Dalton Transactions最新文献_第6页

Synthesis, characterization and induction of ferroptosis of iridium(III) complexes against melanoma B16 cells 抗黑色素瘤B16细胞的铱（III）复合物的合成、表征和诱导凋亡

IF 4 3区化学

Dalton Transactions Pub Date : 2025-05-19 DOI: 10.1039/d5dt00899a

Zhujun Sheng, Yuanzheng Liu, Li Xu, Xin Yao, Ju Chen, Yunjun Liu, Xiu-Zhen Wang

{"title":"Synthesis, characterization and induction of ferroptosis of iridium(III) complexes against melanoma B16 cells","authors":"Zhujun Sheng, Yuanzheng Liu, Li Xu, Xin Yao, Ju Chen, Yunjun Liu, Xiu-Zhen Wang","doi":"10.1039/d5dt00899a","DOIUrl":"https://doi.org/10.1039/d5dt00899a","url":null,"abstract":"The synthesis of ligand, 2-(2-methyl-4-hydroxyl)phenyl-1H-imidazo[4,5-f][1,10]phenanthroline (MHIP), and corresponding new iridium(III) complexes: [Ir(ppy)2(MHIP)]PF6 (ppy = 2-phenylpyridine, 9a), [Ir(bzq)2(MHIP)]PF6 (bzq = benzo[h]quinolone, 9b) and [Ir(piq)2(MHIP)]PF6 (piq = 1-phenylisoquinoline, 9c) were reported. The antiproliferative activity of compounds 9a-9c on cancer HepG2, B16, A549 cells, normal LO2 cells were tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, it was found that the three complexes showed moderate cytotoxicity on A549 and B16 cells. However, after further irradiation, the cytotoxicity was greatly enhanced, especially, 9a, 9b and 9c display significant cytotoxicity toward B16 cells with a low IC50 value of 3.1 ± 0.3 µM for 9a, 4.9 ± 0.8 µM for 9b, and 0.4 ± 0.1 µM for 9c, respectively. The effects of 9a-9c on the invasive ability of B16 cells were explored by colony formation and scratch experiments, the results demonstrate that the complexes can efficiently block the cell proliferation and migration. The co-localization assay found that 9a-9c accumulate in the mitochondria and lead to the apoptosis of B16 cells by decreasing the mitochondrial membrane potential, altering the structure of microtubule proteins, damaging the structure of the cellular DNA, and changing the expression of related proteins. The decrease of glutathione (GSH) concentration, the increase of malondialdehyde (MDA), the downregulation of GPX4, and C11-BODIPY staining results confirmed that 9a, 9b and 9c led to ferroptosis. In addition, we explored the relevant signaling pathways through RNA sequencing assay and speculated on possible anticancer mechanisms. Together, these results indicate that the synthesized new iridium(III) complexes 9a-9c can induce cell death via a ROS-mediated mitochondrial dysfunction apoptosis and ferroptosis.","PeriodicalId":71,"journal":{"name":"Dalton Transactions","volume":"17 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144088191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of ether coordination on the solid-state luminescence of a lithium β-diketiminate complex. 醚配位对β-二氯乙酸锂配合物固态发光的影响。

IF 4 3区化学

Dalton Transactions Pub Date : 2025-05-19 DOI: 10.1039/d5dt00954e

Shunichiro Ito,Kazuo Tanaka,Yoshiki Chujo

引用次数: 0

Halogen Bonds-enhanced Spin Dynamics: Investigating Co-crystallization Effects on Spin Crossover in Mononuclear Mn(III) Schiff-base Complexes 卤素键增强的自旋动力学：研究单核Mn（III）席夫碱配合物中自旋交叉的共结晶效应

IF 4 3区化学

Dalton Transactions Pub Date : 2025-05-17 DOI: 10.1039/d5dt00841g

Sheng-Ze Zhao, Liwen Chen, Hai Zhu, Hao-Zhe Zhang, Chang Liu, Chun-Yan Qin, Hai-Ying Wang, Yong-Hua Li, Shi Wang

{"title":"Halogen Bonds-enhanced Spin Dynamics: Investigating Co-crystallization Effects on Spin Crossover in Mononuclear Mn(III) Schiff-base Complexes","authors":"Sheng-Ze Zhao, Liwen Chen, Hai Zhu, Hao-Zhe Zhang, Chang Liu, Chun-Yan Qin, Hai-Ying Wang, Yong-Hua Li, Shi Wang","doi":"10.1039/d5dt00841g","DOIUrl":"https://doi.org/10.1039/d5dt00841g","url":null,"abstract":"We present co-crystallization with 1,3,5-trifluoro-2,4,6-triiodobenzene (TFTIB) as an approach to tuning spin crossover (SCO) properties of mononuclear Mn(III) Schiff-base complexes. The isostructural complexes [Mn(naphth-sal-N-1,5,8,12)]Y (Y= Br (1) and Y=I (2) and (naphth-sal-N-1,5,8,12)2− is a big conjugated hexadentate Schiff-base ligand) share similar magnetic behaviors and among them complex 2 shows a gradual SCO with transition temperature T1/2 ~ 380 K. Complexes [Mn(naphth-sal-N-1,5,8,12)]∙TFTIB∙Y (Y= Br (3) and Y=I (4)) are synthesized by the co-crystallization of their parent complexes 1 and 2 with the TFTIB and they both exhibit more gradual SCO with T1/2 rising to over 400 K. For comparison, complex [Mn(5-F-sal-N-1,5,8,12)]∙2TFTIB∙Br∙CH3CN (5) was also synthesized, which maintains a high spin (HS) state over the measured temperature range. An anion-TFTIB network connected by halogen-halogen bonds has a significant influence on cation-anion crystal packing and finally the cooperative effects of the SCO complexes.","PeriodicalId":71,"journal":{"name":"Dalton Transactions","volume":"10 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144067051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive hydrogen-bonding strategy driven 0D manganese-based metal halides with multifunctional fluorescent applications. 自适应氢键策略驱动的0D锰基金属卤化物与多功能荧光应用。

IF 4 3区化学

Dalton Transactions Pub Date : 2025-05-16 DOI: 10.1039/d5dt00491h

Jiamin Liu,Yuntao Ruan,Qiaoqi Qin,Yong Shen,Zhengliang Wang,Daibin Kuang,Long Jiang

引用次数: 0

Dimensionality-driven photoluminescence enhancement in Cl/Br mixed-halide organic–inorganic hybrid cadmium halides Cl/Br混合卤化物有机-无机杂化镉卤化物的尺寸驱动光致发光增强

IF 4 3区化学

Dalton Transactions Pub Date : 2025-05-16 DOI: 10.1039/d5dt00908a

Boyoung Kim, Kang Min Ok

引用次数: 0

A comparative study on nido- and closo-carborane supported zinc-salen catalysts for the ROCOP of epoxides and anhydrides† 环氧化物和酸酐ROCOP反应中氮氧基和近碳硼烷负载锌-salen催化剂的比较研究。

IF 3.5 3区化学

Dalton Transactions Pub Date : 2025-05-16 DOI: 10.1039/D5DT00946D

Jin-Bian Xue, Jia-Ni Wang, Ke-Cheng Chen, Qian Cheng, Jia-Ying Zhang and Xu-Qiong Xiao

引用次数: 0

Interpreting solvent effects on complex dihydrogenphosphate binding using amidobenzimidazole functionalised emissive ruthenium diimine complexes 用偕胺苯并咪唑功能化钌二亚胺配合物解释溶剂对磷酸二氢配合物结合的影响

IF 4 3区化学

Dalton Transactions Pub Date : 2025-05-16 DOI: 10.1039/d5dt00842e

Andrew J. Stocker, Chloe L. Howells, Nicholas C Fletcher

{"title":"Interpreting solvent effects on complex dihydrogenphosphate binding using amidobenzimidazole functionalised emissive ruthenium diimine complexes","authors":"Andrew J. Stocker, Chloe L. Howells, Nicholas C Fletcher","doi":"10.1039/d5dt00842e","DOIUrl":"https://doi.org/10.1039/d5dt00842e","url":null,"abstract":"The photophysical behaviour of two amidobenzimidazole complexes, [Ru(bpy)2(bbiab)](PF6)2 and [Ru(phen)2(bbiab)](PF6)2 (where bbiab = 4,4`-bis(N-1H-benzimidazol-2-yl-carboxamidyl)-2,2`-bipyridine) in a variety of solvents suggest that the 3MLCT state is sensitive to the introduction of small aliquots of solvent (dilution) resulting in distinct incremental changes to the absorption spectra, and quenching in emission. This solvent dependency is more pronounced in polar media and is proposed to be a consequence of “dimerization” of these complexes, which is supported by 1H-DOSY-NMR spectroscopy and gas phase DFT studies on the free ligands. The pH behaviour of these complexes indicates that protonation of the imidazole results in changing the emissive state from the bpy and phen ligands to bbiab. Significant quenching in both complexes is seen on the introduction of acetate, which 1H-NMR spectroscopy suggests is association with the bbiab imidazole groups. On the introduction of HSO4− and H2PO4− salts, the photophysical response suggests several distinct interactions are present as anion concentration increases, with both the amide and imidazole groups able to act as hydrogen-bond donors and acceptors. These effects are solvent dependent implying a complex set of equilibria, ranging from protonation of the imidazole in non-protic solvents, dissociation of the complex dimer, a simple one-to-one species, and a combined bis(dihydrogenphosphate)-complex anion, with speciation reliant on complex charge, associated ligand hydrophobicity, and solvent.","PeriodicalId":71,"journal":{"name":"Dalton Transactions","volume":"57 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron oxide nanospheres: dual functionality as MRI contrast agents and magnetic fluid hyperthermia therapeutics. 氧化铁纳米球：作为MRI造影剂和磁流体热疗的双重功能。

IF 4 3区化学

Dalton Transactions Pub Date : 2025-05-16 DOI: 10.1039/d5dt00609k

Margherita Porru,Francesca Brero,Carlos Dìaz-Ufano,Manuel Mariani,Francesco Orsini,Paolo Arosio,Marìa Del Puerto Morales,Alessandro Lascialfari

{"title":"Iron oxide nanospheres: dual functionality as MRI contrast agents and magnetic fluid hyperthermia therapeutics.","authors":"Margherita Porru,Francesca Brero,Carlos Dìaz-Ufano,Manuel Mariani,Francesco Orsini,Paolo Arosio,Marìa Del Puerto Morales,Alessandro Lascialfari","doi":"10.1039/d5dt00609k","DOIUrl":"https://doi.org/10.1039/d5dt00609k","url":null,"abstract":"Magnetic nanoparticles offer the possibility of combining diagnostic and therapeutic purposes within a single nano-object. In this work, we explore two distinct sets of iron oxide-based nanospheres for their application as contrast agents in magnetic resonance imaging and as heating mediators in magnetic fluid hyperthermia. The nanoparticles were produced with the green microwave polyol-assisted method. The nanoparticles in the first set have a mean core diameter of 11 nm and are coated with polyacrylic acid (PAA), carboxymethyl-dextran (CM-D), or dimercaptosuccinic acid (DMSA). The second set has nanoparticles of a mean diameter of 14 nm, which are coated with PAA or CM-D. The longitudinal and transverse 1H-NMR nuclear relaxivities (r1,2) exhibit a field behavior that depends on the particle core size and on the coating. It is shown that the combination of size and coating is relevant to optimize the relaxometric efficiency, with the PAA coating being able to double the r2 efficiency for the smallest size. The heating release was evaluated under various combinations of external alternating magnetic fields, with frequency values ranging from 102.2 kHz to 971.2 kHz and amplitude values ranging from 7 mT to 40 mT. The results indicate that the heating efficiency is independent of the coating for both the 11 and 14 nm particles, while it is significantly higher for the samples of largest size. We conclude that the combination of size and coating (i.e., surface modifications) of the magnetic nanoparticles can play a crucial role in the relaxometric and heating properties of magnetic nanoparticles with core size of <15 nm.","PeriodicalId":71,"journal":{"name":"Dalton Transactions","volume":"28 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural Diversity of Nucleotide Coordination Polymers of Cytidine Mono-, Di-, and Tri-Phosphates and Their Selective Recognition of Tryptophan and Tyrosine 胞苷单、二、三磷酸核苷酸配位聚合物的结构多样性及其对色氨酸和酪氨酸的选择性识别

IF 4 3区化学

Dalton Transactions Pub Date : 2025-05-16 DOI: 10.1039/d5dt00786k

Yaqoot khan, Yunyun Du, Li Yan, Niu Zhang, Menglei Zhang, Hongwei Ma, Hui Li

{"title":"Structural Diversity of Nucleotide Coordination Polymers of Cytidine Mono-, Di-, and Tri-Phosphates and Their Selective Recognition of Tryptophan and Tyrosine","authors":"Yaqoot khan, Yunyun Du, Li Yan, Niu Zhang, Menglei Zhang, Hongwei Ma, Hui Li","doi":"10.1039/d5dt00786k","DOIUrl":"https://doi.org/10.1039/d5dt00786k","url":null,"abstract":"Understanding the coordination geometry of nucleotide mono-, di-, and triphosphates is pivotal for unraveling the intricate relationships between molecular structure and biological function, particularly in metal–ligand interactions and their role in biomolecular recognition. This study investigates the structure of nucleotide-metal polymers and their selective interactions with amino acids, specifically Tryptophan (Trp) and Tyrosine (Tyr). We synthesized and comprehensively analyzed five coordination polymers of cytidine-nucleotides: cytidine monophosphate (CMP), deoxycytidine monophosphate (dCMP), cytidine diphosphate (CDP), and cytidine triphosphate (CTP): {[Cu(CMP)(bpa)(H₂O)₃](CMP)·3H₂O}n (1), {[Cu₂(dCMP)(4,4′-bipy)₂(H₂O)₂]·4H₂O}n (2), {[Cu₂(CDP)₂(azpy)(H₂O)]·3H₂O}n (3), {[Cd₂(CDP)₂(bpa)₂(H₂O)₂]·8H₂O}n (4), and {[Cu(CTP)(2,2′-bipy)]·2H₂O}n (5), where (3), (4) and (5) mark the first report of CDP and CTP coordination complexes. Single crystal X-ray diffraction unveiled the structure of the polymers to be one-dimensional (1, 5) or two-dimensional (2, 3, 4). Circular dichroism (CD) spectroscopy in both the solid and solution states elucidates the chirality-driven assembly in these nucleotide-metal polymers. The selective interactions of coordination polymers with Tryptophan (Trp) and Tyrosine (Tyr) were studied using spectroscopic titrations. Experimental and computational analyses reveal distinct interactions between all five coordination polymers and the amino acids, highlighting their biosensing potential. Binding affinity variations across the polymers offer insights into nucleotide-metal coordination chemistry and suggest applications in molecular recognition and functional materials.","PeriodicalId":71,"journal":{"name":"Dalton Transactions","volume":"15 1","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144066322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergence of a bismuth-based metal-organic framework as an X-ray scintillator 作为x射线闪烁体的铋基金属有机骨架的出现

IF 4 3区化学

Dalton Transactions Pub Date : 2025-05-16 DOI: 10.1039/d5dt00965k

Peng Lin, junpu yang, Weinan Sun, Xiaoyuan Zhou, Fangbo Zhao, Jian Lin

引用次数: 0