Cancer diagnosis & prognosis最新文献_第6页

Short-term Outcomes of Robotic Left Colectomy Reconstructed by Intracorporeal Overlap Anastomosis for Left-sided Colon Cancer: A Single-center Report from Japan. 体腔内重叠吻合术重建机器人左结肠切除术治疗左侧结肠癌的短期疗效：日本单中心报告

Cancer diagnosis & prognosis Pub Date : 2024-11-03 eCollection Date: 2024-11-01 DOI: 10.21873/cdp.10390

Toshikatsu Nitta, Masatsugu Ishii, Masataka Taki, Ryutaro Kubo, Norihiro Hosokawa, Takashi Ishibashi

{"title":"Short-term Outcomes of Robotic Left Colectomy Reconstructed by Intracorporeal Overlap Anastomosis for Left-sided Colon Cancer: A Single-center Report from Japan.","authors":"Toshikatsu Nitta, Masatsugu Ishii, Masataka Taki, Ryutaro Kubo, Norihiro Hosokawa, Takashi Ishibashi","doi":"10.21873/cdp.10390","DOIUrl":"10.21873/cdp.10390","url":null,"abstract":"Background/aim: Surgery for colon cancer requires covering a wide area and performing both tumor resection and precise lymph node dissection. Robotic left-sided colectomy (RLC) has not been thoroughly established due to the rarity of descending colon cancer. Therefore, we investigated 19 patients who underwent RLC for left-sided colon cancer.Patients and methods: Between January 2023 and July 2024, a total of 19 consecutive patients underwent robotic radical left colectomy, which included mobilization of the splenic flexure. We compared the intra- and postoperative factors between left-sided colectomy with and without stent placement.Results: Total operative time (p=0.002), console time (p=0.001), and lymph node harvest time (p=0.001) were significantly different. The total operative time with stent placement was longer than that without stent placement (421.6 vs. 302.0, p<0.01). Console time with stent placement was longer than that without stent placement (315.0 vs. 202.0, p<0.01). More lymph nodes were harvested with stent placement than without (33.1 vs. 11.0, p<0.01).Conclusion: We did not experience any conversions to open surgery, and two Grade II complications were observed according to the Clavien-Dindo classification. Both total operative and console times were longer in cases with stent placement compared to those without. Nevertheless, we safely performed robotic left colectomy, regardless of whether the left-sided colon cancer was treated with stent placement, even in cases where the anastomosis overlapped naturally. Our postoperative outcomes showed no anastomosis-related complications. Therefore, RLC reconstruction using an intracorporeal overlap anastomosis is feasible for left-sided colon cancer, both in terms of intraoperative and postoperative outcomes.","PeriodicalId":72510,"journal":{"name":"Cancer diagnosis & prognosis","volume":"4 6","pages":"743-747"},"PeriodicalIF":0.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral Dermoid Ovarian Cysts in a Young Woman - A Case Report and Literature Review. 一名年轻女性的双侧皮样卵巢囊肿--病例报告和文献综述。

Cancer diagnosis & prognosis Pub Date : 2024-11-03 eCollection Date: 2024-11-01 DOI: 10.21873/cdp.10402

Sravya Pinnamaneni, Sunayana Sayani, Premsai Chilakuluri, Stergios Boussios

{"title":"Bilateral Dermoid Ovarian Cysts in a Young Woman - A Case Report and Literature Review.","authors":"Sravya Pinnamaneni, Sunayana Sayani, Premsai Chilakuluri, Stergios Boussios","doi":"10.21873/cdp.10402","DOIUrl":"10.21873/cdp.10402","url":null,"abstract":"Background/aim: Ovarian tumors are a common type of neoplasm in women, with mature cystic teratomas being the most frequent variant. These tumors occur bilaterally in approximately 10% of cases. However, bilateral and multiple occurrences are rarely reported.Case report: A 22-year-old nulliparous woman presented with amenorrhea and sudden, generalized, dull lower abdominal pain. Diagnostic imaging, including ultrasound and computed tomography (CT) scans, revealed large solid-cystic lesions in both ovaries, with internal hyperechoic foci consistent with fat and calcification, along with thin internal septations. A laparoscopic cystectomy was successfully performed, preserving ovarian function. Histopathological examination confirmed the presence of stratified keratinized squamous epithelium, sebaceous glands, hair follicles, mature adipose tissue, blood vessels, and lymphatic vessels within the resected cysts, with no evidence of malignancy.Conclusion: This unique case provides valuable insights into the understanding and management of bilateral dermoid cysts, highlighting the importance of preserving ovarian function in young women.","PeriodicalId":72510,"journal":{"name":"Cancer diagnosis & prognosis","volume":"4 6","pages":"819-824"},"PeriodicalIF":0.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Between Serum and Tissue SIRT1 Levels in Patients With Esophageal Squamous Cell Carcinoma. 食管鳞状细胞癌患者血清和组织 SIRT1 水平的相关性

Cancer diagnosis & prognosis Pub Date : 2024-11-03 eCollection Date: 2024-11-01 DOI: 10.21873/cdp.10393

Hiroki Morishita, Ryota Otsuka, Takeshi Toyozumi, Yasunori Matsumoto, Nobufumi Sekino, Koichiro Okada, Tadashi Shiraishi, Toshiki Kamata, Shinichiro Iida, Tenshi Makiyama, Yuri Nishioka, Masanari Yamada, Hisahiro Matsubara

{"title":"Correlation Between Serum and Tissue SIRT1 Levels in Patients With Esophageal Squamous Cell Carcinoma.","authors":"Hiroki Morishita, Ryota Otsuka, Takeshi Toyozumi, Yasunori Matsumoto, Nobufumi Sekino, Koichiro Okada, Tadashi Shiraishi, Toshiki Kamata, Shinichiro Iida, Tenshi Makiyama, Yuri Nishioka, Masanari Yamada, Hisahiro Matsubara","doi":"10.21873/cdp.10393","DOIUrl":"10.21873/cdp.10393","url":null,"abstract":"Background/aim: Identifying prognostic and molecular markers as therapeutic targets for esophageal squamous cell carcinoma (ESCC) could enhance the efficacy of multidisciplinary treatments. While tissue expression of sirtuin 1 (SIRT1) has been linked to tumor progression in ESCC, prognostic significance of serum SIRT1 levels and their correlation with tissue SIRT1 remains unexplored. This study aimed to investigate the correlation between serum and tissue SIRT1 levels in patients with ESCC.Patients and methods: A total of 38 patients diagnosed with ESCC who were untreated preoperatively were recruited for this study. SIRT1 expression in the surgical specimens was assessed through immunostaining, while serum SIRT1 levels were measured using an enzyme-linked immunosorbent assay. We analyzed the association between tissue and serum SIRT1 levels, clinicopathological features, and patient prognosis.Results: Positive SIRT1 expression in tissue was significantly associated with deeper tumor depth (p=0.020). It was also significantly associated with poorer overall survival (OS) and relapse-free survival (RFS) (p=0.041 and p=0.012, respectively). Elevated serum SIRT1 levels were significantly correlated with increased tumor depth and weight loss (p=0.012 and p=0.030). While higher serum SIRT1 levels tended to be associated with poorer OS (p=0.069), no significant correlation was found between SIRT1 expression in tissue and its concentration in serum.Conclusion: SIRT1 tissue expression may be a valuable prognostic marker in ESCC. However, the clinical significance of serum SIRT1 levels appears to differ from that of its tissue expression. Future research is required to clarify the role of serum SIRT1 in ESCC.","PeriodicalId":72510,"journal":{"name":"Cancer diagnosis & prognosis","volume":"4 6","pages":"762-768"},"PeriodicalIF":0.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Androgen Receptor Signaling Inhibitor Withdrawal Syndrome After Castration-resistant Prostate Cancer. 阉割耐药前列腺癌患者雄激素受体信号抑制剂戒断综合征

Cancer diagnosis & prognosis Pub Date : 2024-11-03 eCollection Date: 2024-11-01 DOI: 10.21873/cdp.10382

Masuda Hiroshi

{"title":"Androgen Receptor Signaling Inhibitor Withdrawal Syndrome After Castration-resistant Prostate Cancer.","authors":"Masuda Hiroshi","doi":"10.21873/cdp.10382","DOIUrl":"10.21873/cdp.10382","url":null,"abstract":"Androgen-deprivation therapy is an extremely effective treatment for progressive prostate cancer. Previously, the first-line treatment for progressive prostate cancer was combined androgen blockade (CAB). If the disease progressed to castration-resistant prostate cancer, the administration of androgen receptor signaling inhibitors (ARSIs) was recommended. When elevated serum prostate-specific antigen (PSA) levels are seen during CAB treatment, it is important to suspect antiandrogen withdrawal syndrome (AWS), discontinue CAB, and monitor the changes in the serum PSA levels. If a reduction in the patient's PSA levels is subsequently observed, antiandrogens should be discontinued and the patient should be followed, but if their PSA level rises they should be transitioned to ARSI treatment. Recently, there have been reports of withdrawal syndrome (WS) after ARSI treatment. With the increased use of ARSIs, such as abiraterone acetate, enzalutamide, apalutamide, and dalorutamide, it is necessary to consider ARSI WS when a patient's serum PSA level increases during ARSI treatment. Unnecessary treatment can be avoided if the confirmation of ARSI WS is prioritized. Conversely, if it is not confirmed there is a risk that second-line treatment will be delayed. This is a review of recent studies of ARSI WS. It also discusses future prospects in this field.","PeriodicalId":72510,"journal":{"name":"Cancer diagnosis & prognosis","volume":"4 6","pages":"684-688"},"PeriodicalIF":0.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C-reactive Protein-albumin-lymphocyte Index as a Novel Biomarker for Progression in Patients Undergoing Surgery for Renal Cancer. 将 C 反应蛋白-白蛋白-淋巴细胞指数作为肾癌手术患者病情进展的新型生物标记物

Cancer diagnosis & prognosis Pub Date : 2024-11-03 eCollection Date: 2024-11-01 DOI: 10.21873/cdp.10391

Hiroshi Hirata, Nakanori Fujii, Shintaro Oka, Kimihiko Nakamura, Kosuke Shimizu, Keita Kobayashi, Toshiya Hiroyoshi, Naohito Isoyama, Koji Shiraishi

{"title":"C-reactive Protein-albumin-lymphocyte Index as a Novel Biomarker for Progression in Patients Undergoing Surgery for Renal Cancer.","authors":"Hiroshi Hirata, Nakanori Fujii, Shintaro Oka, Kimihiko Nakamura, Kosuke Shimizu, Keita Kobayashi, Toshiya Hiroyoshi, Naohito Isoyama, Koji Shiraishi","doi":"10.21873/cdp.10391","DOIUrl":"10.21873/cdp.10391","url":null,"abstract":"Background/aim: Some patients with renal cell carcinoma (RCC) develop early or late recurrence after surgery. However, there is no clear consensus on which patients with postoperative RCC should be treated. This study aimed to establish a biomarker for selecting patients who are at a higher risk of relapse following renal cancer surgery.Patients and methods: A total of 378 patients who underwent nephrectomy or partial nephrectomy for a diagnosis of RCC at our hospital were included, with a focus on pT3 cases at high risk of recurrence. Factors associated with postoperative progression, including pathological and hematological parameters, were examined.Results: Sarcomatoid features, Fuhrman grade 4, and C-reactive protein-albumin-lymphocyte (CALLY) index were statistically significant predictive factors for progression-free survival after surgery (p<0.0011, p=0.0047, and p<0.0001, respectively). In the multivariate Cox proportional regression analysis, the CALLY index was the most statistically significant predictor of the risk of postoperative recurrence (p=0.0002).Conclusion: In addition to the existing risk factors for RCC recurrence, such as sarcomatoid features and Fuhrman grade, we propose that the CALLY index is a predictor of postoperative recurrence and that patients with a low CALLY index are good candidates for postoperative treatment. Our study may help select patients with pT3 disease with a high risk of recurrence who require postoperative treatment.","PeriodicalId":72510,"journal":{"name":"Cancer diagnosis & prognosis","volume":"4 6","pages":"748-753"},"PeriodicalIF":0.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Desmoplastic Fibroblastoma (Collagenous Fibroma) of the Knee: A Case Report and Literature Review. 膝关节脱屑性纤维母细胞瘤（胶原性纤维瘤）：病例报告和文献综述。

Cancer diagnosis & prognosis Pub Date : 2024-11-03 eCollection Date: 2024-11-01 DOI: 10.21873/cdp.10403

Yuki Shinohara, Yoshiro Chijiiwa, Jun Nishio

{"title":"Desmoplastic Fibroblastoma (Collagenous Fibroma) of the Knee: A Case Report and Literature Review.","authors":"Yuki Shinohara, Yoshiro Chijiiwa, Jun Nishio","doi":"10.21873/cdp.10403","DOIUrl":"10.21873/cdp.10403","url":null,"abstract":"Background/aim: Desmoplastic fibroblastoma, also known as collagenous fibroma, is a rare benign mesenchymal neoplasm that primarily arises in the subcutaneous tissue of upper extremities and limb girdles. The knee is an uncommon location for desmoplastic fibroblastoma. Recent studies have demonstrated the presence of immunoreactivity for FOS like 1 (FOSL1) and rearrangements of FOSL1.Case report: A 70-year-old woman presented with a 1-year history of a palpable mass in the medial aspect of the right knee. Physical examination revealed a 4-cm, elastic hard, mobile, nontender mass. Magnetic resonance imaging (MRI) showed a well-defined mass with prominent low signal intensity on all pulse sequences. Contrast-enhanced MRI demonstrated mild internal enhancement with rim enhancement. After an open biopsy, the lesion was successfully treated by complete excision. Histologically, the tumor was composed of bland spindle or stellate-shaped cells embedded in an abundant collagenous stroma. Immunohistochemically, the tumor cells showed diffuse nuclear positivity for FOSL1. These findings were consistent with a diagnosis of desmoplastic fibroblastoma. The patient was asymptomatic and there was no evidence of local recurrence eight months after surgery.Conclusion: Desmoplastic fibroblastoma is a distinctive benign soft-tissue tumor with FOSL1 immunoreactivity and should be clearly distinguished from more biologically aggressive mesenchymal neoplasms.","PeriodicalId":72510,"journal":{"name":"Cancer diagnosis & prognosis","volume":"4 6","pages":"825-827"},"PeriodicalIF":0.0,"publicationDate":"2024-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11534051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Preoperative MRI Evaluation of Glandular Tissue in Subcutaneous Mastectomy and its Influence on the Implant Volume. 皮下乳房切除术中腺体组织的术前 MRI 评估及其对植入物体积影响的比较

Cancer diagnosis & prognosis Pub Date : 2024-09-01 DOI: 10.21873/cdp.10369

Hanna Fritsch, Rebecca Tumeltshammer, Jens Hachenberg, Mathias Warm, Barbara Krug, Wolfram Malter, Christian Eichler

{"title":"Comparison of the Preoperative MRI Evaluation of Glandular Tissue in Subcutaneous Mastectomy and its Influence on the Implant Volume.","authors":"Hanna Fritsch, Rebecca Tumeltshammer, Jens Hachenberg, Mathias Warm, Barbara Krug, Wolfram Malter, Christian Eichler","doi":"10.21873/cdp.10369","DOIUrl":"10.21873/cdp.10369","url":null,"abstract":"Background/aim: This study examined the influence of preoperative MRI on the choice of implant volume in patients undergoing subcutaneous mastectomy with immediate breast reconstruction. It was postulated that preoperative MRI scans can adequately estimate glandular tissue, which in turn correlates with implant size.Patients and methods: Preoperative and postoperative MRI scans were used in oncological and prophylactical subcutaneous mastectomy scenarios in 67 cases at the Department of Gynaecology, Breast Cancer Center, University of Cologne, Germany. The preoperative MRI was used to estimate the resected tissue and the postoperative MRI was used to scan for residual glandular tissue. In addition, a correlation found by Malter et al. in 2021 was evaluated with the available data.Results: Preoperative MRIs result in an adequate estimation of resected tissue. This in turn correlates with implant volume. The correlation by Malter et al. also holds when estimating implant volume. The likelihood of residual gland was low if the preoperatively estimate volume was removed.Conclusion: Our results indicate that the use of preoperative and postoperative MRI scans for subcutaneous mastectomies is advantageous. We suggest a routine estimation of glandular tissue, especially for small breasts.","PeriodicalId":72510,"journal":{"name":"Cancer diagnosis & prognosis","volume":"4 5","pages":"599-604"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Perioperative Physical Activity on Skeletal Muscle Loss 6 Months After Esophageal Cancer Surgery. 食管癌术后 6 个月围手术期体育锻炼对骨骼肌损失的影响

Cancer diagnosis & prognosis Pub Date : 2024-09-01 DOI: 10.21873/cdp.10379

Junko Honke, Yoshihiro Hiramatsu, Keiko Mori, Sanshiro Kawata, Yoshifumi Morita, Hirotoshi Kikuchi, Hiroya Takeuchi

{"title":"Effect of Perioperative Physical Activity on Skeletal Muscle Loss 6 Months After Esophageal Cancer Surgery.","authors":"Junko Honke, Yoshihiro Hiramatsu, Keiko Mori, Sanshiro Kawata, Yoshifumi Morita, Hirotoshi Kikuchi, Hiroya Takeuchi","doi":"10.21873/cdp.10379","DOIUrl":"10.21873/cdp.10379","url":null,"abstract":"Background/aim: Sarcopenia contributes to a poor prognosis in patients with esophageal cancer; thus, any clinical support that prevents loss of skeletal muscle mass preoperatively and postoperatively should be actively investigated. This study aimed to evaluate physical activity during the perioperative period and its impact on postoperative skeletal muscle mass.Patients and methods: Sixty-two patients who underwent esophagostomy at the Hamamatsu University School of Medicine between 2019 and 2023 were evaluated. The physical activity (measured by the step count) of patients scheduled for esophagectomy was assessed preoperatively using a fitness tracker. The percentage change in skeletal muscle mass index (SMI) was calculated preoperatively and 6 months postoperatively. Factors associated with decreased SMI 6 months after esophagectomy were analyzed using multivariate analysis.Results: The median decrease in SMI was -6.2%. Multivariate analysis revealed that factors associated with the reduction of SMI were age >69 years [odds ratio (OR)=7.21, 95% confidence interval (CI)=1.36-38.19, p=0.020], preoperative step count <7,800 steps/day (OR=5.17, 95% CI=1.38-19.33, p=0.015), and postoperative step count <2,400 steps/day (OR=3.55, 95% CI=1.01-12.45, p=0.048).Conclusion: A low perioperative step count and older age were significant risk factors for skeletal muscle loss in patients with esophageal cancer undergoing surgery. For patients with a low number of steps in the perioperative period or for older patients, interventions to increase the number of steps may prevent skeletal muscle loss.","PeriodicalId":72510,"journal":{"name":"Cancer diagnosis & prognosis","volume":"4 5","pages":"667-674"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Microsurgery and Fluorescent-reporter Genes in Establishing Mouse Models for Real-Time Imaging of Metastatic Cancer-Cell Trafficking and Colony Formation: A Revolutionary and Disruptive Technology for Metastasis Research. 显微手术和荧光报告基因在建立转移癌细胞迁移和集落形成实时成像小鼠模型中的作用：转移研究的革命性和颠覆性技术。

Cancer diagnosis & prognosis Pub Date : 2024-09-01 DOI: 10.21873/cdp.10362

Sei Morinaga, Norio Yamamoto, Kensuke Yamauchi, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Hiroyuki Tsuchiya, Satoru Demura, Robert M Hoffman

{"title":"The Role of Microsurgery and Fluorescent-reporter Genes in Establishing Mouse Models for Real-Time Imaging of Metastatic Cancer-Cell Trafficking and Colony Formation: A Revolutionary and Disruptive Technology for Metastasis Research.","authors":"Sei Morinaga, Norio Yamamoto, Kensuke Yamauchi, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Hiroyuki Tsuchiya, Satoru Demura, Robert M Hoffman","doi":"10.21873/cdp.10362","DOIUrl":"10.21873/cdp.10362","url":null,"abstract":"The field of experimental microsurgery was pioneered by the great microsurgeon Sun Lee, who developed the foundation of transplant surgery in the clinic. Dr Lee also played a seminal role in introducing microsurgery to establish mouse models of cancer. In 1990, at the age of 70, Dr Lee demonstrated microsurgery techniques to the mouse-model team at AntiCancer Inc., leading to the development of the surgical orthotopic implant (SOI) technique and the first orthotopic mouse models of cancer that metastasized in a pattern similar to clinical cancer. At the beginning of the present century, one of us (NY) from Kanazawa University School of Medicine became a visiting scientist at AntiCancer to learn SOI and develop mouse models of cancer using cancer cells expressing fluorescent reporter genes, such as green fluorescent protein (GFP) and red fluorescent protein (RFP), in order to image metastatic cancer cells trafficking in real time. Since then, a total of eight young surgeons from Kanazawa University have been visiting researchers at AntiCancer, developing SOI mouse models of cancer to visualize cancer cells in vivo, tracking all stages of metastasis in real time. The present perspective review summarizes this seminal work, which has revolutionized the field of metastasis research.","PeriodicalId":72510,"journal":{"name":"Cancer diagnosis & prognosis","volume":"4 5","pages":"544-557"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disproportionality Analysis of Osimertinib-related Adverse Events in Elderly Patients Using the Japanese Pharmacovigilance Database. 利用日本药物警戒数据库对老年患者中奥希替尼相关不良事件进行比例分析

Cancer diagnosis & prognosis Pub Date : 2024-09-01 DOI: 10.21873/cdp.10374

Takashi Omoto, Junichi Asaka, Kenzo Kudo

{"title":"Disproportionality Analysis of Osimertinib-related Adverse Events in Elderly Patients Using the Japanese Pharmacovigilance Database.","authors":"Takashi Omoto, Junichi Asaka, Kenzo Kudo","doi":"10.21873/cdp.10374","DOIUrl":"10.21873/cdp.10374","url":null,"abstract":"Background/aim: Osimertinib is a well-tolerated first- or second-line treatment option for elderly patients with epidermal growth factor receptor mutation-positive advanced non-small cell lung cancer. However, the safety of osimertinib in elderly patients requires further investigation. Herein, we identified safety signals for various osimertinib-related adverse events (AEs) in elderly patients by disproportionality analysis using the Japanese Adverse Drug Event Report (JADER) database.Patients and methods: Data from the JADER database from April 2004 to March 2023 were obtained from the Pharmaceuticals and Medical Devices Agency website. Safety signal detection for osimertinib-related AEs in elderly patients (≥70 years old) was determined using the relative elderly reporting odds ratio (ROR). For osimertinib-related AEs, we extracted 92 preferred terms (PTs) and nine standardized MedDRA queries (SMQs).Results: Safety signals in elderly patients were detected for \"Cardiomyopathy (PT)\" and \"Cardiomyopathy (SMQ)\". The symptoms most frequently associated with \"Cardiomyopathy (SMQ)\" included \"Ejection fraction decreased (PT)\", \"Cardiomyopathy (PT)\", and \"Stress cardiomyopathy (PT)\". Notably, 53.7% of these outcomes were \"Recovery\" or \"Remission\". The median time to the onset of \"Cardiomyopathy (SMQ)\" in elderly patients was 85 days (range=2-537 days).Conclusion: We demonstrated that patients ≥70 years potentially have increased osimertinib-related cardiomyopathy compared with patients <70 years. In the future, it is necessary to conduct research focusing on cardiomyopathy in elderly patients.","PeriodicalId":72510,"journal":{"name":"Cancer diagnosis & prognosis","volume":"4 5","pages":"631-637"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0