Advances in biomarker sciences and technology最新文献

{"title":"The role of obesity on chronic kidney disease development, progression, and cardiovascular complications","authors":"Win Hlaing Than ,&nbsp;Gordon Chun-Kau Chan ,&nbsp;Jack Kit-Chung Ng ,&nbsp;Cheuk-Chun Szeto","doi":"10.1016/j.abst.2020.09.001","DOIUrl":"10.1016/j.abst.2020.09.001","url":null,"abstract":"<div><p>The complex links between obesity, chronic kidney disease (CKD) and cardiovascular disease (CVD) are not completely understood. The objective of this review is to describe and discuss the anatomy, physiology, and biochemistry of the adipose tissue, as well as its involvement in the pathophysiology of CVD and CKD. We searched for original articles in PubMed. The search terms used were “obesity”, “CKD”, and “CVD”. In addition, we also identified publications from our personal databases of literature about obesity, CKD and CVD to identify any important studies that might have been missing from the PubMed search. We further searched the reference lists of identified articles for further relevant papers. Epidemiological studies show that obesity is associated with obesity-related glomerulopathy (ORG) as well as an increase in the risk of CKD in the general population. A number of pathophysiological mechanisms, including renal hemodynamic changes, neurohumoral pathways that activate the sympathetic and renin-angiotensin-aldosterone systems, proinflammatory and profibrotic effects of various adipokines, and insulin resistance may explain the excessive risk of CKD development and progression in obese patients. In patients with mild to moderate CKD, obesity <em>per se</em> contributes a modest increase in cardiovascular risk, while the effect of obesity on the cardiovascular risk of patients with advanced CKD is probably due to the concurrent metabolic syndrome and coexisting cardiovascular risk factors, but the effect of obesity on the cardiovascular risk of patients with advanced CKD is probably the result of the concomitant metabolic syndrome and coexisting cardiovascular risk factors. There are recent data suggesting that subcutaneous and visceral adipose tissue have different and probably opposite effects on the CVD risk in CKD. Further studies are necessary to distinguish the specific clinical implication of different adipose tissue compartments, and to determine the principal mediators that connect obesity, CKD and CVD.</p></div>","PeriodicalId":72080,"journal":{"name":"Advances in biomarker sciences and technology","volume":"2 ","pages":"Pages 24-34"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.abst.2020.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"100012082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNAs and its emerging role as breast cancer diagnostic marker- A review","authors":"Showkat Ahmad Bhat ,&nbsp;Sabhiya Majid,&nbsp;Tehseen Hassan","doi":"10.1016/j.abst.2019.05.001","DOIUrl":"10.1016/j.abst.2019.05.001","url":null,"abstract":"<div><p>Breast cancer causes severe mental stress on the affected woman during investigation, diagnosis and treatment as breast is regarded as a symbol of beauty, sexuality and motherhood. Over and above the primary function of feeding infant, breast symbolizes womanhood and serves as sexual object. Current biomedical research investigations have explored several potential breast cancer (BC) biomarker by utilizing serum proteins, natural oncogenic genes during improvement in molecular technologies as microarray and RNA/DNASeq. Recently smallest noncoding microRNAs are becoming the essential regulators in the oncogenesis pathways and they can act as handy noninvasive clinical diagnostic biomarkers. This newly introduced class of noninvasive biomarkers is rising as a new molecule for the cancer diagnosis and prognosis. A better understanding is the involvement of miRNAs in breast carcinogenesis can make available insights into the mechanisms of tumor development and could help to discover novel early potent noninvasive markers for early detection of breast Cancer. In recent clinical research the discovery of miRNAs in body fluids, such as serum and plasma opens the possibility of using them as noninvasive biomarkers of disease including breast cancer. Here in this review, we summarize the recent research studies supporting the utility of miRNAs as novel early diagnostic and prognostic tool. Thus, here we bring in potential future early stage detection strategies for breast cancer, which indicate the practicality and clinical applications of miRNAs in breast cancer.</p></div>","PeriodicalId":72080,"journal":{"name":"Advances in biomarker sciences and technology","volume":"1 ","pages":"Pages 1-8"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.abst.2019.05.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53921788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bio-molecular characterization of stress enzyme profile on esterase in selected silkworm races of Bombyx mori (L.) for biomarker selection","authors":"S. Vishnu Priya,&nbsp;P. Somasundaram","doi":"10.1016/j.abst.2019.05.002","DOIUrl":"10.1016/j.abst.2019.05.002","url":null,"abstract":"<div><p>Silkworm <em>Bombyx mori</em> exhibits for eliminating pathogenic defenses by their secretory component of haemolymph and gut component. This study aimed to investigate the stress enzyme role of carboxyl esterase, plays a major function in toxic component detoxification by their lipid assembly. Hence, the study has planned to identify their carboxyl esterase role in haemolymph of six silkworm races using innovative tools. The six silkworm races are characterized based on their esterase profiles and their morphological origins. It was concluded that Nistari, Kollegal Jawan and Hosa Mysore are considered as tolerant races and remaining races are susceptible by eliminating the toxic component from their body. Therefore, the present study could be an index for identifying the esterase role and used as a biomarker for the screening of a wide range of silkworm races for identifying genetic hardiness.</p></div>","PeriodicalId":72080,"journal":{"name":"Advances in biomarker sciences and technology","volume":"1 ","pages":"Pages 9-16"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.abst.2019.05.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53921799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recombinant erythropoietin treatment improves serum podocyte marker levels in diabetic kidney disease","authors":"Lingfeng Zeng, J. Ng, W. Fung, G. Chan, K. Chow, C. Szeto","doi":"10.1016/j.abst.2023.06.001","DOIUrl":"https://doi.org/10.1016/j.abst.2023.06.001","url":null,"abstract":"","PeriodicalId":72080,"journal":{"name":"Advances in biomarker sciences and technology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53921988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the circulating micro-RNAs with susceptible and newly diagnosed type 2 diabetes mellitus cases","authors":"Syed Tasleem Raza, S. Rizvi, Sheeba Afreen, Sanchita Srivastava, Z. Siddiqui, Naseem Fatima, Z. Siddiqi, F. Mahdi","doi":"10.1016/j.abst.2023.05.001","DOIUrl":"https://doi.org/10.1016/j.abst.2023.05.001","url":null,"abstract":"","PeriodicalId":72080,"journal":{"name":"Advances in biomarker sciences and technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"53921853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}