发布求助
文献互助 智能选刊 最新文献

Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)最新文献

筛选
英文 中文
COMPUTATIONAL ANALYSIS OF THE NOVEL LQT3 MUTATIONS G1481V AND Q1491H IN MYOCARDIAL AND PURKINJE CELLS. 心肌和浦肯野细胞中lqt3突变g1481v和q1491h的计算分析。
Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online) Pub Date : 2025-05-01 Epub Date: 2025-08-19
Anthony Owusu-Mensah, Omer Berenfeld, Quentin Plumereau, Mohamed Chahine, Michel Audette
{"title":"COMPUTATIONAL ANALYSIS OF THE NOVEL LQT3 MUTATIONS G1481V AND Q1491H IN MYOCARDIAL AND PURKINJE CELLS.","authors":"Anthony Owusu-Mensah, Omer Berenfeld, Quentin Plumereau, Mohamed Chahine, Michel Audette","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Long QT Syndrome type 3 (LQT3) arises from mutations in SCNA5 gene encoding the Nav1.5 sodium channel. We studied two novel mutations (G1481V and Q1491H) found in infants who suffered sudden cardiac death. Using computational modeling, we incorporated experimental data into a Na<sup>+</sup> Markovian model and simulated effects in rabbit cardiac cells. Both mutations caused tissue-specific effects, with Purkinje cells showing more severe action potential prolongation than myocardial cells. At slow heart rates, these mutations triggered early afterdepolarizations (EADs) and delayed afterdepolarizations (DADs) exclusively in Purkinje cells, with Q1491H displaying greater arrhythmogenic potential which was absent in myocardial cells. Enhanced late sodium current underlies these effects, especially in Purkinje cells with fewer repolarization reserves. Our findings suggest targeted therapies: late Na<sup>+</sup> current blockers or Purkinje fiber ablation for patients with these mutations.</p>","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12948445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFECTS OF TORSO IMPEDANCE ON IN SILICO VOLTAGE MAPPING OF CARDIAC DIPOLES OF ROTORS. 躯干阻抗对转子心脏偶极子硅电压映射的影响。
Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online) Pub Date : 2025-05-01 Epub Date: 2025-08-19
Estela Sánchez-Carballo, Francisco M Melgarejo-Meseguer, José Luis Rojo-Álvarez, Omer Berenfeld
{"title":"EFFECTS OF TORSO IMPEDANCE ON IN SILICO VOLTAGE MAPPING OF CARDIAC DIPOLES OF ROTORS.","authors":"Estela Sánchez-Carballo, Francisco M Melgarejo-Meseguer, José Luis Rojo-Álvarez, Omer Berenfeld","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Self-sustained pivoting patterns of cardiac impulses are termed rotors and are proposed as drivers of fibrillation. However, the impact of the impedance properties of the torso on mapping the rotors and their filaments remains unclear. This study aims to conceptually demonstrate how those impedance properties affect the distribution of voltages resulting from rotors in simulations on a torso model segmented from a chest axial CT. Torso compartments were assigned conductivity and capacitance values, and two counter-rotating myocardial rotors were modeled as two dipoles with counter-phase cosine potential waves. Quasi-electrostatic and impedance formalisms were solved using finite element methods to simulate torso voltage and phase distributions. Results revealed that rotor filaments did not reach the surface in the quasi-electrostatic simulations, with the impedance formalism, rotor filaments appeared on the body surface in both potential and phase maps. These computational simulations demonstrate that impedance properties can be relevant for detecting cardiac rotors.</p>","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"2025 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12935134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147312083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ELUCIDATING THE ROLE OF THE HIS-PURKINJE SYSTEM DURING LONG QT MEDIATED ARRHYTHMIAS. 阐明 His-purkinje 系统在长 QT 介导的心律失常中的作用。
Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online) Pub Date : 2023-05-01 Epub Date: 2023-06-26
Anthony Owusu-Mensah, Omer Berenfeld, Michel Audette
{"title":"ELUCIDATING THE ROLE OF THE HIS-PURKINJE SYSTEM DURING LONG QT MEDIATED ARRHYTHMIAS.","authors":"Anthony Owusu-Mensah, Omer Berenfeld, Michel Audette","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mutation in the hERG gene leading to partial or complete blockade of the rapid delayed rectifier current causes Long QT Type 2 (LQT2) phenotype, the second most common form of Long QT Syndrome. However, the exact involvement of the His-Purkinje System (HPS) remains elusive. We utilized a finite element model of the rabbit ventricles integrated with a HPS to elucidate the role of HPS during LQT2-mediated arrhythmia. Following the induction of persistent reentry from an ectopic stimulus, we isolated the HPS at different time points. Moreover, we varied the coupling resistance and the number of myocytes at the Purkinje-Myocardial Junctions (PMJs) to ascertain how the junctional parameters altered reentry dynamics. Reentry was terminated with the earliest termination time for reentry coinciding with the earliest time the HPS was isolated. This observation provides evidence of direct involvement of the HPS during LQT2-mediated ventricular arrhythmia. Increasing the coupling resistance or the number of myocytes at the PMJs reduced the percentage of successful retrograde propagation during reentry. Thus, the HPS alters reentry dynamics. Our multi-scale computer modeling outcomes offer important new understandings of probable arrhythmia mechanisms under LQT2 circumstances.</p>","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"2023 ","pages":"393-401"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10705055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138800223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Influence Research of eWOM on Mindful Consumption Behavior of Second-Hand Clothes eWOM对二手服装有意识消费行为的影响研究
Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online) Pub Date : 2023-01-01 DOI: 10.12677/mos.2023.125396
越 姜
{"title":"The Influence Research of eWOM on Mindful Consumption Behavior of Second-Hand Clothes","authors":"越 姜","doi":"10.12677/mos.2023.125396","DOIUrl":"https://doi.org/10.12677/mos.2023.125396","url":null,"abstract":"","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75843425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative Study on Different Particle Size Distributions of Porous Electrodes 多孔电极不同粒径分布的比较研究
Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online) Pub Date : 2023-01-01 DOI: 10.12677/mos.2023.123264
佳兴 杨
{"title":"Comparative Study on Different Particle Size Distributions of Porous Electrodes","authors":"佳兴 杨","doi":"10.12677/mos.2023.123264","DOIUrl":"https://doi.org/10.12677/mos.2023.123264","url":null,"abstract":"","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"194 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74482860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application Research of Wind Power Simulation Platform Based on Prototype Controller 基于原型控制器的风电仿真平台应用研究
Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online) Pub Date : 2023-01-01 DOI: 10.12677/mos.2023.121032
吉祥 吴
{"title":"Application Research of Wind Power Simulation Platform Based on Prototype Controller","authors":"吉祥 吴","doi":"10.12677/mos.2023.121032","DOIUrl":"https://doi.org/10.12677/mos.2023.121032","url":null,"abstract":"","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73353364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research on Behavior-Based Programming for Unmanned Aerial Vehicle Navigation System 基于行为的无人机导航系统规划研究
Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online) Pub Date : 2023-01-01 DOI: 10.12677/mos.2023.124342
飞 王
{"title":"Research on Behavior-Based Programming for Unmanned Aerial Vehicle Navigation System","authors":"飞 王","doi":"10.12677/mos.2023.124342","DOIUrl":"https://doi.org/10.12677/mos.2023.124342","url":null,"abstract":"","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74152578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on Air Distribution of Air-Cooled Refrigerator Box 风冷式冷冻箱气流组织的研究
Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online) Pub Date : 2023-01-01 DOI: 10.12677/mos.2023.123265
浩翔 鲁
{"title":"Study on Air Distribution of Air-Cooled Refrigerator Box","authors":"浩翔 鲁","doi":"10.12677/mos.2023.123265","DOIUrl":"https://doi.org/10.12677/mos.2023.123265","url":null,"abstract":"","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72740308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling Research on the Treatment of Deep Brain Electrical Stimulation in Parkinson’s Disease 脑深部电刺激治疗帕金森病的模型研究
Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online) Pub Date : 2023-01-01 DOI: 10.12677/mos.2023.123247
腾 苏
{"title":"Modeling Research on the Treatment of Deep Brain Electrical Stimulation in Parkinson’s Disease","authors":"腾 苏","doi":"10.12677/mos.2023.123247","DOIUrl":"https://doi.org/10.12677/mos.2023.123247","url":null,"abstract":"","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74851024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Relationship between Per Capita Consumption Expenditure and Per Capita Disposable Income of Urban Residents in the Central Region of China 中部地区城镇居民人均消费支出与人均可支配收入关系研究
Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online) Pub Date : 2023-01-01 DOI: 10.12677/mos.2023.123298
昭颖 吴
{"title":"Exploring the Relationship between Per Capita Consumption Expenditure and Per Capita Disposable Income of Urban Residents in the Central Region of China","authors":"昭颖 吴","doi":"10.12677/mos.2023.123298","DOIUrl":"https://doi.org/10.12677/mos.2023.123298","url":null,"abstract":"","PeriodicalId":72238,"journal":{"name":"Annual Modeling and Simulation Conference (ANNSIM). Annual Modeling and Simulation Conference (Online)","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75897932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书