Advanced Biomedicine最新文献

{"title":"DEBRIDEMENT IN DIABETIC FOOT ULCER","authors":"Gudisa Bereda","doi":"10.54730/abm.2022.040302","DOIUrl":"https://doi.org/10.54730/abm.2022.040302","url":null,"abstract":"Wound debridement is defined as the removal of foreign material and dead contaminated tissue from (or adjacent to) a traumatic or infected lesion to expose healthy tissue and removal of foreign material that has become embedded in the wound. The main reason for debriding a wound is to avoid substratum for bacterial growth, ongoing inflammation, and leukocyte infiltration with delayed progression to the proliferative and remodelling phases of wound healing, compromised restoration of the structure and function of the skin, odor management issues, and other negative effects. The objective of operative debridement is to remove all hyperkeratotic tissue (ie, callus), necrotic tissue, functionally abnormal senescent cells, and infected tissue, all of which inhibit wound healing. The International Working Group on the Diabetic Foot recommended the application of sharp/surgical debridement in preference to other techniques such as topical debridement agents (i.e., autolytic dressing or biological debridement) because it is the least expensive, fastest method of wound bed preparation and is available in all geographic areas.","PeriodicalId":7179,"journal":{"name":"Advanced Biomedicine","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84696198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Malnutrition in Patients Following Bariatric Surgery","authors":"Milad Kheirvari, Hamidreza Goudarzi, Mahsa Hemmatizadeh, Taha Anbara","doi":"10.54730/abm.2022.040301","DOIUrl":"https://doi.org/10.54730/abm.2022.040301","url":null,"abstract":"Background and Aims: Bariatric surgery is one of the efficient methods for losing weight in morbidly obese cases and it is associated with a risk of presenting some complications following bariatric surgery which depend on nutritional deficiencies. The main aim of this survey was to investigate the prevalence of preoperative and postoperative micronutrient deficiencies after bariatric surgery in the literatures. Methods: This is a review article that we collected all related articles published recently on bariatric surgery patients that experienced nutritional deficiency. Results: Preoperative monitoring of a combination of several nutritional deficits could be used to identify patients at risk and prevent the onset of deficiency and its consequences after bariatric surgery. Identification and correction of micronutrients deficiencies is essential for treating postoperative complications. Conclusions: To sum up, it is necessary to monitor nutrient status in bariatric surgery patients, which those deficiencies are easily preventable and treatable with proper supplementation and supervised interventions.","PeriodicalId":7179,"journal":{"name":"Advanced Biomedicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85941016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Count Under the Effect of Erythropoietin (EPO) in Patients with Chronic Hemodialysis","authors":"Elvedin Osmanović, Mersiha Cerkezovic, Almir Jagodic","doi":"10.54730/abm.2022.040210","DOIUrl":"https://doi.org/10.54730/abm.2022.040210","url":null,"abstract":"One of the most common associated diseases in dialysis patients is anemia. The number of erythrocytes, hemoglobin and hematocrit is reduced in patients that suffer from anemia. These three measurement parameters represent the most important \"red part\" of the blood count. Due to renal insufficiency, patients on hemodialysis do not have enough erythropoietin, which healthy kidneys excreted, and is necessary for hematopoiesis. Erythropoietin (EPO) is the main regulator of the daily production of red blood cells. EPO that is execrated by peritubular capillary membrane cells in the kidneys circulates within plasma in order to interact with target cells in the bone marrow to maintain or stimulate erythropoiesis. The main purpose of the action of EPO is the formation of erythroid colonies. During observation of differences in the ordination of EPO in each group between men and women, there is no statistical significance evident in the incidence of anemia before and after therapy, as in p=0.70. The target concentration of hemoglobin, which must be constantly maintained in people with chronic renal anemia, is 110-120 g/l, while the target value of the number of red blood cells is 4-5x10 12/l and the hematocrit value is 0.35-4.5 l/l, with a slight outflow depending on the gender of the patient. The final values of the participants in our study treated with epoetin alpha show higher values of hemoglobin, hematocrit and erythrocytes, while the average values recorded in participants treated with darbepoetin decreased.","PeriodicalId":7179,"journal":{"name":"Advanced Biomedicine","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85217253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of Liver Enzymes Abnormalities in Patients with SARS-CoV-2 Infection","authors":"Waseem F. Al Tameemi, Anas Habeeb Mohammed Matar Al","doi":"10.54730/abm.2022.040202","DOIUrl":"https://doi.org/10.54730/abm.2022.040202","url":null,"abstract":"Background: Liver function derangements have been reported in COVID-19, but reported rates are variable. Treatment in intensive care units (ICU) has become a major challenge; therefore, early recognition of severe and critical cases is absolutely essential for timely triaging of patients. Objectives: to review incidence of acute liver injury in patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Patients and methods: obtaining clinical records and laboratory results prospectively from one hundred patients with PCR-confirmed or radiography-confirmed COVID-19, who are admitted to the isolation wards and emergency departments of three different hospitals in Baghdad from 1st of December 2020 to 31st of March 2021. Results: The mean age group of study sample was (61.2±12.36) years, males formed 59%. GI manifestations were recorded in 47% of total cases, and were statistically correlated with disease severity (P value 0.001). Wide range of LFT abnormalities are found in patients with COVID-19, but none of which showed statistical significance in relation to disease severity. When LFT results were reviewed in relation to previous comorbidities, GGT was found to be statistically correlated with the underlying CLD (P value 0.001), and ALP with both underlying CLD and DM (P values <0.001 and 0.029, respectively) and even in the absence of underlying comorbidity (P value 0.006). Conclusion: Liver enzyme derangements are increasingly reported in patients with COVID-19, but are not necessarily correlate with disease severity. Cholestatic picture of liver enzyme derangement is a more commonly recorded manifestation.","PeriodicalId":7179,"journal":{"name":"Advanced Biomedicine","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89827505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Diseases During Systemic Inflammatory Diseases in the Internal Medicine and Medical Oncology Department of NTHC-HKM of Cotonou","authors":"Azon Kouanou Angèle, Wanvoegbè Finagnon Armand, Agbodandé Kouessi Anthelme, Saïzonou Saïzonou Franck, Ahmed Adama, A. Adébayo, Dovonou Comlan Albert, Zannou Djimon Marcel, Houngbé Fabien","doi":"10.54730/abm.2022.040209","DOIUrl":"https://doi.org/10.54730/abm.2022.040209","url":null,"abstract":"Systemic inflammatory diseases are characterized by multivisceral involvement at some point in their evolution. This involvement can concern almost all organs, including the heart. Each systemic condition has a unique cardiac expression. The target of this study is to determine the frequency of cardiac involvement in systemic inflammatory diseases. This study is a cross-sectional, descriptive, and analytical study that was conducted within 07 months. The aim was to screen 23 patients followed for systemic inflammatory diseases for cardiac involvement. The mean age was 44 (±12) years old with a minimum of 24 and a maximum 64 years. Most of patients were women with a sex ratio (M/F) of 0.09. An echocardiographic abnormality was found in 26.1% of patients and 73.1% had an ECG abnormality. They included left atrial hypertrophy (43.4%), left ventricular hypertrophy (30.4%), right axial deviation (26.1%), low voltage (21.7%), right atrial hypertrophy (8.6%), S1Q3 appearance (8, 6%), pulmonary hypertension (8.6%), repolarization disorders (8.6%), sinus tachycardia (8.6%), middle tricuspid insufficiency (4.3%), middle pulmonary insufficiency (4.3%), and pericarditis (4.3%). Patients with systemic inflammatory diseases had cardiac disorders with rare clinical manifestations but with an incidental discovery either on ECG or on cardiac echodoppler. Hence, a systematic cardiac exploration in these patients was essential.","PeriodicalId":7179,"journal":{"name":"Advanced Biomedicine","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73714913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Colorectal Cancer Rate in Turner Syndrome: A Case Control Study","authors":"Venkata Subhash Gorrepati, Djibril M. Ba, Guodong Liu, J. Levenick, T. Mcgarrity","doi":"10.54730/abm.2022.040208","DOIUrl":"https://doi.org/10.54730/abm.2022.040208","url":null,"abstract":"Female sex hormonal supplementation had been shown to be protective against Colorectal cancer (CRC). Turner syndrome (TS) is a rare X lined chromosomal disorder associated with sex hormonal deficiency. Hence, we hypothesized that that females with TS would be at an increased risk of CRC. From the Truven Health Marketscan Commercial Claims and Encounters Database, female patients who had colonoscopy with TS were compared to aged matched to controls. For these patients we obtained demographic variables, risk factors (diabetes, morbid obesity, smoking, use of non-steroidal anti-inflammatory drugs and statins) and endoscopic results (adenoma and cancer detection) from the database. Multivariate logistic regression analysis was performed to compare the cancer detection rates in both groups. Of the 7,77,36,681 patients of age 35 or older in the database 3265 had TS. Of those 546 (17%) patients had a colonoscopy that was reported. These patients were compared to 1059 age matched controls. Prevalence of diabetes (14.3 vs 8.4, P<0.001), and smoking (2.6 vs 0.9, p=0.01) was higher in patients with TS. Cancer detection rate was higher in patients with TS (1.1% vs 0.2%, p=0.01). After adjustment for the above variables, patients with TS have an adjusted odds ratio of 9.5 for CRC at any colonoscopy (95% CI 1.7-52.8, p =0.008). Hence, we concluded that in the studied cohort of TS patients there was a higher colorectal cancer detection rate at any colonoscopy when compared to their age matched female counterparts. TS patients represent a ‘disparity group’ who warrant enhanced CRC screening.","PeriodicalId":7179,"journal":{"name":"Advanced Biomedicine","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86214411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocomposite Polymer Scaffolds Responding under External Stimuli for Drug Delivery and Tissue Engineering Applications","authors":"A. Hébraud, G. Schlatter, J. Goetz, S. Harlepp, S. Bégin-Colin, D. Mertz","doi":"10.54730/abm.2022.040102","DOIUrl":"https://doi.org/10.54730/abm.2022.040102","url":null,"abstract":"The blossoming development of nanomaterials and polymer science has opened the way toward new biocompatible scaffolds responding remotely to external stimuli (magnetic field, light, electric field). Such smart scaffolds are envisioned as new implantable tissues displaying multiple therapeutic and imaging functionalities. They hold great promises to achieve a controlled delivery of therapeutics for various diseases, or to ensure a stimuli-induced cellular response for bone, cardiac, or muscle tissue engineering.","PeriodicalId":7179,"journal":{"name":"Advanced Biomedicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89088024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isoform-specific upregulation of FynT kinase expression is associated with tauopathy and glial activation in Alzheimer's disease and Lewy body dementias","authors":"Michelle G. K. Tan, Mitchell K. P. Lai, Paul T. Francis, C. Ballard, Chingli Lee, Frances T. W. Lim, Jasinda H. Lee, Clara Y. B. Low","doi":"10.54730/abm.2022.040105","DOIUrl":"https://doi.org/10.54730/abm.2022.040105","url":null,"abstract":"Cumulative data suggest the involvement of Fyn tyrosine kinase in Alzheimer's disease (AD). Previously, our group has shown increased immunoreactivities of the FynT isoform in AD neocortex (with no change in the alternatively spliced FynB isoform) which associated with neurofibrillary degeneration and reac-tive astrogliosis. Since both the aforementioned neuropathological features are also variably found in Lewy Body dementias (LBD), we investigated potential perturbations of Fyn expression in the post-mortem neocortex of patients with AD, as well as those diagnosed as having one of the two main subgroups of LBD: Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB). We found selective upregulation of FynT expression in AD, PDD, and DLB which also correlated with cognitive impairment. Furthermore, increased FynT expression correlated with hallmark neuropathological lesions, soluble β-amyloid, and phosphorylated tau, as well as markers of microglia and as-trocyte activation. In line with the human post-mortem studies, cortical FynT expression in aged mice transgenic for human P301S tau was upregulated and further correlated with accumulation of aggregated phosphorylated tau as well as with microglial and astrocytic markers. Our findings provide further evi-dence for the involvement of FynT in neurodegenerative dementias, likely via effects on tauopathy and neuroinflammation.","PeriodicalId":7179,"journal":{"name":"Advanced Biomedicine","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81154319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Insight into ACE2 Expression Associated Complexities of COVID-19 and the Possible Vaccine Strategies to Control Viral Entry into Host Cells","authors":"Hasan Mahmud Syfuddin, Khandaker Atkia Fariha","doi":"10.54730/abm.2021.030603","DOIUrl":"https://doi.org/10.54730/abm.2021.030603","url":null,"abstract":"The first detected COVID-19 virus in China in late December 2019, has now spread to over 200 countries and territories across the globe. As it is a novel virus, in course of time, new symptoms and new complexities in patients have arisen, which demand immediate attention. This ambiguous, fast mutating nature and strain variations of SARS CoV2 have hindered the way of vaccine development. However, recognizing this new virus as a member of coronavidae family and its similarity with previously prevailed SARS-Cov virus has advantages in order for its further characterization and identification of the route of entry. Hence, this review aims at providing an overview of the viral entry pathway and explaining the reasons behind the vulnerability of an individual based on his/her age, sex, weight, other existing diseases and genetic make-up. It will also try to explicate various newly emerged symptoms of COVID-19 from the perspective of cytokinin storm theory. Furthermore, it summarizes all the therapeutic strategies based on preventing virus entry, some of which are already developed or under trial or yet confined in theory using currently published literature, scientific reports and research articles about SARS-CoV2. This review will help better understand the COVID-19 complicacies with latest concepts on therapeutic strategies against SARS-CoV2.","PeriodicalId":7179,"journal":{"name":"Advanced Biomedicine","volume":"156 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77781287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Reinfection in 60-Year-Old Man with Diabetes Mellitus, East Nusa Tenggara, Indonesia","authors":"Heri Sutrisno Prijopranoto, Albert William Hotomo","doi":"10.54730/abm.2021.030601","DOIUrl":"https://doi.org/10.54730/abm.2021.030601","url":null,"abstract":"Coronavirus Disease 2019 (COVID-19) is an infectious disease which is caused by a new strain of coronavirus. Older individuals and people with comorbidities have a higher risk to develop more severe illness. COVID-19 survivors will have active immunity in conjunction with increase of SARS-CoV-2 antibody (Ab) titer 2-weeks after the symptoms onset and will be lasted until 12-weeks. Therefore, it will give protection against reinfection of COVID-19. This study reports a case of COVID-19 rapid reinfection in sixty-year-old man with diabetes mellitus. Case illustration: a sixty-year-old man presented to the emergency department with fever accompanied by cough, runny nose, malaise, and metallic taste since one day before admission to hospital. There was a history of uncontrolled diabetes mellitus (DM) and COVID-19 infection 35-days before hospital admission without any symptoms. The current physical examinations demonstrated a mild dyspnea with oxygen saturation 97%, and diffuse rhonchi at the right area of chest auscultation. Chest X-ray discovered a multiple consolidation of the right lung, with suspicion of viral pneumonia. Fasting blood glucose (FBG) was 205 mg/dl, and 2-hour postprandial glucose was 508 mg/dl. The polymerase chain reaction (PCR) of SARS-CoV-2 via nasopharyngeal swab was taken and the result was positive. COVID-19 Ab titers IgM and IgG were 0.18 U/ml and 0.43 U/ml (<0.8 U/ml → non-reactive), respectively. The patient was diagnosed with COVID-19 reinfection and DM. The patient was treated with convalescent plasma, antivirus, antibiotics, insulin, steroid, anticoagulant, and other symptomatic medications. As the results, a well improvement of his clinical condition and the increase of Ab COVID-19 IgM and IgG evaluation test after convalescent plasma administration, 0.28 AU/ml and 17.67 AU/ml, respectively, were recorded. Summary: Researches revealed that DM might cause the specific immunity system dysfunction and the low production of antibody. This study found that poor blood-glucose control with a low Ab of SARS-CoV-2 production might induce this patient to have a COVID-19 reinfection. Advance immunological study about the correlation between DM and COVID-19 is very essential in the management of COVID-19 patients with DM.","PeriodicalId":7179,"journal":{"name":"Advanced Biomedicine","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87022372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}