BBA clinical最新文献

{"title":"Pattern of circulating microparticles in chronic heart failure patients with metabolic syndrome: Relevance to neurohumoral and inflammatory activation","authors":"Alexander E. Berezin ,&nbsp;Alexander A. Kremzer ,&nbsp;Tatyana A. Berezina ,&nbsp;Yulia V. Martovitskaya","doi":"10.1016/j.bbacli.2015.07.002","DOIUrl":"10.1016/j.bbacli.2015.07.002","url":null,"abstract":"<div><h3>Background</h3><p>The role of pattern of circulating endothelial cell-, platelet-, and monocyte-derived microparticles in metabolic syndrome (MetS) patients with chronic heart failure (CHF) is not still understood.</p><p>The aim of the study was to investigate a pattern of circulating MPs in MetS patients with CHF in relation to neurohumoral and inflammatory activation.</p></div><div><h3>Methods</h3><p>The study retrospectively involved 101 patients with MetS (54 subjects with CHF and 47 patients without CHF) without documented coronary artery stenosis &gt;<!--> <!-->50% at least of one artery and 35 healthy volunteers. Biomarkers were measured at baseline of the study. Circulating MPs were phenotyped by flow cytometry technique.</p></div><div><h3>Results</h3><p>The results of the study have shown that numerous of the circulating platelet-derived and monocyte-derived MPs in subjects with MetS (with or without CHF) were insufficiently distinguished from the level obtained in healthy volunteers. We found an elevated level of CD31<!--> <!-->+/annexin V<!--> <!-->+ MPs in association with a lower level of CD62E<!--> <!-->+ MPs. All these led to decreased CD62E<!--> <!-->+ to CD31<!--> <!-->+/annexin V<!--> <!-->+ ratio among patients with MetS in comparison with healthy volunteers, as well as in MetS patients with CHF compared with those who did not demonstrated CHF. Therefore, we found that biomarkers of biomechanical stress (NT-proBNP) and inflammation (hs-CRP, osteoprotegerin) remain statistically significant predictors for decreased CD62E<!--> <!-->+ to CD31<!--> <!-->+/annexin V<!--> <!-->+ ratio in MetS patients with CHF.</p><p>In conclusion, decreased CD62E<!--> <!-->+ to CD31<!--> <!-->+/annexin V<!--> <!-->+ ratio reflected impaired immune phenotype of MPs may be discuss surrogate marker of CHF development in MetS population.</p></div>","PeriodicalId":72344,"journal":{"name":"BBA clinical","volume":"4 ","pages":"Pages 69-75"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbacli.2015.07.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54179432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of caloric restriction with or without n-3 polyunsaturated fatty acids on insulin sensitivity in obese subjects: A randomized placebo controlled trial","authors":"Urszula Razny ,&nbsp;Beata Kiec-Wilk ,&nbsp;Anna Polus ,&nbsp;Joanna Goralska ,&nbsp;Malgorzata Malczewska-Malec ,&nbsp;Dominika Wnek ,&nbsp;Anna Zdzienicka ,&nbsp;Anna Gruca ,&nbsp;Caroline E. Childs ,&nbsp;Maria Kapusta ,&nbsp;Krystyna Slowinska-Solnica ,&nbsp;Philip C. Calder ,&nbsp;Aldona Dembinska-Kiec","doi":"10.1016/j.bbacli.2015.05.001","DOIUrl":"10.1016/j.bbacli.2015.05.001","url":null,"abstract":"<div><h3>Background</h3><p>Caloric restriction and n-3 polyunsaturated fatty acid (PUFA) supplementation protect from some of the metabolic complications. The aim of this study was to assess the influence of a low calorie diet with or without n-3 PUFA supplementation on glucose dependent insulinotropic polypeptide (GIP) output and insulin sensitivity markers in obese subjects.</p></div><div><h3>Methods</h3><p>Obese, non-diabetic subjects (BMI 30–40<!--> <!-->kg/m²) and aged 25–65<!--> <!-->yr. were put on low calorie diet (1200–1500<!--> <!-->kcal/day) supplemented with either 1.8<!--> <!-->g/day n-3 PUFA (DHA/EPA, 5:1) (<em>n</em> <!-->=<!--> <!-->24) or placebo capsules (<em>n</em> <!-->=<!--> <!-->24) for three months in a randomized placebo controlled trial. Insulin resistance markers and GIP levels were analysed from samples obtained at fasting and during an oral glucose tolerance test (OGTT).</p></div><div><h3>Results</h3><p>Caloric restriction with n-3 PUFA led to a decrease of insulin resistance index (HOMA-IR) and a significant reduction of insulin output as well as decreased GIP secretion during the OGTT. These effects were not seen with caloric restriction alone. Changes in GIP output were inversely associated with changes in red blood cell EPA content whereas fasting GIP level positively correlated with HOMA-IR index. Blood triglyceride level was lowered by caloric restriction with a greater effect when n-3 PUFA were included and correlated positively with fasting GIP level.</p></div><div><h3>Conclusions</h3><p>Three months of caloric restriction with DHA<!--> <!-->+<!--> <!-->EPA supplementation exerts beneficial effects on insulin resistance, GIP and triglycerides.</p></div><div><h3>General significance</h3><p>Combining caloric restriction and n-3 PUFA improves insulin sensitivity, which may be related to a decrease of GIP levels.</p></div>","PeriodicalId":72344,"journal":{"name":"BBA clinical","volume":"4 ","pages":"Pages 7-13"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbacli.2015.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54176808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dictionary of epidemiology — The evolution towards the 6th edition","authors":"D. Canoy","doi":"10.1016/j.bbacli.2015.06.005","DOIUrl":"10.1016/j.bbacli.2015.06.005","url":null,"abstract":"","PeriodicalId":72344,"journal":{"name":"BBA clinical","volume":"4 ","pages":"Pages 42-43"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbacli.2015.06.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54179217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Folate status, folate-related genes and serum miR-21 expression: Implications for miR-21 as a biomarker","authors":"Emma Louise Beckett ,&nbsp;Charlotte Martin ,&nbsp;Jeong Hwa Choi ,&nbsp;Katrina King ,&nbsp;Suzanne Niblett ,&nbsp;Lyndell Boyd ,&nbsp;Konsta Duesing ,&nbsp;Zoe Yates ,&nbsp;Martin Veysey ,&nbsp;Mark Lucock","doi":"10.1016/j.bbacli.2015.06.006","DOIUrl":"10.1016/j.bbacli.2015.06.006","url":null,"abstract":"<div><h3>Background</h3><p>Free circulating microRNA (miRNA) in serum may be valuable biomarkers for disease diagnosis and prognosis. miR-21, the archetypal oncogenic miRNA, has been proposed as a biomarker for colorectal cancer and its benign precursor, adenomatous polyps. However, it is now becoming clear that circulating miRNA profiles may be sensitive to lifestyle and environmental influences. Dietary components involved in one-carbon metabolism are particularly well placed to modulate miRNA expression through an influence on DNA methylation pathways.</p></div><div><h3>Methods</h3><p>We investigated the role of methyl group donors (folate, B12, cysteine, homocysteine), polymorphisms of the enzymes of one-carbon metabolism, and serum miR-21 expression in a primary case–control cohort (colonoscopy confirmed adenomatous colon polyps vs controls; n<!--> <!-->=<!--> <!-->253) and a secondary cross-sectional cohort (over 65s; n<!--> <!-->=<!--> <!-->649). The relationships between these parameters and serum miR-21 levels were assessed, stratified by gender.</p></div><div><h3>Conclusions</h3><p>Serum miR-21 expression was related to occurrence of adenomatous polyps in females, but not males. Folate levels and MTHFR-C677T genotype was associated with miR-21 expression in both genders. Additionally, DHFR-19 del and MSR-A66G were associated with miR-21 expression in females and males, respectively. Stimulation with excess folate increased expression of miR-21 in colon cancer cell lines.</p></div><div><h3>General significance</h3><p>This study demonstrates that serum miR-21 expression correlates with folate status and related genetic status. This may have consequences for the proposed use of miR-21 as a colorectal cancer biomarker.</p></div>","PeriodicalId":72344,"journal":{"name":"BBA clinical","volume":"4 ","pages":"Pages 45-51"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbacli.2015.06.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54179262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simvastatin augmentation for recent-onset psychotic disorder: A study protocol","authors":"Marieke J.H. Begemann ,&nbsp;Maya J.L. Schutte ,&nbsp;Margot I.E. Slot ,&nbsp;Janine Doorduin ,&nbsp;P. Roberto Bakker ,&nbsp;Neeltje E.M. van Haren ,&nbsp;Iris E.C. Sommer","doi":"10.1016/j.bbacli.2015.06.007","DOIUrl":"10.1016/j.bbacli.2015.06.007","url":null,"abstract":"<div><h3>Background</h3><p>There is ample evidence that inflammatory processes play a role in the pathophysiology of schizophrenia. Randomized controlled trials have shown benefit of some (but not all) anti-inflammatory drugs on symptom severity. So far, these drugs have been given for a relatively short period. Simvastatin combines well-established vascular protection with reduction of the inflammatory status of the brain, thus offering an attractive potential to further improve treatment of schizophrenia and related disorders.</p></div><div><h3>Methods/design</h3><p>We are currently undertaking a double-blind placebo-controlled trial, including 250 patients (18–50<!--> <!-->years of age) whom are diagnosed with a schizophrenia spectrum disorder. Onset of their first psychosis should be no longer than three years ago. Patients are randomized 1:1 to either 40<!--> <!-->mg simvastatin or placebo daily during one year, next to their regular antipsychotic treatment. Primary outcome measures are symptom severity and cognitive decline as measured by the Positive and Negative Syndrome Scale (PANSS) and Brief Assessment of Cognition in Schizophrenia (BACS), at baseline and end of treatment. Secondary aims are to establish an attenuation of brain tissue loss and an improvement in general functioning, presence and severity of metabolic syndrome and degree of movement disorders. Lastly, immunological and metabolic parameters are assessed in blood samples to possibly predict treatment response.</p></div><div><h3>Discussion</h3><p>We hypothesize simvastatin to lower symptom severity and to prevent or reduce excessive brain tissue loss and cognitive decline, compared to placebo. We expect that simvastatin will be well-tolerated and lead to decreased prevalence of metabolic syndrome.</p></div><div><h3>Trial registration</h3><p>ClinicalTrails.gov <span>NCT01999309</span><svg><path></path></svg>; EudraCT-number 2013-000834-36.</p></div>","PeriodicalId":72344,"journal":{"name":"BBA clinical","volume":"4 ","pages":"Pages 52-58"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbacli.2015.06.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54179309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative protein profiles in cerebrospinal fluid in elderly hip fracture patients at risk for delirium: A proteomics and validation study","authors":"Dunja Westhoff ,&nbsp;Joost Witlox ,&nbsp;Corneli van Aalst ,&nbsp;Rikie M. Scholtens ,&nbsp;Sophia E. de Rooij ,&nbsp;Barbara C. van Munster ,&nbsp;Jos F.M. de Jonghe ,&nbsp;Alexander P.J. Houdijk ,&nbsp;Piet Eikelenboom ,&nbsp;David J. van Westerloo ,&nbsp;Diederik van de Beek ,&nbsp;Willem A. van Gool ,&nbsp;Leo Koenderman","doi":"10.1016/j.bbacli.2015.10.002","DOIUrl":"10.1016/j.bbacli.2015.10.002","url":null,"abstract":"<div><h3>Background</h3><p>A neuroinflammatory response is suggested to play an important role in delirium, a common complication in older hospitalized patients. We examined whether hip fracture patients who develop postoperative delirium have a different proteome in cerebrospinal fluid (CSF) prior to surgery.</p></div><div><h3>Methods</h3><p>Patients (≥<!--> <!-->75<!--> <!-->years) were admitted for hip fracture surgery. CSF was collected during spinal anaesthesia; proteins were separated using gel electrophoresis and identified with mass spectrometry. We compared the proteome of patients with and without postoperative delirium. Findings were validated in an independent, comparable cohort using immuno-assays.</p></div><div><h3>Results</h3><p>In the derivation cohort 53 patients were included, 35.8% developed postoperative delirium. We identified differences in levels of eight CSF proteins between patients with and without subsequent delirium: complement factor C3, contactin-1, fibulin-1 and I-beta-1,3-N-acetylglucosaminyltransferase were significantly lower in patients with postoperative delirium, while neural cell adhesion molecule-2, fibrinogen, zinc-α-2-glycoprotein and haptoglobin levels were significantly higher. In the validation cohort 21.2% of 52 patients developed postoperative delirium. Immuno-assays confirmed contactin-1 results although not statistically significant. Complement factor C3 was significantly higher in patients with postoperative delirium.</p></div><div><h3>Conclusion</h3><p>Our results show the complexity of pathophysiological mechanisms involved in delirium and emphasizes the need of independent validation of findings.</p></div><div><h3>General significance</h3><p>This study highlights the challenges and inconsistent findings in studies of delirium, a serious complication in older patients. We analysed proteins in CSF, the most proximal fluid to the brain. All patients were free from delirium at the time of sampling.</p></div>","PeriodicalId":72344,"journal":{"name":"BBA clinical","volume":"4 ","pages":"Pages 115-122"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbacli.2015.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54180132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of carbohydrate counting and insulin dose calculations in paediatric patients with type 1 diabetes mellitus","authors":"Natalie Finner ,&nbsp;Anne Quinn ,&nbsp;Anna Donovan ,&nbsp;Orla O'Leary ,&nbsp;Clodagh S. O'Gorman","doi":"10.1016/j.bbacli.2015.09.002","DOIUrl":"10.1016/j.bbacli.2015.09.002","url":null,"abstract":"<div><h3>Background</h3><p>Patients with type 1 diabetes mellitus (T1DM) who are able to adjust their insulin doses according to the carbohydrate content of a meal, as well as their blood glucose, are likely to have improved glycaemic control (Silverstein et al., 2005). With improved glycaemic control, patients have a lower risk of developing long-term microvascular complications associated with T1DM (Diabetes Control and Complications Trial Research Group, 1993).</p><p>To assess the carbohydrate and insulin knowledge of patients attending our paediatric diabetes clinic at the University Hospital Limerick (UHL), the validated PedCarbQuiz (PCQ) was applied to our clinic population.</p></div><div><h3>Methods</h3><p>This study was completed by applying a questionnaire called the PedCarbQuiz (PCQ) to children exclusively attending our paediatric diabetes clinic at UHL. Of the clinic's 220 patients, 81 participated in the study.</p></div><div><h3>Results</h3><p>The average total PCQ score (%) was higher in the continuous subcutaneous insulin infusion (CSII) group compared with the multiple daily insulin (MDI) injection user group (79.1<!--> <!-->±<!--> <!-->12.1 versus 65.9<!--> <!-->±<!--> <!-->6.6 p<!--> <!-->=<!--> <!-->0.005). The CSII group also had a higher average carbohydrate score (%) compared with the MDI group (79.4<!--> <!-->±<!--> <!-->12.4 versus 66.3<!--> <!-->±<!--> <!-->16.2, p<!--> <!-->=<!--> <!-->0.004).</p></div><div><h3>Conclusions</h3><p>This study demonstrates that in a representative Irish regional paediatric T1DM clinic, knowledge of carbohydrates and insulin is better among patients treated with CSII compared with MDI. However, knowledge in both groups is poorer than in the original US sample.</p></div><div><h3>General significance</h3><p>This study demonstrates that in a representative Irish regional paediatric T1DM clinic, knowledge of carbohydrates and insulin is poorer than in a US based sample, although this knowledge is better among patients treated with CSII compared with MDI. This highlights the need for improved resources for diabetes and carbohydrate counting education for patients with T1DM.</p></div>","PeriodicalId":72344,"journal":{"name":"BBA clinical","volume":"4 ","pages":"Pages 99-101"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbacli.2015.09.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54179736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutaredoxin mediated redox effects of coenzyme Q10 treatment in type 1 and type 2 diabetes patients","authors":"Sergio J. Montano ,&nbsp;Jacob Grünler ,&nbsp;Deepika Nair ,&nbsp;Michael Tekle ,&nbsp;Aristi P. Fernandes ,&nbsp;Xiang Hua ,&nbsp;Arne Holmgren ,&nbsp;Kerstin Brismar ,&nbsp;Johanna S. Ungerstedt","doi":"10.1016/j.bbacli.2015.06.001","DOIUrl":"10.1016/j.bbacli.2015.06.001","url":null,"abstract":"<div><p>The possible beneficial effects of coenzyme Q10 (CoQ10) supplementation on disease progression and oxidant status in diabetes remains debated. In the present study, patients with type 1 and type 2 diabetes were treated with oral CoQ10, 100<!--> <!-->mg twice daily for 12<!--> <!-->weeks. We assessed total antioxidant capacity, intra- and extracellular levels of the redox regulating protein glutaredoxin 1 (Grx1), CoQ10, oxidized LDL-cholesterol, lipid profile and HbA1c. We have previously shown that extracellular Grx1 is increased in patients with type 2 diabetes compared to healthy subjects. In the present study, CoQ10 treatment significantly decreased serum Grx1 activity as well as total antioxidant capacity independent of type of diabetes, indicating an improvement to a less oxidized extracellular environment. The effect on serum Grx1 activity was more prominent in patients not on statin treatment. Conversely, intracellular Grx1 activity as well as mRNA levels increased independent of statin treatment. There was a significant improvement in oxidized LDL-cholesterol and lipid profile, with a tendency to improved metabolic control (HbA1c). Additionally, we describe for the first time that CoQ10 is a direct substrate for glutathione, and that Grx1 catalyzes this reaction, thus presenting a novel mechanism for CoQ10 reduction which could explain our findings of an increased intracellular Grx1. In conclusion, 12<!--> <!-->weeks CoQ10 treatment significantly improved the extracellular redox balance and lipid profile, indicating that prolonged treatment may have beneficial effects also on clinical outcome in diabetes.</p></div>","PeriodicalId":72344,"journal":{"name":"BBA clinical","volume":"4 ","pages":"Pages 14-20"},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbacli.2015.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54179041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between neck circumference and subclinical atherosclerosis — Longitudinal Study of Adult Health (ELSA-Brasil)","authors":"Cristina P. Baena,&nbsp;Itamar S. Santos,&nbsp;Alessandra C. Goulart,&nbsp;Marcio S. Bittencourt,&nbsp;Bruce B. Duncan,&nbsp;Paulo A. Lotufo,&nbsp;Isabela J. Benseñor","doi":"10.1016/j.bbacli.2015.05.027","DOIUrl":"10.1016/j.bbacli.2015.05.027","url":null,"abstract":"","PeriodicalId":72344,"journal":{"name":"BBA clinical","volume":"3 ","pages":"Pages S9-S10"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbacli.2015.05.027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54177438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropometric features and myocardial infarction in very elderly people","authors":"Alessandra M. Campos,&nbsp;Meyrianne Almeida,&nbsp;Valeria N. Figueiredo,&nbsp;Wladimir M. Freitas,&nbsp;Andrei C. Sposito","doi":"10.1016/j.bbacli.2015.05.008","DOIUrl":"10.1016/j.bbacli.2015.05.008","url":null,"abstract":"","PeriodicalId":72344,"journal":{"name":"BBA clinical","volume":"3 ","pages":"Page S3"},"PeriodicalIF":0.0,"publicationDate":"2015-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bbacli.2015.05.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54177248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}