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The Tumor Immune Microenvironment and Therapeutic Efficacy of Trastuzumab Deruxtecan in Gastric Cancer. 胃癌的肿瘤免疫微环境与曲妥珠单抗德舒康的疗效
IF 2
Cancer research communications Pub Date : 2025-01-01 DOI: 10.1158/2767-9764.CRC-24-0302
Shigehiro Koganemaru, Shohei Koyama, Fumitaka Suto, Makito Koga, Koichiro Inaki, Yusuke Kuwahara, Takeo Arita, Tsuyoshi Hirata, Hiroki Goto, Naoya Wada, Maki Kobayashi, Tomoko Shibutani, Tatsuya Okabayashi, Kenji Nakamaru, Akihito Kawazoe, Yousuke Togashi, Hiroyoshi Nishikawa, Kohei Shitara
{"title":"The Tumor Immune Microenvironment and Therapeutic Efficacy of Trastuzumab Deruxtecan in Gastric Cancer.","authors":"Shigehiro Koganemaru, Shohei Koyama, Fumitaka Suto, Makito Koga, Koichiro Inaki, Yusuke Kuwahara, Takeo Arita, Tsuyoshi Hirata, Hiroki Goto, Naoya Wada, Maki Kobayashi, Tomoko Shibutani, Tatsuya Okabayashi, Kenji Nakamaru, Akihito Kawazoe, Yousuke Togashi, Hiroyoshi Nishikawa, Kohei Shitara","doi":"10.1158/2767-9764.CRC-24-0302","DOIUrl":"10.1158/2767-9764.CRC-24-0302","url":null,"abstract":"<p><strong>Significance: </strong>This biomarker study explored HER2 expression levels and immune cell characteristics that may affect response to T-DXd using tumor tissue samples collected from clinical trial participants. The results suggest that HER2 expression levels and tumor characteristics before the initiation of T-DXd may correlate with the efficacy of the drug.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"84-93"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting PRMT1 Reduces Cancer Persistence and Tumor Relapse in EGFR- and KRAS-Mutant Lung Cancer. 靶向PRMT1可减少EGFR-和kras突变肺癌的肿瘤持久性和肿瘤复发。
IF 2
Cancer research communications Pub Date : 2025-01-01 DOI: 10.1158/2767-9764.CRC-24-0389
Xiaoxiao Sun, Karl Kumbier, Savitha Gayathri, Veronica Steri, Lani F Wu, Steven J Altschuler
{"title":"Targeting PRMT1 Reduces Cancer Persistence and Tumor Relapse in EGFR- and KRAS-Mutant Lung Cancer.","authors":"Xiaoxiao Sun, Karl Kumbier, Savitha Gayathri, Veronica Steri, Lani F Wu, Steven J Altschuler","doi":"10.1158/2767-9764.CRC-24-0389","DOIUrl":"10.1158/2767-9764.CRC-24-0389","url":null,"abstract":"<p><strong>Significance: </strong>Eliminating \"persisters\" before relapse is crucial for achieving durable treatment efficacy. This study provides a rationale for developing PRMT1-selective inhibitors to target cancer persisters and achieve more durable outcomes in oncogene-targeting therapies.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"119-127"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11747858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating Ovarian Cancer Risk-Reducing Salpingectomy Acceptance: A Survey. 评估卵巢癌降低风险的输卵管切除术接受度：一项调查。
IF 2
Cancer research communications Pub Date : 2025-01-01 DOI: 10.1158/2767-9764.CRC-24-0566
Alexandra Lukey, Ramlogan Sowamber, David Huntsman, Celeste Leigh Pearce, A Fuchsia Howard, Rafael Meza, Michael R Law, Minh Tung Phung, Gillian E Hanley
{"title":"Evaluating Ovarian Cancer Risk-Reducing Salpingectomy Acceptance: A Survey.","authors":"Alexandra Lukey, Ramlogan Sowamber, David Huntsman, Celeste Leigh Pearce, A Fuchsia Howard, Rafael Meza, Michael R Law, Minh Tung Phung, Gillian E Hanley","doi":"10.1158/2767-9764.CRC-24-0566","DOIUrl":"10.1158/2767-9764.CRC-24-0566","url":null,"abstract":"<p><strong>Significance: </strong>This study found that many participants were willing to consider RRS to prevent ovarian cancer. Further research on RRS should be undertaken to understand how this can be best used for ovarian cancer prevention.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"187-194"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11780486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential Synergistic Effect between Niraparib and Statins in Ovarian Cancer Clinical Trials. 卵巢癌临床试验中尼拉帕尼和他汀类药物的潜在协同效应。
IF 2
Cancer research communications Pub Date : 2025-01-01 DOI: 10.1158/2767-9764.CRC-24-0191
Hailei Zhang, Anna Rutkowska, Antonio González-Martín, Mansoor R Mirza, Bradley J Monk, Ignace Vergote, Bhavana Pothuri, Whitney A Spannuth Graybill, Carsten Goessel, Olena Barbash, Giovanna Bergamini, Bin Feng
{"title":"Potential Synergistic Effect between Niraparib and Statins in Ovarian Cancer Clinical Trials.","authors":"Hailei Zhang, Anna Rutkowska, Antonio González-Martín, Mansoor R Mirza, Bradley J Monk, Ignace Vergote, Bhavana Pothuri, Whitney A Spannuth Graybill, Carsten Goessel, Olena Barbash, Giovanna Bergamini, Bin Feng","doi":"10.1158/2767-9764.CRC-24-0191","DOIUrl":"10.1158/2767-9764.CRC-24-0191","url":null,"abstract":"<p><strong>Significance: </strong>The presented retrospective analysis suggests, to the best of our knowledge for the first time, a potential significant interaction between statins and niraparib in clinical settings. Nevertheless, further investigations are required to gain a better understanding of the potential clinical benefit.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"178-186"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Proteomics Reveals Vulnerabilities in Noninvasive Breast Ductal Carcinoma and Drives Personalized Treatment Strategies. 临床蛋白质组学揭示了非侵袭性乳腺导管癌的脆弱性，并推动了个性化的治疗策略。
IF 2
Cancer research communications Pub Date : 2025-01-01 DOI: 10.1158/2767-9764.CRC-24-0287
Georgia Mitsa, Livia Florianova, Josiane Lafleur, Adriana Aguilar-Mahecha, Rene P Zahedi, Sonia V Del Rincon, Mark Basik, Christoph H Borchers, Gerald Batist
{"title":"Clinical Proteomics Reveals Vulnerabilities in Noninvasive Breast Ductal Carcinoma and Drives Personalized Treatment Strategies.","authors":"Georgia Mitsa, Livia Florianova, Josiane Lafleur, Adriana Aguilar-Mahecha, Rene P Zahedi, Sonia V Del Rincon, Mark Basik, Christoph H Borchers, Gerald Batist","doi":"10.1158/2767-9764.CRC-24-0287","DOIUrl":"10.1158/2767-9764.CRC-24-0287","url":null,"abstract":"<p><strong>Significance: </strong>This study provides real-world evidence for DCIS, a disease for which currently no molecular tools or biomarkers exist, and gives an unbiased, comprehensive, and deep proteomic profile, identifying >380 actionable targets.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"138-149"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Missense Mutant p53 Transactivates Wnt/β-Catenin Signaling in Neighboring p53-Destabilized Cells through the COX-2/PGE2 Pathway. 错义突变体p53通过COX-2/PGE2途径激活邻近p53不稳定细胞中的Wnt/β-catenin信号。
IF 2
Cancer research communications Pub Date : 2025-01-01 DOI: 10.1158/2767-9764.CRC-24-0471
Mizuho Nakayama, Hiroshi Saito, Kazuhiro Murakami, Hiroko Oshima, Masanobu Oshima
{"title":"Missense Mutant p53 Transactivates Wnt/β-Catenin Signaling in Neighboring p53-Destabilized Cells through the COX-2/PGE2 Pathway.","authors":"Mizuho Nakayama, Hiroshi Saito, Kazuhiro Murakami, Hiroko Oshima, Masanobu Oshima","doi":"10.1158/2767-9764.CRC-24-0471","DOIUrl":"10.1158/2767-9764.CRC-24-0471","url":null,"abstract":"<p><strong>Significance: </strong>There is intratumor heterogeneity in the stabilization of missense mutant p53, and it has been thought that only cells with nuclear accumulation of mutant p53 have oncogenic function. However, using mouse intestinal tumor-derived organoids, we show that mutant p53-stabilized cells transactivate Wnt/β-catenin signaling in neighboring p53-destabilized cells through activating the COX-2/PGE2 pathway. These results suggest that both p53-stabilized cells and p53-destabilized cells contribute to malignant progression through interaction within the intratumor microenvironment.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"13-23"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autofluorescence Virtual Staining System for H&E Histology and Multiplex Immunofluorescence Applied to Immuno-Oncology Biomarkers in Lung Cancer. 自体荧光虚拟肺组织染色系统及多重免疫荧光在肺癌免疫肿瘤生物标志物研究中的应用。
IF 2
Cancer research communications Pub Date : 2025-01-01 DOI: 10.1158/2767-9764.CRC-24-0327
Jessica Loo, Marc Robbins, Carson McNeil, Tadayuki Yoshitake, Charles Santori, Chuanhe Jay Shan, Saurabh Vyawahare, Hardik Patel, Tzu Chien Wang, Robert Findlater, David F Steiner, Sudha Rao, Michael Gutierrez, Yang Wang, Adrian C Sanchez, Raymund Yin, Vanessa Velez, Julia S Sigman, Patricia Coutinho de Souza, Hareesh Chandrupatla, Liam Scott, Shamira S Weaver, Chung-Wein Lee, Ehud Rivlin, Roman Goldenberg, Suzana S Couto, Peter Cimermancic, Pok Fai Wong
{"title":"Autofluorescence Virtual Staining System for H&E Histology and Multiplex Immunofluorescence Applied to Immuno-Oncology Biomarkers in Lung Cancer.","authors":"Jessica Loo, Marc Robbins, Carson McNeil, Tadayuki Yoshitake, Charles Santori, Chuanhe Jay Shan, Saurabh Vyawahare, Hardik Patel, Tzu Chien Wang, Robert Findlater, David F Steiner, Sudha Rao, Michael Gutierrez, Yang Wang, Adrian C Sanchez, Raymund Yin, Vanessa Velez, Julia S Sigman, Patricia Coutinho de Souza, Hareesh Chandrupatla, Liam Scott, Shamira S Weaver, Chung-Wein Lee, Ehud Rivlin, Roman Goldenberg, Suzana S Couto, Peter Cimermancic, Pok Fai Wong","doi":"10.1158/2767-9764.CRC-24-0327","DOIUrl":"10.1158/2767-9764.CRC-24-0327","url":null,"abstract":"<p><strong>Significance: </strong>We extend the capabilities of virtual staining from AF to a different disease and stain modality. Our work includes newly developed virtual stains for H&E and a multiplex immunofluorescence panel (DAPI, PanCK, PD-L1, CD3, and CD8) for non-small cell lung cancer, which reproduce the key features of real stains.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"54-65"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-Cell RNA Sequencing before and after Light Chain Escape Reveals Intrapatient Multiple Myeloma Subpopulations with Divergent Osteolytic Gene Expression. 轻链逃逸前后的单细胞RNA测序揭示了患者内部具有不同溶骨基因表达的多发性骨髓瘤亚群。
IF 2
Cancer research communications Pub Date : 2025-01-01 DOI: 10.1158/2767-9764.CRC-24-0170
Denis Ohlstrom, Zachary J Walker, Abhishek Pandey, Lorraine N Davis, Krysta L Engel, Zenggang Pan, Peter A Forsberg, Tomer M Mark, Austin E Gillen, Daniel W Sherbenou
{"title":"Single-Cell RNA Sequencing before and after Light Chain Escape Reveals Intrapatient Multiple Myeloma Subpopulations with Divergent Osteolytic Gene Expression.","authors":"Denis Ohlstrom, Zachary J Walker, Abhishek Pandey, Lorraine N Davis, Krysta L Engel, Zenggang Pan, Peter A Forsberg, Tomer M Mark, Austin E Gillen, Daniel W Sherbenou","doi":"10.1158/2767-9764.CRC-24-0170","DOIUrl":"10.1158/2767-9764.CRC-24-0170","url":null,"abstract":"<p><strong>Significance: </strong>scRNA-seq was used to study a patient with high-risk multiple myeloma featuring LCE. LCE was rooted in a transcriptomic subpopulation that corresponded to a genetic subclone and established novel links between LCE and LAMP5 overexpression to osteolysis and prognosis, validated in RNA-seq databases.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"106-118"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11737298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Depletion of Adipose Stroma-Like Cancer-Associated Fibroblasts Potentiates Pancreatic Cancer Immunotherapy. 消耗脂肪基质样癌症相关成纤维细胞可增强胰腺癌免疫治疗。
IF 2
Cancer research communications Pub Date : 2025-01-01 DOI: 10.1158/2767-9764.CRC-24-0298
Joseph Rupert, Alexes Daquinag, Yongmei Yu, Yulin Dai, Zhongming Zhao, Mikhail G Kolonin
{"title":"Depletion of Adipose Stroma-Like Cancer-Associated Fibroblasts Potentiates Pancreatic Cancer Immunotherapy.","authors":"Joseph Rupert, Alexes Daquinag, Yongmei Yu, Yulin Dai, Zhongming Zhao, Mikhail G Kolonin","doi":"10.1158/2767-9764.CRC-24-0298","DOIUrl":"10.1158/2767-9764.CRC-24-0298","url":null,"abstract":"<p><strong>Significance: </strong>This study shows that populations of CAFs have distinct effects on pancreatic cancer progression and shows that depletion of CAFs expressing adipose markers potentiates tumor/metastasis suppression effects of immune checkpoint blockade.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"5-12"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11694247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors. 不确定潜能克隆造血（CHIP）及其与实体肿瘤患者治疗结果和不良事件的关联
IF 2
Cancer research communications Pub Date : 2025-01-01 DOI: 10.1158/2767-9764.CRC-24-0522
Tharani Krishnan, Joao Paulo Solar Vasconcelos, Emma Titmuss, Robert J Vanner, David F Schaeffer, Aly Karsan, Howard Lim, Cheryl Ho, Sharlene Gill, Stephen Yip, Stephen K Chia, Hagen F Kennecke, Derek J Jonker, Eric X Chen, Daniel J Renouf, Chris J O'Callaghan, Jonathan M Loree
{"title":"Clonal Hematopoiesis of Indeterminate Potential and its Association with Treatment Outcomes and Adverse Events in Patients with Solid Tumors.","authors":"Tharani Krishnan, Joao Paulo Solar Vasconcelos, Emma Titmuss, Robert J Vanner, David F Schaeffer, Aly Karsan, Howard Lim, Cheryl Ho, Sharlene Gill, Stephen Yip, Stephen K Chia, Hagen F Kennecke, Derek J Jonker, Eric X Chen, Daniel J Renouf, Chris J O'Callaghan, Jonathan M Loree","doi":"10.1158/2767-9764.CRC-24-0522","DOIUrl":"10.1158/2767-9764.CRC-24-0522","url":null,"abstract":"<p><strong>Significance: </strong>Liquid biopsy is increasingly being used in oncology for tumor molecular characterization. CHIP is a common incidental finding in cfDNA, and its prevalence increases with age. This study builds on growing evidence of common CHIP variants in patients with solid tumors. The results suggest a possible clinical impact of CHIP on treatment outcomes from immunotherapy or chemotherapy. This may have implications for treatment selection for patients with solid tumors.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"66-73"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11713863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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