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Cell & gene therapy insights最新文献

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Developing non-viral delivery & cell engineering technologies for ex vivo T cell immunotherapies 开发用于体外T细胞免疫治疗的非病毒递送和细胞工程技术
Cell & gene therapy insights Pub Date : 2023-07-19 DOI: 10.18609/cgti.2023.091
Julie Shi, N. Bhattacharjee
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引用次数: 0
Investing long-term in the cell & gene therapies of the future 对未来的细胞和基因疗法进行长期投资
Cell & gene therapy insights Pub Date : 2023-07-19 DOI: 10.18609/cgti.2023.047
Geeta Vemuri
{"title":"Investing long-term in the cell & gene therapies of the future","authors":"Geeta Vemuri","doi":"10.18609/cgti.2023.047","DOIUrl":"https://doi.org/10.18609/cgti.2023.047","url":null,"abstract":"","PeriodicalId":72538,"journal":{"name":"Cell & gene therapy insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47548032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Driving the expansion of mRNA into the therapeutic sphere 推动信使核糖核酸向治疗领域的扩展
Cell & gene therapy insights Pub Date : 2023-07-19 DOI: 10.18609/cgti.2023.098
Alejandro J. Becerra, Andreas Kuhn, Metin Kurtoglu
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引用次数: 0
An optimized & streamlined approach for upstream & downstream lentiviral production 优化和流线型的方法为上游和下游慢病毒生产
Cell & gene therapy insights Pub Date : 2023-07-19 DOI: 10.18609/cgti.2023.092
Gregory Piscitello, Paul Turiano
{"title":"An optimized & streamlined approach for upstream & downstream lentiviral production","authors":"Gregory Piscitello, Paul Turiano","doi":"10.18609/cgti.2023.092","DOIUrl":"https://doi.org/10.18609/cgti.2023.092","url":null,"abstract":"","PeriodicalId":72538,"journal":{"name":"Cell & gene therapy insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46047792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gene therapy CMC and analytics—Foreword 基因治疗CMC与分析——前言
Cell & gene therapy insights Pub Date : 2023-07-19 DOI: 10.18609/cgti.2023.113
Lauren Drouin
{"title":"Gene therapy CMC and analytics—Foreword","authors":"Lauren Drouin","doi":"10.18609/cgti.2023.113","DOIUrl":"https://doi.org/10.18609/cgti.2023.113","url":null,"abstract":"","PeriodicalId":72538,"journal":{"name":"Cell & gene therapy insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49656050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Facing potential chemistry, manufacturing, & control (CMC) development challenges with recombinant adeno-associated viral vectors: available regulatory guidance & recommendations 面对重组腺相关病毒载体潜在的化学、制造和控制(CMC)开发挑战:可用的监管指导和建议
Cell & gene therapy insights Pub Date : 2023-07-19 DOI: 10.18609/cgti.2023.101
Stuart Beattie
{"title":"Facing potential chemistry, manufacturing, & control (CMC) development challenges with recombinant adeno-associated viral vectors: available regulatory guidance & recommendations","authors":"Stuart Beattie","doi":"10.18609/cgti.2023.101","DOIUrl":"https://doi.org/10.18609/cgti.2023.101","url":null,"abstract":"","PeriodicalId":72538,"journal":{"name":"Cell & gene therapy insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43020396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can novel bioreactors improve the cost of goods of viral vectors? 新型生物反应器能提高病毒载体的商品成本吗？
Cell & gene therapy insights Pub Date : 2023-07-19 DOI: 10.18609/cgti.2023.087
C. Stamatis, A. Chatel, S. Farid
{"title":"Can novel bioreactors improve the cost of goods of viral vectors?","authors":"C. Stamatis, A. Chatel, S. Farid","doi":"10.18609/cgti.2023.087","DOIUrl":"https://doi.org/10.18609/cgti.2023.087","url":null,"abstract":"Lentiviral and adeno-associated viral vectors make up the vast majority of gene therapy candidates for in-vivo and in-vitro applications. While effective for treating a range of debilitating diseases, they are also currently very expensive to produce, which hampers patient accessibility. While other biologics have been studied and optimized for several decades, viral vectors still suffer from relatively low titers, difficulty in scaling up and poor downstream recovery. A review of available technologies focusing on upstream solutions highlights that despite the development of randomly packed bed bioreactors for adherent cells and the move to suspension cell cultures in stirred tank bioreactors, technology design flaws hamper efforts to cost-effectively bring new therapies to the market. In this paper, the scale-X™ and NevoLine™ technologies are shown to provide conditions that support two to ten-fold increase in cell specific productivity for AAV and LVV relative to alternative technologies, which results in drug substance cost of goods reduction between −18% and −61%. Furthermore, increased titers, smaller footprint and reduced complexity could improve the efficacy of facility utilization.","PeriodicalId":72538,"journal":{"name":"Cell & gene therapy insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41974403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging derisked AAV vector development & delivery approaches to enhance speed to market for rare disease gene therapies 利用无风险的AAV载体开发和递送方法，加快罕见病基因疗法的上市速度
Cell & gene therapy insights Pub Date : 2023-07-07 DOI: 10.18609/cgti.2023.063
A. Lemoine
{"title":"Leveraging derisked AAV vector development & delivery approaches to enhance speed to market for rare disease gene therapies","authors":"A. Lemoine","doi":"10.18609/cgti.2023.063","DOIUrl":"https://doi.org/10.18609/cgti.2023.063","url":null,"abstract":"","PeriodicalId":72538,"journal":{"name":"Cell & gene therapy insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47840484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating the gene & cell therapy regulatory landscape: when, why and how to deploy GMP gene editing materials 导航基因和细胞治疗监管景观:何时，为什么以及如何部署GMP基因编辑材料
Cell & gene therapy insights Pub Date : 2023-07-07 DOI: 10.18609/cgti.2023.076
Michael Lau
{"title":"Navigating the gene & cell therapy regulatory landscape: when, why and how to deploy GMP gene editing materials","authors":"Michael Lau","doi":"10.18609/cgti.2023.076","DOIUrl":"https://doi.org/10.18609/cgti.2023.076","url":null,"abstract":"","PeriodicalId":72538,"journal":{"name":"Cell & gene therapy insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43659328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell culture in immune cell therapies: do more with less 免疫细胞疗法中的细胞培养:事半功倍
Cell & gene therapy insights Pub Date : 2023-07-07 DOI: 10.18609/cgti.2023.070
Anastasiya Smith, Josh Ludwig, D. Hermanson
{"title":"Cell culture in immune cell therapies: do more with less","authors":"Anastasiya Smith, Josh Ludwig, D. Hermanson","doi":"10.18609/cgti.2023.070","DOIUrl":"https://doi.org/10.18609/cgti.2023.070","url":null,"abstract":"","PeriodicalId":72538,"journal":{"name":"Cell & gene therapy insights","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47825068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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