Christianne Tolêdo de Souza Leal, M. Cruzeiro, A. H. Hallack Neto
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引用次数: 0
摘要
巴西Juiz de Fora联邦大学医院(huu - ufjf)血液学服务开展了一项研究项目,重点评估洛莫司汀进行性剂量与依托opo苷和环磷酰胺联合用于淋巴瘤患者自体造血干细胞移植(AHSCT)调节方案的毒性和有效性。在随访期间,一名属于400 mg/m2洛莫司汀组的31岁女性在AHSCT后6个月出现神经肌肉并发症。最初,患者出现弥漫性疼痛,主要是下肢近端无力;然而,在接种疫苗10天后,情况有所恶化。她的发展伴有快速上升的运动恶化,行走能力下降,足部感觉异常,双眼复视,反射性松弛,球和自主神经异常症状,如出汗,心动过速和体位性低血压。她在被转到HU-UFJF重症监护室前72小时出现晕厥发作。
Guillain-Barré Syndrome after Hematopoietic Transplantation
The Hematology Service at the University Hospital of Federal University of Juiz de Fora (HU-UFJF)/Brazil carried out a research project focused on assessing the toxicity and effectiveness of progressive Lomustine doses in association with Etoposide and Cyclophosphamide in the Autologous Hematopoietic Stem Cell Transplantation (AHSCT) conditioning regimen adopted for lymphoma patients. During the follow-up, a 31-year-old woman belonging to the 400 mg/m2 Lomustine cohort evolved with neuromuscular complications 6 months after AHSCT. Initially, she experienced diffuse pain, mainly proximal weakness in the lower limbs; however, it got worse 10 days after vaccine protocol application. She evolved with rapidly ascending motor worsening, decreased ability to walk, foot paresthesia, binocular diplopia, areflexia, bulbar and dysautonomic symptoms such as sweating, tachycardia and postural hypotension. She experienced syncope episodes 72 h before being referred to intensive care unit at HU-UFJF.