Addiction and substance abuse最新文献

{"title":"Decisional incentive sensitivity is linked to contingency management outcome and striatal dopamine signaling in individuals with cocaine use disorder: a preliminary study.","authors":"Nehal P Vadhan, Kenneth M Carpenter, Elysia Benedict, Catherine E Myers, Mark A Gluck, Diana Martinez, Edward V Nunes","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Nontreatment-seeking individuals with cocaine use disorder (CUD) have been found to exhibit decision-making on laboratory tasks that is risky but also sensitive to monetary incentive, relative to controls.</p><p><strong>Objective: </strong>The purpose of this study was to replicate these findings in treatment-seeking individuals and explore their relationships with voucher-based treatment outcome and striatal dopamine (DA) release.</p><p><strong>Methods: </strong>This study was approved by the Institutional Review Board, and all participants provided written informed consent to participate. Eighteen briefly-abstinent individuals seeking treatment for CUD and 19 control participants were compared on performance of a modified Iowa Gambling task (mIGT) under both hypothetical and cash earning conditions. The CUD participants subsequently received Positron Emission Tomography (PET) scans with [¹¹C]raclopride with methylphenidate (60 mg) challenge and then 12 weeks of Community Reinforcement Approach plus Vouchers (CRA+V) treatment.</p><p><strong>Results: </strong>On the mIGT, the CUD participants' advantageous card selection was selectively more sensitive to the presence of a monetary incentive, relative to controls (F4,128 = 3.10, p<0.05). Among the male CUD participants, those who exhibited greater DA release in the ventral striatum (VSt), and those who responded to the CRA+V treatment, exhibited greater mIGT incentive sensitivity than those who were nonresponders (F_4,44 = 5.84, p<0.01), and who exhibited relatively decreased VSt DA release (F_4,48 = 2.55, p<0.05).</p><p><strong>Conclusions: </strong>Participants seeking treatment for CUD exhibited selectively increased decisional incentive sensitivity, relative to controls. For the male CUD participants, greater incentive sensitivity was associated with greater VSt DA release and better CRA+V outcome. These findings appear partially consistent with previous findings on cognition and motivation in individuals with CUD, and suggest a heuristic model connecting striatal DA, incentive sensitivity, and CRA+V outcome.</p>","PeriodicalId":72066,"journal":{"name":"Addiction and substance abuse","volume":"4 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impulsive responding increases during a laboratory model of a cocaine binge in individuals who use cocaine: A preliminary study.","authors":"Nehal P Vadhan, Sean P Madden, Majnu John, Stephanie Collins Reed, Suzanne K Vosburg, John G Keilp, Richard W Foltin","doi":"10.46439/addiction.3.010","DOIUrl":"10.46439/addiction.3.010","url":null,"abstract":"<p><strong>Background: </strong>Individuals with a binge pattern of cocaine use have been found to exhibit cognitive decrements relative to controls, but also experience increases in cognitive performance during binge cocaine administration in the laboratory.</p><p><strong>Objective: </strong>We examined cognitive performance during binge cocaine administration in the laboratory, but with varied amounts of cocaine, to better estimate its cognitive effects in the natural ecology.</p><p><strong>Methods: </strong>This study was approved by the Institutional Review Board of the New York State Psychiatric Institute, and all participants provided written informed consent to participate. Twelve individuals who used cocaine regularly (males=91.7%) and were physically/psychiatrically - healthy, completed a nightly counterbalanced cognitive battery during 2 phases of cocaine administration, separated by a period of cocaine abstinence (all phases maximum 5 days each). During cocaine phases, participants smoked cocaine up to 12 times per day (25 mg per occasion) as part of an experimenter-administered or self-administered protocol.</p><p><strong>Results: </strong>On average, participants exhibited decreased attentional response inhibition (<i>F</i>(2,48)=12.70, <i>p</i><0.05) during Binge 1 (M=1072.5 mg cocaine), relative to Abstinence (0.0 mg cocaine) and Binge 2 (M=650.0 mg cocaine). The self-administration group exhibited decreased motor tracking (<i>F</i>=6.11(1,12.4), <i>p</i><0.05) during Binge 2, relative to the other study phases, whereas the experimenter-administration group did not.</p><p><strong>Conclusions: </strong>These data suggest that response inhibition, but not immediate memory or psychomotor speed, was impaired during periods of binge cocaine administration in experienced users. This finding has important implications for behaviors that require inhibitory control, such as driving, during cocaine intoxication.</p>","PeriodicalId":72066,"journal":{"name":"Addiction and substance abuse","volume":"3 1","pages":"12-17"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12916013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between resilience promotion factors during childhood and risk of drug use disorder during adulthood.","authors":"Ann Aschengrau,&nbsp;Michael R Winter,&nbsp;Margaret G Shea","doi":"10.46439/addiction.2.007","DOIUrl":"https://doi.org/10.46439/addiction.2.007","url":null,"abstract":"<p><p>Few studies have been conducted on the relationship between \"outside-residing\" resilience characteristics and the risk of developing drug use disorder later in life. These characteristics include responsive and caring parenting, household routines involving regular family meals and bedtime routines, social support from peers, participation in organized activities, and religious service attendance. We quantified the association between these resilience promotion factors during childhood and the risk of developing criteria for drug use disorder during adulthood using data from a retrospective cohort study of 618 adults born in Massachusetts during 1969-1983, including those with adverse childhood experiences (ACEs). Self-administered questionnaires gathered information on criteria for drug use disorder, ACEs, and family and community resilience promotion factors. Compared to individuals with \"low\" numbers of resilience promotion factors, 30% (95% CI: 0.5-0.9) and 50% reductions (95% CI: 0.4-0.8) in the risk of developing one or more criteria for drug use disorder were observed among those with \"moderate\" and \"high\" numbers of resilience factors, respectively (p value for trend=0.003). Overall, family factors were associated with greater risk reductions than comparable numbers of community factors. Among individuals with ACEs, a \"high\" number of family factors but not community factors were associated with a reduction in risk (RR:0.6, 95% CI:0.4-1.0 for family factors, RR:1.0, 95% CI:0.5-1.8 for community factors). These results suggest that the risk of developing criteria for drug use disorder decreases in a dose-response fashion according to the number of \"outside-residing\" resilience promotion factors during childhood, and that family factors are associated with greater risk reductions than community factors, particularly among individuals with ACEs. Coordinated prevention efforts at the family and community level are recommended to reduce the risk of this important societal problem.</p>","PeriodicalId":72066,"journal":{"name":"Addiction and substance abuse","volume":"2 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10326717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9801582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clay eating in pregnancy in French Guiana: How does one understand the practices and act for prevention?","authors":"","doi":"10.46439/addiction.1.006","DOIUrl":"https://doi.org/10.46439/addiction.1.006","url":null,"abstract":"","PeriodicalId":72066,"journal":{"name":"Addiction and substance abuse","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73484641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of some synthetic cannabinoids (FUB-AMB and AB-FUBINACA) in blood and urine using gas chromatography-mass spectrometry liquid–liquid extraction","authors":"AM El-Essawy, Ahmed MA Shihata, Emad HA Mohamed","doi":"10.46439/addiction.1.003","DOIUrl":"https://doi.org/10.46439/addiction.1.003","url":null,"abstract":"has a binding affinity CB1 receptor that is four times greater than of THC and ten than Abstract In recent years, various types of synthetic cannabinoids have become widely distributed and are causing social and health problems in most parts of the world. Synthetic cannabinoids are currently the largest group of new psychoactive substances. Those that have been subjected to legal control are replaced by newer controlled and uncontrolled substances. Some of the most recent synthetic cannabinoids that have distributed on the market among youth are FUB-AMB and AB-FUBINACA. This study quantified blood and urine of two cases smoking tobacco mixed with AMB-FUB 0.06-0.03 ng/mL and 1.7-2.9 ng/mL AB-FUB in urine and blood respectively.","PeriodicalId":72066,"journal":{"name":"Addiction and substance abuse","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86571453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide, opioids, chronic pain, and mental health disorders: a narrative review","authors":"","doi":"10.46439/addiction.1.004","DOIUrl":"https://doi.org/10.46439/addiction.1.004","url":null,"abstract":"","PeriodicalId":72066,"journal":{"name":"Addiction and substance abuse","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89856625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Portrayal of substance use in media and its effects on substance use disorders among youth","authors":"Mark A. Stillman, S. T. Daddis","doi":"10.46439/addiction.1.001","DOIUrl":"https://doi.org/10.46439/addiction.1.001","url":null,"abstract":"A variety of behavioral, environmental, developmental, and genetic factors have been documented as contributing to the development of Substance Use Disorders (SUDs) in youth. For example, it has been suggested that things such as the perceived availability of substances, familial history of antisocial behavior, and personal attitudes favorable towards drug use all have strong correlations to the development of substance use in youth [1]. What’s especially troubling is that use initiation at younger ages is also correlated with stronger likelihoods of developing a SUD [2]. Thus, it is crucial that researchers continue to explore contributing factors to youth’s likelihood of substance use.","PeriodicalId":72066,"journal":{"name":"Addiction and substance abuse","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88088543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Filter ventilation and the risk associated with cigarette smoking","authors":"P. Lee","doi":"10.46439/addiction.1.005","DOIUrl":"https://doi.org/10.46439/addiction.1.005","url":null,"abstract":"It has long been clear that cigarette smoking is causally linked to many diseases, particularly lung cancer, chronic obstructive pulmonary disease and various forms of cardiovascular disease. For lung cancer, for example, a meta-analysis my colleagues and I conducted, based on epidemiological evidence published in the 1900s [1], estimated that current smoker/never smoker relative risks, were around 10 in North America and Europe, though lower (around three) in Asia. They were higher for squamous cell carcinoma than for adenocarcinoma, were very strongly related to amount smoked, and declined with increasing years of cessation of smoking.","PeriodicalId":72066,"journal":{"name":"Addiction and substance abuse","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88072226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of relapse in alcohol use disorder: Identifying individuals most vulnerable to relapse","authors":"Mark A. Stillman, Jane Sutcliff","doi":"10.46439/addiction.1.002","DOIUrl":"https://doi.org/10.46439/addiction.1.002","url":null,"abstract":"linear new multiple Abstract This paper reviews the literature discussing the various biological, psychological, environmental, and social factors contributing to the risk of relapse for individuals with Alcohol Use Disorder (AUD). Identifying these risk factors and understanding their complex interactions in contributing to relapse vulnerability is crucial to improving relapse prevention interventions and outcomes. The impact of chronic alcohol abuse on brain structure and function are discussed. Specifically, altered reward circuitry, modified stress pathways, and compromised frontal white matter integrity in regions associated with decision making, impulse control, and executive functioning are identified as risk factors associated with predicting long- term abstinence. Neural adaptations increased craving, which has been attributed to relapse vulnerability. The literature examined alcohol attentional-bias, coping style, early onset alcohol dependence, duration of treatment, attendance at AA, personality traits, self-efficacy, comorbid depression, deficits in social cognition, interpersonal relationships, and facial emotion recognition ability as risk factors that may be predictive of relapse. Clinicians should encourage AA attendance, treat depressive symptoms, address coping mechanisms, and enhance social support in the first year of abstinence. Future studies that focus on establishing the strength of the predictability of these risk factors, as well as identifying protective factors, could make substantive contributions to improving outcomes for individuals who are most vulnerable to the relapse process. Identifying risk factors at the brain and biological level could establish biomarkers for relapse risk, which would have implications for clinical practice and treatment of AUD by enhancing targeted interventions and individualized care.","PeriodicalId":72066,"journal":{"name":"Addiction and substance abuse","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78894399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personality, Internet Addiction, and Other Technological Addictions","authors":"Zaheer Hussain, H. Pontes","doi":"10.4018/978-1-5225-8449-0.CH003","DOIUrl":"https://doi.org/10.4018/978-1-5225-8449-0.CH003","url":null,"abstract":"Research into technological addictions, such as Internet addiction, smartphone addiction and social networking addiction has greatly increased. It is important to understand how technological addictions may be related to different personality types and key individual differences associated to personality. This chapter provides empirical and conceptual insights into how technological addictions may be related to different personality types and key individual differences associated to personality. This chapter focuses on a number of technological addictions and illustrates how research and theory in this area has developed in relation to commonly researched personality traits (e.g., extraversion, introversion, neuroticism, conscientiousness, openness to experience, and narcissism) and key individual differences related to personality (e.g., personality disorders). The complex nature of personality and technological addictions is discussed together with areas for future research.","PeriodicalId":72066,"journal":{"name":"Addiction and substance abuse","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80091690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}