Annals of clinical case reports最新文献

Correlation between Transillumination Echocardiography and Pathologic Anatomy in a Left Atrial Myxoma: A Case Report 左心房粘液瘤超声心动图与病理解剖的相关性研究（附1例报告）

Annals of clinical case reports Pub Date : 2023-02-10 DOI: 10.25107/2474-1655-v8-id2391

Ibarra-Moreno A, Vives-Ledesma G, Abril-Vázquez Ap, Singer-De-la-Garza J, Bautista-Perez-Gavilan A, Villa-Ramirez Ca, Rodríguez-Salazar Ma, Molina-Castillo S, Rubalcava-Gracia-Medrano M, Flores-Peralta Jh, Espinola-Zavaleta N, Fraustro Aa, Alexanderson-Rosas E

引用次数: 0

Pancreatic Neuroendocrine Tumour as a Cause of Ectopic Cushing’s Syndrome: A Rare Case Report 胰腺神经内分泌肿瘤作为异位库欣综合征的原因:一个罕见的病例报告

Annals of clinical case reports Pub Date : 2022-07-22 DOI: 10.25107/2474-1655-v7-id2261

Jocelyn Ward J, Tahir Omer, Ibrahim M Souar El-Dahab

引用次数: 0

Tocotrienols: Exciting Biological and Pharmacological Properties of Tocotrienols and Naturally Occurring Compounds, Part II. 生育三烯酚：生育三烯酚和天然化合物令人兴奋的生物和药理特性，第二部分。

Annals of clinical case reports Pub Date : 2022-07-01 Epub Date: 2022-07-18

Asaf A Qureshi

{"title":"Tocotrienols: Exciting Biological and Pharmacological Properties of Tocotrienols and Naturally Occurring Compounds, Part II.","authors":"Asaf A Qureshi","doi":"","DOIUrl":"","url":null,"abstract":"δ-Tocotrienol plus AHA Step-1 diet in hypercholesterolemic subjects caused reductions in lipid parameters (14% to 18%) with 250 mg/d dose, and 500 mg/d resulted induction in these parameters. Although, α-tocopherol is the most bioavailable form of vitamin E. There are few reports on bioavailability of tocotrienols in humans. Pharmacokinetics and bioavailability of δ-tocotrienol was quantified on plasma levels of tocol isomers, cytokines, and microRNAs. Subjects were fed doses of 125 mg/d to 500 mg/d. Plasma samples collected between 0 h to 10 h, levels of tocols estimated by HPLC, which resulted dose-dependent increases in AUC0-10, Cmax0-∞, Tmaxh, t1/2h, Cl-T 1/h, Vd/f, keh-1. Maximum plasma levels of δ-tocotrienol were at 3 h (125 mg/d to 250 mg/d), 6 h (500 mg/d). Effects of 32 compounds were evaluated on TNF-α secretion, nitric oxide production, and gene expression (TNF-α, IL-1β, IL-6, iNOS activity) in PPAR-α knockout mice. Anticancer activities of thiostrepton, dexamethasone, 2-methoxyestradiol, δ-tocotrienol, quercetin, amiloride, quinine sulfate showed significant anti-proliferative properties in Hela cells, pancreatic, prostate, breast, lungs, melanoma, B-lymphocytes, T-cells (40% to 95%). Results of plasma total mRNAs after δ-tocotrienol feeding to hepatitis C patients revealed significant down-regulated gene expression of pro-inflammatory cytokines. A mixture of δ-tocotrienol, resveratrol, vitamin D3 (NS-3) were given two capsules/d or cellulose/olive oil as placebo to individuals with T2DM (24-weeks). Significant down-regulation (15% to 74%) of gene expression in diabetes biomarkers and decreases i n serum levels of fasting-glucose, HbA1c, hs-CRP, fasting-insulin, HOMA-IR, MDA (9% to 23%) were observed with NS-3 treated T2DM. Pure plasma mRNAs and miRNAs of pre-dose vs. post-dose of NS-3 treated samples were analyzed by Next Generation Sequencing (NGS). Venn diagrams have established genetic regulatory network images and canonical signaling pathways for mRNA, miRNA, and paired mRNA-miRNA.","PeriodicalId":72215,"journal":{"name":"Annals of clinical case reports","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9762682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9355558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BioNTech/Pfizer-Vaccine, Statin Therapy and Self Limiting Rhabdomyolysis BioNTech/辉瑞-疫苗，他汀类药物治疗和自限性横纹肌溶解

Annals of clinical case reports Pub Date : 2022-05-03 DOI: 10.25107/2474-1655-v7-id2178

H. J., M. M, S. B, Hansen Hc

{"title":"BioNTech/Pfizer-Vaccine, Statin Therapy and Self Limiting Rhabdomyolysis","authors":"H. J., M. M, S. B, Hansen Hc","doi":"10.25107/2474-1655-v7-id2178","DOIUrl":"https://doi.org/10.25107/2474-1655-v7-id2178","url":null,"abstract":"In mid July 2021 an 80-year-old woman received her second COVID-19 immunization with the BioNTech/Pfizer-vaccine (Comirnaty©). After 24 h she developed severe myalgia in her thighs (8/10 NRS) followed by a progressive muscle weakness. Ten days later, she presented herself to our emergency room with a proximal tetraparesis without sensory deficits. She had no fever and reported no relevant trauma or toxic exposures. She complained of general malaise and had painful thigh and deltoid muscles on palpation. She was neither able to walk nor to rise out of bed without assistance but could lift her head and showed symmetrical abdominal contractions and no scapula alata. Handgrip, speech, swallowing and ocular motor functions remained intact throughout. Her lab results revealed elevated serum Creatine Kinase (CK) (9.603 U/L, ref. <195 U/L) and myoglobin (11.162 μg/L, ref. 25 μg/L to 58 μg/L) levels while TSH, fT4 and CRP were unremarkable. She had no hyperkalemia (4.0 mmol/L) taking hydrochlorothiazide (25 mg) on a regular basis. To avoid further muscle damage we halted her long running statin therapy (80 mg simvastatin) and ensured adequate volume substitution. She developed no signs of acute kidney injury. Within the next seven days her deficits and lab results progressively improved and finally returned to normal (Figure 1). We discharged her seven days later after making a full recovery apart from minor residual muscle pain. In a follow-up over the telephone four weeks later, she indicated no lasting symptoms or deficits.","PeriodicalId":72215,"journal":{"name":"Annals of clinical case reports","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46572186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tocotrienols: Exciting Biological and Pharmacological Properties of Tocotrienols and other Naturally Occurring Compounds, Part I. 生育三烯酚：生育三烯酚和其他天然化合物令人兴奋的生物和药理特性，第一部分。

Annals of clinical case reports Pub Date : 2022-05-01 Epub Date: 2022-05-12

A A Qureshi

{"title":"Tocotrienols: Exciting Biological and Pharmacological Properties of Tocotrienols and other Naturally Occurring Compounds, Part I.","authors":"A A Qureshi","doi":"","DOIUrl":"","url":null,"abstract":"Inflammation has been implicated in cardiovascular disease and tocotrienols are potent hypocholesterolemic agents that reduce β-hydroxy-β-methyl-glutaryl coenzyme A reductase activity, which is degraded via the ubiquitin-proteasome pathway. Impact of various tocotrienols (α-, γ-, or δ-tocotrienol) treatments inhibit the chymotrypsin-like activity of 20S rabbit muscle proteasome (>50%) in RAW 264.7 cells and BALB/c mice. Moreover, the effect of various tocotrienols (α-, γ-, or δ-tocotrienol), α-tocopherol, quercetin, riboflavin, (-) Corey lactone, amiloride, dexamethasone supplemented diets fed to chickens (4-weeks) resulted in reduction of total cholesterol, LDL-cholesterol, and triglycerides. This trend was also observed in macrophages from RAW 264.7 cells, in LPS-induced thioglycolate-elicited peritoneal macrophages derived from C57BL/6, BALB/c, LMP7/MECL-1-/-, and PPAR-α-/- knockout mice from young (4-week-old) and senescent (42-week-old) mice, resulting in significant inhibition of TNF-α and nitric oxide levels (30% to 70%), blocked degradation of P-IκB protein, and decreased activation of NF-κB, followed gene suppression of mRNA levels of TNF-α, IL-1β, IL-6, and iNOS. In human study, normal or hypercholesterolemic subjects administered two capsules/d of NS-7 or NS-6 (4-weeks) showed decrease in serum CRP, NO, γ-GT, total cholesterol, LDL-cholesterol, and triglycerides levels in normal as compared to hypercholesterolemic subjects (12% to 39%). In second study, hypercholesterolemic subjects were given increasing doses of δ-tocotrienol (125 mg, 250 mg, 500 mg, and 750 mg/day) plus AHA Step-1 diet (4-weeks). The most effective dose of tocotrienols (250 mg/day) may be used to lower serum NO (40%), CRP (40%), MDA (34%), γ-GT (22 %), and inflammatory cytokines IL-1α, IL-12, IFN-γ by 15% to 17%, and increase TAS levels by 22%.","PeriodicalId":72215,"journal":{"name":"Annals of clinical case reports","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9426648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guillain-Barré Syndrome after Hematopoietic Transplantation 造血移植后格林-巴利综合征

Annals of clinical case reports Pub Date : 2022-04-20 DOI: 10.25107/2474-1655-v7-id2161

Christianne Tolêdo de Souza Leal, M. Cruzeiro, A. H. Hallack Neto

引用次数: 0

A New Minimally Invasive Procedure for Muscle, Back, Neck Pain and Radiculopathy - The Myofascial Nerve Block. 一种治疗肌肉、背部、颈部疼痛和神经根病的新微创手术-肌筋膜神经阻滞。

Annals of clinical case reports Pub Date : 2022-01-01 DOI: 10.25107/2474-1655-v7-id2233

S Omoigui, A Fadare

引用次数: 2

Does Autoimmunity have a Role in Myoclonic Astatic Epilepsy? A Case Report of Voltage Gated Potassium Channel Mediated Seizures. 自身免疫在肌阵挛性失稳性癫痫中起作用吗?电压门控钾通道介导癫痫发作1例报告。

Annals of clinical case reports Pub Date : 2016-01-01 Epub Date: 2016-11-03

Deepa Sirsi, Alison Dolce, Benjamin M Greenberg, Drew Thodeson

{"title":"Does Autoimmunity have a Role in Myoclonic Astatic Epilepsy? A Case Report of Voltage Gated Potassium Channel Mediated Seizures.","authors":"Deepa Sirsi, Alison Dolce, Benjamin M Greenberg, Drew Thodeson","doi":"","DOIUrl":"","url":null,"abstract":"Background: There is expanding knowledge about the phenotypic variability of patients with voltage gated potassium channel complex (VGKC) antibody mediated neurologic disorders. The phenotypes are diverse and involve disorders of the central and peripheral nervous systems. The central nervous system manifestations described in the literature include limbic encephalitis, status epilepticus, and acute encephalitis.Patient description: We report a 4.5 year-old boy who presented with intractable Myoclonic Astatic Epilepsy (MAE) or Doose syndrome and positive VGKC antibodies in serum. Treatment with steroids led to resolution of seizures and electrographic normalization.Conclusion: This case widens the spectrum of etiologies for MAE to include autoimmunity, in particular VGKC auto-antibodies and CNS inflammation, as a primary or contributing factor. There is an evolving understanding of voltage gated potassium channel complex mediated autoimmunity in children and the role of inflammation and autoimmunity in MAE and other intractable pediatric epilepsy syndromes remains to be fully defined. A high index of suspicion is required for diagnosis and appropriate management of antibody mediated epilepsy syndromes.","PeriodicalId":72215,"journal":{"name":"Annals of clinical case reports","volume":"1 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5754005/pdf/nihms855319.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35715611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0