ACS symposium series. American Chemical Society最新文献

Designing Cell-Permeable Peptide Therapeutics That Enter the Cell by Endocytosis. 设计通过内吞作用进入细胞的细胞渗透性肽疗法。

ACS symposium series. American Chemical Society Pub Date : 2022-01-01 DOI: 10.1021/bk-2022-1417.ch007

Dehua Pei

引用次数: 0

A Biomimetic System for Studying Salicylate Dioxygenase. 研究水杨酸双加氧酶的仿生系统。

ACS symposium series. American Chemical Society Pub Date : 2019-01-01 Epub Date: 2019-07-12 DOI: 10.1021/bk-2019-1317.ch004

Atanu Banerjee, Jia Li, Monika A Molenda, William W Brennessel, Ferman A Chavez

{"title":"A Biomimetic System for Studying Salicylate Dioxygenase.","authors":"Atanu Banerjee, Jia Li, Monika A Molenda, William W Brennessel, Ferman A Chavez","doi":"10.1021/bk-2019-1317.ch004","DOIUrl":"https://doi.org/10.1021/bk-2019-1317.ch004","url":null,"abstract":"We report the characterization of [Fe(T1Et4iPrIP)(sal)] (2) (T1Et4iPrIP = tris(1-ethyl-4-isopropyl-imidazolyl)phosphine; sal2- = salicylate dianion), which serves as a model for substrate-bound salicylate dioxygenase (SDO). Complex 2 crystallizes in the monoclinic space group P21/n with a = 10.7853(12) Å, b = 16.5060(19) Å, c = 21.217(2) Å, β = 94.489(2)°, and V = 3765.5(7) Å3. The structure consists of FeII bonded in distorted square pyramidal geometry (τ = 0.32) with two salicylate oxygens and two T1Et4iPrIP nitrogens serving as the base and the apical position occupied by the other ligand nitrogen. [Fe(T1Et4iPrIP)(OTf)2] (1), the precursor for 2, catalyzes the cleavage of 1,4-dihydroxy-2-naphthoate in the presence of O2. Complex 1 is also capable of cleaving the salicylate aromatic ring in the presence of H2O2. The progression of this reaction toward product formation involves an FeIII-phenoxide species.","PeriodicalId":72050,"journal":{"name":"ACS symposium series. American Chemical Society","volume":"1317 4","pages":"71-83"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1021/bk-2019-1317.ch004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38883747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engaging Early-Career Students in Research Using a Tiered Mentoring Model. 使用分层指导模型吸引早期职业学生参与研究。

ACS symposium series. American Chemical Society Pub Date : 2018-01-01 DOI: 10.1021/BK-2018-1275.CH016

S. Hayes

{"title":"Engaging Early-Career Students in Research Using a Tiered Mentoring Model.","authors":"S. Hayes","doi":"10.1021/BK-2018-1275.CH016","DOIUrl":"https://doi.org/10.1021/BK-2018-1275.CH016","url":null,"abstract":"Incorporating research into undergraduate curricula, especially at an early stage, has been linked to improved critical thinking, intellectual independence, and student retention. This results in a graduating population more ready to enter the workforce or graduate school. Similarly, mentoring has been linked to enhanced self-efficacy, persistence, and desire to pursue graduate studies. We have designed two linked courses that engage second-year undergraduate students in developing self-directed research projects, proposal writing. These courses also serve to nucleate relationships with graduate student mentors enrolled in the companion course. Early-career undergraduate students, with no previous research experience, receive formal training in the process of scientific research from a faculty process mentor while working with a graduate student content mentor to develop an independent research project and write a proposal and embed themselves in an active research group. Undergraduate students may elect to submit their proposals for funding to continue the project, either as part of the upper division research course required for graduation or independently. Graduate students enrolled in the companion course gain experience in mentoring through formal training and actively mentoring early-career undergraduates. This chapter presents both the model and early assessment of our integrated approach to engaging early career undergraduates in developing and funding independent research projects with the support of empowering mentoring relationships.","PeriodicalId":72050,"journal":{"name":"ACS symposium series. American Chemical Society","volume":"28 1","pages":"273-289"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82694989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Introduction to Environmental Chemistry of the Arctic: An Introductory, Lab-Based Course Offered Both Face-to-Face and by Distance. 北极环境化学导论:以实验室为基础的介绍性课程，提供面对面和远程授课。

ACS symposium series. American Chemical Society Pub Date : 2018-01-01 DOI: 10.1021/BK-2018-1276.CH001

J. Guerard, S. Hayes

{"title":"Introduction to Environmental Chemistry of the Arctic: An Introductory, Lab-Based Course Offered Both Face-to-Face and by Distance.","authors":"J. Guerard, S. Hayes","doi":"10.1021/BK-2018-1276.CH001","DOIUrl":"https://doi.org/10.1021/BK-2018-1276.CH001","url":null,"abstract":"In this chapter, we present a model for an entry-level lab-based undergraduate environmental chemistry course delivered simultaneously by face-to-face and distance modalities. This course frames conceptual chemistry using the theme of Alaskan Arctic environmental issues in order to increase engagement and perceived relevance of chemical principles. Synchronously delivered lectures and guided discussions along with the incorporation of peer-mentored research projects encourage the development of a learning community among students in the course. Distance students participate in the same virtual and \"kitchen\" lab experiments as on-campus students, thus providing an educationally equivalent curriculum to all. In mixed teams of on-campus and distance students, all students participate in research projects to allow entry-level students to explore their interests in STEM fields. Students thereby begin to build an identity as a scientist and hopefully this course will serve as a mechanism to improve recruitment and retention of students, especially from traditionally underrepresented groups, in the chemical sciences and other STEM fields of study. Responses from the first course offering communicated positive attitudes toward the course content and methods.","PeriodicalId":72050,"journal":{"name":"ACS symposium series. American Chemical Society","volume":"30 1","pages":"1-19"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77185442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Surviving an Oxygen Atmosphere: DNA Damage and Repair. 在氧气环境中生存:DNA损伤和修复。

ACS symposium series. American Chemical Society Pub Date : 2009-12-20 DOI: 10.1021/bk-2009-1025.ch008

Cynthia J Burrows

引用次数: 15

New Tricks in Amino Acid Synthesis: Applications to Complex Natural Products. 氨基酸合成的新技巧：应用于复杂的天然产品。

ACS symposium series. American Chemical Society Pub Date : 2009-06-14

Robert M Williams, Cameron M Burnett

引用次数: 0