Advanced Biomedical Research最新文献

{"title":"Quality of Professional Life and Its Association with Emotional Well-Being among COVID-19 Physicians and Nurses.","authors":"Reza Azizkhani, Azita Azimi Meibody, Ahmad Sadeghi, Gloria Meibody-Tabar, Fleuria Flechon-Meibody, Behrooz Ataei, Soheila Kouhestani","doi":"10.4103/abr.abr_173_21","DOIUrl":"10.4103/abr.abr_173_21","url":null,"abstract":"<p><strong>Background: </strong>The present study was to compare the professional quality of life (ProQOL) and its association with the emotional well-being among the physicians and nurses in contact with COVID-19 patients in Iran and France.</p><p><strong>Materials and methods: </strong>The study was performed on 903 nurses and physicians in contact with COVID-19 patients in Iran and France.he subjects completed their demographics online and then answered questions addressing their job stress and emotion associated with their contact with COVID-19 patients and ProQOL. Finally, the collected data were analyzed using the SPSS software (ver. 25).</p><p><strong>Results: </strong>According to the results of the present study, the degree of contact with COVID-19 patients had a significant role in compassion satisfaction, burnout, and compassion fatigue, with the coefficient effects of 0.459, 0.688, and 0.433, respectively (<i>P</i> < 0.05). The emotional well-being had a significant role in increasing compassion satisfaction (<i>B</i> = 0.505, <i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>According to the results of the present study, factors such as contact with a COVID-19 patient, emotional well-being, gender, and marital status had a significant effect on dimensions of ProQOL in both Iran and France. Considering that the entire focus of the physicians and nurses is on the health of COVID-19 patients and they have no concentration on improving their emotional state, it seems that supporting them in terms of psychological self-care and considering its indirect impact on the quality of professional performance are of particular significance.</p>","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1f/89/ABR-12-1.PMC10012020.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9138623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicentricity in Different Molecular Subtypes of Breast Cancer: A Cross-sectional Study in Isfahan.","authors":"Azar Baradaran, Maryam Derakhshan, Saba Raeisi, Sina Neshat, Sina Raeisi","doi":"10.4103/abr.abr_208_21","DOIUrl":"10.4103/abr.abr_208_21","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is the most common cancer leading to death in women. Women with multicentric breast cancer were reported more likely to have poor prognosis. Here, we decided to study and compare the frequency distribution of multicentricity in different subtypes of breast cancer.</p><p><strong>Materials and methods: </strong>This is a cross-sectional study that was performed in 2019-20 on medical records and breast pathology reports of 250 patients who undergone mastectomy due to breast cancer. Demographic data of all patients including age, along with other medical data such as menstruation condition, breast cancer grade, multicentricity status, stage, and expression of estrogen receptor (ER), progesterone (PR), and human epidermal growth factor receptor 2 (HER2) receptors were collected from medical records. Samples were divided into four subtypes of Luminal B, Luminal A, HER2 expressing, and basal-like.</p><p><strong>Results: </strong>The mean age of patients was 50.21 ± 11.15 years. Ninety-five patients (38%) had multicentricity and HER2 expressing (48.5%) and Luminal A (41.4%) were most common in patients with multicentricity. In addition, basal-like group presented with least multicentricity (13.5%) among the subtypes (<i>P</i> = 0.008). We also showed significant increased chances of multicentricity in Luminal B (odds ratio [OR] = 3.782) (<i>P</i> = 0.033), Luminal A (OR = 5.164) (<i>P</i> = 0.002), and HER2-expressing group (OR = 5.393) (<i>P</i> = 0.011).</p><p><strong>Conclusions: </strong>Taken together, we showed significantly increased chances of multicentricity in patients with HER2-expression, Luminal A, and Luminal B groups compared to basal-like group or triple negative. These results were in line with most previous studies; however, we showed higher rates of multicentricity among our population compared to some previous reports.</p>","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"9"},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/a2/ABR-12-9.PMC10012031.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9131158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phospholipase Activity of <i>Candida</i> Species Isolated from Diabetic Patients.","authors":"Negar Amini,&nbsp;Rasoul Mohammadi","doi":"10.4103/abr.abr_87_22","DOIUrl":"https://doi.org/10.4103/abr.abr_87_22","url":null,"abstract":"<p><strong>Background: </strong>Candidiasis is one of the prevalent fungal infections caused by the genus <i>Candida</i>. The clinical manifestation ranges from mucocutaneous colonization to disseminated and fatal infections such as candidemia. Diabetes mellitus is one of the significant predisposing factors for this fungal infection. <i>Candida</i> spp. may release many exoenzymes such as phospholipase to debilitate the immune system and facilitate adherence and invasion of the fungus to the host cells. The aim of the present study is evaluation of phospholipase activity of <i>Candida</i> species isolated from candidemia and gastroesophageal candidiasis (GEC) among diabetic patients.</p><p><strong>Materials and methods: </strong>Eighty-three <i>Candida</i> isolates were evaluated for enzyme activity by phenotypic (the precipitation zone around the colonies) and molecular methods (detection of phospholipase genes using duplex polymerase chain reaction with specific primers).</p><p><strong>Results: </strong>Eight out of eighty-three clinical isolates (9.6%) were negative for phospholipase production. All phospholipase producers among candidemia and GEC isolates were categorized in high production group.</p><p><strong>Conclusions: </strong>Our findings revealed no differences in phospholipase activity among isolates obtained from different body sites (blood, oesophagus and stomach); however, non-<i>albicans Candida</i> species had less phospholipase activity.</p>","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"19"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/aa/28/ABR-12-19.PMC10012014.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9132689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Negative Effects of Opium Tincture on Memory and Hippocampal Neurons in the Presence of Chicory Extract.","authors":"Alireza Bakhshayesh,&nbsp;Roghayeh Eslami Farsani,&nbsp;Reihaneh Seyedebrahimi,&nbsp;Shima Ababzadeh,&nbsp;Fatemeh Heidari,&nbsp;Mohsen Eslami Farsani","doi":"10.4103/abr.abr_210_21","DOIUrl":"https://doi.org/10.4103/abr.abr_210_21","url":null,"abstract":"<p><strong>Background: </strong>Due to the high prevalence of addiction in society and the need to its attention, various methods are used for addiction withdrawal. The side effects of some methods restrict their use and increase the risk of recurrence. One of the Iranian useful methods is consumption of opium tincture (OT) that may cause brain structure and memory defects. Hence, this study aimed the effects of different doses of OT on memory and hippocampal neurons with the use of an antioxidant such as various concentrations chicory.</p><p><strong>Materials and methods: </strong>In the present study, 70 Wistar rats were randomly divided into 10 groups and the effect of various doses of chicory extract and OT were assessed on memory by the passive avoidance test. The neurons and astrocyte cells numbers in dentate gyrus were investigated, using histological examination.</p><p><strong>Results: </strong>In passive avoidance test, the total time in dark compartment was significantly more in groups with 100 and 75 μl OT compared with control and normal saline groups (<i>P</i> < 0.001). Traffic number results showed that there was a significant difference between T100 and control groups (<i>P</i> > 0.05). Moreover, initial latency time was significantly shorter in groups with 75 and 100 μl of OT compared with control and normal saline groups (<i>P</i> < 0.05). However, the presence 250 mg/kg of chicory increases granular layer thickness of dentate gyrus and number of neurons.</p><p><strong>Conclusion: </strong>The use of 250 mg/kg of chicory extract may be promising strategy for inducing neurogenesis and this dose could prevent neural damage.</p>","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"23"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7e/d9/ABR-12-23.PMC10012026.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9132684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothyroidism Evaluation after Radiotherapy of Breast and Supraclavicular in Patients with Breast Cancer.","authors":"Mohammad R Karimijavid,&nbsp;Abdolazim S Pashaki,&nbsp;Shiva Borzouei,&nbsp;Elham Khanlarzadeh,&nbsp;Mohammad H Gholami,&nbsp;Safoora Nikzad","doi":"10.4103/abr.abr_218_21","DOIUrl":"https://doi.org/10.4103/abr.abr_218_21","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the risk of hypothyroidism (HT) after radiotherapy (RT) of breast and supraclavicular in patients with breast cancer (BC).</p><p><strong>Materials and methods: </strong>In a historical cohort study, the records of all patients with BC who had been referred to the Mahdieh radiotherapy Center of Hamadan from 2017 to 2019 were reviewed. Demographic characteristics, clinical information, previous and current used treatment methods (surgery, radiotherapy, chemotherapy), number of RT sessions and doses, and HT (TSH >5 mIU/L) were extracted from the patient's documents. Data were analyzed using SPSS software version 16.</p><p><strong>Results: </strong>Out of 304 patients referred to the Center, 266 patients were investigated. The mean TSH was 6.3 ± 7.9 ml/L (1.5 to 65.4). Approximately half of the patients were in Stage 2 of the disease. 37 (16.4%) patients were diagnosed with HT, of which 8.8% were clinical, and 7.5% were subclinical. The mean total dose of HT patients (5621.62 ± 491.67) was significantly higher than other patients (5304.76 ± 937.98). 21 patients (56.8%) in Stage 3 and 4 and 16 (43.2%) patients in Stages 1 and 2 had HT (<i>P</i> = 0.006). Spearman correlation coefficient showed that there was a significant relationship between total dose and TSH hormone (r = 0.624), the number of RT sessions with TSH hormone (r = 0.237), and total dose with T4 hormone (r = -0.232).</p><p><strong>Conclusion: </strong>The findings of this study showed that the risk of HT increases significantly in patients with BC who undergo RT of breast and supraclavicular. Patients with higher stage, more radiation, and more RT sessions are at higher risk of HT.</p>","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"44"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d6/fa/ABR-12-44.PMC10086662.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9305339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Hydroxychloroquine in Pre-exposure Severe Acute Respiratory Syndrome Coronavirus 2 Prophylaxis among High-Risk HealthCare Workers: A Multicenter Study.","authors":"Elahe Nasri,&nbsp;Hamed Fakhim,&nbsp;Mehrdad Salahi,&nbsp;Safiyeh Ghafel,&nbsp;Samane Pourajam,&nbsp;Ali Darakhshandeh,&nbsp;Nazila Kassaian,&nbsp;Somayeh Sadeghi,&nbsp;Behrooz Ataei,&nbsp;Shaghayegh Haghjooy Javanmard,&nbsp;Afsane Vaezi","doi":"10.4103/abr.abr_104_21","DOIUrl":"https://doi.org/10.4103/abr.abr_104_21","url":null,"abstract":"<p><strong>Background: </strong>Prophylaxis could be an established strategy to potentially prevent and control infectious diseases and should be considered in the coronavirus disease 2019 (COVID-19) pandemic. The present study aimed to assess the effectiveness of hydroxychloroquine as a prophylaxis treatment strategy in the reduction of the risk of COVID-19 among health professionals.</p><p><strong>Materials and methods: </strong>The health professionals were randomly assigned (1:1) to the control group without receiving any hydroxychloroquine as prophylaxis and the hydroxychloroquine group receiving a weekly hydroxychloroquine dose of 400 mg up to 12 weeks.</p><p><strong>Results: </strong>A total of 146 health professionals were randomly enrolled in this study between August 11 and November 11 in 2020. Among the screened health professionals, 21 (14.6%) were infected with COVID-19 during the 12 weeks, and 14 (66.6%) out of the 21 health professionals were in the control group. Most participants with COVID-19 had mild symptoms (62%). In addition, 9.5% (<i>n</i> = 2) of the participants suffered from moderate disease and 28.5% were diagnosed with severe symptoms. In the hydroxychloroquine group, 5 (7.1%) and 2 (2.8%) participants were reported with mild and moderate symptoms of COVID-19, respectively, and 2 participants had moderate, 8 (10.9%) participants had mild symptoms, and 6 (8.2%) participants had severe symptoms in the control group, within 3 months. Severe symptoms of COVID-19 were not observed in the hydroxychloroquine group.</p><p><strong>Conclusion: </strong>This study addressed the effect and benefit of hydroxychloroquine administration for the prevention of COVID-19 among health professionals. The improved perception of prophylaxis might highlight its important role in future COVID-19 outbreaks to prevent hospital transmission, which is a major route of spread.</p>","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"3"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d5/fd/ABR-12-3.PMC10012028.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9191804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular and Neural Invasion in Oral Squamous Cell Carcinoma: A Study in an Iranian Population.","authors":"Nakisa Torabinia,&nbsp;Gholamreza Jahanshahi,&nbsp;Vahid Eslami,&nbsp;Forooz Keshani","doi":"10.4103/abr.abr_220_21","DOIUrl":"https://doi.org/10.4103/abr.abr_220_21","url":null,"abstract":"<p><strong>Background: </strong>Among various parameters used to predict the outcome of malignancy, nerve invasion has been widely considered as a sign of aggressive behavior in oral cancers. According to the importance of neural invasion in predicting the outcome of oral squamous cell carcinoma (OSCC), this study aimed to evaluate the prevalence of neural and vascular invasion in OSCC.</p><p><strong>Materials and methods: </strong>In this descriptive, analytical, and cross-sectional study, paraffin-embedded tissues of 62 OSCC in the health center of surgery and pathology were evaluated (2013-2015). Patients' archives were evaluated and recorded in terms of their age and gender. Hematoxylin and eosin (H&E) slides were then examined by two oral pathologists and scrutinized for the presence of nerve involvement, tumor differentiation, vascular and lymph node invasion, and depth of invasion. Data were analyzed using SPSS version 23, <i>t</i>-test, and one-way ANOVA (<i>P</i> < 0.05).</p><p><strong>Results: </strong>Of 62 tumors, 12 patients showed only nerve invasion, 17 cases had only vascular invasion, and seven patients had both neural and vascular invasion, simultaneously, known as a neurovascular invasion. Furthermore, there was no vascular and neural invasion in 26 cases. There was a statistically significant correlation between vascular and neural invasion and the tumor site (<i>P</i> = 0.045). The highest frequency of neural invasion, as well as vascular invasion, was related to tongue tumors.</p><p><strong>Conclusion: </strong>The relation between neural and vascular invasion in OSCC with tumor's location was statistically significant. Lip and tongue carcinoma had shown more neurovascular invasion without relation to gender, age, and cell differentiation.</p>","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"70"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f2/65/ABR-12-70.PMC10186046.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9544490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality Rate and Risk Factors in Pediatric Intensive Care Unit of Imam Hossein Children's Hospital in Isfahan: A Prospective Cross-Sectional Study.","authors":"Fatemeh S Hajidavalu,&nbsp;Atefeh Sadeghizadeh","doi":"10.4103/abr.abr_371_21","DOIUrl":"https://doi.org/10.4103/abr.abr_371_21","url":null,"abstract":"<p><strong>Background: </strong>Various studies have conducted to report the mortality rates and its risk factors in pediatric intensive care unit. This study aimed to determine the mortality prevalence and risk factors in PICU of Imam Hossein Children's Hospital in Isfahan, which is the main referral pediatric hospital in the center of Iran.</p><p><strong>Materials and methods: </strong>This study was performed on 311 patients during a period of 9 months. The questionnaire which included age, gender, length of stay in the PICU and hospital, mortality, history of resuscitation in other wards and readmission, the causes and sources of hospitalization, pediatric risk of mortality (PRISM)-III score, respiratory supports, morbidities like nosocomial infections, acute kidney injury (AKI), multiple organ dysfunction syndrome (MODS) confirmed by pediatric sequential organ failure assessment score (P-SOFA) and glycemic disorders was filled out.</p><p><strong>Results: </strong>One hundred and seventy-seven (56.9%) were males and 103 (33%) were belonged to the age group of 12-59 months. The most prevalent causes of hospitalization were status epilepticus (12.9%) and pneumonia (11.2%). Mortality rate was 12.2%. The significant factors associated with mortality were readmission and history of resuscitation. PRISM-III index showed a significant difference between nonsurvivors and survivors (7.05 ± 6.36 vs. 3.36 ± 4.34, <i>P</i> = 0.001). Complications like AKI, hypoglycemia, MODS and disseminated intravascular coagulation (DIC), length of mechanical ventilation significantly correlated with mortality.</p><p><strong>Conclusions: </strong>Mortality rate was less than that of other developing countries (12.2%) and this was associated with some risk factors included readmission, history of resuscitation, PRISM-III Index; complications like AKI, acute respiratory distress syndrome (ARDS), DIC, mechanical ventilation duration, MODS, hypoglycemia, and P-SOFA index.</p>","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"92"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/82/57/ABR-12-92.PMC10241639.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9591428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atorvastatin and Flaxseed Effects on Biochemical Indices and Hepatic Fat of NAFLD Model in Rats.","authors":"Zahra Eslami,&nbsp;Abdorreza E Moghanlou,&nbsp;Yahya M N P Kandi,&nbsp;Mehdi S Arabi,&nbsp;Alireza Norouzi,&nbsp;Hamidreza Joshaghani","doi":"10.4103/abr.abr_21_22","DOIUrl":"https://doi.org/10.4103/abr.abr_21_22","url":null,"abstract":"<p><strong>Background: </strong>Non-alcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease that affects about 25% of the general population. No definitive treatment for NAFLD has been identified yet. The aim was to determine the effect of atorvastatin (ATO) and flaxseed on related indicators of NAFLD-induced fat/fructose-enriched diet (FFD).</p><p><strong>Materials and methods: </strong>Forty male Wistar rats were divided into five groups. NAFLD groups received FFD and carbon tetrachloride (CCl4) to induce NAFLD. After intervention with ATO (10 mg/kg/day) and/or flaxseed (7.5 g/kg/day), liver enzymes and lipid profiles in serum were determined at eight week of interventions.</p><p><strong>Results: </strong>Triglycerides (TG) and cholesterol (CHO) in FFD + ATO, FFD + flaxseed, and FFD + ATO + flaxseed had a significant decrease and low-density lipoprotein (LDL) level and LDL/high-density lipoprotein (HDL) ratio showed a significant increase in the FFD + flaxseed compared to the FFD. The levels of aspartate transaminase (AST), alanine transaminase (ALT), and gamma-glutamyltransferase (GGT) were significantly reduced in the FFD + ATO, FFD + flaxseed, and the FFD + ATO + flaxseed. In addition, Alkaline phosphatase (ALP) levels were significantly different between normal and FFD. Fasting blood sugar (FBS) levels were significantly different in the FFD + flaxseed and the FFD + ATO + flaxseed compared to the FFD.</p><p><strong>Conclusion: </strong>ATO therapy along with flaxseed controls NAFLD-related indices and FBS. Therefore, it can be stated with caution that ATO and flaxseed can be used to improve lipid profile and reduce the complications of NAFLD.</p>","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"98"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/58/b5/ABR-12-98.PMC10241636.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9597306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toll-Like Receptor 7 a Novel Non-Invasive Inflammatory Genetic Sensor for Ulcerative Colitis Remission Monitoring.","authors":"Hamid Asadzadeh-Aghdaei,&nbsp;Leili Rejali,&nbsp;Mahyar Nourian,&nbsp;Vahid Chaleshi,&nbsp;Naghmeh Zamani,&nbsp;Shaghayegh Baradaran-Ghavami,&nbsp;Mohsen Nemati,&nbsp;Shabnam Shahrokh,&nbsp;Mohsen Norouzinia,&nbsp;Massoud Vosough,&nbsp;Ehsan Nazemalhosseini-Mojarad,&nbsp;Mohammadreza Zali","doi":"10.4103/abr.abr_24_22","DOIUrl":"https://doi.org/10.4103/abr.abr_24_22","url":null,"abstract":"<p><strong>Background: </strong>Ulcerative colitis (UC) and Crohn's disease (CD) are two major types of inflammatory bowel diseases (IBDs). Toll-like receptors (TLRs) are expressed in the innate immune system compartments, in charge of identifying a wide range of microorganisms. The aim of the present study was to evaluate the expression of <i>TLR-2</i>, -<i>7</i>, and -<i>8</i> in peripheral blood mononuclear cells (PBMC) of UC patients as a novel non-invasive primary inflammation sensor for monitoring the clinical course of UC candidates.</p><p><strong>Materials and methods: </strong>In this cross-sectional study, total RNA was extracted from the PBMC of 42 UC patients along with 20 healthy donors. The mRNA levels of <i>TLR-2</i>, -<i>7</i>, and -<i>8</i> were assessed using the quantitative real-time polymerase chain (qRT-PCR) reaction.</p><p><strong>Results: </strong>The present research study demonstrated no significant changes in <i>TLR-2</i> mRNA expression in UC patients in comparison with the control group (<i>P</i> = 0.1264), whereas significant elevation (<i>P</i> = 0.0008) was distinguished in the <i>TLR-7</i> expression of UC participants specifically during the remission course compared with healthy donors and flareup patients (<i>P</i> = 0.0004 and <i>P</i> = 0.0063, respectively). The last selected TLR, <i>TLR-8</i> was not shown remarkable changes either between UC patients and the control group or between clinical courses of the disease.</p><p><strong>Conclusion: </strong>Here, among three nominated TLRs for predicting UC patients, <i>TLR</i>-7 was potentially selected according to the significant difference in mRNA expression in flareup UC patients and control donors. <i>TLR</i>-7 could be used as a novel non-invasive biomarker for monitoring UC patients in the active course of the disease.</p>","PeriodicalId":7225,"journal":{"name":"Advanced Biomedical Research","volume":"12 ","pages":"54"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cf/4f/ABR-12-54.PMC10086669.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9660731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}