Advances in Analytical Chemistry最新文献

Hydrogel Waveguide Sensors for Breath Acetone Detection 用于呼吸丙酮检测的水凝胶波导传感器

Advances in Analytical Chemistry Pub Date : 2025-01-01 DOI: 10.12677/aac.2025.152024

浩李

{"title":"Hydrogel Waveguide Sensors for Breath Acetone Detection","authors":"浩李","doi":"10.12677/aac.2025.152024","DOIUrl":"https://doi.org/10.12677/aac.2025.152024","url":null,"abstract":"近年来，针对糖尿病的呼吸丙酮(BrAce)检测，新型化学传感器的研发层出不穷。然而，现有的传感器普遍存在以下问题：一方面，操作繁琐，且需配备复杂的样品处理装置；另一方面，要么造价昂贵，要么灵敏度不足，难以满足实际应用的需要。针对上述问题我们提出了一种基于水凝胶波导的BrAce气体传感器。该传感器利用水凝胶的三维多孔结构，高效捕获待测丙酮气体，并使其与波导内部的硫酸羟胺反应生成氢离子(H+)，从而引发波导内部pH值的变化。这种pH值的变化进而导致波导内部溴酚蓝吸收光谱发生改变。通过检测溴酚蓝对波导内部传输光的吸收，实现了对健康成年人的BrAce检测。实验表明，该水凝胶波导传感器能够检测出低于0.9 ppm的丙酮气体浓度，而正常人BrAce浓度在0.3~0.9 ppm，能够有效地检测出正常人体内的BrAce气体。该水凝胶波导传感器制备方法简单，成本低廉，灵敏度高，操作简单，能够有效地应对日常生活中的使用场景。In recent years, various sensors have been developed for the detection of breath acetone (BrAce) in diabete management. However, existing sensors face signification challenges: they are often cumbersome to operate, requiring complex sample-handling devices, or tend to be either expensive or insufficiently sensitive for practical applications. To address these issues, we propose a BrAce gas sensor based on hydrogel waveguides. This sensor leverages the three-dimensional porous structure of hydrogel to efficiently capture acetone gas, which then reacts with hydroxylamine sulfate pre-doped in the waveguide to generate hydrogen ions (H+), thereby triggering a pH change within the waveguide. This change in pH, in turn, alters the absorption spectrum of bromophenol blue within the waveguide. By detecting changes in the absorption spectrum of bromophenol blue, we achieve a highly sensitive BrAce detection. Experimental results demonstrate that the hydrogel waveguide sensor can detect acetone concentrations lower than 0.9 ppm, while the normal BrAce in healthy individuals ranges from 0.3~0.9 ppm. This capability enables effective BrAce detection in healthy individuals. Additionally, the sensor features a simple fabricate process, low cost, high sensitivity and ease of operation, making it permits for everyday use.","PeriodicalId":7233,"journal":{"name":"Advances in Analytical Chemistry","volume":"15 02","pages":"248-258"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pdf.hanspub.org/aac_1560456.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on High Specific Response of Tetrasulfonyl Nickel Phthalocyanine-Pb(II) Optical Probe to Triphosphate in Aqueous Phase 四磺酰基镍酞菁-铅(II)光学探针对三磷酸盐的高比响应研究

Advances in Analytical Chemistry Pub Date : 2023-01-01 DOI: 10.12677/aac.2023.133037

惠卿杨

{"title":"Study on High Specific Response of Tetrasulfonyl Nickel Phthalocyanine-Pb(II) Optical Probe to Triphosphate in Aqueous Phase","authors":"惠卿杨","doi":"10.12677/aac.2023.133037","DOIUrl":"https://doi.org/10.12677/aac.2023.133037","url":null,"abstract":"A series of reactions between cationic ions and nickel tetrasulfonated phthalocyanine (nickel 4,4’,4’,4’-tetrasulfophthalocyanine, NiS 4 Pc) were performed and demonstrated that water-soluble NiS 4 Pc can complex with Pb 2+ to form an insoluble compound, many acid anions can dissolve this compound. However, the presence of acidic materials (acid inhibitors) can inhibit the dissolution of this compound by acid anions. Screening of acid inhibitors led to an important finding. In the presence of a low concentration of citric acid, the precipitate dissolution by most anions was completely or significantly inhibited; only 5 3 10 P O − could still dissolve the precipitate compound, NiS 4 Pc-Pb(II), to release NiS 4 Pc. The solution phase shows the characteristic color and absorption spectroscopy of NiS 4 Pc-Pb(II), thus providing a specific optical probe for 5 3 10 P O − . In addition, the color and absorption intensity of the solution remained stable for a long time (more than three months), indicating significant stability of the optical probe. Based on this finding, a new spectrophotometric technique has been established for detecting and quantifying aqueous","PeriodicalId":7233,"journal":{"name":"Advances in Analytical Chemistry","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80895408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphate-Modulated Luminol-Tb Fluorescent Probe for the Ratiometric Detection of Anthrax Biomarker 磷酸盐调制鲁米诺- tb荧光探针比值检测炭疽生物标志物

Advances in Analytical Chemistry Pub Date : 2023-01-01 DOI: 10.12677/aac.2023.133040

浩哲孙

{"title":"Phosphate-Modulated Luminol-Tb Fluorescent Probe for the Ratiometric Detection of Anthrax Biomarker","authors":"浩哲孙","doi":"10.12677/aac.2023.133040","DOIUrl":"https://doi.org/10.12677/aac.2023.133040","url":null,"abstract":"Achieving sensitive and selective detection of Bacillus anthracis is of great significance for preventing anthrax infection. This work constructs a Luminol-Tb fluorescent complex based on phosphate (Pi) regulation (Luminol-Tb-Pi) for the rapid, sensitive, and visual detection of anthrax bio-marker (2,6-pyridyldicarboxylic acid, DPA). U nder the regulation of Pi, with Luminol as the organic ligand and Tb 3+ as the central ion, DPA can significantly enhance the characteristic fluorescence of Tb 3+ and cause quenching of Luminol. DPA acts as the antenna ligand of Tb 3+ to sensitize its luminescence, and Pi enhances the sensitization of DPA by reducing the distan ce between DPA and Tb 3+ . In addition, the coordination of Pi with Tb 3+ can reduce the quenching effect by water molecules, further enhancing Tb 3+ fluorescence. Due to the competitive binding between DPA and Tb 3+ , the coordination between Luminol and Tb 3+ i s weakened, and some Luminol become free, leading to their fluorescence quenching. Based on the dual fluorescence signal, the ratiometric detection of DPA is achieved with a quantitative range of 0.2 ~ 45 μM. In addition, the visual dete c-tion of DPA can be achieved based on the fluorescence color change of this sensing system. The sensing method developed is simple, low cost, and possesses potential in actual applications.","PeriodicalId":7233,"journal":{"name":"Advances in Analytical Chemistry","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88515338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Organic Sulfones by Transition Metal-Catalyzed Coupling of SO2 Surrogates 过渡金属催化SO2代物偶联合成有机砜

Advances in Analytical Chemistry Pub Date : 2023-01-01 DOI: 10.12677/aac.2023.132027

瑶瑶卢

引用次数: 0

MXene-GO Thin Film Driver Based on Humidity Control 基于湿度控制的MXene-GO薄膜驱动器

Advances in Analytical Chemistry Pub Date : 2023-01-01 DOI: 10.12677/aac.2023.133032

明辉邹

引用次数: 0

Circulating Tumor Cell Clusters Enrichment Based on Microfluidic Technology 基于微流体技术的循环肿瘤细胞簇富集

Advances in Analytical Chemistry Pub Date : 2023-01-01 DOI: 10.12677/aac.2023.133028

声锋柯

引用次数: 0

Study on HPLC Fingerprint of Sophorae tonkinensis Radix et Rhizoma Medicinal Materials and Formula Granules 苦参根茎药材及配方颗粒HPLC指纹图谱研究

Advances in Analytical Chemistry Pub Date : 2023-01-01 DOI: 10.12677/aac.2023.133031

梅刘

引用次数: 0

Diethanolamine-Assisted Solvothermal Synthesis of ZnO Nanocrystalline 二乙醇胺辅助溶剂热合成ZnO纳米晶

Advances in Analytical Chemistry Pub Date : 2023-01-01 DOI: 10.12677/aac.2023.133029

飞凡史

引用次数: 0

Development of ZnIn2S4 and Its Modified Materials in the Field of Photocatalysis ZnIn2S4及其改性材料在光催化领域的研究进展

Advances in Analytical Chemistry Pub Date : 2023-01-01 DOI: 10.12677/aac.2023.131003

梦想葛

引用次数: 0

Study on the Optimal Process ofCellulase-Assisted Extraction of Flavonoids from Tobacco Leaves 纤维素酶辅助提取烟叶黄酮类化合物最佳工艺研究

Advances in Analytical Chemistry Pub Date : 2023-01-01 DOI: 10.12677/aac.2023.131007

绘珍尹

引用次数: 0