Advances in pediatric research最新文献_第4页

“An innovative new technique of paediatric vaccination: Take both hands and hold the needle to avoid damage of nociceptors and capillaries” “一种创新的儿科疫苗接种新技术:双手握针，避免伤害感受器和毛细血管”

Advances in pediatric research Pub Date : 2019-01-01 DOI: 10.35248/2385-4529.19.6.26

S. Bittmann, E. Luchter

引用次数: 1

The Global Child Development Corps 全球儿童发展团

Advances in pediatric research Pub Date : 2019-01-01 DOI: 10.35248/2385-4529.19.6.30

G. Katzman

引用次数: 1

Dose dependence of pediatric thyroid cancer prevalence in the 6 years after the Fukushima nuclear power plant accident 福岛核电站事故后6年儿童甲状腺癌发病率的剂量依赖性

Advances in pediatric research Pub Date : 2019-01-01 DOI: 10.35248/2385-4529.19.6.28

T. Katō

{"title":"Dose dependence of pediatric thyroid cancer prevalence in the 6 years after the Fukushima nuclear power plant accident","authors":"T. Katō","doi":"10.35248/2385-4529.19.6.28","DOIUrl":"https://doi.org/10.35248/2385-4529.19.6.28","url":null,"abstract":"Background: After the Fukushima nuclear accident in March 2011, Fukushima Prefecture initiated thyroid ultrasound screening as part of the Fukushima Health Management Survey (FHMS). Regional differences in external radiation dose were often reported not associated with thyroid cancer prevalence in the firstround screening E-I (2011-2013). The association between childhood thyroid cancer and radiation exposure in the 6 years after the accident is studied by analyzing the results of the first and second-round examinations E-I+II (2011-2015). Methods: Dose dependence of thyroid cancer proportion in E-I and E-II for all residents aged ≤18 years at the accident was analyzed for FHMS external dose and UNSCEAR effective dose by regression analysis using Microsoft Excel. Two divisions of Fukushima prefecture, O-model in the order of decreasing external dose and S-model according to the initial screening schedule, were adopted. Results: In O-model, thyroid cancer proportion per 100,000 in E-II and in E-I+II were found to increase linearly to FHMS external dose in 0.2–1.4 mSv range and UNSCEAR effective dose in 1.6–5 mSv range. Thyroid cancer proportion in E-II and E-I+II was observed to increase linearly to effective dose in Smodel. Conclusion: The observed linear prevalence–dose relation after 6 years from the accident and incidencedose relation during 4-6 years after exposure suggest a possible association between pediatric thyroid cancer and radiation exposure. Regional differences were not obvious in E-I presumably because of the short interval from exposure to screening in high-dose areas. High prevalence of thyroid cancer cannot be attributed only to mass screening effect that does not depend on radiation dose and elapsed time from exposure.","PeriodicalId":72104,"journal":{"name":"Advances in pediatric research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70015139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Novel mutation of SCN9A gene in a family with Paroxysmal Extreme Pain Disorder (PEPD): Considerations of paediatric interest 阵发性极度疼痛障碍(PEPD)家族中SCN9A基因的新突变:对儿科兴趣的考虑

Advances in pediatric research Pub Date : 2019-01-01 DOI: 10.35248/2385-4529.19.6.32

Jerez Calero Antonio, Y. Yáñez, Munoz Gallego Maria Angeles, Augustin Morales Maria Carmen, Contreras Chova Francisco, Molina Carballo Antonio, Munoz Hoyos Antonio

{"title":"Novel mutation of SCN9A gene in a family with Paroxysmal Extreme Pain Disorder (PEPD): Considerations of paediatric interest","authors":"Jerez Calero Antonio, Y. Yáñez, Munoz Gallego Maria Angeles, Augustin Morales Maria Carmen, Contreras Chova Francisco, Molina Carballo Antonio, Munoz Hoyos Antonio","doi":"10.35248/2385-4529.19.6.32","DOIUrl":"https://doi.org/10.35248/2385-4529.19.6.32","url":null,"abstract":"Introduction: Paroxysmal Extreme Pain Disorder (PEPD) is a rare autosomal dominant disease, caused by mutations in the SCN9A gene, which encodes the NaV1.7 voltage-gated sodium channel alpha subunit. Symptoms generally begin in early infancy with episodes of excruciating, burning and spreading pain in the lower part of the body, typically in the anorectal area, which can last from seconds to hours. Case description: We describe the case of a 5-year-old male with PEPD and a novel heterozygous mutation c.5825c>T (p. Thr1942ile) in the SCN9A gene. This is a novel mutation that has not previously been reported. Discussion: According to the available information, the clinical significance of the variant c.5825c>T (p. Thr1942ile) is unknown. However, its presence in the patient and in others affected family members, reinforces its possible pathogenicity and is suggestive of mutation segregation with the disease in this family. Conclusion: We consider that it is a family case of interest to the pediatrician, for allowing: 1) To be able to intuit it by the clinic early and 2) To be able to confirm it by means of the corresponding genetic study.","PeriodicalId":72104,"journal":{"name":"Advances in pediatric research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70015705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of fluorescent and led lighting on students attitudes and behavior in the classroom 荧光灯和led照明对学生课堂态度和行为的影响

Advances in pediatric research Pub Date : 2018-07-21 DOI: 10.24105/APR.2018.5.15

Brenda L. Morrow, S. Kanakri

{"title":"The impact of fluorescent and led lighting on students attitudes and behavior in the classroom","authors":"Brenda L. Morrow, S. Kanakri","doi":"10.24105/APR.2018.5.15","DOIUrl":"https://doi.org/10.24105/APR.2018.5.15","url":null,"abstract":"Introduction: This study examined empirical research on the effects of high correlated color temperature light-emitting diodes (LED) and fluorescent lighting on students in the classroom. LED is becoming the most recent lighting option for optimal energy efficiency over fluorescent technology. \u0000Background: A review of the literature indicates correlated color temperature (CCT) of lighting has non-visual effects on students, with higher CCT positively impacting attitudes and behavior. The review also revealed current studies regarding dynamic or tunable lighting that adjusts CCT based on desired activity and mood. Data from an original survey analyzed teacher insights and perceptions regarding student attitudes and behaviors associated with existing classroom lighting and the impact of higher color temperature LED. \u0000Methods: Participants were pre-K through high school qualified teachers from three schools and/or personal contacts of the principal investigator. Seventy-five teachers responded to the online questionnaire. The survey data suggests teachers perceive higher color temperature lighting positively impacts student alertness, attitude, and energy level; and adjusting light levels throughout a school day positively impacts student engagement. \u0000Results and conclusion: Results supported the perception of higher correlated color temperature lighting positively impacting alertness, attitude, and energy level. Findings also supported the ability to change light levels throughout the school day to positively impact student engagement and mood. There were mixed results regarding higher correlated color temperature impacting attention and on-task/off- task behaviors. Results regarding the impact of sound and flickering from fluorescent lights were not significant.","PeriodicalId":72104,"journal":{"name":"Advances in pediatric research","volume":"5 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2018-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69015436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Overweight and Obesity in Early Childhood A Systematic Review of Individual, Family, and Peer Risk Factors 儿童早期超重和肥胖:个人、家庭和同伴风险因素的系统回顾

Advances in pediatric research Pub Date : 2018-07-01 DOI: 10.12715/APR.2018.5.5

Nadja Frate, B. Jenull, H. Foran

{"title":"Overweight and Obesity in Early Childhood A Systematic Review of Individual, Family, and Peer Risk Factors","authors":"Nadja Frate, B. Jenull, H. Foran","doi":"10.12715/APR.2018.5.5","DOIUrl":"https://doi.org/10.12715/APR.2018.5.5","url":null,"abstract":"Purpose: The prevalence of children who are overweight or obese has been increasing worldwide. While a variety of biological as well as sociodemographic correlates have been identified and reviewed, a systematic review of psychosocial factors, particularly among preschool aged children, is lacking. This systematic review synthesizes the research on individual, family and peer risk factors for overweight and obesity in preschool aged children. Method: A systematic review of the recent literature on psychosocial factors and overweight or rather obesity in the early stages of childhood was conducted. Results: A total of 27 studies from 2011-2016 were identified that examined individual, family and social risk factors for obesity in children. Results indicate the importance of eating regulation as well as family factors in understanding early childhood risk for obesity. There was mixed support for associations between behavioral and emotional symptoms and obesity among this age group. For other risk factors examined, too few studies exist to be able to make strong conclusions about their relevance for understanding preschool obesity risk. Conclusions: Psychosocial factors are associated with overweight and obesity among preschool aged children. However, this review also highlights the dearth of research on several potentially important risk factors for childhood obesity in this age group (such as family violence, parental and peer relationships). Longitudinal studies, which examine multiple risk factors simultaneously over this important developmental period, are sorely needed.","PeriodicalId":72104,"journal":{"name":"Advances in pediatric research","volume":"5 1","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45020572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Real-time PCR for the diagnosis of invasive Haemophilus influenzaebacteraemia and meningitis in children: A diagnostic accuracy study ofover 2,000 samples 实时PCR诊断儿童侵袭性流感嗜血杆菌血症和脑膜炎:一项超过2000个样本的诊断准确性研究

Advances in pediatric research Pub Date : 2018-01-01 DOI: 10.12715/APR.2018.5.2

H. O. Brien, M. Nielsen, K. Meyler, N. Sullivan, R. Cunney, R. Drew

{"title":"Real-time PCR for the diagnosis of invasive Haemophilus influenzaebacteraemia and meningitis in children: A diagnostic accuracy study ofover 2,000 samples","authors":"H. O. Brien, M. Nielsen, K. Meyler, N. Sullivan, R. Cunney, R. Drew","doi":"10.12715/APR.2018.5.2","DOIUrl":"https://doi.org/10.12715/APR.2018.5.2","url":null,"abstract":"results in a paediatric patient cohort and to review discordant results. Methods: A retrospective audit of all blood and CSF samples from a tertiary referral paediatric hospital sent to the Irish Meningitis and Sepsis Reference Laboratory over a four-year period. All PCR tests performed for H. influenzae which had a contemporaneous culture performed were included in the analysis. Results: For the blood PCR test, there were 10 positive samples out of 1,367 samples tested. The sensitivity was shown to be 60% (95% CI 14.6–94.73%) and the specificity was 99% (95% CI 98–99.7%). For the CSF assay, the sensitivity was 100% (95% CI 15.8–100%) with a specificity of 99% (95% CI 99.2–99.9%) and there were 5 positive samples by PCR out of the 1,224 samples tested. Ten patients had positive PCR results, with a negative corresponding culture (blood=7, CSF=3). Three of the 10 cases were deemed to be primary H. influenzae infections, while seven were deemed to be likely co-infection (respiratory syncytial virus=2, Influenza=2, measles=1, rotavirus=1, Staphylococcus aureus pneumonia=1). Conclusions: The incidence of invasive H. influenzae disease was low in this population. The sensitivity and specificity of the assay in CSF was excellent, but the sensitivity of the assay in blood was lower at 60%. Most patients with discordant PCR/culture results had viral co-infections. A more rational approach to requesting PCR is required in paediatric patients.","PeriodicalId":72104,"journal":{"name":"Advances in pediatric research","volume":"5 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66240223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Advances in pediatric research 儿科研究进展

Advances in pediatric research Pub Date : 2018-01-01 DOI: 10.24105/APR.2018.5.9

S. Bittmann

引用次数: 0

Twin study confirms virtually identical prenatal alcohol exposures can lead to markedly different fetal alcohol spectrum disorder outcomes-fetal genetics influences fetal vulnerability. 双胞胎研究证实，几乎相同的产前酒精暴露可导致明显不同的胎儿酒精谱系障碍结果--胎儿遗传影响胎儿的易感性。

Advances in pediatric research Pub Date : 2018-01-01 Epub Date: 2019-01-12 DOI: 10.24105/apr.2019.5.23

Susan J Astley Hemingway, Julia M Bledsoe, Allison Brooks, Julian K Davies, Tracy Jirikowic, Erin M Olson, John C Thorne

{"title":"Twin study confirms virtually identical prenatal alcohol exposures can lead to markedly different fetal alcohol spectrum disorder outcomes-fetal genetics influences fetal vulnerability.","authors":"Susan J Astley Hemingway, Julia M Bledsoe, Allison Brooks, Julian K Davies, Tracy Jirikowic, Erin M Olson, John C Thorne","doi":"10.24105/apr.2019.5.23","DOIUrl":"10.24105/apr.2019.5.23","url":null,"abstract":"Background: Risk of fetal alcohol spectrum disorder (FASD) is not based solely on the timing and level of prenatal alcohol exposure (PAE). The effects of teratogens can be modified by genetic differences in fetal susceptibility and resistance. This is best illustrated in twins.Objective: To compare the prevalence and magnitude of pairwise discordance in FASD diagnoses across monozygotic twins, dizygotic twins, full-siblings, and half-siblings sharing a common birth mother.Methods: Data from the Fetal Alcohol Syndrome Diagnostic & Prevention Network clinical database was used. Sibling pairs were matched on age and PAE, raised together, and diagnosed by the same University of Washington interdisciplinary team using the FASD 4-Digit Code. This design sought to assess and isolate the role of genetics on fetal vulnerability/resistance to the teratogenic effects of PAE by eliminating or minimizing pairwise discordance in PAE and other prenatal/postnatal risk factors.Results: As genetic relatedness between siblings decreased from 100% to 50% to 50% to 25% across the four groups (9 monozygotic, 39 dizygotic, 27 full-sibling and 9 half-sibling pairs, respectively), the prevalence of pairwise discordance in FASD diagnoses increased from 0% to 44% to 59% to 78%. Despite virtually identical PAE, 4 pairs of dizygotic twins had FASD diagnoses at opposite ends of the fetal alcohol spectrum-Partial Fetal Alcohol Syndrome versus Neurobehavioral Disorder/Alcohol-Exposed.Conclusion: Despite virtually identical PAE, fetuses can experience vastly different FASD outcomes. Thus, to protect all fetuses, especially the most genetically vulnerable, the only safe amount to drink is none at all.","PeriodicalId":72104,"journal":{"name":"Advances in pediatric research","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757639/pdf/nihms-1649310.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38752009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Focus group or individual interviews for exploring children's health behaviour: the example of physical activity 探讨儿童健康行为的焦点小组或个人访谈:以身体活动为例

Advances in pediatric research Pub Date : 2018-01-01 DOI: 10.24105/apr.2018.5.11

K. Woolley, K. Edwards, C. Glazebrook

{"title":"Focus group or individual interviews for exploring children's health behaviour: the example of physical activity","authors":"K. Woolley, K. Edwards, C. Glazebrook","doi":"10.24105/apr.2018.5.11","DOIUrl":"https://doi.org/10.24105/apr.2018.5.11","url":null,"abstract":"Background: Children's health behaviours affect their current and future health. An appreciation of children’s perceptions regarding these behaviours can inform health promotion initiatives. Focus groups and individual interviews have increasingly been used to explore health-related issues with children although the rationale for choosing any one method is not often explained and despite considerable debate about their benefits and drawbacks these methods have rarely been compared directly. This study aimed to explore the relative merits of the two approaches when collecting information from children about their perceptions of physical activity. Methods: Twelve children from Year 6 classes at one UK primary school were randomly allocated to an 'interview group' or a 'focus group' and asked questions about facilitators and barriers relating to their physical activity at school. Focus group interactions and interviews were recorded and transcribed verbatim. Qualitative data were analysed using exploratory thematic analysis and subsequently content analysis was undertaken to quantify differences between the groups. Results: Although both methods were suitable for collecting information from children about physical activity, children who were interviewed spoke on more occasions and offered more information about facilitators for physical activity. They also spoke more frequently about potentially important aspects of the school outdoor environment with regard to physical activity promotion. The focus group was more time efficient in this setting. Conclusion: Qualitative methods for exploring health behaviours may not be equivalent and need to be chosen carefully depending on the specific research problem and practical constraints within a project.","PeriodicalId":72104,"journal":{"name":"Advances in pediatric research","volume":"5 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69015002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6