BoneKEy reports最新文献_第8页

Cancer-targeted therapies and radiopharmaceuticals. 癌症靶向治疗和放射性药物。

BoneKEy reports Pub Date : 2015-06-03 eCollection Date: 2015-01-01 DOI: 10.1038/bonekey.2015.76

Tilman D Rachner, Franz Jakob, Lorenz C Hofbauer

引用次数: 2

Determinants of hypercalcemia and hypercalciuria in immobilized trauma patients. 固定创伤患者高钙血症和高钙尿的决定因素。

BoneKEy reports Pub Date : 2015-06-03 eCollection Date: 2015-01-01 DOI: 10.1038/bonekey.2015.78

Moruf B Yusuf, Akinyele L Akinyoola, Ayodele E Orimolade, Ademola A Idowu, Tajudeen A Badmus, Taofeek O Adeyemi

{"title":"Determinants of hypercalcemia and hypercalciuria in immobilized trauma patients.","authors":"Moruf B Yusuf, Akinyele L Akinyoola, Ayodele E Orimolade, Ademola A Idowu, Tajudeen A Badmus, Taofeek O Adeyemi","doi":"10.1038/bonekey.2015.78","DOIUrl":"https://doi.org/10.1038/bonekey.2015.78","url":null,"abstract":"Hypercalcemia and hypercalciuria secondary to immobilization can be occasionally severe, producing an array of symptoms. This study looked at possible determinants of hypercalcemia and hypercalciuria in immobilized trauma patients. This is a prospective observational study carried out over a period of 7 months. Fifty-five immobilized trauma patients were evaluated weekly for 4 weeks for symptoms of hypercalcemia, total serum calcium and 24-h urinary calcium. The number of limbs immobilized had a significant relationship with hypercalcemia at the end of week 1 (P<0.001) and week 4 (P=0.008) and with hypercalciuria at the end of week 1 only (P<0.001). The number of bones fractured also had a significant relationship with hypercalcemia at the end of week 1 (P=0.005) and week 4 (P=0.019), as well as with hypercalciuria at the end of week 1 (P<0.001) and week 2 (P=0.036). Weight loss was significantly associated with hypercalcemia at the end of week 4 (P=0.014) and with hypercalciuria at the end of week 3 (P<0.001) and week 4 (P<0.001), whereas polyuria and polydipsia had a significant association with hypercalciuria at the end of week 2 (P<0.001) and week 3 (P=0.030). The number of limbs immobilized and bones fractured showed an early significant relationship with the development of hypercalcemia and hypercalciuria. Weight loss showed late association with hypercalcemia and hypercalciuria, whereas polyuria and polydipsia showed early association with hypercalciuria. ","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":" ","pages":"709"},"PeriodicalIF":0.0,"publicationDate":"2015-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/bonekey.2015.78","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34251921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Erratum: Bone composition: relationship to bone fragility and antiosteoporotic drug effects. 勘误:骨成分:与骨脆性和抗骨质疏松药物作用的关系。

BoneKEy reports Pub Date : 2015-06-03 eCollection Date: 2015-01-01 DOI: 10.1038/bonekey.2015.79

Adele L Boskey

引用次数: 12

Alteration of Type I collagen microstructure induced by estrogen depletion can be prevented with drug treatment. 雌激素耗竭引起的I型胶原微结构改变可通过药物治疗加以预防。

BoneKEy reports Pub Date : 2015-05-27 eCollection Date: 2015-01-01 DOI: 10.1038/bonekey.2015.66

Meagan A Cauble, Edward Rothman, Kathleen Welch, Ming Fang, Le T Duong, Brenda L Pennypacker, Bradford G Orr, Mark M Banaszak Holl

{"title":"Alteration of Type I collagen microstructure induced by estrogen depletion can be prevented with drug treatment.","authors":"Meagan A Cauble, Edward Rothman, Kathleen Welch, Ming Fang, Le T Duong, Brenda L Pennypacker, Bradford G Orr, Mark M Banaszak Holl","doi":"10.1038/bonekey.2015.66","DOIUrl":"https://doi.org/10.1038/bonekey.2015.66","url":null,"abstract":"Two independent biological replicates of estrogen depletion were employed with differing drug treatment conditions. Data Set I consisted of 9-month-old New Zealand white female rabbits treated as follows: sham-operated (n=11), ovariectomized (OVX; n=12), OVX+200 μg kg(-1) alendronate (ALN), 3 × a week for 27 weeks (n=12) and OVX+10 mg kg(-1) Cathepsin-K inhibitor (CatKI) daily for 27 weeks. Data Set II consisted of 6-month-old New Zealand white female rabbits that were sham-operated (n=12), OVX (n=12) or OVX+0.05 mg kg(-1) 17β-estradiol (ERT) 3 × a week for 13 weeks (n=12). Samples from the cortical femur were polished and demineralized to make them suitable for atomic force microscopy (AFM) imaging. Type I collagen fibrils present in bundles or sheets, running parallel to each other, were combined into a class termed Parallel. Fibrils present outside of such structures, typically in images with an angular range of non-parallel fibrils, were combined into a class termed Oblique. The percentage of fibrils coded as Parallel for Sham animals in Data Sets I and II was 52% and 53%, respectively. The percentage of fibrils coded as Parallel for OVX animals in Data Sets I and II was 35% in both cases. ALN and ERT drug treatments reduced the change from 18 to 12%, whereas CatKI treatment reduced the change to 5%. ","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":" ","pages":"697"},"PeriodicalIF":0.0,"publicationDate":"2015-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/bonekey.2015.66","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34251918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Effects of estrogen depletion and drug treatment on collagen microstructure: implications. 雌激素耗竭和药物治疗对胶原结构的影响:意义。

BoneKEy reports Pub Date : 2015-05-27 eCollection Date: 2015-01-01 DOI: 10.1038/bonekey.2015.67

Joseph M Wallace, Henry G Bone

引用次数: 0

Bone marrow as a metastatic niche for disseminated tumor cells from solid tumors. 骨髓是实体瘤扩散肿瘤细胞的转移龛。

BoneKEy reports Pub Date : 2015-05-20 eCollection Date: 2015-01-01 DOI: 10.1038/bonekey.2015.57

Yusuke Shiozawa, Matthew R Eber, Janice E Berry, Russell S Taichman

引用次数: 0

Cancer-associated muscle weakness: What's bone got to do with it? 癌症相关的肌肉无力:与骨骼有什么关系?

BoneKEy reports Pub Date : 2015-05-20 eCollection Date: 2015-01-01 DOI: 10.1038/bonekey.2015.59

David L Waning, Theresa A Guise

引用次数: 31

Cancer Treatment-Induced Bone Loss in women with breast cancer. 乳腺癌妇女因癌症治疗引起的骨质流失。

BoneKEy reports Pub Date : 2015-05-20 eCollection Date: 2015-01-01 DOI: 10.1038/bonekey.2015.60

Peyman Hadji

{"title":"Cancer Treatment-Induced Bone Loss in women with breast cancer.","authors":"Peyman Hadji","doi":"10.1038/bonekey.2015.60","DOIUrl":"10.1038/bonekey.2015.60","url":null,"abstract":"Osteoporosis is one of the most frequent diseases in postmenopausal women, leading to an increased fracture risk due to the physiologic loss of the bone protective effects of estrogen. Hereby, several risk factors for fracture such as prevalent fracture, low bone mineral density (BMD), age, low body mass index, family history, tendency to falls, smoking, use of SSRIs, glucocorticoid use etc. have been identified. In addition, the further reduction in endogenous estrogens with chemotherapy (CHT), GnRH analoga or aromatase inhibitors (AIs) continuously increases fracture risk. Breast cancer (BC) on the other hand is the most frequent cancer type in women. Recent reports indicate a continuous increased incidence, whereas mortality, due to early diagnosis and treatment improvements, is decreasing. Dependent on specific tumor characteristics, radiation, CHT, antibody treatment as well as endocrine treatment have been included into the adjuvant clinical treatment setting. Some but not all of these cancer-specific treatments interfere with bone turnover, leading to an accelerated bone loss referred to as cancer treatment-induced bone loss (CTIBL). Whereas CHT leads to an unspecific increase in bone resorption, AI reduces residual serum endogenous estrogen level and is associated with a decrease in BMD and increased fracture risk. Independent of the type of AI administered, bone loss is 2-3-fold increased compared with healthy, age-matched postmenopausal controls. Therefore, several guidelines have emerged to help managing CTIBL in women with BC including strategies to identify and treat those at highest risk for fractures. This review summarizes the current knowledge on CTIBL and fracturing risk and indicates preventative strategies. ","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":" ","pages":"692"},"PeriodicalIF":0.0,"publicationDate":"2015-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4440228/pdf/bonekey201560.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33349700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A new WNT on the bone: WNT16, cortical bone thickness, porosity and fractures. 一种新的骨WNT: WNT16，皮质骨厚度，孔隙度和骨折。

BoneKEy reports Pub Date : 2015-05-13 eCollection Date: 2015-01-01 DOI: 10.1038/bonekey.2015.36

Francesca Gori, Ulf Lerner, Claes Ohlsson, Roland Baron

{"title":"A new WNT on the bone: WNT16, cortical bone thickness, porosity and fractures.","authors":"Francesca Gori, Ulf Lerner, Claes Ohlsson, Roland Baron","doi":"10.1038/bonekey.2015.36","DOIUrl":"https://doi.org/10.1038/bonekey.2015.36","url":null,"abstract":"The last decade has provided abundant data implicating the WNT pathway in bone development and in the regulation of skeletal homeostasis. Rare human mutations together with gain- and loss-of-function approaches in mice have clearly demonstrated that disrupted regulation of this pathway leads to altered bone mass. In addition to these rare human and mice mutations, large population-based genome-wide association studies (GWASs) have identified single-nucleotide polymorphisms in ∼60 loci strongly associated with variations in bone mineral density (BMD) at different skeletal sites. Among the loci/genes identified by BMD GWAS, components of the WNT signaling pathway are numerous and have been shown to contribute to skeletal development and homeostasis. Within the components of WNT signaling, the gene coding for WNT16, one of the 19 WNT ligands of the human genome, has been found strongly associated with specific bone traits such as cortical bone thickness, cortical porosity and fracture risk. Recently, the first functional characterization of Wnt16 has confirmed the critical role of Wnt16 in the regulation of cortical bone mass and bone strength in mice. These reports have extended our understanding of Wnt16 function in bone homeostasis and have not only confirmed the unique association of Wnt16 with cortical bone and fracture susceptibility, as suggested by GWAS in human populations, but have also provided novel insights into the biology of this WNT ligand and the mechanism(s) by which it regulates cortical but not trabecular bone homeostasis. Most interestingly, Wnt16 appears to be a strong anti-resorptive soluble factor acting on both osteoblasts and osteoclast precursors. ","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":" ","pages":"669"},"PeriodicalIF":0.0,"publicationDate":"2015-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/bonekey.2015.36","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33190392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 64

Tumour-derived miRNAs and bone metastasis. 肿瘤来源的mirna与骨转移。

BoneKEy reports Pub Date : 2015-05-13 eCollection Date: 2015-01-01 DOI: 10.1038/bonekey.2015.56

Martine Croset, Casina Kan, Philippe Clézardin

{"title":"Tumour-derived miRNAs and bone metastasis.","authors":"Martine Croset, Casina Kan, Philippe Clézardin","doi":"10.1038/bonekey.2015.56","DOIUrl":"https://doi.org/10.1038/bonekey.2015.56","url":null,"abstract":"Skeletal metastases are complications of epithelial cancers, among which breast, prostate and lung carcinomas are the most osteotropic. In primary tumours, a subset of cancer cells undergoes epithelial-mesenchymal transition, acquires mobility to migrate into the surrounding stroma and seeds at distant sites to grow. The specific development of bone metastasis requires the recruitment of circulating tumour cells in the bone marrow, their adaptation to survive in the surrounding microenvironment where they alter the functions of osteoclasts and osteoblasts, and hijack signals coming from the bone matrix. Each of the molecular pathways underlining these steps is regulated by multiple factors, through the tight control of genes expressed by cancer cells interacting with cells from the bone microenvironment. In this context, miRNAs can act as master regulators of gene expression to control multiple aspects of bone metastasis formation, including cancer cell escape from the primary tumour site, cancer cell dissemination to bone and invasion of the bone marrow, as well as secondary outgrowth and tumour-stroma cell interactions. In the clinic, specific miRNA signatures have been identified in osteotropic cancer cells, raising the possibility that miRNAs could be used as biomarkers of bone metastasis. The regulatory activity of miRNAs in the bone microenvironment also suggests that miRNAs could be promising therapeutic targets. ","PeriodicalId":72441,"journal":{"name":"BoneKEy reports","volume":" ","pages":"688"},"PeriodicalIF":0.0,"publicationDate":"2015-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1038/bonekey.2015.56","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33190395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37