BOHR International journal of neurology and neuroscience最新文献

Development of prospects for adjuvant treatment of malignant brain tumors in experiments on C6 glioma 恶性脑肿瘤辅助治疗C6胶质瘤的研究进展

BOHR International journal of neurology and neuroscience Pub Date : 2023-01-01 DOI: 10.54646/bijnn.2023.11

Gridina N, Khokhlov A, Zvyagintseva T, M. I, Khrystosenko R, K. L, Belousova A, Guk A, V. E

{"title":"Development of prospects for adjuvant treatment of malignant brain tumors in experiments on C6 glioma","authors":"Gridina N, Khokhlov A, Zvyagintseva T, M. I, Khrystosenko R, K. L, Belousova A, Guk A, V. E","doi":"10.54646/bijnn.2023.11","DOIUrl":"https://doi.org/10.54646/bijnn.2023.11","url":null,"abstract":"The treatment of malignant tumors and their postoperative relapses is largely limited by toxic manifestations from a large number of known chemotherapy drugs. Finding a way to reduce the toxicity of drugs while maintaining their antitumor activity is a major challenge. In this work, the highly toxic drug gemcitabine was diluted 100 and 10,000 times with ion-free water and, together with verapamil hydrochloride, at a dilution of 10,000 times, was studied for the ability, when used together, to influence the blood cell aggregation. Our previous studies with low concentrations of verapamil showed a satisfactory effect in the treatment of malignant brain gliomas. In an experiment with C6 glioma in Wistar rats, the blood cell aggregation (SPR indicators) was determined daily in vitro under the combined action of gemcitabine and verapamil at low concentrations. The daily effect of these drugs on the level of blood cell aggregation turned out to be very variable, which is an important argument against the use of chemotherapy drugs in doses that are narrowly limited by protocols. The study of the correlation coefficients between the surface plasmon resonance (SPR indicators) and the quantitative composition of cell fractions in rats after transplantation of C6 glioma made it possible to determine the scope of regenerative processes in the tumor tissue and its microenvironment, which can also make changes in the methods of tumor treatment.","PeriodicalId":72438,"journal":{"name":"BOHR International journal of neurology and neuroscience","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91317354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Wearing Earrings Cause Headaches? 戴耳环会导致头痛吗?

BOHR International journal of neurology and neuroscience Pub Date : 2023-01-01 DOI: 10.54646/bijnn.007

W. L. Huang

引用次数: 0

Recurrent meningioma: When to intervene. 复发性脑膜瘤：何时干预？

BOHR International journal of neurology and neuroscience Pub Date : 2023-01-01 Epub Date: 2023-03-10 DOI: 10.54646/bijnn.008

Mohammad-Reza Hosseini-Siyanaki, Zahra Hasanpour Segherlou, Sophie Liu, Mohammed A Azab, Majid Khan, Brandon Lucke-Wold

引用次数: 0

Spinal tumor embolization: benefit for surgical resection. 脊柱肿瘤栓塞术：手术切除的好处。

BOHR International journal of neurology and neuroscience Pub Date : 2023-01-01 Epub Date: 2023-07-27 DOI: 10.54646/bijnn.2023.10

Krisna Maddy, Delano Trenchfield, Henson Destine, Vanesha Waiters, Daniel Nwatu, Brandon Lucke-Wold

{"title":"Spinal tumor embolization: benefit for surgical resection.","authors":"Krisna Maddy, Delano Trenchfield, Henson Destine, Vanesha Waiters, Daniel Nwatu, Brandon Lucke-Wold","doi":"10.54646/bijnn.2023.10","DOIUrl":"10.54646/bijnn.2023.10","url":null,"abstract":"The embolization of hypervascular spinal tumors preoperatively has shown to be a worthwhile adjunctive procedure to minimize the elevated risks associated with surgical resection, such as intraoperative blood loss and its associated complications. Resection of these hypervascular tumors is necessary for local tumor control, reduction in patient-reported pain, improved neurological functioning, and spinal stability. This adjunctive procedure has been associated with improved surgical outcomes and easier facilitation of surgical resection. As such, we provide a review of the current literature examining the employment of this technique. Specifically, this article (a) reviews the techniques of embolization, with anatomical considerations of the arterial framework of the spinal network; (b) relativizes and outlines the post-embolization management of spinal tumor resection; (c) provides a critical outlook on the reported benefit of preoperative embolization before surgical resection with support from clinical studies in the literature; and (d) discusses the efficacy and reliability of provocative testing and post-procedural management and follow-up. Ultimately, a thorough and updated review of preoperative spinal tumor embolization and its clinical benefits will summarize the current fund of knowledge and encourage future research toward continued improvements in patient outcomes for those needing to undergo surgical resection of spinal lesions.","PeriodicalId":72438,"journal":{"name":"BOHR International journal of neurology and neuroscience","volume":"1 2","pages":"71-80"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10008227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracranial venous sinus thrombosis: Medical and surgical management considerations. 颅内静脉窦血栓形成：内科和外科治疗注意事项。

BOHR International journal of neurology and neuroscience Pub Date : 2023-01-01 Epub Date: 2023-05-15 DOI: 10.54646/bijnn.2023.09

Abdurrahman F Kharbat, Michelot Michel, Ryan D Morgan, Miguel Tusa Lavieri, Brandon Lucke-Wold

引用次数: 0

Reporting A Case of Spontaneous Ocular Hypotony After the Neurosurgical Procedure 神经外科手术后自发性低眼压1例报告

BOHR International journal of neurology and neuroscience Pub Date : 2022-01-01 DOI: 10.54646/bijnn.005

Swaminathan Divya, P. S, Aishvarya Shree N., Vasudevan M. C., K. G.

引用次数: 0

Invasive Sinu-Naso-Orbital Aspergilloma Following Dacryocystorhinostomy in an Immunocompetent Patient: A Rare Case Report and Literature Review 免疫功能正常患者泪囊鼻腔造口术后发生侵袭性鼻窦炎:一例罕见病例报告及文献复习

BOHR International journal of neurology and neuroscience Pub Date : 2022-01-01 DOI: 10.54646/bijnn.006

Riad Habib, N. Jahan, Atikur Rahman, Nafaur Rahman, E. Mahmood

{"title":"Invasive Sinu-Naso-Orbital Aspergilloma Following Dacryocystorhinostomy in an Immunocompetent Patient: A Rare Case Report and Literature Review","authors":"Riad Habib, N. Jahan, Atikur Rahman, Nafaur Rahman, E. Mahmood","doi":"10.54646/bijnn.006","DOIUrl":"https://doi.org/10.54646/bijnn.006","url":null,"abstract":"Background: Invasive sinu-naso-orbital aspergilloma is a rare disease with variable clinical features, but in an immunocompetent patient, it is rarely considered and often resulted in a poor prognosis due to its diagnostic and therapeutic challenges. In this article, we report a rare case of invasive sinu-naso-orbital aspergillosis with intracranial extension following dacryocystorhinostomy. To the best of our knowledge, this is the only reported case in the past 109 years. Case Description: A 61-year-old normotensive nondiabetic male was referred to us from an ophthalmologist with complaints of retro-orbital pain followed by progressive dimness of vision and later blindness on right eye after dacryocystorhinostomy. Diagnosis and Intervention: His MRI reveals an isointense lesion in the T1W and T2W images in the right maxillary, ethmoidal sinus with orbital and retro-orbital, and intracranial extension with heterogeneous contrast enhancement. A radiologist suggested a case of inflammatory pseudotumor, and initially he was treated with steroids due to a lack of clinical response; later, antifungal was given, but the patient still was nonresponsive. A right pterional craniotomy was performed on the patient to access the optic nerve and perform the biopsy. Aspergillus infection was seen by histopathology. Postoperatively, he was treated with voriconazole. Lessons: In immunocompetent individuals, invasive sino-orbital aspergillosis is uncommon. For effective care, early diagnosis is essential. Our advice is that a patient with vague symptoms or retro-orbital discomfort should encourage the doctor to investigate this diagnosis due to the diagnostic difficulties and greater mortality and morbidity rates. Abbreviations: DCR: dacryocystorhinostomy, PL: Perception of light, PR: Projection of rays","PeriodicalId":72438,"journal":{"name":"BOHR International journal of neurology and neuroscience","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85968867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Development of Transcranial Magnetic Stimulation 经颅磁刺激的发展

BOHR International journal of neurology and neuroscience Pub Date : 2022-01-01 DOI: 10.54646/bijnn.002

Bradley J. Roth

引用次数: 0

Whole-Body vibration therapy: an overview 全身振动疗法:概述

BOHR International journal of neurology and neuroscience Pub Date : 2022-01-01 DOI: 10.54646/bijnn.2023.12

Jasmin Nisamudeen, B. Mathew K V, Roshan Bijlee K. N

引用次数: 0

Diabetes Mellitus Management in the Context of Cranial Tumors. 颅脑肿瘤背景下的糖尿病管理。

BOHR International journal of neurology and neuroscience Pub Date : 2022-01-01 Epub Date: 2022-12-28 DOI: 10.54646/bijnn.004

Marco Foreman, Aashay Patel, Sohum Sheth, Akshay Reddy, Brandon Lucke-Wold

{"title":"Diabetes Mellitus Management in the Context of Cranial Tumors.","authors":"Marco Foreman, Aashay Patel, Sohum Sheth, Akshay Reddy, Brandon Lucke-Wold","doi":"10.54646/bijnn.004","DOIUrl":"10.54646/bijnn.004","url":null,"abstract":"The study of the relationship between cancer and diabetes mellitus (DM) has been under investigation for many decades. Particularly in the field of neurology and neurosurgery, increasing emphasis has been put on the examination of comorbid DM in patients with cranial tumors. Namely, as the most common and invasive type of malignant adult brain tumor, glioblastoma (GBS) has been the focus of said research. Several mechanisms have been described in the attempt to elucidate the underlying association between DM and GBS, with the metabolic phenomenon known as the Warburg effect and its consequential downstream effects serving as the resounding culprits in recent literature. Since the effect seen in cancers like GBS exploits an upregulated form of aerobic glycolysis, the role of a sequela of DM, known as hyperglycemia, will be investigated. In particular, in the treatment of GBS, surgical resection and subsequent chemotherapy and/or radiotherapy are used in conjunction with corticosteroid therapy, the latter of which has been linked to hyperglycemia. Unsurprisingly, comorbid DM patients are significantly susceptible to this disposition. Further, this fact is reflected in recent literature that demonstrates the impact of hyperglycemia on cancer advancement and patient outcomes in several preclinical and clinical studies. Thus, this review will aim to underline the significance of diabetes and glycemic control via standard-of-care treatments such as metformin administration, as well as to describe emerging treatments such as the signaling modulation of insulin-like growth factor and the employment of the ketogenic diet.","PeriodicalId":72438,"journal":{"name":"BOHR International journal of neurology and neuroscience","volume":"1 1","pages":"29-39"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9149231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0