Annals of case reports最新文献_第9页

The Effect of Multidisciplinary Approach: A Retrospective Analysis of Congenital Heart Defects from a Tertiary Referral Centre In Bucharest-Romania 多学科方法的效果：罗马尼亚布加勒斯特一家三级转诊中心先天性心脏缺陷的回顾性分析

Annals of case reports Pub Date : 2024-01-08 DOI: 10.29011/2574-7754.101581

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Case Report on Complete Response to Treatment of Metastatic Metaplastic Breast Cancer with Sacituzumab Govitecan 萨妥珠单抗戈维替康治疗转移性变性乳腺癌完全应答病例报告

Annals of case reports Pub Date : 2024-01-05 DOI: 10.29011/2574-7754.101579

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Incomplete Drainage of Total Pulmonary Lavage as a Cause of Double-Lumen Tube Malposition: A Case Report 导致双腔管错位的全肺灌洗引流不完全：病例报告

Annals of case reports Pub Date : 2024-01-05 DOI: 10.29011/2574-7754.101578

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Salvage Therapy Using Mesenchymal Stromal Cells “MSC-FFM” For a Severe Gastrointestinal Steroid-Refractory Acute Graft-Versus-Host Disease in a 12-Year-Old Boy with Sickle Cell Disease 利用间充质干细胞 "间充质干细胞-FFM "对一名 12 岁镰状细胞病男孩的严重胃肠道类固醇难治性急性移植物抗宿主病进行挽救性治疗

Annals of case reports Pub Date : 2024-01-04 DOI: 10.29011/2574-7754.101577

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Spontaneous Regression Accompanied by Concomitant Immune Alterations in a Patient with Chronic Lymphocytic Leukemia 一名慢性淋巴细胞白血病患者伴随免疫改变的自发性病情缓解

Annals of case reports Pub Date : 2024-01-04 DOI: 10.29011/2574-7754.101539

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Bilateral Limb-Kinetic Apraxia Following Left PeriCentral Sulcus Hemorrhage 左侧中央沟周围出血后的双侧肢体运动障碍

Annals of case reports Pub Date : 2024-01-04 DOI: 10.29011/2574-7754.101576

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Deferoxamine Intradermal Delivery Patch for Treatment of a Radiation Therapy Associated Breast Wound. 去铁胺皮内贴片治疗放射治疗相关乳腺伤口。

Annals of case reports Pub Date : 2024-01-01 Epub Date: 2024-06-13 DOI: 10.29011/2574-7754.101844

David Perrault, Kellen Chen, Rahim Nazerali, Derrick Wan

{"title":"Deferoxamine Intradermal Delivery Patch for Treatment of a Radiation Therapy Associated Breast Wound.","authors":"David Perrault, Kellen Chen, Rahim Nazerali, Derrick Wan","doi":"10.29011/2574-7754.101844","DOIUrl":"10.29011/2574-7754.101844","url":null,"abstract":"Purpose: Radiation therapy is used in over 60% of cancer patients and can lead to radiation dermatitis, radiation induced fibrosis, hyperpigmentation, telangiectasias, fat necrosis, and poor wound healing. Deferoxamine (DFO) is an iron-chelating agent that has been used systemically to treat iron overload conditions and more recently been studied to treat radiation fibrosis. Through iron chelation, DFO stabilizes hypoxia inducible factor-1α, driving downstream upregulation of angiogenic factors, and reduces formation of reactive oxygen species, thereby offering a potential therapy for radiation associated chronic wounds. The purpose of this work was to describe treatment of a refractory wound following radiation treatment that had failed conventional therapy.Methods: The patient is a 71-year-old female with inflammatory breast cancer that developed a radiation related wound after mastectomy, chemotherapy, and radiation therapy. The wound did not show any signs of improvement with five months of wound care and risk factor modification. The patient was offered treatment with a topical Deferoxamine Intradermal Delivery Patch through the FDA single patient investigative new drug pathway.Results: After two weeks of treatment, the wound healed. Additionally, serum was collected at cessation of therapy and 5 weeks after, with both samples showing no significant systemically detectible level of the drug to be present. Subjectively the patient reported improvement in appearance and quality of the skin.Conclusion: Topical deferoxamine is a promising therapy for radiation wounds. Although this report is limited to a single patient experience, we believe this work is important in describing the first in-human use of topical deferoxamine to heal a radiation therapy associated wound.","PeriodicalId":72213,"journal":{"name":"Annals of case reports","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Striking Power of Amniotic Fluid and Its Exosomes Collected at the End of a Normal Pregnancy on Severe Inflammation and Tissue Repair. 正常妊娠末期收集羊水及其外泌体对严重炎症和组织修复的影响。

Annals of case reports Pub Date : 2024-01-01 Epub Date: 2024-12-02 DOI: 10.29011/25747754.102099

Pascal J Goldschmidt Clermont, Brock Sevilla, Alex Jp Goldschmidt, Ian A White

{"title":"The Striking Power of Amniotic Fluid and Its Exosomes Collected at the End of a Normal Pregnancy on Severe Inflammation and Tissue Repair.","authors":"Pascal J Goldschmidt Clermont, Brock Sevilla, Alex Jp Goldschmidt, Ian A White","doi":"10.29011/25747754.102099","DOIUrl":"10.29011/25747754.102099","url":null,"abstract":"With this short communication, which contains a new case report on diabetic ulcer, we summarize our research progress in treating several complex conditions at a point where currently available treatments were failing to help the affected patients. We review the first case of lower back pain due to severe spondylitis (T12-L1) treated with intravenous injections of a sterile fraction of human purified amniotic fluid (ViX001) obtained from thoroughly screened volunteers at the time of planned c-section at the term of normal pregnancies. Then, we review the first case of recalcitrant diabetic ulcer treated successfully by twice-daily applications of ViX001 directly on the wound and describe another case of diabetic ulcer treated successfully with ViX001. Next, we review the treatment of severe burns with direct application of ViX001 on the burns leading to accelerated improvement of the burn lesions. Finally, we review the first treatment of a patient with advanced pyoderma gangrenosum with ViX001, with significant reduction of pain, inflammation, and observation of tissue regeneration. We conclude our review with speculations on the mechanism of action of ViX001, the importance of extracellular vesicles in the amniotic fluid for its biological activity, and the need for expanding our studies to generate a better understanding of the omics signature of this incredibly beneficial material.","PeriodicalId":72213,"journal":{"name":"Annals of case reports","volume":"9 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real Time Visualization of Enhanced Lymphatic Flow When Using a Non-Pneumatic Active Compression Device (NPCD) 使用非气动主动加压装置（NPCD）时增强淋巴流动的实时可视化效果

Annals of case reports Pub Date : 2023-12-26 DOI: 10.29011/2574-7754.101564

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First Case of Severe Pain and Inflammation Reduction by Application of Purified Amniotic Fluid on Active Lesions of a Patient with Pyoderma Gangrenosum 首例通过在脓疱疮患者的活动性病灶上涂抹纯化羊水减轻疼痛和炎症的病例

Annals of case reports Pub Date : 2023-12-26 DOI: 10.29011/2574-7754.101566

引用次数: 0