AME medical journal最新文献_第8页

Vanishing mediastinal mass associated with mRNA SARS-CoV-2 vaccination: a rare case report 消失性纵隔肿块与信使核糖核酸严重急性呼吸系统综合征冠状病毒2型疫苗接种相关：一例罕见病例报告

AME medical journal Pub Date : 2022-01-01 DOI: 10.21037/amj-22-13

T. Kosaka, S. Nakazawa, T. Ibe, K. Shirabe

{"title":"Vanishing mediastinal mass associated with mRNA SARS-CoV-2 vaccination: a rare case report","authors":"T. Kosaka, S. Nakazawa, T. Ibe, K. Shirabe","doi":"10.21037/amj-22-13","DOIUrl":"https://doi.org/10.21037/amj-22-13","url":null,"abstract":"Background: Thymic hyperplasia has occasionally been reported as an immune response to vaccination for severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). We herein report a rare case of a vanishing mediastinal mass associated with mRNA SARS-CoV-2 vaccination. Case Description: A woman in her forties presented with continuous fever after receiving her first mRNA-1273 SARS-CoV-2 vaccination. Chest computed tomography (CT) examination revealed an anterior mediastinal mass of 66-mm in diameter. She was referred to our hospital for evaluation of the anterior mediastinal mass.18F-fluorodeoxyglucose positron emission tomography (FDG-PET) revealed markedly increased uptake in the mediastinal mass. The differential diagnosis included thymoma, thymic cancer, and lymphoma. Although a CT scan performed 25 days after vaccination showed that the mediastinal mass had shrunk to 32 mm, the lesion was still present and a needle biopsy was performed. Unfortunately, accurate pathological examination could not be achieved because of small specimen. A surgical biopsy by the thoracoscopic approach was next planned to rule out malignancy. However, a CT scan prior to surgical biopsy performed 2 months after vaccination revealed that the mediastinal mass had completely disappeared. The surgical biopsy was cancelled. Because there was no residual lesion at 6 months, we concluded that the mediastinal mass was an adverse effect of the SARS-CoV-2 vaccination, presenting as a transient hyperplasia of the thymus. Conclusions: It is important to distinguish an immune response from a malignancy to avoid unnecessary surgery or treatment. Our case warns us that we should take into account the timing of SARS-CoV2 vaccination when we encounter a patient with mediastinal mass. © AME Medical Journal. All rights reserved.","PeriodicalId":72157,"journal":{"name":"AME medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44895054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Literature review on the efficacy of treatments for urinary incontinence in irradiated vs. non-radiated men treated for prostate cancer 前列腺癌放疗与非放疗患者尿失禁治疗效果的文献综述

AME medical journal Pub Date : 2022-01-01 DOI: 10.21037/amj-22-5

J. Griffith, L. Wiegand

引用次数: 0

A brief comment on the true origin of myocardial revascularization procedures 对心肌血运重建术的真正起源的简要评论

AME medical journal Pub Date : 2021-09-25 DOI: 10.21037/amj-21-36

Yoandy López-de la Cruz, L. B. Pérez-Machado

引用次数: 0

A narrative review of the role of prostatic artery embolization in the management of post-radiation prostatitis 前列腺动脉栓塞在放射后前列腺炎治疗中的作用综述

AME medical journal Pub Date : 2021-06-03 DOI: 10.21037/AMJ-20-189

N. Parikh, B. Manley, J. Pow-Sang, K. Yamoah

{"title":"A narrative review of the role of prostatic artery embolization in the management of post-radiation prostatitis","authors":"N. Parikh, B. Manley, J. Pow-Sang, K. Yamoah","doi":"10.21037/AMJ-20-189","DOIUrl":"https://doi.org/10.21037/AMJ-20-189","url":null,"abstract":"Definitive radiation remains a mainstay of treatment for men who have been diagnosed with localized prostate cancer (PCa). Acute and chronic genitourinary (GU) toxicity after definitive radiotherapy (RT) can cause significant morbidity for patients. Furthermore, pinpointing the prostate and related prostatitis as the source of symptoms is very difficult and often comes down to a process of elimination. The pathophysiology underlying this prostatitis represents an even more frustrating challenge and is also poorly understood. When it has been identified as the source, radiation-induced prostatitis can be considered a form of chronic, non-bacterial prostatitis based on the NIH classification system. In this classification, radiationinduced prostatitis is exceedingly challenging to manage, with therapy focused on the three “A”s of chronic prostatitis: Anti-inflammatories, Antibiotics, and Alpha-blockers. Unfortunately, approximately 50% of men will have symptoms refractory to medical therapy with limited effectiveness of alternative medical and invasive options. Prostatic artery embolization (PAE) has been shown to be a minimally invasive, safe and clinically effective treatment for lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). While evidence for both the diagnosis and management of post-radiation prostatitis is significantly lacking, this review evaluates the novel role of PAE for the management of refractory, symptomatic radiation-induced prostatitis.","PeriodicalId":72157,"journal":{"name":"AME medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44952279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The long road to penile allotransplantation in South Africa 南非实现阴茎异体移植的漫长道路

AME medical journal Pub Date : 2021-04-23 DOI: 10.21037/AMJ-20-163

G. Mantica, A. van der Merwe

引用次数: 0

Surgical management of genitourinary malignancies 泌尿生殖系统恶性肿瘤的外科治疗

AME medical journal Pub Date : 2021-04-09 DOI: 10.21037/AMJ-21-11

R. Pessoa, Simon P. Kim

引用次数: 0

Eosinophilic cellulitis secondary to occult strongyloidiasis, case report 隐匿性圆线虫病继发的嗜酸性蜂窝织炎1例

AME medical journal Pub Date : 2021-03-25 DOI: 10.21037/AMJ-20-150

Llewelyn Yi Chang Tan, Dingyuan Wang, J. Lee, B. Ho, J. H. Lim

{"title":"Eosinophilic cellulitis secondary to occult strongyloidiasis, case report","authors":"Llewelyn Yi Chang Tan, Dingyuan Wang, J. Lee, B. Ho, J. H. Lim","doi":"10.21037/AMJ-20-150","DOIUrl":"https://doi.org/10.21037/AMJ-20-150","url":null,"abstract":": Eosinophilic cellulitis (EC), also known as Wells syndrome, is a rare reactive inflammatory dermatosis which may masquerade as bacterial cellulitis. A 59-year-old gentleman who presented with an acute onset of pruritic rashes affecting the chest and abdomen, along with painful induration over bilateral lower limbs, in association with blistering on his right leg. He had peripheral blood eosinophilia ranging from 0.91 to 1.17×10 9 /L with no biochemical evidence of sepsis. Skin biopsy revealed dermal interstitial lymphocytic infiltration with numerous eosinophils at various stages of degranulation, along with flame figures. EC causing pseudo-cellulitis was suspected. Three fecal samples were unyielding for ova and cysts, but Strongyloides immunoglobulin G serology was positive. The diagnosis of EC secondary to occult strongyloidiasis was made and the patient was treated with oral anti-helminthics and topical steroids with all the skin lesions resolving within 4 days. To our knowledge, this association has never been hitherto reported. This case showcases the following instructive points to the internist, namely (I) the low threshold to consider pseudo-cellulitis in apparent “bilateral lower limb cellulitis”; (II) the awareness of the entity of EC and the need to evaluate for underlying etiologies that cause this reactive dermatoses, such as including occult helminthic infections; (III) the correct way to perform a thorough evaluation for, and optimal treatment of helminthiasis.","PeriodicalId":72157,"journal":{"name":"AME medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43889149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Narrative review of hyperbaric oxygen therapy for radiation induced hemorrhagic cystitis 高压氧治疗放射性出血性膀胱炎综述

AME medical journal Pub Date : 2021-03-07 DOI: 10.21037/AMJ-20-178

Robert Dieu, Kevin R. Heinsimer

{"title":"Narrative review of hyperbaric oxygen therapy for radiation induced hemorrhagic cystitis","authors":"Robert Dieu, Kevin R. Heinsimer","doi":"10.21037/AMJ-20-178","DOIUrl":"https://doi.org/10.21037/AMJ-20-178","url":null,"abstract":"To evaluate the benefits of hyperbaric oxygen in the treatment of radiation-induced hemorrhagic cystitis (HC). Hyperbaric oxygen has been shown to be an effective long-term treatment for early and late radiationand chemotherapy-induced HC. It has been proven safe for adult and pediatric patients. Treatment typically required 10–40 “dives” for 60–120 min, making it very time intensive for patients. Complete response has been reported in up to 87% of patients with recurrence ranging from 0–35% in most studies. It works both as an initial treatment and after less time-intensive therapies have failed. Better responses have been seen with initiation within 6-month of presentation. Additional risk factors for treatment failure include: higher radiation doses, more severe hematuria, incomplete treatment, and blood thinner use. In addition to being effective for hematuria, it has also been shown to improve the lower urinary tract symptoms associated with radiation cystitis. Repeat treatments are effective for some patients, but if hematuria fails to resolve after hyperbaric oxygen therapy (HBOT), patients must be reassessed for malignancy as a source of their hematuria. The overall complication rate is low, and these tend to be self-limited with the most common adverse effects being blurred vision and ear pain which resolve after treatment. While expensive and time intensive, it may prove to be cheaper in the long run and offer a better alternative to patients otherwise facing bladder embolization or cystectomy.","PeriodicalId":72157,"journal":{"name":"AME medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49028292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical principles of penile cancer for penectomy and inguinal lymph node dissection: a narrative review 阴茎癌阴茎切除术和腹股沟淋巴结清扫的手术原则:叙述回顾

AME medical journal Pub Date : 2021-03-01 DOI: 10.21037/AMJ-20-159

N. Coddington, K. Redger, T. Higuchi

{"title":"Surgical principles of penile cancer for penectomy and inguinal lymph node dissection: a narrative review","authors":"N. Coddington, K. Redger, T. Higuchi","doi":"10.21037/AMJ-20-159","DOIUrl":"https://doi.org/10.21037/AMJ-20-159","url":null,"abstract":"Penile cancer is a rare and serious disease. Early local and regional disease is surgically curable, but advanced regional disease portends a poor prognosis—with inguinal node metastases being the most important prognostic factor. An initial histologic diagnosis with a punch, excisional, or incisional biopsy is recommended to determine the risk of lymph node involvement prior to proceeding with surgery. Magnetic resonance imaging (MRI) or ultrasound can used adjunctively to determine the depth of invasion. Total or partial penectomy with 5mm resection margins is the standard of care for primary disease, although penilepreserving procedures—such as circumcision for preputial lesions, laser ablation, wide local excision, glans resurfacing, glansectomy, and Mohs micrographic surgery—are initially indicated for tumors of lower grade, favorable histology, and favorable location. Inguinal lymphadenectomy is required for nodal disease, but has been associated with a high rate of complications. Patients with bulky or initially unresectable nodal disease should referred to medical oncologist to consider neoadjuvant therapy prior to resection. Dynamic sentinel lymph node biopsies, modified dissection templates, and minimally invasive surgical techniques have been adopted to decrease the morbidity of the procedure. Treatment for penile cancer continues to evolve as new technologies become available, but the rarity of the disease creates knowledge gaps in the best treatment approach. Currently, surgery remains the cornerstone for treatment of penile cancer.","PeriodicalId":72157,"journal":{"name":"AME medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41476469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A narrative overview of the prognostic significance of the immune cellular milieu in tumor draining lymph nodes in non-small cell lung cancer 非小细胞肺癌肿瘤引流淋巴结免疫细胞环境预后意义的综述

AME medical journal Pub Date : 2021-02-22 DOI: 10.21037/AMJ-20-171

P. Sridhar, A. Sailer

{"title":"A narrative overview of the prognostic significance of the immune cellular milieu in tumor draining lymph nodes in non-small cell lung cancer","authors":"P. Sridhar, A. Sailer","doi":"10.21037/AMJ-20-171","DOIUrl":"https://doi.org/10.21037/AMJ-20-171","url":null,"abstract":"Lung cancer is both the most common malignancy in the United States and the most fatal. Non-small cell lung cancer accounts for most lung malignancies and involves a complex immune response that has become the recent target of systemic therapy. Late-stage disease is now effectively treated with immunotherapy. As the role of immunotherapy expands, it is becoming increasingly important to understand the biology of the immune response in patients with non-small cell lung cancer and the association of this response with response to therapy and outcomes. In this narrative overview, we review the role of immune cells comprising tumor draining lymph nodes, the structure of tumor draining lymph nodes, and their role in the tumor microenvironment. To identify relevant immune cell interactions within the tumor draining lymph nodes, we reviewed published papers focusing on tumor draining lymph nodes and delineated the significance of the immune cells to the tumor microenvironment in both animal models and humans. This is the first comprehensive review of tumor-draining lymph nodes and their role in the tumor microenvironment and provides a foundation for further investigating the tumor microenvironment and the role of humoral and innate immune response mechanisms in non-small cell lung cancer.","PeriodicalId":72157,"journal":{"name":"AME medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49188140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0