Cardiology discovery最新文献_第10页

Rationale and Design of a Randomized Controlled Trial on Intensive Management of Blood PRESSure and Cholesterol in Elderly Chinese with Hypertension and Atrial FibrillatION (IMPRESSION) 中国老年高血压合并心房颤动患者血压和胆固醇强化管理的随机对照试验的基本原理和设计

Cardiology discovery Pub Date : 2021-07-08 DOI: 10.1097/CD9.0000000000000026

Wei Zhang, Yi Chen, Qi-Fang Huang, Ji-Guang Wang

{"title":"Rationale and Design of a Randomized Controlled Trial on Intensive Management of Blood PRESSure and Cholesterol in Elderly Chinese with Hypertension and Atrial FibrillatION (IMPRESSION)","authors":"Wei Zhang, Yi Chen, Qi-Fang Huang, Ji-Guang Wang","doi":"10.1097/CD9.0000000000000026","DOIUrl":"https://doi.org/10.1097/CD9.0000000000000026","url":null,"abstract":"Abstract Hypertension significantly increases the risk of embolic stroke and systemic embolism in patients with atrial fibrillation, while statin therapy can improve long-term outcomes in hypertensive patients at high risk. However, it is still unclear whether patients with both hypertension and atrial fibrillation can benefit from intensive management of blood pressure and cholesterol. IMPRESSION is a 3-year prospective, randomized, open-label, blinded-endpoint investigation. A total of 1200 hypertensive patients with atrial fibrillation from about 40 clinical centers nationwide will be included upon confirming the presence of both hypertension and atrial fibrillation and will be randomly assigned to groups for intensive or standard management of blood pressure and cholesterol. Patients in all groups will have office and home blood pressure measured by the end of the first month and every 3 months thereafter. The effects of blood pressure and cholesterol management strategies in patients with hypertension and atrial fibrillation on fatal and non-fatal stroke, acute myocardial infarction, and cardiovascular death at 3 years will be assessed. The IMPRESSION study protocol has received approval from the Ethics Committee of Ruijin Hospital, Shanghai Jiaotong University School of Medicine. The procedures set out in this protocol are in accordance with the principles of the Declaration of Helsinki and Good Clinical Practice guidelines. The results will be published following the CONSORT statement in a peer-reviewed scientific journal (Trial registration number: NCT04111419).","PeriodicalId":72524,"journal":{"name":"Cardiology discovery","volume":"1 1","pages":"173 - 178"},"PeriodicalIF":0.0,"publicationDate":"2021-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41704145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Implementing the Guideline of the Primary Prevention of Cardiovascular Diseases in China to Daily Practice: Promoting the Transition from “Treatment-Centered” to “People's Health-Centered” 《中国心血管疾病一级预防指南》落实到日常实践:促进从“以治疗为中心”向“以人民健康为中心”的转变

Cardiology discovery Pub Date : 2021-05-21 DOI: 10.1097/cd9.0000000000000021

D. Hu

引用次数: 1

Surgical Treatment of Left Atrial Dissection and Severe Mitral Valve Obstruction 左心房夹层合并严重二尖瓣梗阻的外科治疗

Cardiology discovery Pub Date : 2021-04-12 DOI: 10.1097/cd9.0000000000000022

A. Chen, Guo-qiang Ma, Deyan Yang, Chenyu Wang, Yingxian Liu

引用次数: 0

Bivalirudin in Primary PCI: Can Its Glory Being Restored? 比伐鲁定在原发性PCI中的应用:它的辉煌还能恢复吗?

Cardiology discovery Pub Date : 2021-04-06 DOI: 10.1097/CD9.0000000000000016

Yang Li, Yi Li, G. Stone, Yaling Han

引用次数: 1

Insomnia and Coronary Artery Diseases: A Mendelian Randomisation Study 失眠和冠状动脉疾病:孟德尔随机研究

Cardiology discovery Pub Date : 2021-04-06 DOI: 10.1097/CD9.0000000000000019

Wen-Jia Zhang, Lingfeng Zha, Jiangtao Dong, Qianwen Chen, Jianfei Wu, T. Tang, N. Xia, Min Zhang, Jiao Jiao, Tian Xie, Chengqi Xu, X. Tu, Shaofang Nie

{"title":"Insomnia and Coronary Artery Diseases: A Mendelian Randomisation Study","authors":"Wen-Jia Zhang, Lingfeng Zha, Jiangtao Dong, Qianwen Chen, Jianfei Wu, T. Tang, N. Xia, Min Zhang, Jiao Jiao, Tian Xie, Chengqi Xu, X. Tu, Shaofang Nie","doi":"10.1097/CD9.0000000000000019","DOIUrl":"https://doi.org/10.1097/CD9.0000000000000019","url":null,"abstract":"Abstract Objective: Observational studies indicate that insomnia may increase the risk of developing and/or dying from cardiovascular diseases, especially coronary artery disease (CAD). Our purpose is to explore the underlying causal relationship between genetic variants susceptible to insomnia and the risk of CAD by Mendelian randomization analysis. Methods: The study was conducted using publicly available statistical data on genetic variants identified from a genome-wide association meta-analysis of insomnia (n = 113,006 individuals) and a genome-wide association meta-analysis of CAD (n = 184,305 individuals), which consisted of both cases and non-cases. The genetic association between variants and CAD was assessed by the variants’ association with insomnia, and estimations were integrated by an inverse-variance weighted meta-analysis. Results: Among the Mendelian randomized analytical sample, 8 variants were associated with insomnia complaints and CAD. And there was no pleiotropic association with the latent confounders. In addition, in the inverse-variance weighted meta-analysis (the estimations combined from the 8 variants), the odds ratio was 1.15 (95% CI: 1.05–1.25; P = 0.002) for CAD, and in the weighted method analysis, the odds ratio was 1.14 (95% CI: 1.03–1.27; P = 0.015) for CAD. Conclusions: All of the data indicated that some valuable variants might involve in the development of CAD by leading the insomnia. Therefore, insomnia might be a causal factor for CAD, and improving the quality of sleep might be a new way for populations with insomnia to prevent CAD.","PeriodicalId":72524,"journal":{"name":"Cardiology discovery","volume":"1 1","pages":"154 - 162"},"PeriodicalIF":0.0,"publicationDate":"2021-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48536535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Upregulation of Cartilage Oligomeric Matrix Protein and Bone Morphogenetic Protein-2 May Associate with Calcific Aortic Valve Disease 软骨寡聚基质蛋白和骨形态发生蛋白-2的上调可能与钙化性主动脉瓣病有关

Cardiology discovery Pub Date : 2021-04-06 DOI: 10.1097/CD9.0000000000000015

Yueyue Xu, Yide Cao, Yafeng Liu, Jingsong Wang, Ganyi Chen, ZhongHao Tao, Yiwei Yao, Y. Cai, Yunzhang Wu, Wen Chen

{"title":"Upregulation of Cartilage Oligomeric Matrix Protein and Bone Morphogenetic Protein-2 May Associate with Calcific Aortic Valve Disease","authors":"Yueyue Xu, Yide Cao, Yafeng Liu, Jingsong Wang, Ganyi Chen, ZhongHao Tao, Yiwei Yao, Y. Cai, Yunzhang Wu, Wen Chen","doi":"10.1097/CD9.0000000000000015","DOIUrl":"https://doi.org/10.1097/CD9.0000000000000015","url":null,"abstract":"Abstract Objective: Calcific aortic valve disease (CAVD) affects millions of elderly people, and there is currently no effective way to stop or slow down its progression. Therefore, exploring the pathogenesis of CAVD is very important for prevention and treatment. Cartilage oligomeric matrix protein (COMP) have important role in cell phenotype change. This study is aimed to confirm whether COMP participate in CAVD and try to find the possible mechanisms. Methods: Human aortic valve tissues from Nanjing First Hospital (CAVD group, n = 20; control group, n = 11) were harvested. The expression level of COMP was tested by western blot and immunohistochemistry. Dual immunofluorescence staining was used for locating COMP. Bone morphogenetic protein-2 (BMP2) signalling were tested by western blot. The animal model was also used to detect COMP level by immunohistochemistry. Results: The results showed that the expression level of COMP was significantly increased in the calcific valve samples when compared with that of the control valve (P < 0.05); COMP was expressed near the calcific nodules and co-localized with α-smooth muscle actin (α-SMA). The protein levels of BMP2 and p-Smads 1/5/9 were markedly more highly expressed in the CAVD group than the control group (P < 0.05). Furthermore, immunofluorescence detection showed that COMP and BMP2 were co-located in calcific valves. Conclusions: The above results suggested that upregulation of COMP and BMP2 may be associated with aortic valve calcification and that COMP may become a potential therapeutic target in human CAVD.","PeriodicalId":72524,"journal":{"name":"Cardiology discovery","volume":"1 1","pages":"105 - 111"},"PeriodicalIF":0.0,"publicationDate":"2021-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48280144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cardiology Discovery—A New English Official Journal of the Chinese Society of Cardiology 《心脏病学发现》中国心脏病学会英文新刊

Cardiology discovery Pub Date : 2021-03-01 DOI: 10.1097/cd9.0000000000000012

Yaling Han

引用次数: 0