Anthony Owusu-Mensah, Omer Berenfeld, Michel Audette
{"title":"ELUCIDATING THE ROLE OF THE HIS-PURKINJE SYSTEM DURING LONG QT MEDIATED ARRHYTHMIAS.","authors":"Anthony Owusu-Mensah, Omer Berenfeld, Michel Audette","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mutation in the hERG gene leading to partial or complete blockade of the rapid delayed rectifier current causes Long QT Type 2 (LQT2) phenotype, the second most common form of Long QT Syndrome. However, the exact involvement of the His-Purkinje System (HPS) remains elusive. We utilized a finite element model of the rabbit ventricles integrated with a HPS to elucidate the role of HPS during LQT2-mediated arrhythmia. Following the induction of persistent reentry from an ectopic stimulus, we isolated the HPS at different time points. Moreover, we varied the coupling resistance and the number of myocytes at the Purkinje-Myocardial Junctions (PMJs) to ascertain how the junctional parameters altered reentry dynamics. Reentry was terminated with the earliest termination time for reentry coinciding with the earliest time the HPS was isolated. This observation provides evidence of direct involvement of the HPS during LQT2-mediated ventricular arrhythmia. Increasing the coupling resistance or the number of myocytes at the PMJs reduced the percentage of successful retrograde propagation during reentry. Thus, the HPS alters reentry dynamics. Our multi-scale computer modeling outcomes offer important new understandings of probable arrhythmia mechanisms under LQT2 circumstances.</p>","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"2023 ","pages":"393-401"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10705055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Influence Research of eWOM on Mindful Consumption Behavior of Second-Hand Clothes","authors":"越 姜","doi":"10.12677/mos.2023.125396","DOIUrl":"https://doi.org/10.12677/mos.2023.125396","url":null,"abstract":"","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75843425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative Study on Different Particle Size Distributions of Porous Electrodes","authors":"佳兴 杨","doi":"10.12677/mos.2023.123264","DOIUrl":"https://doi.org/10.12677/mos.2023.123264","url":null,"abstract":"","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"194 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74482860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Application Research of Wind Power Simulation Platform Based on Prototype Controller","authors":"吉祥 吴","doi":"10.12677/mos.2023.121032","DOIUrl":"https://doi.org/10.12677/mos.2023.121032","url":null,"abstract":"","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73353364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study on Air Distribution of Air-Cooled Refrigerator Box","authors":"浩翔 鲁","doi":"10.12677/mos.2023.123265","DOIUrl":"https://doi.org/10.12677/mos.2023.123265","url":null,"abstract":"","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72740308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modeling Research on the Treatment of Deep Brain Electrical Stimulation in Parkinson’s Disease","authors":"腾 苏","doi":"10.12677/mos.2023.123247","DOIUrl":"https://doi.org/10.12677/mos.2023.123247","url":null,"abstract":"","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74851024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the Relationship between Per Capita Consumption Expenditure and Per Capita Disposable Income of Urban Residents in the Central Region of China","authors":"昭颖 吴","doi":"10.12677/mos.2023.123298","DOIUrl":"https://doi.org/10.12677/mos.2023.123298","url":null,"abstract":"","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75897932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Smart City Construction and Carbon Emission Reduction Performance of Energy-Consuming Enterprises: Intrinsic Mechanisms and Empirical Evidence","authors":"永善 薛","doi":"10.12677/mos.2023.125393","DOIUrl":"https://doi.org/10.12677/mos.2023.125393","url":null,"abstract":"","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80082812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}