regulation of gene expression, critical signal cascade, and the impacts on cellular phenotypes. This review focus on the recent studies of Hic-5 related to its impacts on signal transduction and transcription responsible for tumor progression. Hic-5 may regulate mitogen-activated protein kinase cascade for cell migration and invasion in various systems. Hic-5 can mediate transforming growth factor-β1-induced epithelial-mesenchymal transition (EMT) via RhoA- and Src-dependent signaling. Moreover, Hic-5 plays a central role in a positive feedback Hic-5-NADPH oxidase-ROS-JNK signal cascade. This sustained signaling is required for regulating EMT-related genes including E-cadherin, Snail, MMP9, and Zeb-1. In addition, Hic-5 can be a transcription coregulatory factor for a lot of nuclear receptors. Owing to the critical role of Hic-5 in signal transduction and transcription responsible for tumor progression, it can be a potential therapeutic target for the prevention of tumor metastasis.</p>","PeriodicalId":72593,"journal":{"name":"Ci ji yi xue za zhi = Tzu-chi medical journal","volume":"32 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2019-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/0d/TCMJ-32-1.PMC7015009.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37688202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low serum adiponectin level is associated with central arterial stiffness in patients undergoing peritoneal dialysis. 腹膜透析患者血清脂肪连接蛋白水平低与中心动脉僵化有关。
Ci ji yi xue za zhi = Tzu-chi medical journal Pub Date : 2019-08-02 eCollection Date: 2020-07-01 DOI: 10.4103/tcmj.tcmj_67_19
Ti-Kang Chen, Yu-Chien Pan, Chih-Hsien Wang, Jia-Sian Hou, Bang-Gee Hsu
{"title":"Low serum adiponectin level is associated with central arterial stiffness in patients undergoing peritoneal dialysis.","authors":"Ti-Kang Chen, Yu-Chien Pan, Chih-Hsien Wang, Jia-Sian Hou, Bang-Gee Hsu","doi":"10.4103/tcmj.tcmj_67_19","DOIUrl":"10.4103/tcmj.tcmj_67_19","url":null,"abstract":"<p><strong>Objective: </strong>Adiponectin has antidiabetic, anti-atherosclerotic, and anti-inflammatory functions and protects against vascular damage. Carotid-femoral pulse wave velocity (cfPWV) is a noninvasive method for measuring central artery stiffness, which is known to be associated with cardiovascular disease in peritoneal dialysis (PD) patients. This study was conducted to evaluate the relationship between central arterial stiffness and serum adiponectin levels in PD patients.</p><p><strong>Materials and methods: </strong>Fasting blood samples were obtained from 60 PD patients, and the cfPWV value was measured using a validated tonometry system. In this study, cfPWV values of >10 m/s were used to define the high arterial stiffness group according to the European Society of Hypertension and the European Society of Cardiology guidelines.</p><p><strong>Results: </strong>Among 60 patients with PD, 19 patients (31.7%) were included in the high arterial stiffness group. When compared to those in the control group, the high arterial stiffness group patients were older (<i>P</i> = 0.029), had longer PD vintage (<i>P</i> = 0.001), higher diastolic blood pressures (<i>P</i> = 0.030), higher fasting glucose (<i>P</i> = 0.014), and lower serum adiponectin levels (<i>P</i> = 0.001). After multivariable logistic regression analysis, serum adiponectin (odds ratio, 0.612; 95% confidence interval: 0.426-0.879; <i>P</i> = 0.008) was identified as an independent predictor of arterial stiffness. The multivariable regression analysis also showed that the adiponectin level (β = -0.408; adjusted <i>R</i> <sup>2</sup> change = 0.183; <i>P</i> < 0.001) was negatively associated with cfPWV values in patients undergoing PD.</p><p><strong>Conclusion: </strong>Low serum adiponectin level is an independent marker of arterial stiffness in patients undergoing PD.</p>","PeriodicalId":72593,"journal":{"name":"Ci ji yi xue za zhi = Tzu-chi medical journal","volume":" ","pages":"272-277"},"PeriodicalIF":0.0,"publicationDate":"2019-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/9a/TCMJ-32-272.PMC7485669.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38401829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uncertainty and health literacy in dementia care. 痴呆症护理中的不确定性和健康素养。
Ci ji yi xue za zhi = Tzu-chi medical journal Pub Date : 2019-08-02 eCollection Date: 2020-01-01 DOI: 10.4103/tcmj.tcmj_116_19
Raymond Y Lo
{"title":"Uncertainty and health literacy in dementia care.","authors":"Raymond Y Lo","doi":"10.4103/tcmj.tcmj_116_19","DOIUrl":"10.4103/tcmj.tcmj_116_19","url":null,"abstract":"<p><p>The number of dementia cases increases with age, and the prevalence of dementia at the age above 80 is approaching 20% in Taiwan. Dementia is not simply a neurological disorder, but also a long-term care issue in public health and a matter of social adaptation. Scientific discoveries about dementia diagnostics, therapeutics, and preventive strategy have become the focus of media attention, but always updated and overwhelmed, which appears to increase rather than decrease the uncertainty and complexity of health communication in dementia care. Health literacy is essential for patients to understand medical information, utilize medical resources, and make shared decisions; however, the capacity to handle health information is often compromised in older adults with cognitive decline. Both ends of the increased uncertainty in dementia science and the reduced capacity in older adults are major challenges in dementia care. Dementia literacy, defined as knowledge and beliefs regarding dementia that aid recognition, management, or prevention, plays a vital role in effective care risk assessment and communication. However, little is known about the current state of dementia literacy among older adults, people with dementia, and their caregivers, and how well the dementia care practice can be implemented at the individual level is questionable. Empowering caregivers with adequate dementia literacy and developing a risk communication model in practice will translate the power of knowledge to effective care strategies, thus ameliorating the caregiver burden and enhancing the life quality of people with dementia in the long run.</p>","PeriodicalId":72593,"journal":{"name":"Ci ji yi xue za zhi = Tzu-chi medical journal","volume":"32 1","pages":"14-18"},"PeriodicalIF":0.0,"publicationDate":"2019-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f9/58/TCMJ-32-14.PMC7015016.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37687575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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