Advanced neurology最新文献

Most utilized rodent models for Alzheimer’s and Parkinson’s disease: A critical review of the past 5 years 最常用的阿尔茨海默病和帕金森病啮齿动物模型：过去五年的重要回顾

Advanced neurology Pub Date : 2024-06-11 DOI: 10.36922/an.2903

Ana Flávia F. Ferreira, Marina Meira, Livia M. Lemuchi, Maria E. Bianchetti, Nicole M. Kamidai, Livia M. Kilinsky, Luiz R. G. Britto

{"title":"Most utilized rodent models for Alzheimer’s and Parkinson’s disease: A critical review of the past 5 years","authors":"Ana Flávia F. Ferreira, Marina Meira, Livia M. Lemuchi, Maria E. Bianchetti, Nicole M. Kamidai, Livia M. Kilinsky, Luiz R. G. Britto","doi":"10.36922/an.2903","DOIUrl":"https://doi.org/10.36922/an.2903","url":null,"abstract":"The past few years have witnessed extensive research on the two most common neurodegenerative diseases, Alzheimer’s disease (AD), and Parkinson’s disease (PD). With an urgent need for new treatments, drug targets, and a better understanding of the pathophysiological mechanisms underlying these conditions, researchers have turned to animal models, especially rodents, to address these issues. However, the abundance of reported models poses a challenge when choosing the most suitable model for a specific study. In this critical review, we systematically scrutinized studies using rodent models of AD or PD over the past 5 years. A comprehensive literature search was conducted on PubMed, followed by the meticulous screening of the identified studies. Among the retrieved publications, 1,222 studies reported the use of rodent models of PD, with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, α-synuclein, and 6-hydroxydopamine emerging as the most frequently used models. Similarly, 2,961 studies reported the use of rodent models of AD, with APP/PS1, 5×FAD, APP-based models, and 3×Tg being the most prevalent. In this review, we summarize and highlight the main characteristics of these models. By providing a comprehensive overview of their features and applications, this review guides future studies in the AD and PD field, eventually aiding in the selection of the most appropriate animal model tailored to the specific research question under scrutiny.","PeriodicalId":72072,"journal":{"name":"Advanced neurology","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141356076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation in ischemic stroke patients with type 2 diabetes – Part II: Potential therapeutic targets 2 型糖尿病缺血性中风患者的炎症--第二部分：潜在的治疗目标

Advanced neurology Pub Date : 2024-06-05 DOI: 10.36922/an.1694

Liqun Zhang, Ying Chen, Jingxian Xu, Christopher P. Corpe, A. Shtaya, Philip Benjamin, Yun Xu

{"title":"Inflammation in ischemic stroke patients with type 2 diabetes – Part II: Potential therapeutic targets","authors":"Liqun Zhang, Ying Chen, Jingxian Xu, Christopher P. Corpe, A. Shtaya, Philip Benjamin, Yun Xu","doi":"10.36922/an.1694","DOIUrl":"https://doi.org/10.36922/an.1694","url":null,"abstract":"Stroke is the leading cause of disability and the second leading cause of death worldwide. Diabetes mellitus is a critical independent cardiovascular risk factor in patients, irrespective of age, smoking, and hypertension. Approximately one-third of first-time ischemic stroke patients have diabetes. Inflammation is among the most important pathological mechanisms in atheroma formation, the damage cascades of the acute phase, as well as during the subacute and chronic phases after stroke. Diabetes, as a common risk factor for stroke, is often present for a long time before a stroke occurs, causing low-grade inflammation, and disrupting the proper functioning of the neurovascular units. These proinflammatory processes and maladaptive immune mechanisms are further accelerated after cerebral ischemia and worsen the stroke outcome in diabetic patients. Clinical treatments for ischemic stroke are currently focused on restoring cerebral blood flow (reperfusion) in the acute phase, including thrombolysis and mechanical thrombectomy, which are not applicable to patients that fall outside of the treatment window and/or without large-vessel occlusion. There are few approved treatments targeting cellular injury caused by inflammation. There are even fewer data on effective treatment for diabetic stroke targeting inflammation. This paper presents the first part of a review focusing on the temporospatial aspects of inflammation in ischemic stroke pathophysiology in stroke patients with type 2 diabetes.","PeriodicalId":72072,"journal":{"name":"Advanced neurology","volume":"11 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141382569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of foot sole insensitivity and reduced nerve conduction velocity on postural control and functional gait 足底不敏感和神经传导速度降低对姿势控制和功能步态的影响

Advanced neurology Pub Date : 2024-06-05 DOI: 10.36922/an.2900

Kelsey L. Lewis, Menzi Sun, Barry Joyner, Barr Munkasy, Li Li

{"title":"Impact of foot sole insensitivity and reduced nerve conduction velocity on postural control and functional gait","authors":"Kelsey L. Lewis, Menzi Sun, Barry Joyner, Barr Munkasy, Li Li","doi":"10.36922/an.2900","DOIUrl":"https://doi.org/10.36922/an.2900","url":null,"abstract":"Peripheral neuropathy is characterized by decreased foot sole sensitivity and slowed nerve conduction velocity, leading to impaired postural control and functional gait performance. This study assessed the differential effects of reduced foot sole sensitivity and slowed nerve conduction velocity on postural control and functional gait. Thirty-five participants were evaluated for two main clinical symptoms: the H-index and foot sole sensitivity. Two times the square of the height (H) of the individual divided by the latency (T) between the onsets of the M- and H-waves of the H-reflex were used to calculate the H-index (2 × [H/T]2). Foot sole sensitivity was evaluated using a monofilament on five sites at the bottom of the foot. Participants were categorized into three symptomological groups: (i) less affected (LA), (ii) moderately affected (MA), and (iii) severely affected (SA), based on their H-index ranges of 78.0 – 109.4, 42.8 – 76.6, and 45.6 – 75.5 cm2/ms2, respectively, and foot sole sensitivity score ranges of 6 – 10, 6 – 10, and 0 – 5, respectively. Outcome variables included center of pressure (COP) standard deviation in the anteroposterior direction and COP average velocity (Vavg) during 30 s of eyes-open quiet standing, as well as 6-min walk distance (6MWD) and timed-up-and-go duration (TUG). Multivariate analysis revealed significant group differences (P < 0.05), with post hoc analysis showing significant differences between LA and SA in Vavg (F4,30 = 3.752; P = 0.014). Discriminant analysis revealed Vavg as the primary determinant, while 6MWD and TUG were secondary determinants of group separation. Notably, enhanced functional gait was associated solely with sensitive foot soles and heightened nerve conduction velocity within the LA group, not in the MA or SA groups. Disease severity mediated the specific effects on postural control and functional gait, underscoring the importance of tailoring rehabilitation protocols to address individual symptoms.","PeriodicalId":72072,"journal":{"name":"Advanced neurology","volume":"31 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141385103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation in ischemic stroke patients with type 2 diabetes – Part I: Atherosclerosis formation, acute ischemia, post-stroke infection, and long-term sequelae 2 型糖尿病缺血性中风患者的炎症--第一部分：动脉粥样硬化形成、急性缺血、中风后感染和长期后遗症

Advanced neurology Pub Date : 2024-06-04 DOI: 10.36922/an.1683

Liqun Zhang, Ying Chen, Jingxian Xu, Christopher P. Corpe, A. Shtaya, Philip Benjamin, Yun Xu

{"title":"Inflammation in ischemic stroke patients with type 2 diabetes – Part I: Atherosclerosis formation, acute ischemia, post-stroke infection, and long-term sequelae","authors":"Liqun Zhang, Ying Chen, Jingxian Xu, Christopher P. Corpe, A. Shtaya, Philip Benjamin, Yun Xu","doi":"10.36922/an.1683","DOIUrl":"https://doi.org/10.36922/an.1683","url":null,"abstract":"Stroke is the leading cause of disability and the second leading cause of death worldwide. Diabetes mellitus is a critical independent cardiovascular risk factor in patients, irrespective of age, smoking, and hypertension. Approximately one-third of first-time ischemic stroke patients have diabetes. Inflammation is among the most important pathological mechanisms in atheroma formation, the damage cascades of the acute phase, as well as during the subacute and chronic phases after stroke. Diabetes, as a common risk factor for stroke, is often present for a long time before a stroke occurs, causing low-grade inflammation, and disrupting the proper functioning of the neurovascular units. These proinflammatory processes and maladaptive immune mechanisms are further accelerated after cerebral ischemia and worsen the stroke outcome in diabetic patients. Clinical treatments for ischemic stroke are currently focused on restoring cerebral blood flow (reperfusion) in the acute phase, including thrombolysis and mechanical thrombectomy, which are not applicable to patients that fall outside of the treatment window and/or without large-vessel occlusion. There are few approved treatments targeting cellular injury caused by inflammation. There are even fewer data on effective treatment for diabetic stroke targeting inflammation. This paper presents the first part of a review focusing on the temporospatial aspects of inflammation in ischemic stroke pathophysiology in stroke patients with type 2 diabetes.","PeriodicalId":72072,"journal":{"name":"Advanced neurology","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141266750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Linkage between SARS-CoV-2 infection and neurodegenerative disorders: Review and current update SARS-CoV-2 感染与神经退行性疾病之间的联系：回顾与最新进展

Advanced neurology Pub Date : 2024-03-14 DOI: 10.36922/an.2200

Amaan Javed, Anika Batra, Mehak Singh, Parnica Sarkar

{"title":"Linkage between SARS-CoV-2 infection and neurodegenerative disorders: Review and current update","authors":"Amaan Javed, Anika Batra, Mehak Singh, Parnica Sarkar","doi":"10.36922/an.2200","DOIUrl":"https://doi.org/10.36922/an.2200","url":null,"abstract":"The emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002, followed by the Middle East respiratory syndrome coronavirus (MERS-CoV) that causes fatal illness in 2012, has made coronaviruses a public health concern. Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection does not only affect the respiratory system but has also been observed to elicit neurological manifestations, with anosmia and ageusia being the most common, followed by headache, seizures, neuropathies, and encephalopathy. In addition to SARS-CoV and MERS-CoV which have been proven to be neuroinvasive, SARS-CoV-2 has been found to worsen preexisting long-term neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease, apart from triggering the acute neurological symptoms. The association between COVID-19 and relatively rare neurodegenerative disorders such as amyotrophic lateral sclerosis and Huntington’s disease has yet to be corroborated due to limited significant data. Studies have shown that COVID-19 does not seem to exacerbate these disorders, and the severity of COVID-19-related disease and fatalities is not significantly higher in the affected patients than in the general population. However, increased complications have been reported among the patients in advanced stages of these diseases. Hence, it is imperative to conduct long-term, comprehensive investigations on the effects of SARS-CoV-2 on neurodegenerative disorders, with the ultimate aim of developing appropriate interventions. Studies involving larger cohorts of people of varying ages, disease duration, and ethnicity are urgently warranted.","PeriodicalId":72072,"journal":{"name":"Advanced neurology","volume":"17 S1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140244496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the challenges of diagnosing dementia with Lewy bodies in a patient with alcohol and benzodiazepine misuse: A case study-based review 解读诊断酗酒和苯并二氮杂卓滥用患者路易体痴呆症的挑战：基于病例研究的综述

Advanced neurology Pub Date : 2024-03-13 DOI: 10.36922/an.2232

Kelly Tuchman, Fraser C. Henderson Sr

{"title":"Unraveling the challenges of diagnosing dementia with Lewy bodies in a patient with alcohol and benzodiazepine misuse: A case study-based review","authors":"Kelly Tuchman, Fraser C. Henderson Sr","doi":"10.36922/an.2232","DOIUrl":"https://doi.org/10.36922/an.2232","url":null,"abstract":"Dementia with Lewy bodies (DLBs) is the second most common cause of neurodegenerative dementia in the United States, after Alzheimer’s disease, and is often misdiagnosed. A history of substance use disorder (SUD) complicates the diagnosis process, and side effects of substance misuse can mirror or mask signs of degenerative dementia. The fluctuating cognition and mobility which would normally point toward DLB are erroneously seen as signs of SUD or polypharmacy. However, a history of SUD should not preclude the diagnosis of DLB or other forms of proteinopathy, as substance misuse can contribute to the development of neurodegenerative dementias. Both alcohol and benzodiazepines have a sedative effect as ligands to gamma-aminobutyric acid (GABA) receptors. Long-term use, misuse, and withdrawals can upset the delicate GABAergic/glutamatergic balance, resulting in adverse neuroimmune and neuroinflammatory responses which contribute to the pathologies seen in degenerative dementias, such as DLB. In this paper, we review the challenges, including limitations of standardized instruments for dementia and the harms of delayed diagnosis, in DLB diagnosis, in combination with our experiences drawn from studying a polypharmacy-practicing 68-year-old man with a 40-year history of benzodiazepine and alcohol use. Understanding the underlying mechanisms of SUD serves to destigmatize the condition to expedite treatment and further our knowledge of the relationship between neuroinflammation and dementia.","PeriodicalId":72072,"journal":{"name":"Advanced neurology","volume":"29 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140247662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactive antibodies against brain antigens as serological biomarkers of neurodegenerative diseases 作为神经退行性疾病血清生物标志物的脑抗原反应性抗体

Advanced neurology Pub Date : 2024-03-13 DOI: 10.36922/an.2058

June Egiguren-Ortiz, Celtia Domínguez-Fernández, Jone Razquin, Laura De las Heras-García, E. Astigarraga, Cristina Miguelez, G. Barreda-Gómez

{"title":"Reactive antibodies against brain antigens as serological biomarkers of neurodegenerative diseases","authors":"June Egiguren-Ortiz, Celtia Domínguez-Fernández, Jone Razquin, Laura De las Heras-García, E. Astigarraga, Cristina Miguelez, G. Barreda-Gómez","doi":"10.36922/an.2058","DOIUrl":"https://doi.org/10.36922/an.2058","url":null,"abstract":"The aging of the population, attributed to increased life expectancy, coincides with a rise in the prevalence of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. The symptoms of these disorders, such as motor disturbances and cognitive impairment, occur only after significant neurological damage, greatly diminishing the effectiveness of treatments. Consequently, achieving early diagnosis of neurodegenerative diseases stands as a paramount global health challenge. These conditions are characterized by the progressive loss of specific neuronal groups in the nervous system, resulting in dysfunction and eventual cell death in the brain. Although the exact cause of neuronal degeneration remains largely unknown, recent studies have revealed the significant involvement of the immune system in the pathogenesis of these diseases. Notably, the identification of reactive antibodies targeting specific antigens has highlighted a close association between immune mechanisms and the neurodegenerative process. Thus, the aim of this review is to explore the mechanisms of the adaptive immune system and their impact on the pathogenesis of neurodegenerative diseases, with a particular focus on reactive antibodies and their potential as diagnostic biomarkers.","PeriodicalId":72072,"journal":{"name":"Advanced neurology","volume":"9 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140247434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fried-Breadstick sign: A novel marker for healthy vasculature in magnetic resonance angiography 油炸面包棒征：磁共振血管造影中健康血管的新标记

Advanced neurology Pub Date : 2023-12-21 DOI: 10.36922/an.1238

Yannan Yu, Yu-yuan Xu, Xue Man, Ming-Li Li, Bo Hou, Shan Gao, Feng Feng, D. Liebeskind, Wei-Hai Xu

{"title":"Fried-Breadstick sign: A novel marker for healthy vasculature in magnetic resonance angiography","authors":"Yannan Yu, Yu-yuan Xu, Xue Man, Ming-Li Li, Bo Hou, Shan Gao, Feng Feng, D. Liebeskind, Wei-Hai Xu","doi":"10.36922/an.1238","DOIUrl":"https://doi.org/10.36922/an.1238","url":null,"abstract":"The Fried-Breadstick sign is characterized as a continuous signal loss at the center of the intracranial internal carotid artery (ICA) on time-of-flight magnetic resonance angiography (TOF-MRA). In this study, we present a novel imaging marker on TOF-MRA and investigate its potential association with ICA-middle cerebral artery (ICA-MCA) atherosclerosis and ischemic stroke. Vessel wall magnetic resonance imaging data were obtained from patients with recent clinical stroke or asymptomatic patients with suspected middle cerebral artery (MCA) atherosclerosis, covering the period from January 2007 to August 2015. We conducted a comparative analysis of ICA stenosis, MCA atherosclerosis and stenosis degree, and the terminal ICA bifurcation angle between ICA-MCAs with and without the Fried-Breadstick sign, involving a total of 1,005 ICA-MCAs from 553 patients. The Fried-Breadstick sign exhibited a higher prevalence in non-to-mild stenotic ICAs (57.5% vs. 9.8% in severely stenotic ICA, P < 0.001) and plaque-free MCAs (53.2% vs. 26.6% in MCAs with plaque, P < 0.001). Factors independently associated with the presence of the Fried-Breadstick sign included MCA stenosis degree (odds ratio [OR]: 0.85/10% increase, 95% confidence interval [CI]: 0.80 – 0.90), ICA stenosis (compared to non-to-mild stenosis, moderate stenosis: OR: 0.39, 95% CI: 0.28 – 0.54, severe stenosis: OR: 0.10, 95% CI: 0.06 – 0.17), and terminal ICA bifurcation angle (OR: 0.86/10° increase, 95% CI: 0.79 – 0.93). In atherosclerotic MCAs without luminal narrowing, the Fried-Breadstick sign was also less frequently observed than in plaque-free MCAs (34.6% vs. 53.2%, P = 0.012). In conclusion, the presence of the Fried-Breadstick sign is associated with healthier ICA-MCAs devoid of stenosis or plaque. The Fried-Breadstick sign may signify healthy ICA-MCA hemodynamics, serving as a potential screening tool for intracranial atherosclerosis without incurring additional cost or risk.","PeriodicalId":72072,"journal":{"name":"Advanced neurology","volume":"30 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138948822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Worsening of cerebral palsy following neonatal encephalopathy: A meta-analysis 新生儿脑病导致的脑瘫恶化：荟萃分析

Advanced neurology Pub Date : 2023-12-15 DOI: 10.36922/an.1719

Meng Yang, Sarah Eide, Emily W. Y. Tam, V. Chau, S.R. Wayne Chen, S. Miller, Hong-Shuo Sun, Zhong-ping Feng

{"title":"Worsening of cerebral palsy following neonatal encephalopathy: A meta-analysis","authors":"Meng Yang, Sarah Eide, Emily W. Y. Tam, V. Chau, S.R. Wayne Chen, S. Miller, Hong-Shuo Sun, Zhong-ping Feng","doi":"10.36922/an.1719","DOIUrl":"https://doi.org/10.36922/an.1719","url":null,"abstract":"Cerebral palsy (CP), the most common motor disorder in early childhood, arises from neonatal brain injury. The potential role of neonatal encephalopathy (NE) as a risk factor for cerebral palsy has been postulated, yet a systematic examination of its clinical impact on cerebral palsy patients remains absent. This meta-analysis aims to delineate the incidence of commonly reported complications associated with cerebral palsy following NE compared to those without a history of NE. A systematic search of PubMed and Google Scholar yielded 424 studies, with 7 meeting the inclusion criteria. These studies reported at least one comparison of cerebral palsy symptoms between patients with or without NE and provided the corresponding case numbers for each group. Utilizing RevMan 5.4, we analyzed the data and assessed potential publication bias. Among the 7 studies included, we compared the characteristics of 117 patients with cerebral palsy with preceding NE to 287 without such antecedents. Significantly, the incidence of the spastic quadriplegic subtype of cerebral palsy was higher in patients with NE (odds ratio [OR]: 4.34, 95% confidence interval [CI]: 2.69 – 7.00, P < 0.00001). CP patients following NE exhibited a significantly increased incidence of severe communication difficulties (OR: 2.33, 95% CI: 1.32 – 4.10, P = 0.003), difficulty swallowing (OR: 2.50, 95% CI: 1.31 – 4.77, P = 0.005), and cognitive impairment (OR: 2.73, 95% CI: 1.45 – 5.13, P = 0.002). Children with cerebral palsy born following NE were more predisposed to the most severe spastic quadriplegic subtype and encountered significant comorbidities. It is essential to acknowledge the limitations of this study, primarily the small number of studies that separately reported cerebral palsy cases with or without NE. Nevertheless, these findings contribute valuable insights for a more accurate clinical prognosis and the prospective development of targeted treatments for specific complications associated with cerebral palsy in patients with NE.","PeriodicalId":72072,"journal":{"name":"Advanced neurology","volume":"7 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138970711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The coexistence of narcolepsy and multiple sclerosis: A case report 嗜睡症与多发性硬化症并存：病例报告

Advanced neurology Pub Date : 2023-12-14 DOI: 10.36922/an.1913

Jinglong Hu, Minkai Zhang, Linjie Yu, Meijuan Zhang

引用次数: 0