BMJ mental health最新文献

{"title":"Brief depressive and anxiety symptom measures rank alongside comorbidity burden as predictors of health-related quality of life in 15 countries.","authors":"Xun Li, Calvin Wei Jie Chern, Xin Zhang, Annushiah Vasan Thakumar, Ling Jie Cheng","doi":"10.1136/bmjment-2026-303070","DOIUrl":"https://doi.org/10.1136/bmjment-2026-303070","url":null,"abstract":"","PeriodicalId":72434,"journal":{"name":"BMJ mental health","volume":"29 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Centralised referral platform for child and adolescent mental health services: a mixed-methods evaluation of implementation processes and care pathways.","authors":"Léa Gonnon, Rachel Foare, Tristan Dagonneau, Camille Grandvallet, Pierre Fourneret, Laurence Willermoz, Julie Haesebaert, Bruno Falissard, Marie-Maude Geoffray","doi":"10.1136/bmjment-2026-302840","DOIUrl":"https://doi.org/10.1136/bmjment-2026-302840","url":null,"abstract":"","PeriodicalId":72434,"journal":{"name":"BMJ mental health","volume":"29 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teacher-rated childhood emotional, behavioural and social problems and alcohol-related, drug-related and intentional self-harm-related hospitalisation and mortality in adulthood (18-40 years): a population-based cohort study.","authors":"Minjae Choi, Sylvana M Côté, Caroline E Temcheff, Marc Dorais, Frank Vitaro, Richard E Tremblay, Marie-Claude Geoffroy","doi":"10.1136/bmjment-2026-302932","DOIUrl":"10.1136/bmjment-2026-302932","url":null,"abstract":"","PeriodicalId":72434,"journal":{"name":"BMJ mental health","volume":"29 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13663761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological and anthropometric outcomes in preschool children exposed to antenatal maternal obesity: modelling of early life risk factors.","authors":"Julie Sigurdardottir, Kathryn Dalrymple, Mary Rutherford, Lucilla Poston","doi":"10.1136/bmjment-2026-302738","DOIUrl":"10.1136/bmjment-2026-302738","url":null,"abstract":"","PeriodicalId":72434,"journal":{"name":"BMJ mental health","volume":"29 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse sexual and reproductive health outcomes in female adolescents with ADHD and their associations with ADHD medication: a Swedish register-based study.","authors":"Helena Kopp Kallner, Xinchen Wang, Le Zhang, Taalke Maria Sitter, Lisa B Thorell, Charlotte Skoglund, Zheng Chang","doi":"10.1136/bmjment-2026-302883","DOIUrl":"10.1136/bmjment-2026-302883","url":null,"abstract":"","PeriodicalId":72434,"journal":{"name":"BMJ mental health","volume":"29 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the impact of a postnatal singing intervention on mental health, well-being measures and mother-infant interaction: results from the SHAPER-PND trial.","authors":"Riddhi Laijawala, Rebecca H Bind, Sorcha Alford, Carolina Estevao, Katie Hazelgrove, Kristi Priestley, Lavinia Rebecchini, Madeline Kirkpatrick, Celeste Miller, Vaheshta Sethna, Anthony J Woods, Nikki Crane, Manonmani Manoharan, Alexandra Burton, Hannah Dye, Tim Osborn, Lorna Greenwood, Paola Dazzan, Carmine M Pariante, Daisy Fancourt","doi":"10.1136/bmjment-2026-302774","DOIUrl":"10.1136/bmjment-2026-302774","url":null,"abstract":"","PeriodicalId":72434,"journal":{"name":"BMJ mental health","volume":"29 1","pages":""},"PeriodicalIF":6.6,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149172150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early interventions for primary care patients with stress-related mental ill health: a randomised controlled non-inferiority trial of a nurse-led collaborative care intervention versus cognitive behavioural therapy","authors":"Evelina Kontio,Victoria Sennerstam,Frank Svärdman,Conrad Samuelsson,Janina Hettman,Nathalie Broman,Ludwig Franke Föyen,Kersti Ejeby,Elin Lindsäter,Erik Hedman-Lagerlöf","doi":"10.1136/bmjment-2026-302797","DOIUrl":"https://doi.org/10.1136/bmjment-2026-302797","url":null,"abstract":"Background Stress-related mental ill health is highly prevalent, and most individuals first seek help in primary care where access to psychological support is often limited. Objective To test whether nurse-led collaborative care (CC) is non-inferior to cognitive behavioural therapy delivered as psychologist-guided self-help (GSH-CBT) in reducing stress for adult primary care patients with stress-related mental ill health. Methods A randomised controlled non-inferiority trial where 172 adult primary care patients with mild to moderate stress-related mental ill health were allocated to nurse-led CC or GSH-CBT (1:1). The primary outcome was the Perceived Stress Scale-10 administered every 3 weeks during the 12-week treatment phase. The a priori non-inferiority margin was 0.3 d , requiring the one-sided 95% CI of the effect size to fall within this bound. Secondary outcomes were symptoms of exhaustion, sleep problems, depressive symptoms, general anxiety and quality of life. Findings In both conditions, participants showed large, significant within-group improvements on the primary outcome and all secondary outcomes. The primary outcome showed a small between-group difference ( d =0.22), favouring GSH-CBT, with the CI upper bound (0.52) exceeding the non-inferiority margin. For secondary outcomes, GSH-CBT led to a greater reduction in exhaustion ( d =0.28; 95% CI 0.64 to 0.002). No other between-group differences were observed. Conclusions Nurse-led CC was not non-inferior to GSH-CBT. Effect differences were small, but improvements were slightly larger in GSH-CBT. Clinical implications Given that nurse-led CC is safe, easy to administer, and that significant within-group improvements were observed across all measures, this intervention could be a viable option in primary care settings where psychologist-delivered treatment is limited.","PeriodicalId":72434,"journal":{"name":"BMJ mental health","volume":"13 1","pages":"e302797"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149089465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six-year clinical course of depressive and anxiety disorders: analysis by age","authors":"Federico Triolo,Laura K M Han,Hans W Jeuring,Erik J Giltay,Brenda W J H Penninx","doi":"10.1136/bmjment-2026-302895","DOIUrl":"https://doi.org/10.1136/bmjment-2026-302895","url":null,"abstract":"Background Evidence on the association between age and the long-term course of affective disorders remains mixed. Objective This study examined the 6-year symptom and diagnostic trajectories of depression and anxiety in relation to age, and assessed whether social, lifestyle, somatic and clinical factors explained observed age-related differences. Methods A cohort of 1701 participants aged 18–65 years with a current depressive and/or anxiety disorder from the Netherlands Study of Depression and Anxiety were assessed biennially over 6 years. Clinical diagnoses were ascertained using the Composite International Diagnostic Interview, while symptom severities were measured with the Inventory of Depressive Symptomatology, Beck Anxiety Inventory, Fear Questionnaire and Penn State Worry Questionnaire. Linear mixed-effects models examined age differences in symptom changes over time; multinomial logistic regression examined age differences in diagnostic course. Models were sequentially adjusted for social, lifestyle, somatic and clinical factors to explain observed age-related differences. Findings Over the 6-year follow-up, older age was associated with slower improvement in depressive (b per 10 years =0.191 (0.103 to 0.279)) and anxiety symptoms (b per 10 years =0.119 (0.048 to 0.191)), but not for fear or worry. Older age was associated with a higher likelihood of a chronic course versus early remission (RRR per 10 years =1.19 (1.05 to 1.36)), primarily driven by depression chronicity. Age-related differences in symptom trajectories persisted across all adjusted models, while associations with depression diagnostic chronicity were attenuated after adjustment for social and lifestyle factors. Conclusions Higher chronological age is an independent risk factor for a less favourable long-term course of affective disorders, particularly depression, characterised by slower symptom improvement and increased chronicity. Clinical implications Age-tailored depression management, including closer follow-up and timely treatment optimisation, may help improve clinical course in later life.","PeriodicalId":72434,"journal":{"name":"BMJ mental health","volume":"2 1","pages":"e302895"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149089467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EDIT-B consortium: an external pan-European validation of an innovative machine learning-based test for bipolar disorder diagnosis","authors":"Dinah Weissmann,Nicolas Salvetat,Christopher Cayzac,Francisco Checa-Robles,Diana Vetter,Francisco Santos Schneider,Lara Walczer-Baldinazzo,Giovanna Ruggeri,Maurizio Ferrari,Andrea Miranda-Mendizabal,Victor Chavarria,Oscar Soto-Angona,Juan Zambrano,Jeff Zarp,Anna Gimenez-Palomo,Marc Valenti,Josep Maria Haro,Lars Vedel Kessing,Chantal Henry,Eduard Vieta","doi":"10.1136/bmjment-2026-302859","DOIUrl":"https://doi.org/10.1136/bmjment-2026-302859","url":null,"abstract":"Background Differentiating bipolar disorder (BD) from major depressive disorder (MDD) during major depressive episodes remains a significant challenge. EDIT-B is an in vitro diagnostic test based on machine learning (ML) method integrating clinical metadata with adenosine-to-inosine (A-to-I) RNA editing signatures in eight genes ( GAB2 , IFNAR1 , IL17RA , LYN , MDM2 , PRKCB , PTPRC , ZNF267 ) to differentiate BD from MDD. Objective The objective of this study is to assess and confirm the diagnostic performance of EDIT-B in a new, independent, double-blind, external, multicentre European cohort. Methods We evaluated EDIT-B results across four European centres (Spain, France, Denmark) compared with physician diagnoses. Explainability and sensitivity analyses were performed to identify the primary drivers of the model. Findings In 393 patients with current major depressive episode (238 MDD; 155 BD), EDIT-B demonstrated robust performance: area under the curve-receiver operating characteristic of 0.873 (95% CI 0.837 to 0.909), sensitivity of 82.6% (95% CI 75.7% to 88.2%) and specificity of 80.3% (95% CI 74.6% to 85.1%). Performances were consistent across sites and all stratified patient subgroups, corroborating previous results. Explainability analysis pointed to RNA editing biomarkers as the most important variables for EDIT-B diagnosis. Conclusion This study confirms the diagnostic performances of EDIT-B showing that A-to-I RNA editing coupled with ML methods is a reliable approach to distinguish BD from MDD. Clinical implications EDIT-B represents an innovative, reliable and complementary diagnostic tool supporting psychiatric practice and enhancing clinical outcomes with potential impact in reducing diagnostic delays, tailoring the therapeutic strategy and improving therapeutic alliances. These findings may represent a significant advance towards precision psychiatry, with potential to reduce misdiagnosis and inappropriate treatment. Trial registration number NCT05603819 .","PeriodicalId":72434,"journal":{"name":"BMJ mental health","volume":"17 1","pages":"e302859"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149089545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomised controlled trial of fluoxetine versus naltrexone in compulsive sexual behaviour disorder","authors":"Josephine Savard,Marta Piwowar,Roberth Adebahr,Markus Byström,Jonas Hallberg,Cecilia Dhejne,Katarina Görts Öberg,Jussi Jokinen","doi":"10.1136/bmjment-2026-302953","DOIUrl":"https://doi.org/10.1136/bmjment-2026-302953","url":null,"abstract":"Background Compulsive sexual behaviour disorder (CSBD), characterised by preoccupation with and loss of control over sexual behaviours, is associated with negative consequences in several areas of life. Evidence for pharmacological treatment remains limited, with only two previous randomised controlled trials and no studies comparing fluoxetine and naltrexone. Objective To investigate whether naltrexone was more efficient and tolerable than fluoxetine in the treatment of CSBD. Methods In this open-label superiority trial, 80 participants diagnosed with CSBD according to International Classification of Diseases-11 criteria were randomly assigned (1:1) to receive fluoxetine (starting dose 20 mg/day) or naltrexone (starting dose 25 mg/day) for 8 weeks followed by 6 weeks without treatment. Symptom severity was recurringly assessed using the Hypersexual Disorder: Current Assessment Scale (HD:CAS). Linear mixed models were used for intention-to-treat and per-protocol analyses of treatment effects. Findings 79 men and 1 woman were randomised to receive fluoxetine (n=40) or naltrexone (n=40). Analysis showed no statistically significant difference in HD:CAS score reduction between treatments at primary endpoint; naltrexone was not superior to fluoxetine. However, participants in the two treatment groups showed different patterns of symptom improvement over time. Two participants (5.1%) receiving fluoxetine were withdrawn due to adverse events (urticaria and elevated liver enzymes) and four participants (10.3%) discontinued treatment; six participants (15%) receiving naltrexone discontinued treatment. Conclusions Although no statistically significant between-group difference was observed at week 8, symptom trajectories and adverse effect profiles differed between groups. Clinical implications Symptom-change patterns and adverse effect profiles may guide individualised treatment decisions.","PeriodicalId":72434,"journal":{"name":"BMJ mental health","volume":"22 1","pages":"e302953"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149089466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}