Archives of clinical and medical case reports最新文献

{"title":"A Comprehensive Analysis of Dermatological Manifestations in Lower Limb Para-Athletes.","authors":"Andre Aabedi, Vera Wang, Devendra K Agrawal","doi":"10.26502/acmcr.96550745","DOIUrl":"10.26502/acmcr.96550745","url":null,"abstract":"<p><p>In this article, a critical evaluation of current evidence is presented on the prevalence, mechanisms, prevention, and management of sport-related skin complications in amputee athletes using lower limb prostheses, highlighting emerging technologies aimed at improving skin health and athletic performance. Skin complications were highly prevalent, affecting 34%-77% of lower limb prosthesis users, with even greater frequency among athletes. The most common conditions included maceration, friction blisters, pressure ulcers, contact dermatitis, verrucous and epidermal hyperplasia, and bacterial or fungal infections. Key risk factors encompassed poor prosthetic fit, elevated activity levels, increased perspiration, prolonged wear, inadequate hygiene, and hot or humid environments. Mechanical loading and shear stress at the socket-skin interface, compounded by moisture and heat retention, were central pathophysiologic drivers. Prevention and management strategies emphasize meticulous prosthetic fitting, consistent hygiene practices, routine skin inspection, and prompt intervention for early lesions. Multidisciplinary collaboration among dermatologists, prosthetists, and rehabilitation specialists improves detection and management outcomes. Recent innovations including vented liners, temperature-regulating materials, antimicrobial coatings, and sensor-based \"smart prosthetics\" show promise in reducing friction, heat, and infection risk, though evidence in athletic populations remains limited. Cutaneous complications in amputee athletes are common, multifactorial, and preventable. Optimal prosthetic fit, athlete education, and coordinated interdisciplinary care are essential for minimizing morbidity and maintaining athletic participation. Technological advancements such as real-time pressure and temperature monitoring, antimicrobial materials, and adaptive socket systems may transform prevention strategies, but further sport-specific, longitudinal research is required to validate their clinical impact and guide evidence-based practice.</p>","PeriodicalId":72280,"journal":{"name":"Archives of clinical and medical case reports","volume":"10 1","pages":"18-25"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13038035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Care of HIV Patients in Long-Term Care Facilities: A Growing Concern and a Call to Action.","authors":"Minghsun Liu, William D King, Derrick Butler, Mitchell H Liu","doi":"10.26502/acmcr.96550727","DOIUrl":"10.26502/acmcr.96550727","url":null,"abstract":"<p><p>As the population of people living with HIV (PWH) ages, they face increased risks of chronic diseases and may require care in nursing homes (NHs). This study identifies systemic barriers to optimal HIV care in NHs through three case examples, illustrating issues such as knowledge gaps in HIV management across the care spectrum, miscommunication during transition of care, and stigma. Proposed solutions include targeted education, improved drug interaction software, and enhanced protocols for HIV care in NHs. Addressing these gaps is crucial for improving outcomes for this aging and vulnerable population.</p>","PeriodicalId":72280,"journal":{"name":"Archives of clinical and medical case reports","volume":"9 4","pages":"164-170"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12410836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case of Nisin Oral Ingestion and its LC-MS/MS Detection in Human Urine Over Time: A Case Report.","authors":"Pachiyappan Kamarajan, Ahmad Kassem, Allan Radaic, James Wohlschlegel, Yvonne L Kapila","doi":"10.26502/acmcr.96550707","DOIUrl":"10.26502/acmcr.96550707","url":null,"abstract":"<p><strong>Objective: </strong>Nisin is a bioactive peptide with antibacterial properties that has been examined for its therapeutic potential. This case report documents the development of a targeted mass spectrometry assay that accurately measures nisin levels in human urine following oral ingestion.</p><p><strong>Case presentation: </strong>Nisin ZP was orally ingested by a 59-year-old healthy white female then LC-MS/MS methodology was used to detect its excretion in human urine over time over 2 days. Briefly, 20 grams of nisin were ingested in two doses of 10 grams/150 ml of water. Sterile urine was then collected over 2 days. Urine was centrifuged to precipitate insoluble material followed by filtration through a 10 kilodalton molecular weight cutoff membrane. The filtrate was then concentrated by lyophilization, desalted, and then analyzed by LC-MS/MS. After online fractionation using C18 reversed-phase chromatography, the sample was electrosprayed into a Thermo Fusion Lumos mass spectrometer. Data was acquired using a parallel reaction monitoring (PRM) strategy focused on the +5 charge states of nisin. Extracted ion chromatograms for MS/MS fragments corresponding to those charge states were generated using the skyline algorithm and used for quantitation of nisin. Western blotting was also used to evaluate the presence of nisin in the urine samples.</p><p><strong>Results: </strong>Orally ingested nisin can be detected early in human urine after oral ingestion. Mass spectrometry data revealed that nisin was detected in urine samples 4-20 hours after the first ingestion and up to 14 hours after the second ingestion, indicating a potentially fast turnover and excretion of nisin in the human body. In line with the mass spectrometry data, immunoblotting data validated the findings, further supporting the notion of a fast turnover and excretion of nisin.</p><p><strong>Conclusion: </strong>We successfully applied the LC-MS/MS method to analyze nisin in urine obtained after oral administration of therapeutic doses of nisin. To the best of our knowledge, this constitutes the first report of nisin's detection following human oral ingestion and its presence in urine after excretion.</p>","PeriodicalId":72280,"journal":{"name":"Archives of clinical and medical case reports","volume":"9 2","pages":"38-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Critical Analysis of the Clinical Use of Incretin-Based Therapies: Efficacy and Adverse Events.","authors":"Ilana Radparvar, Devendra K Agrawal","doi":"10.26502/acmcr.96550740","DOIUrl":"10.26502/acmcr.96550740","url":null,"abstract":"<p><p>Obesity is a major public health challenge in the United States, despite widespread implementation of regulated diet plans, exercise programs, behavioral interventions, and surgical procedures. The emergence of incretin-based therapies, particularly GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide) receptor agonists, has transformed the therapeutic landscape for initially type 2 diabetes and now obesity. Beyond their metabolic effects, incretin therapies exert meaningful cardiovascular, gastrointestinal, and neuroprotective actions. Semaglutide, a GLP-1 receptor agonist, and tripeptide, a dual GLP-1/GIP agonist, demonstrate substantial weight reduction, improved glycemic control, and reductions in cardiometabolic risk factors. Tirzepatide consistently produces greater weight loss effects than semaglutide, likely due to synergistic dual-receptor effects. However, these therapies are accompanied by adverse effects, most commonly gastrointestinal disturbances, and, less frequently, gallbladder disease, pancreatitis, or rare ophthalmologic concerns. Long-term safety data remain limited, particularly in older adults, pediatric patients, pregnant women, and individuals with comorbid disease. Emerging evidence also suggests potential roles in cancer prevention, hypertension, and neurodegenerative disease. As the indications for incretin-based therapies continue to expand, longer-duration trials and more diverse study populations will be essential to fully examine their long-term clinical effects. Though these agents hold considerable promise, careful and informed use remain vital.</p>","PeriodicalId":72280,"journal":{"name":"Archives of clinical and medical case reports","volume":"9 6","pages":"242-253"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nisin ZP Combined with Limited Chemotherapy in Oropharyngeal Squamous Cell Carcinoma: A Case Report.","authors":"Qianlin Ye, Aimin He, Yeping Wu, Yvonne L Kapila","doi":"10.26502/acmcr.96550671","DOIUrl":"10.26502/acmcr.96550671","url":null,"abstract":"<p><strong>Objective: </strong>This case report describes and discusses the therapeutic potential of nisin ZP as adjunctive therapy in patients with oral squamous cell carcinoma (OSCC).</p><p><strong>Case report: </strong>A 43-year-old Asian male with OSCC initiated treatment with Paclitaxel and Cisplatin chemotherapy. Nisin ZP was administrated during and after the chemotherapy.</p><p><strong>Results: </strong>The patient experienced symptom relief and significant tumor regression following administration of nisin ZP.</p><p><strong>Conclusion: </strong>Nisin ZP shows promising potential as an adjunctive therapy for OSCC, offering symptom relief and contributing to tumor size reduction.</p>","PeriodicalId":72280,"journal":{"name":"Archives of clinical and medical case reports","volume":"8 3","pages":"112-115"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12945336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual Skin Adverse Event after Switching from Intravenous to Subcutaneous VEDOLIZUMAB Therapy in Patients with Ulcerative Colitis","authors":"Anne-Sophie Peaucelle, C. Gay, M. Lefèvre, M. Barrau, G. Boschetti, S. Nancey, X. Roblin","doi":"10.26502/acmcr.96550576","DOIUrl":"https://doi.org/10.26502/acmcr.96550576","url":null,"abstract":". Soon, she complained about occurrence of","PeriodicalId":72280,"journal":{"name":"Archives of clinical and medical case reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69343888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report of Modified Sauvé-Kapandji Technique Using Endobutton Suture in Secondary Treatment of Madelung Deformity","authors":"Ghassan Zakhia-Douaihy, Yehia Tfayli, Ahmad Salaheddine Naja, M. Issa, Jean Paul Rizk","doi":"10.26502/acmcr.96550587","DOIUrl":"https://doi.org/10.26502/acmcr.96550587","url":null,"abstract":"The Sauvé-Kapandji technique is considered a useful treatment option for distal radioulnar joint instability encountered in many conditions, such as Madelung deformity or in post-traumatic entities. However, post-operative instability of the proximal ulnar stump and radioulnar convergence may be symptomatic and is still a major concern. Despite proximal ulnar stump stabilization with various techniques, many patients still complain of pain and limitation of wrist movement. We report a case of a patient with Madelung disease treated initially by corrective radial and ulnar osteotomy, and then encountered a post-traumatic distal radioulnar joint instability. This condition was treated with a modified Sauvé-Kapandji procedure using a single endobutton suture, leading to good clinical and radiological results.","PeriodicalId":72280,"journal":{"name":"Archives of clinical and medical case reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69343955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nivolumab PD-1 Blockade as Bridge to Allogeneic Stem Cell Transplant (HSCT) in Gray-Zone Lymphoma: Case Report","authors":"M. Nicolosi, Chiara Maria Dellacasa, M. Novo, A. Busca, R. Freilone, B. Botto","doi":"10.26502/acmcr.96550614","DOIUrl":"https://doi.org/10.26502/acmcr.96550614","url":null,"abstract":"Received: April 17, 2023 Accepted: May 25, 2023 Published: June 21, 2023 Abstract Mediastinal Gray-zone lymphoma (GZL) is a rare entity of lymphoma, with a typical overlapping in terms of biologic and morphologic features between classic Hodgkin lymphoma (cHL) and primary mediastinal large B-cell lymphoma (PMBCL). The therapeutic approaches for these patients remain controversial, and most standard approaches include a combination of chemotherapy, immunotherapy, and, recently, radiation. Unfortunately, overall survival (OS) and progression free survival (PFS) remain dreary. This case report will discuss an adult patient with mediastinal GZL treated as first line with chemotherapy approaches; after an initial lack of response, we decided for a strategy with the anti PD-1 blockade Nivolumab as bridge to the allogeneic hematopoietic stem cell transplant (HSCT). The patient obtained a complete response before the HSCT maintaining this result after the HSCT with temporary grade I and II GVHD, suggesting the important role of the checkpoint inhibitor in this setting of patients. Clinical trials, with larger groups of patients, and longer follow-up are needed to better define safety and prognostic impact of anti PD1 and subsequent allogeneic HCT for the treatment of GZL.","PeriodicalId":72280,"journal":{"name":"Archives of clinical and medical case reports","volume":"2017 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69344313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Herpesvirus 6 Reactivation: A Rare Case of Acute Liver Failure and Literature Review","authors":"H. Wozniak, Jeanne-Laure Vionnet, M. Schibler, Claudia Paula Heidegger, J. Pugin, L. Spahr, S. Cereghetti","doi":"10.26502/acmcr.96550564","DOIUrl":"https://doi.org/10.26502/acmcr.96550564","url":null,"abstract":",","PeriodicalId":72280,"journal":{"name":"Archives of clinical and medical case reports","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69344326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Huaier Effects on Prevention and Inhibition of Spontaneous SARS-CoV-2 Virion Production by Repeated Pfizer-BioNTech mRNA Vaccination","authors":"Manami Tanaka, Tomoo Tanaka, Fei Teng, Xiaolong Zhu, Hong Lin, Zhu-Quan Luo, S. Sadahiro, Toshiyuki Suzuki, Y. Maeda, Ding Wei, Zheng Lu","doi":"10.26502/acmcr.96550568","DOIUrl":"https://doi.org/10.26502/acmcr.96550568","url":null,"abstract":",","PeriodicalId":72280,"journal":{"name":"Archives of clinical and medical case reports","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69344338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}